Catalyzing Collaboration: The Developing Infrastructure for Federal Public Private Partnerships

There is growing interest on the part of government, philanthropy and business to work together to achieve greater impact. Partnerships that span the sectors have the potential to achieve more than any sector can achieve on its own by leveraging the strengths of each. However, such partnerships also give rise to added costs and entail greater risks. To address these challenges, offices of strategic partnerships are emerging at the federal level to provide an infrastructure to catalyze cross-sectoral partnerships. This report examines 21 such offices in federal departments and agencies whose purpose is to facilitate and accelerate partnerships with philanthropy and business -- ranging from the Department of Housing and Urban Development and the Department of Education, to the Department of State and the Agency for International Development, to the Department of Homeland Security and the Federal Emergency Management Agency. The formation of these offices has been driven by champions within government -- many with prior experience in philanthropy or business -- that have witnessed the power of working collaboratively with other sectors. Their actions have often been reinforced by executive orders and other directives conducive to their growth. In the case of those offices that have been created in the last few years, they have also been encouraged by the examples of their more established counterparts

Offices of Strategic Partnerships: Helping Philanthropy and Government Work Better Together

· There is a growing interest on the part of philanthropy and government in working together to address problems of common interest. But crosssectoral collaborations are not easy. In response, a new organizational structure – the office of strategic partnerships – is emerging that catalyzes, fosters, and accelerates such partnerships. · These offices help to overcome the barriers of working across sectors by sharing knowledge and information about the sectors, identifying and convening stakeholders to discuss shared solutions, and leveraging resources to support public-problem solving. · Based on interviews and a convening of principals of six of these offices at the city, state, and federal levels, this article1 examines the lessons for making these offices successful in facilitating government-philanthropic partnerships. · In particular, it focuses on the need to determine appropriate roles and expectations, match philanthropic and government interests, find and field the right leadership, and build a record of success that encourages the sustainability of these offices

CIRCE: Coordinated Ionospheric Reconstruction Cubesat Experiment

The Coordinated Ionospheric Reconstruction Cubesat Experiment (CIRCE) is a collaborative space mission between the UK Defence Science and Technology Laboratory (Dstl), and the US Naval Research Laboratory (NRL) in developing small satellite ionospheric physics capability. CIRCE will characterise space weather effects on a regional scale in the ionosphere/thermosphere system. Properly characterising the dynamic ionosphere is important for a wide range of both civil and defence applications such as GPS, communications, and sensing technology. Consisting of two near-identical 6U (2x3U) CubeSat buses, the CIRCE nanosatellites will fly in a lead-follow tandem configuration in co-planar near-polar orbits at 500km altitude. Provided by Blue Canyon Technologies (BCT), the two buses will use differential drag to achieve and maintain an in-track separation of between 250 and 500km, allowing short time-scale dynamics to be observed in-situ. These nanosatellites each carry a complement of 5 individual scientific instruments, contributed from academic, industrial, and government partners across the UK and US. Scheduled to launch in 2021 via the US Department of Defence Space Test Program, the two CIRCE satellites will provide observations to enable a greater understanding of the driving processes of geophysical phenomena in the ionosphere/thermosphere system, distributed across a wide range of latitudes, and altitudes, as the mission progresses

Climate warming, marine protected areas and the ocean-scale integrity of coral reef ecosystems

Coral reefs have emerged as one of the ecosystems most vulnerable to climate variation and change. While the contribution of a warming climate to the loss of live coral cover has been well documented across large spatial and temporal scales, the associated effects on fish have not. Here, we respond to recent and repeated calls to assess the importance of local management in conserving coral reefs in the context of global climate change. Such information is important, as coral reef fish assemblages are the most species dense vertebrate communities on earth, contributing critical ecosystem functions and providing crucial ecosystem services to human societies in tropical countries. Our assessment of the impacts of the 1998 mass bleaching event on coral cover, reef structural complexity, and reef associated fishes spans 7 countries, 66 sites and 26 degrees of latitude in the Indian Ocean. Using Bayesian meta-analysis we show that changes in the size structure, diversity and trophic composition of the reef fish community have followed coral declines. Although the ocean scale integrity of these coral reef ecosystems has been lost, it is positive to see the effects are spatially variable at multiple scales, with impacts and vulnerability affected by geography but not management regime. Existing no-take marine protected areas still support high biomass of fish, however they had no positive affect on the ecosystem response to large-scale disturbance. This suggests a need for future conservation and management efforts to identify and protect regional refugia, which should be integrated into existing management frameworks and combined with policies to improve system-wide resilience to climate variation and change

