8 research outputs found
The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy
- Author
- Aawsaj Yousif
- Abayomi Michael
- Acharya Vikas
- Aggarwal Smeer Kumar
- Ahmad Anwar
- Ahmed Irfan
- Ahmed Jamil
- Ahmed Javed
- Ahmed Talat
- Ainley Paul
- Akhtar Mansoor
- Al Amari Khalid
- Al-Abed Yahya A.
- Al-Akash Musallam
- Al-Bahrani Ahmed Z.
- Al-Khyatt Waleed
- Al-Muhktar Ahmed
- Al-Sarireh Bilal
- Al-Taan Omer
- Alagaratnam Swethan
- Alam Imran
- Alberts Justin
- Alderson Derek
- Aldridge Roland C.
- Aleksandrov Danail
- Ali Haythem
- Ali Shahda
- Amin Khalid
- Andrew David R.
- Appleton Shaun
- Arhi Chanpreet
- Aroori Somaiah
- Aryal Kamal
- Asad Mehek
- Aseem Rabiya
- Asprou Fotini M.
- Awan Altaf
- Ayaani Soofiyah
- Aymon null
- Babu Benoy I.
- Bajwa Dalvir S.
- Bajwa Farrukh M.
- Baker Andrew L.
- Balfe Paul
- Ball William R.
- Ballance Laura
- Banwell Victoria
- Barnes James
- Barrie Jenifer
- Bartlett Francis
- Basheer Mohammed
- Bashir Gareth
- Basra Melvinder
- Basu Sanjoy
- Basynat Pradeep
- Batt Jeremy
- Bausbacher Harald
- Bawa Sadiq
- Beasley William D.
- Belding Rowena
- Bellini Maria Irene
- Bennett Stephen P.
- Bhandari Santosh
- Bharamgoudar Reshma
- Bhattacharya Vish
- Blane Christine
- Blazeby Jane M.
- Boal Matthew
- Boddy Alexander
- Boland Michael
- Bond-Smith Giles
- Booth Michael I.
- Borowski David W.
- Bowen Laura
- Boyce Kathryn M.
- Boyd Alan T.
- Bradley Donal
- Bradley Neil
- Brennan Stephen
- Brett Daniel
- Broadhurst Jack
- Brooke Eleanor
- Brown Timothy H.
- Bryant Alice
- Buchan Joanna
- Bullen Naomi
- Bunnell Catherine
- Bunting David M.
- Burke Paul
- Byrne James P.
- Byrnes Colman K.
- Campbell William
- Carney Kate
- Carney Kate
- Carroll Paul
- Carter C. Ross
- Carter Nicholas C.
- Carty Nick
- Cassidy John T.
- Chambers Adam
- Chambers Alice
- Chambers Alice
- Chan Wei Ming
- Chang Jessica
- Charalabopoulos Alexandros
- Chauhan Neal
- Cheung Melanie
- Chhabra Alok
- Chishti Imran A.
- Chitre Vivek
- Choy Alfred
- Cieplucha Krzysztos
- Clements Joshua M.
- Coats Maria
- Cockbain Andrew J.
- Coe Peter O.
- Connelly Martin
- Cooke Fiachra
- Courtney Michael J.
- Cowley Jonathan B.
- Cross Keith S.
- Cuming Tamzin
- Cunha Pedro
- Dalgaty Faith
- Dar Farooq
- Date Ravindra
- Dave Rajiv V.
- Davey Phil
- Davies James
- Dawson Suzanne
- De Marchi Joshua A.
- de Siqueira Jonathan
- Deguara Jean
- Delisle Theo G.
- Dennison A. R.
- Derbyshire Laura
- Devoto Laurence
- Dhillon Ajit
- Diamond Tom
- Dickson-Lowe Richard
- Digney Ruairi
- Dindyal Shiva
- Dobbins Brian
- Doe Matthew
- Dorrian Emmet
- Doulias Triantafyllos
- Downing Justine
- Drake Benjamin
- Driscoll Peter J.
- Duke Diana
- Durkin Damien
- Dwerryhouse Simon J.
- D’Costa Conrad
- Ebdewi Hamdi
- Ebied Husam
- Eisawi Abdalla
- El-Dhuwaib Yesar
- El-Hasani Shamsi S.
- Elkheir Natalie
- Elmasry Mohamed
- Elsayed Mohammed
- Elshaer Mohamed
- Emesih Sophie
- Farag Sameh F.
