9 research outputs found
Genomewide comparison and novel ncRNAs of Aquificales
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Background The Aquificales are a diverse group of thermophilic bacteria that thrive in terrestrial and marine hydrothermal environments. They can be divided into the families Aquificaceae, Desulfurobacteriaceae and Hydrogenothermaceae. Although eleven fully sequenced and assembled genomes are available, only little is known about this taxonomic order in terms of RNA metabolism. Results In this work, we compare the available genomes, extend their protein annotation, identify regulatory sequences, annotate non-coding RNAs (ncRNAs) of known function, predict novel ncRNA candidates, show idiosyncrasies of the genetic decoding machinery, present two different types of transfer-messenger RNAs and variations of the CRISPR systems. Furthermore, we performed a phylogenetic analysis of the Aquificales based on entire genome sequences, and extended this by a classification among all bacteria using 16S rRNA sequences and a set of orthologous proteins. Combining severalin silicofeatures (e.g. conserved and stable secondary structures, GC-content, comparison based on multiple genome alignments) with an in vivo dRNA-seq transcriptome analysis of Aquifex aeolicus, we predict roughly 100 novel ncRNA candidates in this bacterium. Conclusions We have here re-analyzed the Aquificales, a group of bacteria thriving in extreme environments, sharing the feature of a small, compact genome with a reduced number of protein and ncRNA genes. We present several classical ncRNAs and riboswitch candidates. By combining in silico analysis with dRNA-seq data of A. aeolicus we predict nearly 100 novel ncRNA candidates
Minimal and RNA-free RNase P in Aquifex aeolicus
- Author
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- Field of study
Crossed beaks in a local Swiss chicken breed
- Author
- AF Pourlis
- AL Blankenship
- Alois von Rotz
- Astrid Spiri
- B Doneley
- B Gartrell
- BL Chen
- BP Tangredi
- C Clabaut
- C Hemert Van
- Christine Flury
- CM Handel
- CM Handel
- Cord Drögemüller
- CW Benkman
- Daniela Schweizer-Gorgas
- DE Pomeroy
- DH Clayton
- EJ Temeles
- Erwin Kump
- F Al-Qudsi
- F Lindner
- F Smith
- F-V Salomon
- FG Wouterlood
- Flurina Bertschinger
- G Vezzoli
- H Bai
- H Bai
- I Robertson
- J Schräpel
- JA Craves
- M Tsudzuki
- P Macwhirter
- P Stettenheim
- PT Boag
- R Nickel
- RG Cooper
- S Gfeller
- S Purcell
- Sara Joller
- TH Galligan
- W Landauer
- W Landauer
- WA Landauer
- WA Threlfall
- Y Benjamini
- YS Aulchenko
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Comparison of computed tomography and high-field (3.0 T) magnetic resonance imaging of age-related variances in selected equine maxillary cheek teeth and adjacent tissues
- Author
- A Arencibia
- A Bienert
- A Krasny
- Astrid Bienert-Zeit
- AT Assaf
- B Kress
- Bernhard Ohnesorge
- C Gaudino
- C Nasel
- C Staszyk
- C Staszyk
- CD Torneck
- Christin Schoppe
- CW Newton
- D Idiyatullin
- D Weishaupt
- DD Barbee
- DJ Hillmann
- DJ Shaw
- EM Merkle
- G Katti
- G Manso-Díaz
- GJ Baker
- GJ Baker
- GM Johnston
- H Gasse
- I Dacre
- I Dacre
- IT Dacre
- IT Dacre
- J Kaminsky
- K Gerlach
- K Gerlach
- K Gerlach
- K Gerlach
- K Orhan
- K Syngcuk
- Karl Rohn
- KD Budras
- KD Kirkland
- KM Dyce
- M Brinkschulte
- M Bühler
- M Floyd
- M Geibel
- Maren Hellige
- MB Casey
- MP Moore
- N Illenberger
- O Tymofiyeva
- PM Dixon
- PM Dixon
- R Fuhrmann
- R Nickel
- R Ordinola-Zapata
- RL Tucker
- RW Waguespack
- S Kopke
- S Veraa
- S Şener
- SL Kraft
- T Lundström
- U Hirschfelder
- V Cordes
- W Henninger
- WF Gilsenan
- WH Tremaine
- Z Windley
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
LifeTime and improving European healthcare through cell-based interceptive medicine
- Author
- Aerts S. (Stein)
- Alberi L. (Lavinia)
- Alexander S. (Stephanie)
- Alexandrov T. (Theodore)
- Almouzni G. (Geneviève)
- Amit I. (Ido)
- Arenas E. (Ernest)
- Bagni C. (Claudia)
- Balderas R. (Robert)
- Bandelli A. (Andrea)
- Becher B. (Burkhard)
- Becker M. (Matthias)
- Beerenwinkel N. (Niko)
- Benkirame M. (Monsef)
- Bertero M.G. (Michela G.)
