Analysis of Plasma Bubble Signatures in the Ionosphere

Plasma bubbles are large scale structures of depleted plasma density in Earth\u27s ionosphere that disrupt radio and satellite communications, to include global navigation satellite systems. This study used the Ionospheric Forecast Model (IFM) to analyze affected look angles and total electron content (TEC) differences due to plasma bubbles of various sizes for 27 geophysical conditions consisting of different seasons and levels of solar and geomagnetic activity at 421 GPS ground stations worldwide. Overall, different geographic locations and plasma bubble configurations produced different affected look angle profiles. Bigger plasma bubbles, larger density depletion factors, higher levels of solar activity and the equinoctial months resulted in greater slant TEC differences and, hence, greater communication problems. The results of this study not only improved the accuracy of the Air Force\u27s operational ionospheric model and space weather forecasting capability, but also provided military leaders with a clear picture of the expected plasma bubble impacts to communications reliability when planning and executing military operations from the strategic to tactical level

Global Sporadic-E Occurrence Rate Climatology Using GPS Radio Occultation and Ionosonde Data

An updated global climatology of blanketing sporadic E (Es) is developed from a combined data set of Global Positioning System (GPS) radio occultation (RO) and ground-based ionosonde soundings over the period of September 2006–January 2019. A total of 46 sites and 3.2 million total soundings from the Global Ionosphere Radio Observatory network in combination with 3.0 million occultations from the Constellation Observing System for Meteorology, Ionosphere, and Climate constellation are used to calculate global occurrence rates (ORs) for two blanketing frequency thresholds: all blanketing sporadic-E with no limit on intensity (all-Es) and moderate-Es with fbEs ≥ 3 MHz. Following the GPS-RO to ionosonde comparison by Carmona et al. (2022), https://doi.org/10.3390/rs14030581 the all-Es rates are calculated using ionosonde data and an amplitude-based S4 threshold for the GPS-RO data while the moderate-Es rates use a primarily phase-based technique. Occurrence rates are separated by intensity, season, month, and solar local time for quiet geomagnetic conditions. Overall, the general geomagnetic trends agree with previous Es climatologies and the ORs peak near 50% for all-Es and 25% for moderate-Es measured in the mid-latitudes during local summer in the late afternoon. Low ORs are observed near the South Atlantic Anomaly and North America, and a general asymmetry is observed between hemispheres with higher ORs in the Northern Hemisphere. High-latitude and late morning blanketing Es are found to be stronger but less frequent with rates nearly equal to the moderate-Es mid-latitude maximums

Variations of Heavy Ion Abundances Relative to Proton Abundances in Large Solar Energetic (E \u3e 10 MeV) Particle Events

The elemental composition of heavy ions (with atomic number Z \u3e 2) (hi-Z) in large gradual E \u3e 10 MeV nuc-1 SEP events has been extensively studied in the 2-15 MeV nuc-1 range to determine the acceleration processes and transport properties of SEPs. These studies invariably are based on abundances relative to those of a single element such as C or O and often neglect H and He, the elements of primary interest for space weather. The total radiation of an SEP event is determined not only by the H and He properties but also by those of hi-Z ions whose abundances and variations relative to H from one event to another are unknown. We report a study to determine those variations in a group of 15 large SEP events over the period 2000 to 2015. Five hi-Z ions (He, C, O, Mg, & Fe) were selected to determine variations of their fluences relative to those of H in the 13.5-50.7 MeV nuc-1 energy range for each SEP event. Our average hi-Z abundance ratios slightly exceed those reported by [1] at lower energies, with the Fe event abundances showing the largest standard deviation of an order of magnitude. The event abundances were weakly correlated with H fluences and strongly correlated with speeds Vcme of associated coronal mass ejections (CMEs). These correlations may be evidence of streaming limits in the shock regions of H in the largest events