- Farooq Ansar
- Farouk Marwan
- Fasih Tani
- Fawole Adeshina S.
- Fenwick Stephen
- Ferguson Graeme
- Ferris Paul
- Finch David
- Finch J. G.
- Finlay Ian
- Fleming Katie
- Fletcher Ted
- Fordham Imogen J.
- Forouzanfar Amir
- Forrest Craig R.
- Forster Luke
- Fothergill Laura
- Frame Richard J.
- Francombe James
- Frank Lucinda
- Fusai Guiseppe
- Galanopoulos Giorgios
- Gallagher Paul V.
- Garcea Giuseppe
- Gardner-Thorpe James
- Geoghegan Justin G.
- Geogloma Ileana
- Gerakopoulos Stratos
- Ghareeb Essam
- Ghazanfar Mudassar A.
- Gibson Simon
- Giles Mathew
- Giovinazzo Francesco
- Giwa Lola
- Goh Yan Li
- Gopalswamy Sivakumar
- Goscimski Andrzej
- Gossage James A.
- Gough Martin
- Gould Laura
- Gould Laura
- Grant Alan J.
- Gravante Gianpiero
- Griffiths Ewen
- Griffiths Ewen A.
- Gull Sadaf
- Gunasekera Rohan T.
- Gurung Kabita
- Guthrie Graeme J. K.
- Guy Finch J.
- Hafiz Shazia
- Halkias Constantine
- Hall Claire
- Hamady Zayed
- Hamdan Alhafidz
- Hamdan Mohammed F.
- Hamilton Emma
- Hancorn Kate
- Haque Manzarul
- Haque Samer Ul
- Hardy Thomas J.
- Hargreaves Anita
- Harilingam Mohan
- Harris Andrew
- Harrison Ewen
- Hawkins Helen
- Heath Jonathan
- Hebbar Madhusoodhana
- Henderson Lucy T.
- Henley Natasha
- Heshaishi Mohamed
- Hewes James
- Hewes James C.
- Heywood Nick
- Higgs Simon M.
- Hill Arnold D. K.
- Hindley Caroline
- Hirst Natalie A.
- Hisham Elzanati
- Ho Wei-Min
- Hoban Jennifer R.
- Hodgkins Kathryn A.
- Hodson James
- Holroyd David J.
- Hooks Gareth
- Hopwood Benjamin
- Hornby Steve T.
- Hornsby Jane
- Hosie Kenneth B.
- Hosie Kenneth B.
- Hossack Martin R.
- Hossain Tanvir
- Hoti Emir
- Hou David
- Hrycaiczuk Alex
- Hughes Michael
- Hunter David I.
- Hussain Abdulzahra A.
- Hussain Adnan
- Hussain Anwar
- Hussain Najam
- Iftikhar Syed Yusuf
- Iqbal Nusrat
- Iskandar Edrin
- Issa Eyad
- Ivanovski Ivan
- Jackson Andrew
- Jackson Claire
- Jafferbhoy Sadaf F.
- Jambulingam Periyathambi
- Jamdar Saurabh
- Jamel Sara
- Janeczko Adam
- Jaunoo Shameen
- Jayanthi Naga V. G.
- Jelley Clare
- Jennings Neil A.
- Joel Abraham
- Johnpulle Michelle A.
- Johnston Dorothy
- Johnstone Marianne
- Johnstone Marianne
- Joji Nikita
- Jones Claire
- Jones Elinor
- Jones Gareth H.
- Jones M. Angharad
- Jones Michael J.
- Jones Robert P.
- Jones Steven M.
- Kadhim Abbas
- Kadirkamanathan Sritharan
- Kallaway Charlotte
- Kanakala Venkatesh
- Kanavati Osama
- Kansal Nisheeth
- Kaptanis Sarantos
- Karavadra Babu
- Karim Lawen
- Karunakaran Priyadarssini
- Kaur Parminder
- Kausar Ambareen
- Kelly Michael E.
- Kendal Chris
- Kennedy David
- Kenny Ross
- Keogh Ken
- Khalil Ahmed M.
- Khan Amarah
- Khan Mohammad A.
- Khan Muhammad A. S.
- Khan Raja Basit
- Khan Shabuddin
- Khan Shahab
- Khawaja Amir
- Khawaja Zechan
- Khogali Elmoataz
- Kimble Adam
- Kinghorn Alison
- Kirkham Amanda J.
