Comparison of two dimensional computer codes on the case study of the flow computation of the river Bolska near Gomilsko

V diplomski nalogi so z dvodimenzijskimi programi PCFLOW2D, MIKE 21 ter MIKE Flood izvedeni izračuni z različnimi pretoki za reko Bolsko pri Gomilskem. Na začetku sta opisana vodotoka Bolska in Trnavca ter računsko območje, ki je bilo modelirano. Izveden je bil tudi terenski ogled območja, da se je nato lažje določilo različne koeficiente. V nadaljevanju so opisane teoretične osnove računanja pri uporabljenih programih ter priprava računskega modela za posamezne programe. Na podlagi zahtevnosti vnosa računskega modela ter dobljenih rezultatov so na koncu podane prednosti in slabosti posameznih programov ter analizirane razlike v izračunanih poljih hitrosti in globinah.In this diploma thesis, I carried out calculations of various flows for the Bolska river below the town of Gomilsko by two-dimensional programmes PCFLOW 2D, MIKE 21, and MIKE Flood. In the beginning, the Bolska and Trnavca watershed and modelled calculation domain are described. I also performed site surveys of the area in order to define various coefficients more effectively. Moreover, the background of the calculation of specific programmes and the preparation of the calculation model for individual programme is briefly described. Based on the complexity of the input of the calculation model and the obtained results, I finally set out the advantages and weaknesses of each programme and analysed the differences of calculated velocity fields and water depths

Frauen im Sozialstaat subjektive Deutungen, Orientierungen und staatliches Handeln am Beispiel alleinerziehender Sozialhilfeempfaengerinnen

UuStB Koeln(38)-950107756 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

An Investigation of the Factors Influencing UAE Nationals to Undertake Technical and Vocational Education

Technical and vocational skills are essential for the United Arab Emirates (UAE) to secure growth and wealth as per the UAE Vison 2021, Abu Dhabi Vision 2030 and Emiratization strategies. Gaining insights about the factors that influence Emirati students that study technical and vocational education can support the UAE to attract more Emiratis into that area. What are those major influential factors, and are there any differences related to the gender, age level, and location of living in the UAE? The factor analysis revealed five underlying factors; the career factor, the economic factor, the guidance factor, the media factor, and the social environment factor. The career factor (M = 3.48) is perceived as the most influential one, followed by the social environment factor (M = 3.32). The independent sample t-test presented a statistically significant difference between male (M = 2.8, SD = 1.066, N = 178) and female (M = 2.6, SD = 1.066, N = 250) perceptions in the economic factor (t [426] = 2.042 = 0.042, p < 0.05). The result shows that males place more emphasis on the economic aspect when considering their educational paths. The one-way ANOVA revealed a statistically significant variance in the economic factor for the location of living (F [7,420] = 4.278, p < 0.05). The research discloses that the career aspects and future job perspectives in addition to parents of national students are the most considerable influencer, which is forming the basis for this study. Differences in perceptions could be discovered for economic aspects only. The findings reveal it is essential to consider the career, economic aspect, and parents' involvement when marketing technical and vocational education to Emirati students. Social media marketing is recommended as an advertising tool for best results. &nbsp

Statistical evaluation of CZE-UV and CZE-ESI-MS data of intact α-1-acid glycoprotein isoforms for their use as potential biomarkers in bladder cancer

α-1-acid glycoprotein (AGP) is a highly heterogeneous protein that presents a vast number of isoforms (molecules of the protein differing in its peptidic and/or glycosidic moieties). In the last years, several authors have studied the potential use of AGP as a cancer biomarker. These studies focus on the correlation of different features of AGP structure (i.e. fucosylation, antennarity) with cancer or on the total protein blood concentration. In this study, the potential of CZE-UV and CZE-ESI-MS analysis of intact AGP isoforms to study the correlation of this protein with bladder cancer is shown. Samples from 16 individuals (eight healthy, eight bladder cancer) were analyzed and characterized in great detail including data on intact protein isoforms and on released glycans. The analytical data were evaluated employing different statistical techniques (ANOVA; principal component analysis, PCA; linear discriminant analysis; and partial least squares-discriminant analysis). Statistical differences between the two groups of study were observed. The best results were obtained by linear discriminant analysis of the CZE-ESI-MS data for intact AGP isoforms (93.75% of correct classification). Due to MS characterization, it can be observed that differences between the samples are mainly due to higher abundance of AGP isoforms containing tri- and tetra-antennary fucosylated oligosaccharides in cancer patients. The results show the great potential of CE-MS in combination with advanced data processing for the use of intact protein isoforms as disease biomarkers.Peer reviewe

Statistical evaluation of CZE-UV and CZE-ESI-MS data of intact alpha-1-acid glycoprotein isoforms for their use as potential biomarkers

