Prooxidative Role of Hyperinsulinemia in Metabolic Sydrome Formation

Purpose of study To analyze the interrelationships between basal insulinemia and parameters of malondialdehyde and catalase, and influence of metabolic components of metabolic syndrome on these processes. Methods A group of 40 men (mean age 52,4 ± 0,7 years) and 35 women (mean age 49,5 ± 0,8 years) with a diagnosis of MS were examined. Mean levels of systolic and diastolic blood pressure in both groups were 154,05 ± 2,62 / 99,34 ± 1,43 and 150,21 ± 3,12 / 88,28 ± 2,18 mm Hg. Anthropometric parameters of patients - a body mass index (BMI), waist circumference (WC ) and metabolic - total cholesterol (TC), triglycerides (TG), low density lipoproteins (LDL), high-density lipoprotein (HDL) cholesterol, blood glucose and basal insulin ( BI) - are reflected in Figure 1, 2,3. The control group consisted of 10 healthy men and 10 healthy women with normal blood pressure (116,17 ± 1,32 / 74,32 ± 1,27 mm Hg). Insulin levels were determined by ELISA automated method. Lipid levels were measured by the biochemical analyzer. LDL was calculated by Friedwald. The content of lipid peroxidation was assessed by the level in the blood serum of the secondary product - MDA determined by reaction with 2-thiobarbituric acid. Catalase activity was determined from the pressure oxidation molybdate with hydrogen peroxide.Results We identified: higher levels of MDA (p <0.001) and low levels of CA in men MS (p <0.001) in contrast to healthy men and women. informative indicators revealed the relationship of MDA and the spacecraft with BI and WC. When significant differences in the levels of BI, MDA and CA in men and women of the correlation of the same type, which may reflect the value of prooxidant insulinemia regardless of gender. The prooxidant role of BI in men is becoming a significant ( P = 0,35, p <0.05 only in GI conditions. Insulinemia affect OS options in two ways in male patients - directly (correlation with MDA), back (correlation with SC) and indirectly through the characteristics of a more pronounced their AO (BI correlation with RT and RT with MDA, CA). At the same time, the presence of correlation relationship of BI women in the absence of GI can argue the importance they even low levels of insulin in the formation of the MS-clinical marker of abdominal obesity.Conclusion Realization of gender differences in the intensity of the operating system happens through hormonal factors under the influence of age and insulinemia. Possible mechanisms of insulinemias prooxidant role in MS are modulated by AO parameters according to gender. The presence of gender differences of the insulin action to the endothelium explains closer connection of GI and cardiovascular diseases in men, unlike women

Meeting the Expectations of Your Heritage Culture: Links between Attachment Style, Intragroup Marginalisation, and Psychological Adjustment

This article has been made available through the Brunel Open Access Publishing Fund.This article has been made available through the Brunel Open Access Publishing Fund.Do insecurely-attached individuals perceive greater rejection from their heritage culture? Few studies have examined the antecedents and outcomes of this perceived rejection – termed intragroup marginalisation – in spite of its implications for the adjustment of cultural migrants to the mainstream culture. The present study investigated whether anxious and avoidant attachment orientations among cultural migrants were associated with greater intragroup marginalisation and, in turn, with lower subjective well-being and flourishing, and higher acculturative stress. Anxious attachment was associated with heightened intragroup marginalisation from friends and, in turn, with increased acculturative stress; anxious attachment was also associated with increased intragroup marginalisation from family. Avoidant attachment was linked with increased intragroup marginalisation from family and, in turn, with decreased subjective well-being

Skin TLR7 triggering promotes accumulation of respiratory dendritic cells and natural killer cells.

