Linear conjugacy of chemical kinetic systems

Two networks are said to be linearly conjugate if the solution of their dynamic equations can be transformed into each other by a positive linear transformation. The study on dynamical equivalence in chemical kinetic systems was initiated by Craciun and Pantea in 2008 and eventually led to the Johnston-Siegel Criterion for linear conjugacy (JSC). Several studies have applied Mixed Integer Linear Programming (MILP) approach to generate linear conjugates of MAK (mass action kinetic) systems, Bio-CRNs (which is a subset of Hill-type kinetic systems when the network is restricted to digraphs), and PL-RDK (complex factorizable power law kinetic) systems. In this study, we present a general computational solution to construct linear conjugates of any "rate constant-interaction function decomposable" (RID) chemical kinetic systems, wherein each of its rate function is the product of a rate constant and an interaction function. We generate an extension of the JSC to the complex factorizable (CE) subset of RID kinetic systems and show that any non-complex factorizable (NE) RID kinetic system can be dynamically equivalent to a CF system via transformation. We show that linear conjugacy can be generated for any RID kinetic systems by applying the JSC to any NE kinetic system that are transformed to CF kinetic system

Role of membrane curvature on the activation/deactivation of Carnitine Palmitoyltransferase 1A: A coarse grain molecular dynamic study

Carnitine Palmitoyltransferase 1A (CPT 1A) is an enzyme anchored to the outer mitochondrial membrane (OMM), where it regulates the passage of fatty acids into the mitochondria and intervenes in the process of β-oxidation of long-chain fatty acids. Although CPT 1A is inhibited by malonyl-CoA, its activity is also modulated by the curvature of OMM. This modulation depends on the behavior of the N-terminal domain (NTD), which can be adsorbed onto the OMM (nonactive CPT 1A) or interacting with the C-terminal domain (active CPT 1A). Aimed to provide mechanistic insights on the regulatory mechanism of CPT 1A, we studied the influence of the bilayer curvature on the NTD behavior through a series of coarse-grained (CG) molecular dynamics simulations using curved and planar membranes. Comparative analysis suggests that the main determinant for the activation/deactivation of the enzyme is the tilt angle orientation of the transmembrane (TM) domains. Planar membranes induce a wide variation on the tilt angle orientation of TM helices, while curved geometries promote small angles with the membrane normal. Our results identify the first TM domain as an important component of the membrane sensing mechanism.Fil: Frigini, Ezequiel Nazareno. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; ArgentinaFil: Barrera, Exequiel E.. Instituto Pasteur de Montevideo; UruguayFil: Pantano, Sergio. Instituto Pasteur de Montevideo; UruguayFil: Porasso, Rodolfo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; Argentin

El Impuesto a la Transmisión Gratuita de Bienes y su reaparición en Argentina

El presente trabajo tiene por objeto repasar aspectos principales de este gravamen, habida cuenta su reciente instrumentación legal por la Provincia de Buenos Aires, después de más de 30 años de haberse derogado el mismo en todos los fiscos del Paí

Effect of nonlinearity on the dynamics of a particle in dc field-induced systems

Dynamics of a particle in a perfect chain with one nonlinear impurity and in a perfect nonlinear chain under the action of dc field is studied numerically. The nonlinearity appears due to the coupling of the electronic motion to optical oscillators which are treated in adiabatic approximation. We study for both the low and high values of field strength. Three different range of nonlinearity is obtained where the dynamics is different. In low and intermediate range of nonlinearity, it reduces the localization. In fact in the intermediate range subdiffusive behavior in the perfect nonlinear chain is obtained for a long time. In all the cases a critical value of nonlinear strength exists where self-trapping transition takes place. This critical value depends on the system and the field strength. Beyond the self-trapping transition nonlinearity enhances the localization.Comment: 9 pages, Revtex, 6 ps figures include

Avaliação da resistência à ferrugem em progênies de cafeeiro F4 obtidas por cruzamentos de 'icatu' com catimor.