- Beusekom H.M.M. (Heleen) van
- Beyer M. (Marc)
- Bickmore W. (Wendy)
- Biessen E.E.A.L. (Erik E.A.L.)
- Blomberg N. (Niklas)
- Blumcke I. (Ingmar)
- Bock C. (Christoph)
- Bodenmiller B. (Bernd)
- Borroni B. (Barbara)
- Boumpas D.T. (Dimitrios T.)
- Bourgeron T. (Thomas)
- Bowers S. (Sarion)
- Braeken D. (Dries)
- Bredenoord A.L. (Annelien L.)
- Brooksbank C. (Catherine)
- Brose N. (Nils)
- Bruining J. (Hans)
- Bury J. (Jo)
- Caporale N. (Nicolo)
- Cattoretti G. (Giorgio)
- Cavalli G. (Giacomo)
- Chabane N. (Nadia)
- Chiocca S. (Susanna)
- Chneiweiss H. (Hervé)
- Clevers H.C. (Hans)
- Cook S.A. (Stuart A.)
- Curatolo P. (Paolo)
- De Strooper B. (Bart)
- de Witte P. (Peter)
- den Hoecke S.V. (Silvie Van)
- Deplancke B. (Bart)
- der Ven A. (Andre van)
- Dimmeler S. (Stefanie)
- Draganski B. (Bogdan)
- Drews A.-D. (Anna-Dorothee)
- Dumbrava C. (Costica)
- Eggert A. (Angelika)
- Ellenberg J. (Jan)
- Engelhardt S. (Stefan)
- Fernández X.M. (Xosé M.)
- Figlerowicz M. (Marek)
- Gasser S.M. (Susan M.)
- Gasser T. (Thomas)
- Giamarellos-Bourboulis E. (Evangelos)
- Gorski S.A. (Stanislaw A.)
- Graff C. (Caroline)
- Grün D. (Dominic)
- Gut I. (Ivo)
- Hansson O. (Oskar)
- Henshall D.C. (David C.)
- Herland A. (Anna)
- Heutink P. (Peter)
- Heymans S. (Stephane)
- Heyn H. (Holger)
- Huch M. (Meritxell)
- Huitinga I. (Inge)
- Hübner N. (Norbert)
- Jackowiak P. (Paulina)
- Jonge M.I. (Marien) de
- Jongsma K.R. (Karin)
- Journot L. (Laurent)
- Junker J.P. (Jan Philipp)
- Kalle C. (Christof) von
- Katz S. (Shauna)
- Kehren J. (Jeanne)
- Kempa S. (Stefan)
- Kirchhof P. (Paulus)
- Kjems J. (Jørgen)
- Klein C. (Christoph)
- Knoblich J.A. (Jürgen A.)
- Koralewska N. (Natalia)
- Korbel J.O. (Jan)
- Krabbe G. (Grietje)
- Kühnemund M. (Malte)
- Lamond A.I. (Angus I.)
- Lauwers E. (Elsa)
- Le Ber I. (Isabelle)
- Leinonen V. (Ville)
- Lichter P. (Peter)
- Linnarsson S. (Sten)
- Lundberg E. (Emma)
- Lunkes A. (Astrid)
- Maatz H. (Henrike)
- Mann M. (Mathias)
- Marelli L. (Luca)
- Marine J.-C. (J.)
