Parallel FPGA Implementation of RSA with Residue Number Systems - Can side-channel threats be avoided? - Extended version

In this paper, we present a new parallel architecture to avoid side-channel analyses such as: timing attack, simple/differential power analysis, fault induction attack and simple/differential electromagnetic analysis. We use a Montgomery Multiplication based on Residue Number Systems. Thanks to RNS, we develop a design able to perform an RSA signature in parallel on a set of identical and independent coprocessors. Of independent interest, we propose a new DPA countermeasure in the framework of RNS. It is only (slightly) memory consuming (1.5 KBytes). Finally, we synthesized our new architecture on FPGA and it presents promising performance results. Even if our aim is to sketch a secure architecture, the RSA signature is performed in less than 160 ms, with competitive hardware resources. To our knowledge, this is the first proposal of an architecture counteracting electromagnetic analysis apart from hardware countermeasures reducing electromagnetic radiations

Mitchell-Riley Syndrome : Improving Clinical Outcomes and Searching for Functional Impact of RFX-6 Mutations

Aims/HypothesisCaused by biallelic mutations of the gene encoding the transcription factor RFX6, the rare Mitchell-Riley syndrome (MRS) comprises neonatal diabetes, pancreatic hypoplasia, gallbladder agenesis or hypoplasia, duodenal atresia, and severe chronic diarrhea. So far, sixteen cases have been reported, all with a poor prognosis. This study discusses the multidisciplinary intensive clinical management of 4 new cases of MRS that survived over the first 2 years of life. Moreover, it demonstrates how the mutations impair the RFX6 function. MethodsClinical records were analyzed and described in detail. The functional impact of two RFX6(R181W) and RFX6(V506G) variants was assessed by measuring their ability to transactivate insulin transcription and genes that encode the L-type calcium channels required for normal pancreatic beta-cell function. ResultsAll four patients were small for gestational age (SGA) and prenatally diagnosed with duodenal atresia. They presented with neonatal diabetes early in life and were treated with intravenous insulin therapy before switching to subcutaneous insulin pump therapy. All patients faced recurrent hypoglycemic episodes, exacerbated when parenteral nutrition (PN) was disconnected. A sensor-augmented insulin pump therapy with a predictive low-glucose suspension system was installed with good results. One patient had a homozygous c.1517T>G (p.Val506Gly) mutation, two patients had a homozygous p.Arg181Trp mutation, and one patient presented with new compound heterozygosity. The RFX6(V506G) and RFX6(R181W) mutations failed to transactivate the expression of insulin and genes that encode L-type calcium channel subunits required for normal pancreatic beta-cell function. Conclusions/InterpretationMultidisciplinary and intensive disease management improved the clinical outcomes in four patients with MRS, including adjustment of parenteral/oral nutrition progression and advanced diabetes technologies. A better understanding of RFX6 function, in both intestine and pancreas cells, may break ground in new therapies, particularly regarding the use of drugs that modulate the enteroendocrine system.Peer reviewe

Vitamin D in autoimmunity: Molecular mechanisms and therapeutic potential

Over the last three decades, it has become clear that the role of vitamin D goes beyond the regulation of calcium homeostasis and bone health. An important extraskeletal effect of vitamin D is the modulation of the immune system. In the context of autoimmune diseases, this is illustrated by correlations of vitamin D status and genetic polymorphisms in the vitamin D receptor with the incidence and severity of the disease. These correlations warrant investigation into the potential use of vitamin D in the treatment of patients with autoimmune diseases. In recent years, several clinical trials have been performed to investigate the therapeutic value of vitamin D in multiple sclerosis, rheumatoid arthritis, Crohn's disease, type I diabetes, and systemic lupus erythematosus. Additionally, a second angle of investigation has focused on unraveling the molecular pathways used by vitamin D in order to find new potential therapeutic targets. This review will not only provide an overview of the clinical trials that have been performed but also discuss the current knowledge about the molecular mechanisms underlying the immunomodulatory effects of vitamin D and how these advances can be used in the treatment of autoimmune diseases

Anorchidies bilatérales de l'enfant (à propos de 22 cas)

PARIS7-Xavier Bichat (751182101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Parallel FPGA implementation of RSA with residue number systems – can side-channel threats be avoided