A Statistical Analysis of STEVE

There has been an exciting recent development in auroral research associated with the discovery of a new subauroral phenomenon called STEVE (Strong Thermal Emission Velocity Enhancement). Although STEVE has been documented by amateur night sky watchers for decades, it is as yet an unidentified upper atmosphere phenomenon. Observed first by amateur auroral photographers, STEVE appears as a narrow luminous structure across the night sky over thousands of kilometers in the east‐west direction. In this paper, we present the first statistical analysis of the properties of 28 STEVE events identified using Time History of Events and Macroscale Interactions during Substorms (THEMIS) all‐sky imager and the Redline Emission Geospace Observatory (REGO) database. We find that STEVE occurs about 1 hr after substorm onset at the end of a prolonged expansion phase. On average, the AL index magnitude is larger and the expansion phase has a longer duration for STEVE events compared to subauroral ion drifts or substorms. The average duration for STEVE is about 1 hr, and its latitudinal width is ~20 km, which corresponds to ~¼ of the width of narrow auroral structures like streamers. STEVE typically has an equatorward displacement from its initial location of about 50 km and a longitudinal extent of 2,145 km

Risk perception of medicinal marijuana in medical students from northeast Mexico [version 1; referees: awaiting peer review]

Background. Several studies have shown support from the public toward the use of medicinal marijuana. In this cross-sectional study, we assess the risk perception to medicinal marijuana in a sample of medical students. Methods. To estimate risk perception, a visual scale that ranges from 0 cm (without risk) to 10 cm (totally risky) was used. Risk  perception was expressed as the median of the cm marked over the scale. Differences among groups was tested with the Mann-Whitney and Kruskal-Wallis tests, as appropriate. Results. 283 students participated in the study. Risk perception to medicinal marijuana was 4.22, paracetamol 1.56 and sedatives 5.0. A significant difference in risk perception was observed in those that self-reported to smoke and consume alcohol. Conclusions. Risk perception of medicinal marijuana is 4.22 in medical students of northeast of Mexico. Students may underestimate its adverse effects. More studies with respect to this are needed

Perception of the risk of adverse reactions to analgesics: Differences between medical students and residents

Low permeability of many wood species due to their anatomical properties causes problems during timber drying as well as impregnating with preservatives and resins. Microwave (MW) treatment influences heartwood permeability and improves preservative uptake and distribution. In the present study, microwave treatment of chir pine (Pinus roxburghii) wood was done at 2,45 GHz frequency at different level of intensity and radiation time. The gas permeability of chir pine wood was measured in an in-house built apparatus. Preservative uptake was tested using acid copper chromate (ACC) preservative by a dipping process. The effect of radiation intensity and time on preservative uptake and air permeability were studied. The results revealed remarkable increase in longitudinal woodair permeability and preservative uptake with the increase of intensity and time of treatment. The results indicate that this technology can be tested and applied on pilot scale for application in wood preservation industry

Safety and immunogenicity of the protein-based PHH-1V compared to BNT162b2 as a heterologous SARS-CoV-2 booster vaccine in adults vaccinated against COVID-19 : a multicentre, randomised, double-blind, non-inferiority phase IIb trial

