A Multiwavelength Study of Young Massive Star-Forming Regions. III. Mid-Infrared Emission

We present mid-infrared (MIR) observations, made with the TIMMI2 camera on the ESO 3.6 m telescope, toward 14 young massive star-forming regions. All regions were imaged in the N band, and nine in the Q band, with an angular resolution of ~ 1 arcsec. Typically, the regions exhibit a single or two compact sources (with sizes in the range 0.008-0.18 pc) plus extended diffuse emission. The Spitzer-Galactic Legacy Infrared Mid-Plane Survey Extraordinaire images of these regions show much more extended emission than that seen by TIMMI2, and this is attributed to polycyclic aromatic hydrocarbon (PAH) bands. For the MIR sources associated with radio continuum radiation (Paper I) there is a close morphological correspondence between the two emissions, suggesting that the ionized gas (radio source) and hot dust (MIR source) coexist inside the H II region. We found five MIR compact sources which are not associated with radio continuum emission, and are thus prime candidates for hosting young massive protostars. In particular, objects IRAS 14593-5852 II (only detected at 17.7 microns) and 17008-4040 I are likely to be genuine O-type protostellar objects. We also present TIMMI2 N-band spectra of eight sources, all of which are dominated by a prominent silicate absorption feature (~ 9.7 microns). From these data we estimate column densities in the range (7-17)x10^22 cm^-2, in good agreement with those derived from the 1.2 mm data (Paper II). Seven sources show bright [Ne II] line emission, as expected from ionized gas regions. Only IRAS 123830-6128 shows detectable PAH emission at 8.6 and 11.3 microns.Comment: Published in ApJ. 15 pages, 6 figures. Formatted with emulateapj; v2: Minor language changes to match the published versio

Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study.

BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infection, has emerged as a serious illness in children worldwide. Immunoglobulin or glucocorticoids, or both, are currently recommended treatments. METHODS: The Best Available Treatment Study evaluated immunomodulatory treatments for MIS-C in an international observational cohort. Analysis of the first 614 patients was previously reported. In this propensity-weighted cohort study, clinical and outcome data from children with suspected or proven MIS-C were collected onto a web-based Research Electronic Data Capture database. After excluding neonates and incomplete or duplicate records, inverse probability weighting was used to compare primary treatments with intravenous immunoglobulin, intravenous immunoglobulin plus glucocorticoids, or glucocorticoids alone, using intravenous immunoglobulin as the reference treatment. Primary outcomes were a composite of inotropic or ventilator support from the second day after treatment initiation, or death, and time to improvement on an ordinal clinical severity scale. Secondary outcomes included treatment escalation, clinical deterioration, fever, and coronary artery aneurysm occurrence and resolution. This study is registered with the ISRCTN registry, ISRCTN69546370. FINDINGS: We enrolled 2101 children (aged 0 months to 19 years) with clinically diagnosed MIS-C from 39 countries between June 14, 2020, and April 25, 2022, and, following exclusions, 2009 patients were included for analysis (median age 8·0 years [IQR 4·2-11·4], 1191 [59·3%] male and 818 [40·7%] female, and 825 [41·1%] White). 680 (33·8%) patients received primary treatment with intravenous immunoglobulin, 698 (34·7%) with intravenous immunoglobulin plus glucocorticoids, 487 (24·2%) with glucocorticoids alone; 59 (2·9%) patients received other combinations, including biologicals, and 85 (4·2%) patients received no immunomodulators. There were no significant differences between treatments for primary outcomes for the 1586 patients with complete baseline and outcome data that were considered for primary analysis. Adjusted odds ratios for ventilation, inotropic support, or death were 1·09 (95% CI 0·75-1·58; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids and 0·93 (0·58-1·47; corrected p value=1·00) for glucocorticoids alone, versus intravenous immunoglobulin alone. Adjusted average hazard ratios for time to improvement were 1·04 (95% CI 0·91-1·20; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids, and 0·84 (0·70-1·00; corrected p value=0·22) for glucocorticoids alone, versus intravenous immunoglobulin alone. Treatment escalation was less frequent for intravenous immunoglobulin plus glucocorticoids (OR 0·15 [95% CI 0·11-0·20]; p<0·0001) and glucocorticoids alone (0·68 [0·50-0·93]; p=0·014) versus intravenous immunoglobulin alone. Persistent fever (from day 2 onward) was less common with intravenous immunoglobulin plus glucocorticoids compared with either intravenous immunoglobulin alone (OR 0·50 [95% CI 0·38-0·67]; p<0·0001) or glucocorticoids alone (0·63 [0·45-0·88]; p=0·0058). Coronary artery aneurysm occurrence and resolution did not differ significantly between treatment groups. INTERPRETATION: Recovery rates, including occurrence and resolution of coronary artery aneurysms, were similar for primary treatment with intravenous immunoglobulin when compared to glucocorticoids or intravenous immunoglobulin plus glucocorticoids. Initial treatment with glucocorticoids appears to be a safe alternative to immunoglobulin or combined therapy, and might be advantageous in view of the cost and limited availability of intravenous immunoglobulin in many countries. FUNDING: Imperial College London, the European Union's Horizon 2020, Wellcome Trust, the Medical Research Foundation, UK National Institute for Health and Care Research, and National Institutes of Health