Peer reviewe

Evaluation of the effect of the immunopurification-based procedures on the CZE-UV and CZE-ESI-TOF-MS determination of isoforms of intact α-1-acid glycoprotein from human serum

Differences in α-1-acid glycoprotein (AGP) peptidic and glycan moieties originate several isoforms, whose modifications have been related to different pathophysiological situations. Differences in the isoforms of AGP existing in serum of individuals suffering from different diseases compared to healthy ones could be potentially used as biomarkers. CZE has been proven to be a useful technique for the analysis of glycoprotein isoforms. However, direct CZE analysis of AGP isoforms in serum samples needs efficient purification methods that allow the protein analysis. In this work two new and fast methods to purify AGP from human serum are evaluated in regard to their effect on the determination of isoforms of the intact glycoprotein by CZE-UV and by a developed CZE-ESI-TOF-MS method. Both preparation methods, which differ in the pre-treatment of the sample prior to an anti-AGP immunochromatographic step are shown to be adequate to analyze isoforms of intact AGP. Comparison of both purification methods by CZE-UV and CZE-ESI-TOF-MS indicates that serum AGP purified without acidic precipitation as pre-treatment is more adequate due to AGP higher yield, which leads to better CZE-Mass spectra. Both CZE methods show no indication that acidic precipitation influences the glycosylation (including sialylation) of AGP. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.Peer Reviewe

In-situ Schliessungsexperiment Abschlussbericht

SIGLEAvailable from TIB Hannover: DtF QN1(94,60) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung und Forschung, Berlin (Germany)DEGerman

Transformation of Aerosol Chemical Properties due to Transport Over a City

The change of the chemical composition of the near-ground level atmospheric aerosol was studied during two summer episodes by a Lagrangian type of experimental approach. Bulk and single-particle chemical analyses of ions and elements in the particulate phase were deployed. N(-III) and N(V) components were also measured in the gas-phase. The measurements were completed by particle size distributions. Secondary inorganic aerosols (SIA) and fine particles of ≈0.2–0.4 μm size were still elevated 50 km downwind of the city. The direct comparison of transport over the city in contrast to transport over the surrounding areas showed that SIA was formed from emission from the city within less than 3 h. Relative increases, i.e., enrichment during transport were observed for primary and secondary aerosol components. The degree of mixing on the individual particle level increased significantly during transport in the area. In particular, newly emitted carbonaceous particles became internally mixed within hours with pre-existing sulphate particles. Mostly due to secondary aerosol formation the average particle size (mass median diameter) of major constituents of the aerosol was significantly decreased while being transported over 13 h. Given recent insights which link fine particles number and mass concentrations with health risks, the results suggest that rural populations in areas which frequently are located within an urban plume might run an elevated health risk relative to populations in areas not affected by urban plumes.JRC.H.2-Climate chang

Analysis of black carbon and carbon monoxide observed over the Indian Ocean: Implications for emissions and photochemistry

[1] Air from South Asia carries heavy loadings of organic and light-absorbing aerosol but low concentrations of ozone. We investigate ambient pollutant concentrations measured during the Indian Ocean Experiment (INDOEX), and we estimate emissions to determine the origin, magnitude, and impacts of air pollution from South Asia and to understand better the uncertainty in emission inventories. In India, the preponderance of motorcycles with small, two-stroke engines and the practice of adulterating gasoline with kerosene lead to high CO emission factors; for 1999, we estimate release of 15 Tg yr(-1) from fossil fuel use and 40 Tg yr(-1) from biomass burning. With the addition of isoprene oxidation, the total CO emissions were 67 Tg yr(-1) from India and 87 Tg( CO) yr(-1) from all of South Asia. These values indicate a somewhat larger contribution from fossil fuels but slightly lower overall emissions when compared to prior emission inventories. Two- stroke engines also exhibit high emission factors for volatile organic compounds (VOC) and particulate organic matter but produce only modest amounts of NOx. Near sources in India, VOC to NOx ratios appear too high for efficient O-3 formation, although other factors probably contribute to observed low O-3 mixing ratios. An inventory based on source characteristics and known emission factors for black carbon (BC) from South Asia yields 0.7 Tg yr(-1) (upper limit of about 1.0 Tg yr(-1)) with biomass burning as the dominant source. We can test this inventory with measurements of ambient CO and BC-ship, island, and aircraft observations of air from South Asia all show a positive correlation between CO and BC (r(2) = 0.71-0.81). Such strong correlations have also been observed over North America and Europe, but with a lower BC/CO slope. Ambient concentrations indicate high BC emission from South Asia: 2-3 Tg(BC) yr(-1). This disagreement with emission inventories demonstrates the need for direct measurements from sources in India