- Knight Benjamin
- Knight Katrina
- Kourkulos Michail
- Krysztopik Richard
- Kumar Pradeep
- Kynaston James
- Kyriakidis Dimitrios
- Lalla Kushik
- Lambert Joel
- Lammy Simon
- Lane Risha
- Larkin David
- Law Jennifer
- Lawther Roger
- Lazim Taha
- Lee Kathryn
- Lee Matthew
- Leeder Paul
- Lennon Hannah
- Lewis Michael
- Lim Henry C. C.
- Lim Pei J.
- Lindsay David
- Lloyd David
- Lo Christina
- Lodhia Joshil
- Longbotham David A.
- Loughlin Paula
- Lovett Bryony
- Luhmann Andreas
- Luther Ali Alison
- Lyons Emma M.
- Macano Christina A. W.
- MacArtney Matthew
- Macdonald Andrew
- Madanipour Suroosh
- Madbak Khaliel
- Madurska Marta
- Magee Conor J.
- Maguire Donal
- Maharaj Geta
- Majeed Ali
- Malcolm Cathy
- Malde Deep
- Malik Nabeela S.
- Mallik Mekhlola
- Mansour Sami
- Manu Mangta
- Manzelli Antonio
- Marriott Paul
- Martin Jack
- Martin Sean T.
- Martin Serena
- Marudanayagam Ravi
- Mason Denise
- Mathur Pawan
- Mawhinney Abi
- Mbuvi James
- McAree Barry
- McCain Stephen
- McCallum Iain J. D.
- McClarey Andrew
- McCune Ken
- McDermott Frank
- McEntee Gerry P.
- McGlone Emma R.
- McGuigan Andrew
- McIlmunn Colin
- McKay Damian
- McKenzie Stephen
- McNair Angus G. K.
- Mealy Ken
- Menzies Donald
- Mercer Stuart J.
- Milburn James
- Mirza Ahmed K.
- Mirza Darius
- Miu Victor
- Mockford Justine Downing Katherine A.
- Mohamed Sarah
- Mohan Helen M.
- Mok Kam Wa Jessica
- Monk David
- Morcous Paul
- Morrison Tamsin E. M.
- Mothe Bhavani Sidhartha
- Mowbray Nicholas
- Mozolowski Kirsty L.
- Mukherjee Dipankar
- Murphy James O.
- Murtaza Ghulam
- Nally Deirdre M.
- Napetti Sara
- Nassar Ahmad H.
- Naumann David
- Nedujchelyn Yuwaraja
- Needham Paul J.
- Newton Katy
- Newton Richard C.
- Ngu Wee Sing
- Nicholson Gary A.
- Nicholson James
- Nicholson James A.
- Nicol Laura
- Nicolay Christopher R.
- Nieto Tom
- Nijjar Rajwinder S.
- Nilsen-Nunn April
- Nilsson Frida
- Noble Fergus
- Nofal Emma
- Noor Nigel
- Nunes Quentin M.
- Obeidallah Mohd Rami
- Ogedegbe Arikoge
- Old Oliver J.
- Orchard Philippa
- Orizu Mavis N.
- O’Dwyer Patrick
- O’Neill Maeve A.
- O’Neill Stephen
- O’Reilly Derek A.
- O’shea Kathryn M.
- O’Sullivan Adrian W.
- Packer Jessica R.
- Padwick Robert
- Pannu Arslan
- Panteleimonitis Sofoklis
- Parappally Ciny P.
- Parmar J.
- Pasquali Sandro
- Patel Abhilasha
- Patel Krashna
- Patel Shakira
- Pati Pradeep
- Pearce Belinda
- Pearson Katherine L.
- Peirce Colin
- Pellen Mike
- Peter Mark B.
- Peterson Mark
- Pezzuto Roberto
- Photi Evangelos
- Phull Manraj
- Pinho-Gomes Ana C.
- Pollock Sarah
- Popplewell Matthew
- Pore Naresh
- Porter Jonathan
- Prasad Abheesh R.
- Prasad Raj
- Preston Shaun R.
- Preziosi Giuseppe
- Prince Sarah
- Psica Alicja
- Puig Sonia
- Puntis Daniel J.
- Puri Yogesh
- Qandeel Haitham
- Rabie Mohamed
- Radwan Rami
- Rae David M.
- Rahman Saquib
- Rajaganeshan Rajasundaram
- Rajendran Ilayaraja
- Ramage Michael I.
- Rao Sudhindra T. V.