- Marioni J. (John)
- Marti-Renom M.A. (Marc A.)
- Matser V. (Vera)
- Matthews P.M. (P.)
- Mechta-Grigoriou F. (Fatima)
- Menon R. (Radhika)
- Netea M.G. (Mihai)
- Nickel D. (Dörthe)
- Nielsen A.F. (Anne F.)
- Nollmann M. (Marcelo)
- Novak H.R. (Halina R.)
- Pagani M. (Massimiliano)
- Parkinson H. (Helen)
- Pasterkamp R.J. (Jeroen)
- Piccolo S. (Stefano)
- Pinheiro I. (Inês)
- Pitkanen A. (Asla)
- Pombo A. (Ana)
- Popescu V. (Valentin)
- Popp C. (Christian)
- Pottier C. (Cyril)
- Puisieux A. (Alain)
- Rademakers R. (Rosa)
- Rajewsky N. (Nikolaus)
- Reik W. (Wolf)
- Reiling D. (Dory)
- Reiner O. (Orly)
- Remondini D. (Daniel)
- Ritchie C. (Craig)
- Rohrer J.D. (Jonathan D.)
- Roman-Roman S. (Sergio)
- Rosenstiel P. (Philip)
- Saliba A.-E. (Antione-Emmanuel)
- Santosuosso A. (Amedeo)
- Sauter A. (Arnold)
- Scheltema R.A. (Richard A.)
- Scheltens P. (Philip)
- Schiller H.B. (Herbert B.)
- Schneider A. (Anja)
- Schultze J.L. (Joachim)
- Seibler P. (Philip)
- Sheehan-Rooney K. (Kelly)
- Shields D. (David)
- Sleegers K. (Kristel)
- Smit G. (Guus)
- Smith K.G.C. (Kenneth G. C.)
- Smolders I. (Ilse)
- Stegle O. (Oliver)
- Strooper B. (Bart) de
- Swieten J.C. (John) van
- Synofzik M. (Matthis)
- Sánchez-Valle R. (Raquel)
- Tam W.L. (Wai Long)
- Tanay A. (Amos)
- Teichmann S. (Sarah)
- Testa G. (Giuseppe)
- Thanos D. (Dimitris)
- Theis F. (Fabian)
- Thom M. (Maria)
- Tobon A.L. (Alejandro Lopez)
- Torres-Padilla M.-E. (Maria-Elena)
- Turco M.Y. (Margherita Y.)
- Valencia A. (Alfonso)
- Vallot C. (Céline)
- Van de Poel E. (Ellen)
- van der Zee J. (Julie)
- van Lunzen J. (Jan)
- van Minnebruggen G. (Geert)
- van Oudenaarden A. (Alexander)
- van Oudenaarden A. (Alexander)
- Van Paesschen W. (Wim)
- van Vught R. (Remko)
- Vandenberghe R. (Rik)
- Verhage M. (Matthijs)
- Verstreken P. (Patrik)
- Vidal M. (Marie)
- Villa C.E. (Carlo Emanuele)
- Voet T. (Thierry)
- Vogel J. (Jörg)
- Walter J. (Jörn)
- Weckhuysen S. (Sarah)
- Weichert W. (Wilko)
- Wood L. (Louisa)
- Ziegler A.-G. (Anette-Gabriele)
- Zipp F. (Frauke)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
LifeTime aims to track, understand and target human cells during the onset and progression of complex diseases and their response to therapy at single-cell resolution. This mission will be implemented through the development and integration of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during progression from health to disease. Analysis of such large molecular and clinical datasets will discover molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. Timely detection and interception of disease embedded in an ethical and patient-centered vision will be achieved through interactions across academia, hospitals, patient-associations, health data management systems and industry. Applying this strategy to key medical challenges in cancer, neurological, infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.We would like to acknowledge all participants that have attended and contributed to LifeTime meetings and workshops through many exciting presentations and discussions. We thank Johannes Richers for artwork. LifeTime has received funding from the European Unionʼs Horizon 2020 research and innovation framework programme under Grant agreement 820431
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LifeTime and improving European healthcare through cell-based interceptive medicine
- Author
- Aerts Stein
- Alberi Lavinia
- Alberi Lavinia
- Alexander Stephanie
- Alexander Stephanie
- Alexandrov Theodore
- Alexandrov Theodore
- Almouzni Geneviève
- Amit Ido
- Arenas Ernest
- Arenas Ernest
- Bagni Claudia
- Bagni Claudia
- Balderas Robert
- Balderas Robert
- Bandelli Andrea
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- Becher Burkhard
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- Becker Matthias
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- Beerenwinkel Niko
- Beerenwinkel Niko
- Benkirame Monsef
- Benkirane Monsef
- Ber Isabelle Le
- Bertero Michela, G
- Beusekom Heleen M. M. Van
- Beyer Marc
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- Bickmore Wendy
- Bickmore Wendy A.