La comunicación en contextos de reclusión. El Taller de Periodismo y la construcción de sentidos en el penal de San Martín

Este proyecto propone analizar las estrategias de comunicación que se ponen en juego entre personas que permanecen en situación de encierro dentro de una cárcel y que comparten un espacio educativo no formal que apuesta a la generación devínculos horizontales y solidarios. Si se considera que las prácticas autoritarias, individualistas y burocráticas predominan como ejes estructurantes de las relaciones entre las personas que allí conviven, la creación de espacios para la comunicación adquiere un particular interés. Es pertinente preguntarse, en consecuencia, si en un ámbito atravesado fuertemente por acciones violentas y deshumanizantes es posible inaugurar nuevos modos para que los sujetos puedan reconocerse como tales, a través de la palabra y el diálogo. Se pretenden conocer cuáles son las representaciones que tienen los presos acerca del trabajo, la educación, la familia, los derechos, la salud y el encierro carcelario; y rastrear las estrategias comunicativas que se ponen en juego para compartir sus vivencias y opiniones

Taller de Periodismo en el Penal de San Martín (2002-2008)

Este proyecto surge del trabajo que un equipo de comunicadores sociales llevamos adelante desde el año 2002 en el Establecimiento Penitenciario Nº 2 de barrio San Martín de la ciudad de Córdoba y que consiste en la realización de un Taller de Periodismo al que asisten semanalmente alrededor de 25 presos. Este taller se desarrolla como una actividad de educación no formal, cuya principal tarea es la elaboración de producciones periodísticas y la generación de acciones de comunicación dentro de la cárcel. Desde este espacio se valoriza la palabra, los pensamientos y los vínculos como instancias necesarias para la toma de conciencia y expresión de las vivencias de los participantes. Mientras que la estructura física y organizativa de la cárcel determina formas de relacionamiento cargadas de autoritarismo, segregación e inmovilización, nuestra propuesta es conformar y trabajar en un espacio que confronte con estas lógicas, a partir del diálogo, la reflexión, la construcción y la acción colectiva

Consenso sobre el abordaje diagnóstico y terapéutico del dolor y el estrés en el recién nacido