A SARS-CoV-2 protein-based heterodimer vaccine, PHH-1V, has been shown to be safe and well-tolerated in healthy young adults in a first-in-human, Phase I/IIa study dose-escalation trial. Here, we report the interim results of the Phase IIb HH-2, where the immunogenicity and safety of a heterologous booster with PHH-1V is assessed versus a homologous booster with BNT162b2 at 14, 28 and 98 days after vaccine administration. The HH-2 study is an ongoing multicentre, randomised, active-controlled, double-blind, non-inferiority Phase IIb trial, where participants 18 years or older who had received two doses of BNT162b2 were randomly assigned in a 2:1 ratio to receive a booster dose of vaccine-either heterologous (PHH-1V group) or homologous (BNT162b2 group)-in 10 centres in Spain. Eligible subjects were allocated to treatment stratified by age group (18-64 versus ≥65 years) with approximately 10% of the sample enrolled in the older age group. The primary endpoints were humoral immunogenicity measured by changes in levels of neutralizing antibodies (PBNA) against the ancestral Wuhan-Hu-1 strain after the PHH-1V or the BNT162b2 boost, and the safety and tolerability of PHH-1V as a boost. The secondary endpoints were to compare changes in levels of neutralizing antibodies against different variants of SARS-CoV-2 and the T-cell responses towards the SARS-CoV-2 spike glycoprotein peptides. The exploratory endpoint was to assess the number of subjects with SARS-CoV-2 infections ≥14 days after PHH-1V booster. This study is ongoing and is registered with , . From 15 November 2021, 782 adults were randomly assigned to PHH-1V (n = 522) or BNT162b2 (n = 260) boost vaccine groups. The geometric mean titre (GMT) ratio of neutralizing antibodies on days 14, 28 and 98, shown as BNT162b2 active control versus PHH-1V, was, respectively, 1.68 (p < 0.0001), 1.31 (p = 0.0007) and 0.86 (p = 0.40) for the ancestral Wuhan-Hu-1 strain; 0.62 (p < 0.0001), 0.65 (p < 0.0001) and 0.56 (p = 0.003) for the Beta variant; 1.01 (p = 0.92), 0.88 (p = 0.11) and 0.52 (p = 0.0003) for the Delta variant; and 0.59 (p ≤ 0.0001), 0.66 (p < 0.0001) and 0.57 (p = 0.0028) for the Omicron BA.1 variant. Additionally, PHH-1V as a booster dose induced a significant increase of CD4 + and CD8 + T-cells expressing IFN-γ on day 14. There were 458 participants who experienced at least one adverse event (89.3%) in the PHH-1V and 238 (94.4%) in the BNT162b2 group. The most frequent adverse events were injection site pain (79.7% and 89.3%), fatigue (27.5% and 42.1%) and headache (31.2 and 40.1%) for the PHH-1V and the BNT162b2 groups, respectively. A total of 52 COVID-19 cases occurred from day 14 post-vaccination (10.14%) for the PHH-1V group and 30 (11.90%) for the BNT162b2 group (p = 0.45), and none of the subjects developed severe COVID-19. Our interim results from the Phase IIb HH-2 trial show that PHH-1V as a heterologous booster vaccine, when compared to BNT162b2, although it does not reach a non-inferior neutralizing antibody response against the Wuhan-Hu-1 strain at days 14 and 28 after vaccination, it does so at day 98. PHH-1V as a heterologous booster elicits a superior neutralizing antibody response against the previous circulating Beta and the currently circulating Omicron BA.1 SARS-CoV-2 variants in all time points assessed, and for the Delta variant on day 98 as well. Moreover, the PHH-1V boost also induces a strong and balanced T-cell response. Concerning the safety profile, subjects in the PHH-1V group report significantly fewer adverse events than those in the BNT162b2 group, most of mild intensity, and both vaccine groups present comparable COVID-19 breakthrough cases, none of them severe. HIPRA SCIENTIFIC, S.L.U

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Native diversity buffers against severity of non-native tree invasions

Determining the drivers of non-native plant invasions is critical for managing native ecosystems and limiting the spread of invasive species$^{1,2}$. Tree invasions in particular have been relatively overlooked, even though they have the potential to transform ecosystems and economies$^{3,4}$. Here, leveraging global tree databases$^{5,6,7}$, we explore how the phylogenetic and functional diversity of native tree communities, human pressure and the environment influence the establishment of non-native tree species and the subsequent invasion severity. We find that anthropogenic factors are key to predicting whether a location is invaded, but that invasion severity is underpinned by native diversity, with higher diversity predicting lower invasion severity. Temperature and precipitation emerge as strong predictors of invasion strategy, with non-native species invading successfully when they are similar to the native community in cold or dry extremes. Yet, despite the influence of these ecological forces in determining invasion strategy, we find evidence that these patterns can be obscured by human activity, with lower ecological signal in areas with higher proximity to shipping ports. Our global perspective of non-native tree invasion highlights that human drivers influence non-native tree presence, and that native phylogenetic and functional diversity have a critical role in the establishment and spread of subsequent invasions