- Biessen Erik E. A. L.
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- Blomberg Niklas
- Blomberg Niklas
- Blumcke Ingmar
- Blumcke Ingmar
- Bock Christoph
- Bodenmiller Bernd
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- Borroni Barbara
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- Boumpas Dimitrios T.
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- Bowers Sarion
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- Braeken Dries
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- Brose Nils
- Brose Nils
- Bruining Hilgo
- Bruining Hilgo
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- Cattoretti Giorgio
- Cattoretti Giorgio
- Cavalli Giacomo
- Chabane Nadia
- Chabane Nadia
- Chiocca Susanna
- Chneiweiss Hervé
- Chneiweiss Hervé
- Clevers Hans
- Cook Stuart A.
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- Curatolo Paolo
- de Jonge Marien, I
- de Strooper Bart
- de Strooper Bart
- de Witte Peter
- Deplancke Bart
- Deplancke Bart
- Dimmeler Stefanie
- Dimmeler Stefanie
- Draganski Bogdan
- Draganski Bogdan
- Drews Anna
- Drews Anna
- Dumbrava Costica
- Dumbrava Costica
- Eggert Angelika
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- Giamarellos-Bourboulis Evangelos J.
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- Gut Ivo G.
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- Sheehan-Rooney Kelly
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- Shields David
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- Sleegers Kristel
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- Smit August B.
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- Synofzik Matthis
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- Tam Wai Long
- Tam Wai, Long
- Tanay Amos
- Teichmann Sarah
- Teichmann Sarah A.
- Testa Giuseppe
- Thanos Dimitris
- Theis Fabian, J
- Thom Maria
- Thom Maria
- Tobon Alejandro, Lopez
- Torres-Padilla Maria-Elena
- Turco Margherita Y.
- Turco Margherita, Y
- Valencia Alfonso
- Vallot Céline
- van Beusekom Heleen, M M
- van de Poel Ibo
- van den Hoecke Silvie
- van der Ven Andre
- van der Zee Julie
- van Lunzen Jan
- van Minnebruggen Geert
- van Oudenaarden Alexander
- van Oudenaarden Alexander
- van Paesschen Wim
- van Swieten John
- van Vught Remko
- Vandenberghe Rik
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- Ven Andre van Der
- Verhage Matthijs
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- Verstreken Patrik
- Verstreken Patrik
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- Villa Carlo Emanuele
- Villa Carlo, Emanuele
- Voet Thierry
- Vogel Jörg
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- von Kalle Christof
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- Ziegler Anette-Gabriele
- Ziegler Anette-Gabriele
- Zipp Frauke
- Zipp Frauke
- Publication venue
- Nature Publishing Group
- Publication date
- 07/09/2020
- Field of study
AUTEURS : LifeTime Community Working GroupsInternational audienceHere we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and clinical datasets will identify molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. The timely detection and interception of disease embedded in an ethical and patient-centred vision will be achieved through interactions across academia, hospitals, patient associations, health data management systems and industry. The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade
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- International Educational Exchange
- Islam Iyanatul
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