Poster Abstract: Interconnecting Low-Power Wireless and Power-Line Communications using IPv6

Wireless sensor networks for building automation and energy management has made great progress in recent years, but the inherent indoor radio range limitations can make communication unpredictable and system deployments difficult. Low-power radio can be combined with low-power Power-Line Communication (PLC) to extend the range and predictability of indoor communication for building management and automation systems. We take the first steps towards exploring the system implications for integration of low-power wireless and PLC in the same network. We leverage IPv6, which allow networks to exist over multiple physical communication media as well as the RPL routing protocol for low-power lossy networks

BCL-2 Inhibitor ABT-737 effectively targets leukemia-initiating cells with differential regulation of relevant genes leading to extended survival in a NRAS/BCL-2 mouse model of high risk-myelodysplastic syndrome

During transformation, myelodysplastic syndromes (MDS) are characterized by reducing apoptosis of bone marrow (BM) precursors. Mouse models of high risk (HR)-MDS and acute myelogenous leukemia (AML) post-MDS using mutant NRAS and overexpression of human BCL-2, known to be poor prognostic indicators of the human diseases, were created. We have reported the efficacy of the BCL-2 inhibitor, ABT-737, on the AML post-MDS model; here, we report that this BCL-2 inhibitor also significantly extended survival of the HR-MDS mouse model, with reductions of BM blasts and lineage negative/Sca1+/KIT+ (LSK) cells. Secondary transplants showed increased survival in treated compared to untreated mice. Unlike the AML model, BCL-2 expression and RAS activity decreased following treatment and the RAS:BCL-2 complex remained in the plasma membrane. Exon-specific gene expression profiling (GEP) of HR-MDS mice showed 1952 differentially regulated genes upon treatment, including genes important for the regulation of stem cells, differentiation, proliferation, oxidative phosphorylation, mitochondrial function, and apoptosis; relevant in human disease. Spliceosome genes, found to be abnormal in MDS patients and downregulated in our HR-MDS model, such as Rsrc1 and Wbp4, were upregulated by the treatment, as were genes involved in epigenetic regulation, such as DNMT3A and B, upregulated upon disease progression and downregulated upon treatment

Euclid Near Infrared Spectrometer and Photometer instrument concept and first test results obtained for different breadboards models at the end of phase C

The Euclid mission objective is to understand why the expansion of the Universe is accelerating through by mapping the geometry of the dark Universe by investigating the distance-redshift relationship and tracing the evolution of cosmic structures. The Euclid project is part of ESA's Cosmic Vision program with its launch planned for 2020 (ref [1]). The NISP (Near Infrared Spectrometer and Photometer) is one of the two Euclid instruments and is operating in the near-IR spectral region (900- 2000nm) as a photometer and spectrometer. The instrument is composed of: - a cold (135K) optomechanical subsystem consisting of a Silicon carbide structure, an optical assembly (corrector and camera lens), a filter wheel mechanism, a grism wheel mechanism, a calibration unit and a thermal control system - a detection subsystem based on a mosaic of 16 HAWAII2RG cooled to 95K with their front-end readout electronic cooled to 140K, integrated on a mechanical focal plane structure made with molybdenum and aluminum. The detection subsystem is mounted on the optomechanical subsystem structure - a warm electronic subsystem (280K) composed of a data processing / detector control unit and of an instrument control unit that interfaces with the spacecraft via a 1553 bus for command and control and via Spacewire links for science data This presentation describes the architecture of the instrument at the end of the phase C (Detailed Design Review), the expected performance, the technological key challenges and preliminary test results obtained for different NISP subsystem breadboards and for the NISP Structural and Thermal model (STM)

A 22 GHz mobile microwave radiometer for the study of stratospheric water vapour

We present a new compact and automated ground- based microwave mobile radiometer dedicated to the study of middle atmospheric water vapor, which is convenient for measurement, intercomparison, and validation campaigns, particularly in remote places. The instrument detects the 616-523 H2O transition line at 22.235 GHz by means of balanced beam-switching observation of the atmosphere. Tipping curves are performed to estimate the tropospheric opacity. The sky is used as a cold load for calibration, minimizing the use of liquid nitrogen. The main technical issues are caused by the small horn antenna (a beamwidth of ~12deg) inducing large bias when using pencil- beam approximation for the calculation of elevation-dependent parameters. Numerical methods have been developed to include this effect in the data calibration process. Preliminary vertical profiles are retrieved with the Microwave Odin Line Estimation and REtrieval radiative transfer and inversion tool from 25 to 55 km with a vertical resolution of 10-20 km increasing with height, for an integration time of ~12 h and a measurement error of ~15% (~0.8 ppmv). Preliminary comparisons with the spaceborne instrument Aura/Microwave Limb Sounder show a good agreement (~5%) in the 35-55-km altitude range, whereas a negative bias is detected below (up to -30% at 25 km)

Poster Abstract: Interconnecting Low-Power Wireless and Power-Line Communications using IPv6