El dolor y estrés en el recién nacido (RN) se ha tratado en forma insuficiente; los recién nacidos que ingresan a las unidades de cuidados intensivos neonatales (UCIN), a menudo deben someterse a procedimientos invasivos, dolorosos y estresantes y el tratamiento inadecuado incrementa la morbimortalidad. El V Consenso Clínico de la Sociedad Iberoamericana de Neonatología convocó a 32 neonatólogos de Iberoamérica para establecer las recomendaciones sobre diagnóstico y terapéutica del dolor y estrés neonatal. Se desarrollaron temas de relevancia, utilizando la mejor evidencia científica disponible en bases de datos indizadas. Todos participaron en forma activa en una reunión presencial en Santiago de Chile para consensuar las recomendaciones y conclusiones. El dolor y el estrés neonatal afectan el neurodesarrollo y la conducta a largo plazo, requieren el diagnóstico oportuno, el manejo y la terapéutica adecuada, incluso con fármacos que permitan balancear la efectividad y toxicidad. El Consenso señala la importancia de evaluar el dolor en el RN en forma multidimensional y proporciona recomendaciones de las indicaciones y limitaciones para la terapia farmacológica individualizada. El uso de los analgésicos tiene indicaciones precisas y debe limitarse por la carencia de estudios aleatorizados en RN, ya que en todos los casos existen efectos adversos a considerar. Se proponen medidas no farmacológicas para mitigar el dolor. El manejo del estrés debe comenzar en la sala de partos e incluir el contacto materno, la reducción de estímulos, la implementación de protocolos de intervención reducida, entre otros. SIBEN propone las recomendaciones para mejorar las prácticas clínicas relacionadas con el dolor y el estrés neonatal

Safe oxygen saturation targeting and monitoring in preterm infants: Can we avoid hypoxia and hyperoxia?

Oxygen is a neonatal health hazard that should be avoided in clinical practice. In this review, an international team of neonatologists and nurses assessed oxygen saturation (SpO2) targeting in preterm infants and evaluated the potential weaknesses of randomised clinical trials. Conclusion: SpO2of 85-89% can increase mortality and 91-95% can cause hyperoxia and ill effects. Neither of these ranges can be recommended, and wider intermediate targets, such as 87-94% or 88-94%, may be safer.SCOPUS: re.jFLWOAinfo:eu-repo/semantics/publishe

Cronache meridionali. A. V, n.1-12 (1958)

