Better than words: expressing feelings with foods in Mass Observation wartime diaries

This paper, based on the examination of selected wartime diaries from the Mass Observation Archive, tackles the expression of intimate feelings through food practices. Exploring personal testimonies, it presents how, during a time of scarcity and shortage, food becomes a precious accessory to express personal feelings and a supportive medium to demonstrate love or friendship to friends or loved ones, whomever and wherever they could be. The result of this exploration, supported by various studies and reports on wartime emotions and human behaviours, shows how personal feelings were expressed by something better than words: valuable food. It also demonstrates to what extent the smallest emotional boundary can become vital when facing hard times through some examples of quite peculiar behaviours reported by the diarists. From the gift of a piece of cheese to the sacrifice of the meat ration, this paper suggests that food practices can become a valuable indicator of personal feelings such as love and friendship, but also loneliness and anxiety

'Rationing has not made me like margarine'. Food and Second World War in Britain: a Mass Observation testimony

No description supplie

Multilineage Differentiation for Formation of Innervated Skeletal Muscle Fibers from Healthy and Diseased Human Pluripotent Stem Cells.

Induced pluripotent stem cells (iPSCs) obtained by reprogramming primary somatic cells have revolutionized the fields of cell biology and disease modeling. However, the number protocols for generating mature muscle fibers with sarcolemmal organization using iPSCs remain limited, and partly mimic the complexity of mature skeletal muscle. Methods: We used a novel combination of small molecules added in a precise sequence for the simultaneous codifferentiation of human iPSCs into skeletal muscle cells and motor neurons. Results: We show that the presence of both cell types reduces the production time for millimeter-long multinucleated muscle fibers with sarcolemmal organization. Muscle fiber contractions are visible in 19-21 days, and can be maintained over long period thanks to the production of innervated multinucleated mature skeletal muscle fibers with autonomous cell regeneration of PAX7-positive cells and extracellular matrix synthesis. The sequential addition of specific molecules recapitulates key steps of human peripheral neurogenesis and myogenesis. Furthermore, this organoid-like culture can be used for functional evaluation and drug screening. Conclusion: Our protocol, which is applicable to hiPSCs from healthy individuals, was validated in Duchenne Muscular Dystrophy, Myotonic Dystrophy, Facio-Scapulo-Humeral Dystrophy and type 2A Limb-Girdle Muscular Dystrophy, opening new paths for the exploration of muscle differentiation, disease modeling and drug discovery

Salvage use of allogeneic hematopoietic stem cell transplantation after reduced intensity conditioning from unrelated donors in multiple myeloma. A study by the Plasma Cell Disorders subcommittee of the European Group for Blood and Marrow Transplant Chronic Malignancies Working Party

Non peer reviewe

Iconic dishes, culture and identity: the Christmas pudding and its hundred years’ journey in the USA, Australia, New Zealand and India

Asserting that recipes are textual evidences reflecting the society that produced them, this article explores the evolution of the recipes of the iconic Christmas pudding in the United States, Australia, New Zealand and India between the mid-nineteenth and the mid-twentieth centuries. Combining a micro-analysis of the recipes and the cookbook that provided them with contemporary testimonies, the article observes the dynamics revealed by the preparation and consumption of the pudding in these different societies. The findings demonstrate the relevance of national iconic dishes to the study of notions of home, migration and colonization, as well as the development of a new society and identity. They reveal how the preservation, transformation and even rejection of a traditional dish can be representative of the complex and sometimes conflicting relationships between colonists, migrants or new citizens and the places they live in

Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS.

peer reviewedAllogeneic hematopoietic stem cell transplantation remains the best curative option for higher-risk myelodysplastic syndrome. The presence of monosomal karyotype and/or complex karyotype abnormalities predicts inferior survival after allo-SCT in MDS patients. Haploidentical allo-SCT has been increasingly used in acute leukemia (AL) and has similar results as using HLA-matched donors, but data on higher-risk MDS is sparse. We compared outcomes in 266 patients with higher-risk MDS after HLA-matched sibling donor (MSD, n = 79), HLA-matched unrelated donor (MUD, n = 139) and HLA haploidentical donor (HID, n = 48) from 2010 to 2019. Median donor age differed between the three groups (p < 0.001). The overall survival was significantly different between the three groups with a better OS observed in the MUD group (p = 0.014). This observation could be explained by a higher progression-free survival with MUD (p = 0.014). The cumulative incidence of grade 2-4 acute GvHD was significantly higher in the HID group (p = 0.051). However, in multivariable analysis, patients transplanted using an HID had comparable mortality to patients transplanted using a MUD (subdistribution hazard ratio [sHR]: 0.58 [0.32-1.07]; p = 0.080) and a MSD ([sHR]: 0.56 [0.28-1.11]; p = 0.094). MUD do not remain a significant positive predictor of survival, suggesting that beyond the donor-recipient HLA matching, the donor age might impact recipient outcome

The magical treasure chest and the endless treasure hunt: Mass Observation topic collections and its primary sources on food

The aim of this paper is to introduce the reader to one of the components of Mass Observation Archive, the Topic Collections (TC) and to present its primary sources. Due to the quantity of data held in the collections, it would be impossible to embrace it entirely and present it properly. Therefore, following an introductory part on the MOA and its material, tehn a short presentation of the Topic Collections, this essay focuses mainly a single subject: Food. It explores the primary sources contained in the nine boxes dedicated to this specific theme, introduces thoroughly some of its material, and finally presents an example of research based on a survey carried out by Mass Observation (MO) in 1941

Embolisation des épistaxis

LILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Prévalence des douleurs des mains, des nodosités digitales et des gonalgies dans une population de patients souffrant d obésité morbide

PARIS7-Xavier Bichat (751182101) / SudocSudocFranceF

AESA approach applied to mineral and metal resources use sustainability in the building sector: The MiMOSA method

International audienceAbstract Considering the increase of natural resource use, humanity is facing the problem of resource depletion. The building sector is a major consumer of resources. The most consumed resources are mineral and metal resources. Thereby, the identification, and then optimisation, of mineral and metal resource use in the building sector appears as a necessity. One tool to quantify the use of those resources is LCA. Currently, several authors develop absolute environmental sustainability assessment (AESA) methods, combined with LCA, to compare the pressures of the studied project with the global carrying capacity of the planet. However, most of the AESA approaches do not actually include normalization factors about the use of resources, and in particular mineral and metal resources. Besides, the mainly used LCIA characterization methods of mineral and metal resources present several limits when applied to Circular Economy projects within the building sector. Thereby, the goal of this research project is to answer the following question: Can the consumption of mineral and metal resources for a given building project be considered sustainable? To answer this question, a methodology was developed. This methodology is inspired by the AESA approach by proposing a sustainable resource budget for each mineral or metal substance and will combine the MFA methods to the LCA method to calculate sustainability indicators for each mineral and metal resource. The Mineral and Metal absOlute Sustainability Assessment (MiMOSA) method integrates the circular economy actions and considers an appropriate spatial scale for each resource and will be presented in this paper