Com o objetivo de selecionar progênies de cafeeiro resistentes à ferrugem foram instalados e conduzidos experimentos em Três Pontas, São Sebastião do Paraíso e Machado. Foram avaliadas 17 progênies desenvolvidas pelo programa de Melhoramento Genético do Cafeeiro em Minas Gerais, coordenado pela EPAMIG e obtidas pelo cruzamento ?Icatu? x Catimor, e a cultivar Rubi MG 1192 utilizada como testemunha. O delineamento foi o de blocos casualizados com três repetições. Foram analisadas as características incidência da ferrugem no primeiro semestre de 2006.Os resultados obtidos permitem verificar que as progênies avaliadas apresentam variabilidade para a resistência a ferrugem, isso é confirmado pelas estimativas da herdabilidade que foram de boa magnitude, chegando até o valor de 92,8%. Essa condição aliada à baixa incidência da doença apresentada por algumas progênies, demonstrou que é possível selecionar progênies superiores em relação à resistência a ferrugem na população estudada

Metal-insulator transition in one-dimensional lattices with chaotic energy sequences

We study electronic transport through a one-dimensional array of sites by using a tight binding Hamiltonian, whose site-energies are drawn from a chaotic sequence. The correlation degree between these energies is controlled by a parameter regulating the dynamic Lyapunov exponent measuring the degree of chaos. We observe the effect of chaotic sequences on the localization length, conductance, conductance distribution and wave function, finding evidence of a Metal-Insulator Transition (MIT) at a critical degree of chaos. The one-dimensional metallic phase is characterized by a Gaussian conductance distribution and exhibits a peculiar non-selfaveraging.Comment: 5 pages, 5 figures (one figure replaced). Includes new results and a few additional references. Improved style for publication. Accepted in Physics Letters

Efectos de la exclusión de ganado sobre la calidad ambiental de un arroyo pampeano

For two years, records of channel morphology and quality of the bank on a section of a stream were made because the cattle farming have been excluded at a section of 500 meters of long near the bank and 10 meters at each bank. There were registered also changes in the aquatic vegetation and some physico-chemical parameters. Fish sampling was conducted annually to observe species presence and their relative abundance. It was detected a rapid improvement in the quality of banks and an increase of the richness of fishes in each sample. Contrary to expectations macrophyte richness was reduced and morphological heterogeneity of the channel is not increased. However, the stream ceased to be interrupted and started having more water in the entire stretch. This was as a result of reshaping the banks. Although this register should be validated with future surveys, the results suggest that the recovery of the banks is very fast and the runway and the fish colonization are staggered. Despite this, there was a clear recovery at the studied reach, with the exclusion of cattle in the area as the unique management practice.Facultad de Ciencias Naturales y Muse

Intrinsic chaos and external noise in population dynamics

We address the problem of the relative importance of the intrinsic chaos and the external noise in determining the complexity of population dynamics. We use a recently proposed method for studying the complexity of nonlinear random dynamical systems. The new measure of complexity is defined in terms of the average number of bits per time-unit necessary to specify the sequence generated by the system. This measure coincides with the rate of divergence of nearby trajectories under two different realizations of the noise. In particular, we show that the complexity of a nonlinear time-series model constructed from sheep populations comes completely from the environmental variations. However, in other situations, intrinsic chaos can be the crucial factor. This method can be applied to many other systems in biology and physics.Comment: 13 pages, Elsevier styl

Dynamics of an electron in finite and infinite one dimensional systems in presence of electric field

We study,numerically, the dynamical behavior of an electron in a two site nonlinear system driven by dc and ac electric field separately. We also study, numerically, the effect of electric field on single static impurity and antidimeric dynamical impurity in an infinite 1D chain to find the strength of the impurities. Analytical arguments for this system have also been given.Comment: File Latex, 8 Figures available on reques