N. 1 (gennaio 1958): Alicata, M., L'assemblea democristiana di Reggio Calabria, P. 1 ; Chiaromonte, G., L'immigrazione dal Mezzogiorno al Consiglio provinciale di Torino, P. 7 ; L'assemblea del 18 dicembre 1957 del Comitato nazionale per la rinascita del Mezzogiorno, P. 16 ; Il convegno per istituzione della Regione pugliese, P. 20 ; Amendola, G., Verso le elezioni politiche, ; Un sindaco di paglia, P. 28 ; «Cinque anni difficili, ma non sterili», P. 30 ; Napolitano, G., La crisi dell'Università di Napoli, 31 ; L'onorevole Campilli se ne va, P. 34 ; Ferrara, M., Una conferenza stampa al Grand Hotel, P. 42 ; Colajanni, N., La piena occupazione in Sicilia, P. 44 ; Postiglione, E., Le terme di Castellammare di Stabia, P. 50 ; Ziccardi, A., Riforma agraria e bonifica nel Materano, P. 55 ; De Jaco, A., Roger Vailland: La loi, P. 58 ; Villari, L., Giuseppe Berti: Russia e Stati italiani nel Risorgimento , P. 61 ; Salvemini, G., Questione meridionale e riformismo, P. 75.N. 2 (febbraio 1958): Chiaromonte, G., Bilancio del « primo ciclo», P. 81 ; Grifone, P., Il III congresso dei contadini meridionali, P. 90 ; Pistolese, F., La strage di Sidi Yussef, P. 104 ; Caprara, M., Le illusioni del Mercato comune, P. 108 ; Lo scioglimento del Consiglio comunale di Napoli, P. 113 ; La sciagura di Gessolungo, P. 116 ; Speciale, G., Il convegno di Gela, P. 129 ; Di Marino, G., Panorama elettorale: Salerno, P. 132 ; Pistillo, P., Bari, P. 137 ; Gomez, M., Annuario dell'Agricoltura italiana, P. 147 ; Mastroianni, G., Raffaele Laporta: La libertà nel pensiero di Vincenzo Cuoco, P. 151 ; De Viti De Marco, A., La politica commerciale italiana e il Mezzogiorno, P. 155.N. 3 (marzo 1958): Napolitano, G., Una scelta decisiva per l'avvenire del Mezzogiorno, P. 161 ; Failla, V., La politica dell'E.n.i., P. 171 ; Pistolese, F., L'intervista di Krusciou, P. 186 ; Cinanni, P., Il mercato comune e il tipo d'impresa in agricoltura, P. 189 ; L'emigrazione nel Sud America, P. 191 ; Ancora minacce sull'industria napoletana, P. 196 ; I supremi valori della vita, P. 198 ; Le perplessità di Corbino, P. 198 ; Lauro a Milano, P. 199 ; La morale dell'on. Campilli, P. 200 ; La questione meridionale secondo Olivetti, P. 201 ; Pantaleone, M., L'emigrazione dalla provincia di Caltanissetta, P. 213 ; Fortunato, G., La povertà naturale del Mezzogiorno e la politica economica dello Stato, P. 232.N. 4 (aprile 1958): Le elezioni e il Mezzogiorno, P. 241 Silipo, L., Calabria (panorama preelettorale), P. 246 ; Valenza, P., Lucania (panorama preelettorale), P. 250 ; Amiconi, F., Molise (panorama preelettorale), P. 253 ; Cimino, M., Sicilia (panorama preelettorale), P. 256 ; Per la sospensione del M.e.c., P. 260 ; La politica delle aziende industriali controllate dallo Stato, P. 262 ; Echi della campagna elettorale, P. 266 ; Sereni, E., Note di storia dell'alimentazione nel Mezzogiorno: I napoletani da «mangiafoglia» a «mangiamaccheroni», I, P. 272 ; Ricci, P., Il teatro di Eduardo De Filippo, P. 296 ; Coletti, F., L'emigrazione dal Mezzogiorno, P. 307.N. 5 (maggio 1958): I risultati elettorali nel Mezzogiorno, P. 313 ; Fermariello, C., Il M.e.c. e l'agricoltura nel Mezzogiorno, P. 318 ; Villari, R., Sulla formazione politica di F. S. Nitti, P. 330 ; La sinistra invisibile, P. 343 ; La relazione sulla situazione economica, P. 345 ; Un discorso di Colombo, P. 347 ; Sereni, E., Note di storia dell'alimentazione nel Mezzogiorno: I napoletani da « mangiafoglia» a « mangiamaccheroni », II, P. 353 ; Viviani, V., Teatro napoletano a cura di G. Trevisani, P. 382.N. 6 (giugno 1958): Amendola, G., Situazione aperta, P. 385 ; Caprara, M., L'inchiesta parlamentare sulle condizioni dei lavoratori del Mezzogiorno, I, P. 389 ; Sereni, E., Note di storia dell'alimentazione nel Mezzogiorno: l napoletani da «mangiafoglia» a « mangiamaccheroni », III, P. 398 ; Chiaromonte, G., La riduzione del saggio di sconto, P. 423 ; Alinovi, A., Il voto di Napoli, P. 436 ; Silipo, L., Risultati elettorali nel comprensorio silano-crotonese, P. 444 ; Berlinguer, E., Le elezioni in Sardegna, P. 449 ; De Jaco, A., Lettere dalla provincia, P. 453 ; Villari, R., Sviluppo dello hegelismo in Italia a cura di Mario Rossi, P.456 ; Sturzo, L., La Regione, P. 458 ; Politica estera e questione meridionale, P. 463.N. 7-8 (luglio-agosto 1958): Il programma di Fanfani e la crisi del Medio Oriente, P. 465 ; Vitale, G., La cooperazione nel Mezzogiorno, P. 472 ; Cosenza, L., L’industrializzazione dell'edilizia, P. 481 ; Allegato, L., Uno sciopero dei braccianti di San Severo, P. 486 ; L'assemblea del 22 luglio del Comitato nazionale per la rinascitadel Mezzogiorno, P. 496 ; Cimino, M., Il colpo di mano di La Loggia, P. 507 ; Chiaromonte, G., Per le elezioni a Napoli, P. 509 ; L'inafferrabile «secondo tempo», P. 513 ; A quando la nomina del presidente del Banco di Napoli?, P. 513 ; Uno sciacallo, P. 515 ; Un saluto di solidarietà, P. 518 ; Gomez, M., Gli affitti a canapa, P. 526 ; Chiaromonte, G., Il dissesto finanziario del Comune di Napoli, P. 530 ; Sansone, N., Corrado Alvaro: Un treno nel Sud, P. 549 ; Villari, R., Camillo Porzio: La congiura dei baroni del Regno di Napoli contro il Re Ferdinando primo e gli altri scritti, a cura di Ernesto Pontieri, P. 551 ; Parrella, E., Paisano, P. 553 ; Dorso, G., Autonomismo e rivoluzione meridionale, P. 554.N. 9 (settembre 1958): Napolitano, G., L'industrializzazione alla Fiera del Levante, P. 561 ; Caprara, M., L'inchiesta parlamentare sulle condizioni dei lavoratori nel Mezzogiorno, II, P. 564 ; Cardaci, G., Elezioni provinciali e autonomia regionale in Sicilia, P. 576 ; Chiaromonte, G., Il dibattito sul M.e.c., P. 584 ; Con l'aratro e la prora, P. 587 ; Un uomo del Nord, P. 588 ; Levrero, S., l parassiti del porto di Napoli, P. 598 ; Matarrese, G., Il convegno sulla produzione agricola appulo- Lucana, P. 614; Chiaromonte, G., Vittorio Marrama: Saggio sullo sviluppo economico dei paesi arretrati, P. 618.N. 10 (ottobre 1958): Napolitano, G., Mercato comune e politica di sviluppo del Mezzogiorno, P. 625 ; La sconfitta di La Loggia, P. 647 ; Le sorti della pace, P. 648 ; Poliomelite e irresponsabilità, P. 649 ; Villari, R., Nota per la storia dei movimenti antifeudali in Basilicata dal 1647 al 1799, P. 653 ; Del Rio, D., Il progetto governativo sul riordinamento della finanza locale, P. 683 ; La ripresa degli scavi ad Ercolano, P. 695 ; Foa, V.,La questione dello zolfo siciliano, P. 697.N. 11 (novembre 1958): Dichiarazioni di Paolo D'Anioni, Michele Russo e Mario Ovazza sulla formazione del nuovo governo regionale siciliano, P. 709 ; Natta, A., I meridionali nella provincia di Imperia, P. 715 ; Chiaromonte, G., Storia di una legge speciale, P. 753 ; Esposito, V., La difesa della viticoltura siciliana, P. 761 ; Musolino, E., A proposito di paesi alluvionati e trasferiti, P. 767 ; Napolitano, G., Progresso sovietico contro iniziativa americana, P. 771 ; Sansone, N., Leonardo Sciascia: Gli zii d'America, P. 773 ; Mercato comune europeo e politica di sviluppo del Mezzogiorno, P. 775.N. 12 (dicembre 1958): Pajetta, G. C., Gli avvenimenti di Sicilia, P. 789 ; Chiaromonte, G., Una politica nuova per la: rinascita di Napoli, P. 796 ; Villari, R., «La Rassegna Settimanale» e il dibattito sulla questione sociale (1878-1881), P. 815 ; Un partito alla deriva, P. 842 ; I pirati della salute, P. 843 ; Dalla cronaca alla storia, P. 845 ; Sereni, E., Riconversione della coltura granaria e riordinamento colturale, P. 849 ; Valenza, P., Aspetti del fanfanismo in Lucania, P. 858 ; L'Assemblea delle rappresentanze cittadine napoletane e del Comitato nazionale per la rinascita dd Mezzogiorno, P. 868

Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

BackgroundMultisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infection, has emerged as a serious illness in children worldwide. Immunoglobulin or glucocorticoids, or both, are currently recommended treatments.MethodsThe Best Available Treatment Study evaluated immunomodulatory treatments for MIS-C in an international observational cohort. Analysis of the first 614 patients was previously reported. In this propensity-weighted cohort study, clinical and outcome data from children with suspected or proven MIS-C were collected onto a web-based Research Electronic Data Capture database. After excluding neonates and incomplete or duplicate records, inverse probability weighting was used to compare primary treatments with intravenous immunoglobulin, intravenous immunoglobulin plus glucocorticoids, or glucocorticoids alone, using intravenous immunoglobulin as the reference treatment. Primary outcomes were a composite of inotropic or ventilator support from the second day after treatment initiation, or death, and time to improvement on an ordinal clinical severity scale. Secondary outcomes included treatment escalation, clinical deterioration, fever, and coronary artery aneurysm occurrence and resolution. This study is registered with the ISRCTN registry, ISRCTN69546370.FindingsWe enrolled 2101 children (aged 0 months to 19 years) with clinically diagnosed MIS-C from 39 countries between June 14, 2020, and April 25, 2022, and, following exclusions, 2009 patients were included for analysis (median age 8·0 years [IQR 4·2-11·4], 1191 [59·3%] male and 818 [40·7%] female, and 825 [41·1%] White). 680 (33·8%) patients received primary treatment with intravenous immunoglobulin, 698 (34·7%) with intravenous immunoglobulin plus glucocorticoids, 487 (24·2%) with glucocorticoids alone; 59 (2·9%) patients received other combinations, including biologicals, and 85 (4·2%) patients received no immunomodulators. There were no significant differences between treatments for primary outcomes for the 1586 patients with complete baseline and outcome data that were considered for primary analysis. Adjusted odds ratios for ventilation, inotropic support, or death were 1·09 (95% CI 0·75-1·58; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids and 0·93 (0·58-1·47; corrected p value=1·00) for glucocorticoids alone, versus intravenous immunoglobulin alone. Adjusted average hazard ratios for time to improvement were 1·04 (95% CI 0·91-1·20; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids, and 0·84 (0·70-1·00; corrected p value=0·22) for glucocorticoids alone, versus intravenous immunoglobulin alone. Treatment escalation was less frequent for intravenous immunoglobulin plus glucocorticoids (OR 0·15 [95% CI 0·11-0·20]; p&lt;0·0001) and glucocorticoids alone (0·68 [0·50-0·93]; p=0·014) versus intravenous immunoglobulin alone. Persistent fever (from day 2 onward) was less common with intravenous immunoglobulin plus glucocorticoids compared with either intravenous immunoglobulin alone (OR 0·50 [95% CI 0·38-0·67]; p&lt;0·0001) or glucocorticoids alone (0·63 [0·45-0·88]; p=0·0058). Coronary artery aneurysm occurrence and resolution did not differ significantly between treatment groups.InterpretationRecovery rates, including occurrence and resolution of coronary artery aneurysms, were similar for primary treatment with intravenous immunoglobulin when compared to glucocorticoids or intravenous immunoglobulin plus glucocorticoids. Initial treatment with glucocorticoids appears to be a safe alternative to immunoglobulin or combined therapy, and might be advantageous in view of the cost and limited availability of intravenous immunoglobulin in many countries.FundingImperial College London, the European Union's Horizon 2020, Wellcome Trust, the Medical Research Foundation, UK National Institute for Health and Care Research, and National Institutes of Health