Asian Americans on the Streets: Strategies for Prevention and Intervention

Notably lacking in the literature on Vietnamese and Cambodian youth gangs in the United States and particularly Southern California have been solutions that address the underlying causative factors of gang involvement. Relying on life histories collected over a span of fifteen years, the authors propose a multi-faceted prevention and intervention strategy that includes the community and schools to heighten cultural awareness for children and parents. It is also recommended that policies take into account nuanced differences between Asian communities and bring together multiple stakeholders including officials and hard-core gang members to improve communicative problems that have resulted in gang-policy failures

Asian Americans on the Streets: Strategies for Prevention and Intervention

Notably lacking in the literature on Vietnamese and Cambodian youth gangs in the United States and particularly southern California have been solutions that address the underlying causative factors of gang involvement. Relying on life histories collected over a span of fifteen years, the authors propose a multi-faceted prevention and intervention strategy that includes the community and schools to heighten cultural awareness for children and parents. It is also recommended that policies take into account nuanced differences between Asian communities and bring together multiple stakeholders including officials and hard-core gang members to improve communicative problems that have resulted in gang-policy failures

Solar Resource Variability

International audienc

Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a

Pluripotent embryonic stem cells (ESCs) self-renew or differentiate into all tissues of the developing embryo and cell-specification factors are necessary to balance gene expression. Here we delineate the function of the PHD-finger protein 5a (Phf5a) in ESC self-renewal and ascribe its role in regulating pluripotency, cellular reprogramming, and myoblast specification. We demonstrate that Phf5a is essential for maintaining pluripotency, since depleted ESCs exhibit hallmarks of differentiation. Mechanistically, we attribute Phf5a function to the stabilization of the Paf1 transcriptional complex and control of RNA polymerase II elongation on pluripotency loci. Apart from an ESC-specific factor, we demonstrate that Phf5a controls differentiation of adult myoblasts. Our findings suggest a potent mode of regulation by the Phf5a in stem cells, which directs their transcriptional program ultimately regulating maintenance of pluripotency and cellular reprogramming

Catalytic Hydrogenation Activity and Electronic Structure Determination of Bis(arylimidazol-2-ylidene)pyridine Cobalt Alkyl and Hydride Complexes

The bis(arylimidazol-2-ylidene)pyridine cobalt methyl complex, ((iPr)CNC)CoCH(3), was evaluated for the catalytic hydrogenation of alkenes. At 22 °C and 4 atm of H(2) pressure, ((iPr)CNC)CoCH(3) is an effective pre-catalyst for the hydrogenation of sterically hindered, unactivated alkenes such as trans-methylstilbene, 1-methyl-1-cyclohexene and 2,3-dimethyl-2-butene, representing one of the most active cobalt hydrogenation catalysts reported to date. Preparation of the cobalt hydride complex, ((iPr)CNC)CoH was accomplished by hydrogenation of ((iPr)CNC)CoCH(3). Over the course of 3 hours at 22 °C, migration of the metal-hydride to the 4-position of the pyridine ring yielded (4-H(2)-(iPr)CNC)CoN(2). Similar alkyl migration was observed upon treatment of ((iPr)CNC)CoH with 1,1-diphenylethylene. This reactivity raised the question as to whether this class of chelate is redoxactive, engaging in radical chemistry with the cobalt center. A combination of structural, spectroscopic and computational studies was conducted and provided definitive evidence for bis(arylimidazol-2-ylidene)pyridine radicals in reduced cobalt chemistry. Spin density calculations established that the radicals were localized on the pyridine ring, accounting for the observed reactivity and suggest a wide family of pyridine-based pincers may also be redox active