Abstract — In this paper, we present a new parallel architecture to avoid side-channel analysis such as: timing attack, simple/differential power analysis, fault induction attack and simple/differential electromagnetic analysis. We use a Montgomery Multiplication based on Residue Number Systems. Thanks to RNS, we develop a design able to perform an RSA signature in parallel on a set of identical and independent coprocessors. Of independent interest, we propose a new DPA countermeasure when RNS are used that is only (slightly) memory consuming. Finally, we synthesized our new architecture on FPGA and it presents promising performance results. Even if our aim is to sketch a secure architecture, the RSA signature is performed in less than 150 ms, with competitive hardware resources. To our knowledge, this is the first proposal of an architecture counteracting electromagnetic analysis apart from hardware countermeasures reducing electromagnetic radiations. I

Parallel FPGA implementation of RSA with residue number systems – can side-channel threats be avoided

Abstract. In this paper, we present a new parallel architecture to avoid side-channel analyses such as: timing attack, simple/differential power analysis, fault induction attack and simple/differential electromagnetic analysis. We use a Montgomery Multiplication based on Residue Number Systems. Thanks to RNS, we develop a design able to perform an RSA signature in parallel on a set of identical and independent coprocessors. Of independent interest, we propose a new DPA countermeasure in the framework of RNS. It is only (slightly) memory consuming (1.5 KBytes). Finally, we synthesized our new architecture on FPGA and it presents promising performance results. Even if our aim is to sketch a secure architecture, the RSA signature is performed in less than 160 ms, with competitive hardware resources. To our knowledge, this is the first proposal of an architecture counteracting electromagnetic analysis apart from hardware countermeasures reducing electromagnetic radiations

Effect of dilution on particle size analysis of w/o emulsions by dynamic light scattering

Dynamic Light Scattering (DLS) is a well-known (sub)micron particle size analysis technique. As such, it should be a valuable technique for water droplet size determination in (sub)micron water-in-oil emulsions. In this study, the sample pretreatment conditions were optimized in order to enable accurate droplet size determination by DLS. Whereas DLS was indeed capable of detecting differences between differently produced (sub)micron sized w/o emulsions, it was observed that the estimated droplet size was highly influenced by the measurement conditions used. First of all, the experimentally determined diffusion coefficient decreased with increasing water droplet concentration, which is thought to be due to interaction effects between the water droplets. To minimize this effect, the used concentration should be as low as possible. However, in doing so, the water droplets were frequently observed to disappear during storage or even during analysis, due to their dissolution in the dilution medium. The latter disturbing effect could be avoided by (sufficient) water saturation of the dilution medium and preventing water evaporation by closing the diluted sample and by restricting the head space. Summarizing, (sub)micron water droplets can be characterized using DLS. However, careful selection of the sample preparation and measurement conditions is necessary to obtain reliable data

Clinical, biological and genetic analysis of anorchia in 26 boys.

BACKGROUND: Anorchia is defined as the absence of testes in a 46,XY individual with a male phenotype. The cause is unknown. METHODS: We evaluated the clinical and biological presentation, and family histories of 26 boys with anorchia, and sequenced their SRY, NR5A1, INSL3, MAMLD1 genes and the T222P variant for LGR8. RESULTS: No patient had any associated congenital anomaly. At birth, testes were palpable bilaterally or unilaterally in 13 cases and not in 7; one patient presented with bilateral testicular torsion immediately after birth. The basal plasma concentrations of anti-Müllerian hormone (AMH, n = 15), inhibin B (n = 7) and testosterone (n = 19) were very low or undetectable in all the patients evaluated, as were the increases in testosterone after human chorionic gonadotropin (hCG, n = 12). The basal plasma concentrations of follicle stimulating hormone (FSH) were increased in 20/25, as was that of luteinising hormone in 10/22 cases. Family members of 7/26 cases had histories of primary ovarian failure in the mother (n = 2), or sister 46,XX, together with fetal malformations of the only boy with microphallus and secondary foot edema (n = 1), secondary infertility in the father (n = 2), or cryptorchidism in first cousins (n = 2). The sequences of all the genes studied were normal. CONCLUSION: Undetectable plasma concentrations of AMH and inhibin B and an elevated plasma FSH, together with 46,XY complement are sufficient for diagnosis of anorchia. The hCG test is unnecessary. NR5A1 and other genes implicated in gonadal development and testicle descent were not mutated, which suggests that other genes involved in these developments contribute to the phenotypes