5 research outputs found

    Bi(NO<sub>3</sub>)<sub>3</sub>.5H<sub>2</sub>O catalyzed phosphonylation of aldehydes: An efficient route to α-hydroxyphosphonates

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    <p>The Bi(NO<sub>3</sub>)<sub>3</sub>.5H<sub>2</sub>O mediated synthesis of α-hydroxyphosphonates via phosphonylation of aldehydes is reported herein. Both conventional and microwave technology was efficiently applied to range of aromatic, heteroaromatic, α,β-unsaturated aldehydes under solvent-free conditions. The solvent free conditions, avoidance of toxic reagents and excellent yield are some of the remarkable features of this protocol to access the medicinally privileged structure, α-hydroxyphosphonates.</p
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