La Cueva de la Revilla, un enterramiento colectivo del Bronce Protocogotas en la Sierra de Atapuerca (Burgos)

La riqueza arqueológica de la Sierra de Atapuerca se ve corroborada por la excavación de una pequeña cueva que fue utilizada como panteón colectivo durante el Bronce Medio Protocogotas. Su estudio sirve de punto de partida para valorar el ritual funerario cavernícola de la Edad del Bronce en el reborde nororiental de la submeseta Norte así como para plantear la existencia de diferentes fórmulas de enterramiento vinculadas a distintos espacios geográficos.The excavation in a small cave, which was used as collective pantheon during the middle Bronze Age proto-Cogotas, corroborates the Sierra de Atapuerca's archaelogical richness. Its study serves as initiation into Bronze cavemen's funerary ritual s in the Submeseta Norte (Castilian plateau's) north-eastern border as well as to introduce the different burial customs depending on the geographical area

Identifying the needs of older people living with HIV (≥ 50 years old) from multiple centres over the world: a descriptive analysis

BackgroundOlder People Living with HIV (OPWH) combine both aging and HIV-infection features, resulting in ageism, stigma, social isolation, and low quality of life. This context brings up new challenges for healthcare professionals, who now must aid patients with a significant comorbidity burden and polypharmacy treatments. OPWH opinion on their health management is hardly ever considered as a variable to study, though it would help to understand their needs on dissimilar settings.MethodsWe performed a cross-sectional, comparative study including patients living with HIV aged >= 50 years old from multiple centers worldwide and gave them a survey addressing their perception on overall health issues, psychological problems, social activities, geriatric conditions, and opinions on healthcare. Data was analyzed through Chisquared tests sorting by geographical regions, age groups, or both.ResultsWe organized 680 participants data by location (Center and South America [CSA], Western Europe [WE], Africa, Eastern Europe and Israel [EEI]) and by age groups (50- 55, 56-65, 66-75, >75). In EEI, HIV serostatus socializing and reaching undetectable viral load were the main problems. CSA participants are the least satisfied regarding their healthcare, and a great part of them are not retired. Africans show the best health perception, have financial problems, and fancy their HIV doctors. WE is the most developed region studied and their participants report the best scores. Moreover, older age groups tend to live alone, have a lower perception of psychological problems, and reduced social life.ConclusionsPatients' opinions outline region- and age-specific unmet needs. In EEI, socializing HIV and reaching undetectable viral load were the main concerns. CSA low satisfaction outcomes might reflect high expectations or profound inequities in the region. African participants results mirror a system where general health is hard to achieve, but HIV clinics are much more appealing to them. WE is the most satisfied region about their healthcare. In this context, age-specific information, education and counseling programs (i.e. Patient Reported Outcomes, Patient Centered Care, multidisciplinary teams) are needed to promote physical and mental health among older adults living with HIV/AIDS. This is crucial for improving health-related quality of life and patient's satisfaction

Epidemiologic Features and Control Measures during Monkeypox Outbreak, Spain, June 2022

During June 2022, Spain was one of the countries most affected worldwide by a multicountry monkeypox outbreak with chains of transmission without identified links to disease-endemic countries. We provide epidemiologic features of cases reported in Spain and the coordinated measures taken to respond to this outbreak.S

The imperative for quality control programs in Monkeypox virus DNA testing by PCR: CIBERINFEC quality control

© 2023 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.To evaluate molecular assays for Mpox diagnosis available in various clinical microbiology services in Spain through a quality control (QC) approach. A total of 14 centers from across Spain participated in the study. The Reference Laboratory dispatched eight serum samples and eight nucleic acid extracts to each participating center. Some samples were spiked with Mpox or Vaccinia virus to mimic positive samples for Mpox or other orthopox viruses. Participating centers provided information on the results obtained, as well as the laboratory methods used. Among the 14 participating centers seven different commercial assays were employed, with the most commonly used kit being LightMix Modular Orthopox/Monkeypox (Mpox) Virus (Roche®). Of the 12 centers conducting Mpox determinations, concordance ranged from 62.5% (n = 1) to 100% (n = 11) for eluates and from 75.0% (n = 1) to 100% (n = 10) for serum. Among the 10 centers performing Orthopoxvirus determinations, a 100% concordance was observed for eluates, while for serum, concordance ranged from 87.5% (n = 6) to 100% (n = 4). Repeatedly, 6 different centers reported a false negative in serum samples for Orthopoxvirus diagnosis, particularly in a sample with borderline Ct = 39. Conversely, one center, using the TaqMan™ Mpox Virus Microbe Detection Assay (Thermo Fisher), reported false positives in Mpox diagnosis for samples spiked with vaccinia virus due to cross-reactions. We observed a positive correlation of various diagnostic assays for Mpox used by the participating centers with the reference values. Our results highlight the significance of standardization, validation, and ongoing QC in the microbiological diagnosis of infectious diseases, which might be particularly relevant for emerging viruses.This research was supported by CIBER (Strategic Action for Monkeypox)—Consorcio Centro de Investigación Biomédica en Red—(CB 2021), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea—NextGenerationEU. A. d. S. is supported by ‘Instituto de Salud Carlos III’ (grant number JR22/00055).Peer reviewe