The TLR7 agonist imiquimod has been used successfully as adjuvant for skin treatment of virus-associated warts and basal cell carcinoma. The effects of skin TLR7 triggering on respiratory leukocyte populations are unknown. In a placebo-controlled experimental animal study we have used multicolour flow cytometry to systematically analyze the modulation of respiratory leukocyte subsets after skin administration of imiquimod. Compared to placebo, skin administration of imiquimod significantly increased respiratory dendritic cells (DC) and natural killer cells, whereas total respiratory leukocyte, alveolar macrophages, classical CD4+ T helper and CD8+ T killer cell numbers were not or only moderately affected. DC subpopulation analyses revealed that elevation of respiratory DC was caused by an increase of respiratory monocytic DC and CD11b(hi) DC subsets. Lymphocyte subpopulation analyses indicated a marked elevation of respiratory natural killer cells and a significant reduction of B lymphocytes. Analysis of cytokine responses of respiratory leukocytes after stimulation with Klebsiella pneumonia indicated reduced IFN-γ and TNF-α expression and increased IL-10 and IL-12p70 production after 7 day low dose skin TLR7 triggering. Additionally, respiratory NK cytotoxic activity was increased after 7d skin TLR7 triggering. In contrast, lung histology and bronchoalveolar cell counts were not affected suggesting that skin TLR7 stimulation modulated respiratory leukocyte composition without inducing overt pulmonary inflammation. These data suggest the possibility to modulate respiratory leukocyte composition and respiratory cytokine responses against pathogens like Klebsiella pneumonia through skin administration of a clinically approved TLR7 ligand. Skin administration of synthetic TLR7 ligands may represent a novel, noninvasive means to modulate respiratory immunity

Gas-sensitive properties of thin film heterojunction structures based on Fe2O3-In2O3 nanocomposites

This paper reports an investigation of the gas-sensitive properties of thin film based on the double-layers Fe2O3/In2O3 and Fe2O3-In2O3/In2O3 towards gases with different chemical nature (C2H5OH, CH4, CO, NH3, NO2, O3). As it was found, the -Fe2O3-In2O3 composite (Fe:In = 9:1) is more sensitive to O3; on the contrary, the -Fe2O3-In2O3 system (9:1), possesses an higher sensitivity to NO2. The optimal temperature for detecting both gases is in the range 70 - 100C. Sensors based on the -Fe2O3/In2O3 heterostructure show the maximum response to C2H5OH at considerably higher temperatures (250-300C), but this layer is practically insensitive to other reducing gases like CH4, CO and NH3 in the same temperature range. An explanation of the different gas-sensitive behavior for the these samples resulted from the particular features of their structure and phase stat

The Science of Behavior Change : The Road Ahead

Peer reviewe

Problems and perspectives of formation of agricultural clusters for increasing food security of developing countries

The authors of the article develop the proprietary methodology of integral approach to formation of the projects and programs of socio-economic development, which allows differentiating the sub-system of previously viewed indicators as to the level of users’ demands. The sense of cluster approach to increasing the competitiveness of agro-industrial complex is analyzed, and the problems and perspectives for formation of agricultural clusters for the growth of food security of developing countries are determined. As a result of the research, the authors came to the conclusion that agricultural clusters are a perspective course of increasing food security of developing countries, as they improve competitiveness of domestic agricultural producers and increase food independence and food self-sufficiency of economic systems. However, implementation of internal cluster cooperation requires reconsidering the existing notions of management, related to the level of methods and control, protection of intellectual property, education, and integration. The created system of relations should allow economic agents to keep balance between self-organizing and manageable behavior, combining innovational diversity and freedom of actions with the necessary level of integration. Intercompany cooperation in this regard should be similar to cooperation of ecosystem elements.peer-reviewe

Two-steps versus one-step solidification pathways of binary metallic nanodroplet

The solidification of AgCo, AgNi, and AgCu nanodroplets is studied by molecular dynamics simulations in the size range of 2-8 nm. All these systems tend to phase separate in the bulk solid with surface segregation of Ag. Despite these similarities, the simulations reveal clear differences in the solidification pathways. AgCo and AgNi already separate in the liquid phase, and they solidify in configurations close to equilibrium. They can show a two-step solidification process in which Co-/Ni-rich parts solidify at higher temperatures than the Ag-rich part. AgCu does not separate in the liquid and solidifies in one step, thereby remaining in a kinetically trapped state down to room temperature. The solidification mechanisms and the size dependence of the solidification temperatures are analyzed, finding qualitatively different behaviors in AgCo/AgNi compared to AgCu. These differences are rationalized by an analytical model

2005-2006 Dean\u27s Showcase No. 4

https://spiral.lynn.edu/conservatory_deansshowcase/1048/thumbnail.jp