Abstract Wireless sensor networks for building automation and energy management has made great progress in recent years, but the inherent indoor radio range limitations can make communication unpredictable and system deployments difficult. Low-power radio can be combined with low-power Power-Line Communication (PLC) to extend the range and predictability of indoor communication for building management and automation systems. We take the first steps towards exploring the system implications for integration of low-power wireless and PLC in the same network. We leverage IPv6, which allow networks to exist over multiple physical communication media as well as the RPL routing protocol for low-power lossy networks

Measurement of the production cross section for a W boson in association with a charm quark in proton-proton collisions at s\sqrt{s} = 13 TeV

International audienceThe strange quark content of the proton is probed through the measurement of the production cross section for a W boson and a charm (c) quark in proton-proton collisions at a center-of-mass energy of 13 TeV. The analysis uses a data sample corresponding to a total integrated luminosity of 138 fb$^{-1}$ collected with the CMS detector at the LHC. The W bosons are identified through their leptonic decays to an electron or a muon, and a neutrino. Charm jets are tagged using the presence of a muon or a secondary vertex inside the jet. The W+c production cross section and the cross section ratio $R^\pm_\text{c}$ = $\sigma$(W$^+$+$\bar{\text{c}}$)/$\sigma$(W$^-$+$\text{c}$) are measured inclusively and differentially as functions of the transverse momentum and the pseudorapidity of the lepton originating from the W boson decay. The precision of the measurements is improved with respect to previous studies, reaching 1% in $R^\pm_\text{c}$. The measurements are compared with theoretical predictions up to next-to-next-to-leading order in perturbative quantum chromodynamics

Measurement of the production cross section for a W boson in association with a charm quark in proton-proton collisions at s\sqrt{s} = 13 TeV

The strange quark content of the proton is probed through the measurement of the production cross section for a W boson and a charm (c) quark in proton-proton collisions at a center-of-mass energy of 13 TeV. The analysis uses a data sample corresponding to a total integrated luminosity of 138 fb$^{-1}$ collected with the CMS detector at the LHC. The W bosons are identified through their leptonic decays to an electron or a muon, and a neutrino. Charm jets are tagged using the presence of a muon or a secondary vertex inside the jet. The W+c production cross section and the cross section ratio $R^\pm_\text{c}$ = $\sigma$(W$^+$+$\bar{\text{c}}$)/$\sigma$(W$^-$+$\text{c}$) are measured inclusively and differentially as functions of the transverse momentum and the pseudorapidity of the lepton originating from the W boson decay. The precision of the measurements is improved with respect to previous studies, reaching 1% in $R^\pm_\text{c}$. The measurements are compared with theoretical predictions up to next-to-next-to-leading order in perturbative quantum chromodynamics

Measurement of the production cross section for a W boson in association with a charm quark in proton-proton collisions at s\sqrt{s} = 13 TeV

International audienceThe strange quark content of the proton is probed through the measurement of the production cross section for a W boson and a charm (c) quark in proton-proton collisions at a center-of-mass energy of 13 TeV. The analysis uses a data sample corresponding to a total integrated luminosity of 138 fb$^{-1}$ collected with the CMS detector at the LHC. The W bosons are identified through their leptonic decays to an electron or a muon, and a neutrino. Charm jets are tagged using the presence of a muon or a secondary vertex inside the jet. The W+c production cross section and the cross section ratio $R^\pm_\text{c}$ = $\sigma$(W$^+$+$\bar{\text{c}}$)/$\sigma$(W$^-$+$\text{c}$) are measured inclusively and differentially as functions of the transverse momentum and the pseudorapidity of the lepton originating from the W boson decay. The precision of the measurements is improved with respect to previous studies, reaching 1% in $R^\pm_\text{c}$. The measurements are compared with theoretical predictions up to next-to-next-to-leading order in perturbative quantum chromodynamics

Measurement of the production cross section for a W boson in association with a charm quark in proton-proton collisions at s\sqrt{s} = 13 TeV

International audienceThe strange quark content of the proton is probed through the measurement of the production cross section for a W boson and a charm (c) quark in proton-proton collisions at a center-of-mass energy of 13 TeV. The analysis uses a data sample corresponding to a total integrated luminosity of 138 fb$^{-1}$ collected with the CMS detector at the LHC. The W bosons are identified through their leptonic decays to an electron or a muon, and a neutrino. Charm jets are tagged using the presence of a muon or a secondary vertex inside the jet. The W+c production cross section and the cross section ratio $R^\pm_\text{c}$ = $\sigma$(W$^+$+$\bar{\text{c}}$)/$\sigma$(W$^-$+$\text{c}$) are measured inclusively and differentially as functions of the transverse momentum and the pseudorapidity of the lepton originating from the W boson decay. The precision of the measurements is improved with respect to previous studies, reaching 1% in $R^\pm_\text{c}$. The measurements are compared with theoretical predictions up to next-to-next-to-leading order in perturbative quantum chromodynamics