Pasados y presente. Estudios para el profesor Ricardo García Cárcel

Ricardo García Cárcel (Requena, 1948) estudió Historia en Valencia bajo el magisterio de Joan Reglà, con quien formó parte del primer profesorado de historia moderna en la Universidad Autónoma de Barcelona. En esta universidad, desde hace prácticamente cincuenta años, ha desarrollado una extraordinaria labor docente y de investigación marcada por un sagaz instinto histórico, que le ha convertido en pionero de casi todo lo que ha estudiado: las Germanías, la historia de la Cataluña moderna, la Inquisición, las culturas del Siglo de Oro, la Leyenda Negra, Felipe II, Felipe V, Austrias y Borbones, la guerra de la Independencia, la historia cultural, los mitos de la historia de España... Muy pocos tienen su capacidad para reflexionar, ordenar, analizar, conceptualizar y proponer una visión amplia y llena de matices sobre el pasado y las interpretaciones historiográficas. A su laboriosidad inimitable se añade una dedicación sin límites en el asesoramiento de alumnos e investigadores e impulsando revistas, dosieres, seminarios o publicaciones colectivas. Una mínima correspondencia a su generosidad lo constituye este volumen a manera de ineludible agradecimiento

Arqueología sefardí en Castilla y León: intervención en el yacimiento de "La Mota", en Castrillo Mota de Judíos (Burgos)

The archaeological excavation in the site of “La Mota” is part of an ambitious project to recover and enhance the Sephardic legacy in Castrillo Mota de Judíos (Castrillo Matajudíos before 2015). The documentary study carried out in the first phase of development of this project allowed to establish a very precise historical sequence for this site, from its origin in 1035 from the displacement of the Jewish quarter of Castrojeriz to this place, until its disappearance in the year 1311 when the community was allowed to return to the place from which they were expelled. In this period of time the origin of the present town, located 300m north from “La Mota”, takes place, where the converts were installed continuing, under a new religious faith, with the initial Jewish community. Consequently, “La Mota” is a good opportunity to know, applying the archaeological methodology, ex novo occupation dynamics that take place in this space and the transformations that occur in the site as a consequence of historical circumstances whose story we know quite accurately. The opportunity to contrast and complement both archaeological and documental records, will allow to elaborate a historical account which is very close to the social and material reality of a Sephardic community in this area of the Kingdom of Castile.La intervención arqueológica en el yacimiento de “La Mota” se integra en un ambicioso proyecto de recuperación y puesta en valor del legado sefardí en la localidad burgalesa de Castrillo Mota de Judíos (hasta 2015 Castrillo Matajudíos). El estudio documental realizado en la primera fase de desarrollo de este proyecto permitió establecer una secuencia histórica bastante precisa para este enclave, desde su origen el año 1035 a partir del desplazamiento de la aljama judía de Castrojeriz a este lugar, hasta su desaparición en el año 1311 cuando se permite el regreso de la comunidad al lugar del que habían sido expulsados. En este lapso de tiempo tiene lugar el origen del pueblo actual, situado a unos 300 m al norte de “La Mota”, donde se fueron instalando los conversos que dieron continuidad, ya bajo una nueva fe religiosa, a la comunidad judía originaria. En consecuencia, “La Mota” constituye una buena oportunidad para conocer, aplicando la metodología arqueológica, las dinámicas de ocupación ex novo que tienen lugar en este espacio y las transformaciones que se producen en el yacimiento como consecuencia de unas circunstancias históricas cuyo relato conocemos con bastante precisión. La oportunidad de contrastar y complementar ambos registros, arqueológico y textual, permitirá elaborar un relato histórico bastante ajustado a la realidad social y material de una comunidad sefardí en este sector del reino de Castilla