Understanding the origin and impact of relativistic cosmic particles with very-high-energy gamma-rays

This white paper briefly summarizes the importance of the study of relativistic cosmic rays, both as a constituent of our Universe, and through their impact on stellar and galactic evolution. The focus is on what can be learned over the coming decade through ground-based gamma-ray observations over the 20 GeV to 300 TeV range

Associations with photoreceptor thickness measures in the UK Biobank.

Spectral-domain OCT (SD-OCT) provides high resolution images enabling identification of individual retinal layers. We included 32,923 participants aged 40-69 years old from UK Biobank. Questionnaires, physical examination, and eye examination including SD-OCT imaging were performed. SD OCT measured photoreceptor layer thickness includes photoreceptor layer thickness: inner nuclear layer-retinal pigment epithelium (INL-RPE) and the specific sublayers of the photoreceptor: inner nuclear layer-external limiting membrane (INL-ELM); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (ISOS-RPE). In multivariate regression models, the total average INL-RPE was observed to be thinner in older aged, females, Black ethnicity, smokers, participants with higher systolic blood pressure, more negative refractive error, lower IOPcc and lower corneal hysteresis. The overall INL-ELM, ELM-ISOS and ISOS-RPE thickness was significantly associated with sex and race. Total average of INL-ELM thickness was additionally associated with age and refractive error, while ELM-ISOS was additionally associated with age, smoking status, SBP and refractive error; and ISOS-RPE was additionally associated with smoking status, IOPcc and corneal hysteresis. Hence, we found novel associations of ethnicity, smoking, systolic blood pressure, refraction, IOPcc and corneal hysteresis with photoreceptor thickness

Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure

We previously established that global deletion of the enhancer of trithorax and polycomb (ETP) gene, Asxl2, prevents weight gain. Because proinflammatory macrophages recruited to adipose tissue are central to the metabolic complications of obesity, we explored the role of ASXL2 in myeloid lineage cells. Unexpectedly, mice without Asxl2 only in myeloid cells (Asxl2ΔLysM) were completely resistant to diet-induced weight gain and metabolically normal despite increased food intake, comparable activity, and equivalent fecal fat. Asxl2ΔLysM mice resisted HFD-induced adipose tissue macrophage infiltration and inflammatory cytokine gene expression. Energy expenditure and brown adipose tissue metabolism in Asxl2ΔLysM mice were protected from the suppressive effects of HFD, a phenomenon associated with relatively increased catecholamines likely due to their suppressed degradation by macrophages. White adipose tissue of HFD-fed Asxl2ΔLysM mice also exhibited none of the pathological remodeling extant in their control counterparts. Suppression of macrophage Asxl2 expression, via nanoparticle-based siRNA delivery, prevented HFD-induced obesity. Thus, ASXL2 controlled the response of macrophages to dietary factors to regulate metabolic homeostasis, suggesting modulation of the cells\u27 inflammatory phenotype may impact obesity and its complications

On northern-hemisphere wave patterns associated with winter rainfall events in China

During extended winter (November-April) 43% of the intraseasonal rainfall variability in China is explained by three spatial patterns of temporally coherent rainfall. These patterns were identified with Empirical Orthogonal Teleconnection (EOT) analysis of observed 1982-2007 pentad rainfall anomalies and connected to midlatitude disturbances. However, examination of individual strong EOT events shows that there is substantial inter-event variability in their dynamical evolution, which implies that precursor patterns found in regressions cannot serve as useful predictors. To understand the physical nature and origins of the extratropical precursors, the EOT technique is applied to six simulations of the Met Office Unified Model at horizontal resolutions of 200--40 km and with and without air-sea coupling. All simulations reproduce the observed precursor patterns in regressions, indicating robust underlying dynamical processes. Further investigation into the dynamics associated with observed patterns shows that Rossby wave dynamics can explain the large inter-event variability. The results suggest that the apparently slowly evolving or quasi-stationary waves in regression analysis are a statistical amalgamation of more rapidly propagating waves with a variety of origins and properties