Propuesta de recuperación social de un bien patrimonial olvidado: la Fortaleza de Santa Engracia en Pancorbo (Burgos)

En 2005 el Ayuntamiento de Pancorbo (Burgos) solicitó al equipo de ARATIKOS ARQUEÓLOGOS la realización de una primera valoración sobre la fortaleza de Santa Engracia, un complejo conjunto enclavado en los Montes Obarenes y en una posición estratégica fundamental. Este primer análisis derivó en el posterior estudio y puesta en valor cuyos resultados presentamos en el presente artículo

El yacimiento arqueológico de "Matabuey": aproximación arqueológica al a ocupación del entorno de la civitas de Cauca en época tardorromana

The aim of this work is to present the results of the archaeological intervention carried out in the archaeological site of Matabuey (Nava de la Asunción, Segovia), a site that forms part of the complex settlement system that was developed in the the civitas of Cauca. Although most of the documented evidences represent the occupation of late Roman period, there are a series of indications that allow to raise its origin in previous moments, which makes this site a good reference to know the processes of occupation of Cauca’s territory during e Roman age and the transformations that, on a local scale, would have taken place during this long historical period. The same has been carried out within the framework of the so-called “Commercial Archaeology”, having participated in it a large team of professional archaeologists who, beyond punctual intervention (Negredo, 2013), is involved both in the transmission of the information generated, as well as in the future development of a broader project to advance the social recovery of the site.El objeto de este trabajo es dar a conocer los resultados de la intervención arqueológica realizada en el yacimiento arqueológico de “Matabuey” (Nava de la Asunción, Segovia), un yacimiento que forma parte del complejo sistema de poblamiento que se desarrolló en el entorno de la civitas de Cauca. Si bien la mayor parte de las evidencias documentadas representan la ocupación de época tardorromana, hay una serie de indicios que permiten plantear su origen en momentos anteriores, lo que convierte a este enclave en un buen referente para conocer los procesos de ocupación del territorio caucense durante la época romana y las transformaciones que, a una escala local, habrían tenido lugar a lo largo de este dilatado periodo histórico. El mismo se ha llevado a cabo en el marco de la denominada “arqueología comercial”, habiendo participado en el mismo un amplio equipo de arqueólogos profesionales que, más allá de la mera intervención puntual (Negredo, 2013), está comprometido tanto en la transmisión de la información generada, como en el futuro desarrollo de un proyecto más amplio que permita avanzar en la recuperación social del yacimiento

Maintenance of virologic suppression and improvement in comorbidities after simplification to raltegravir plus boosted darunavir among treatment-experienced HIV-infected patients

BIRDi study group.The use of two potent, well-tolerated, drugs could permit the maintenance of virologic suppression even in heavily pretreated people living with HIV. In this retrospective, multicenter, simplification study (NCT03348449), we included those patients with virologic suppression who switched to raltegravir (RAL) plus boosted darunavir (b/DRV). Overall, 345 patients (75 females, 25%) were included. Patients were largely pretreated (mean, 9.4 regimens), suppressed for a median of 41.1 months. Fifty patients had ≥1 mutation against DRV. At 96 weeks, the efficacy by intention-to-treat analysis (snapshot) was 73% (95%CI, 68.4–77.8%), but 97.1% (95%CI, 95.4–98.9) excluding changes due to non-virologic reasons, and virologic failure was rare (0.9%; 95%CI, 0.1–1.2%). Median CD4/CD8 ratio increased from 0.59 to 0.62 (p < 0.01), CD4+ cell count by +90 cells/µl (p < 0.01), and mean estimated glomerular filtration rate (eGFR) increased from 85.2 to 88.5 ml/min at 96 weeks, greater for patients receiving tenofovir disoproxil fumarate (eGFR, +3.6 ml/min, p = 0.04; serum phosphate +0.33 mg/dl; p < 0.01). There was a continued and significant improvement in the total cholesterol/high-density lipoprotein-cholesterol ratio. In conclusion, the simplification to a dual regimen with the combination of RAL and b/DRV is associated with maintenance of virologic suppression, even in largely pretreated patients, with improvements in CD4+ cell count, CD4/CD8 ratio, and in renal and lipid parameters