- Rate Anthony J.
- Raza Soulat
- Read Edward
- Reddy Marcus
- Reece-Bolton Obuobi
- Reed Joanna
- Reid Alistair
- Rengifo Carla
- Rhys Thomas
- Richards Colin H.
- Riera Manel
- Ritchie Judith
- Robb William
- Roberts Geoffrey P.
- Robinson Sarah
- Robinson Steven J.
- Robinson Stuart
- Rodriguez Dan
- Rodriguez Daniel Urriza
- Roebuck Amanda
- Rogers Paul N.
- Rolph Rachel C.
- Roy Sudipta
- Rutherford Claire L.
- Sadat Mohammed M.
- Sakai Naomi
- Sampat Keerthika
- Samuel Nehemiah
- Sarmah Piyush B.
- Sarvananthan Kas
- Sarveswaran Janahan
- Satheesan Steve
- Saunders Michael
- Sayegh Mazin
- Segaran Ashvina
- Sekhar Hema
- Sen Gourab
- Seymour Keith
- Shabo Wael
- Shah Nayab
- Shah Reena
- Shahin Yousef
- Sheel Andrea R. G.
- Shenoy Hrishikesh
- Shetty Vinutha
- Shier David
- Shingler Guy M.
- Shiwani Muhammad Hanif
- Shrestha Ashish Kiran
- Siddiqi Najaf
- Siddiqui Midhat N.
- Siddiqui Zohaib
- Sillo Toritseju O.
- Silva Michael
- Simpson Duncan J.
- Singh Shailendra
- Singh-Ranger Deepak
- Sinha Sidhartha
- Skelly Brendan L.
- Slavin John P.
- Slawinski Corinna
- Sloane Jake
- Smith Stella R.
- Smith Stella R.
- Sonsale Aniket
- Spearman John
- Spence Gary
- Spreadborough Philip
- Spreadborough Philip
- Starmer Benjamin Z.
- Stevenson Thomas E. J.
- Stewart Duncan J.
- Stirland E.
- Subramanium Dhivya
- Sufi Pratik A.
- Sukha Anisha
- Sutcliffe Robert
- Suttie Stuart
- Sutton Cherith M. L. R.
- Szentpali Karoly
- Tang Cheuk-Bong
- Tanner Nicola
- Tate Sophie
- Tayeh Salim
- Taylor Christopher
- Taylor Greg W.
- Teasdale Rebecca L.
- Templeton Alexa
- Terrace John
- Thakkar Rohan
- Thomas George
- Thompson Ronald L. E.
- Tilston Michael P.
- Toh Simon K. C.
- Tolofari Sotonye
- Tomlinson Mark A.
- Trevatt Alexander E. J.
- Trotter Martin
- Tsang Andrew
- Tsavellas George
- Tuck Liz
- Turner Paul
- Tutton Matthew G.
- Ullah Muhammad Fahad
- Upchurch Emma A.
- Urbonas Tomas
- Varghase Joseph
- Vass David G.
- Vaughan Elizabeth M.
- Vijay Vardhini
- Vijayan Deepak
- Vijayanand Dhakshinamoorthy
- Villatoro Eduardo
- Virupaksha Suvi
- Vitone Louis J.
- Vohra Ravinder S.
- Wadley Martin
- Wainwright Denise
- Wajed Saj
- Wallace Tom
- Wardle Stacy
- Warren Conor
- Watkin Helen
- Watson Angus J. M.
- Watson Nicholas F.
- Wayman John
- Weaver Simon
- Weber Beatrix
- Weber Beatrix
- Weerasinghe Chamindri
- Welbourn Hannah
- Wheatley Kevin
- White Timothy J.
- Wijetunga Imeshi
- Wild Jonathan R. L.
- Wilkinson Marc D.
- Williams Sophie V.
- Williamson Tracey K.
- Willson Peter D.
- Wilson Michael S. J.
- Wilson Timothy R.
- Winter Des C.
- Winter Hannah
- Wood Christopher P. J.
- Wood Peter
- Wood Simon
- Woodman Thomas
- Yahya Salama
- Yao Caroline
- Yeldham Geoffrey
- Yoganathan Thusidaran
- Youssef Haney
- Zafar Sara
- Zafrani Zakhi
- Zarsadias Prizzi
- Zeeshan Saquib
- Zhang Catherine
- Ziprin Paul
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations.
Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves.
Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p 90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score.
Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care
Longevity, mobility, and spare parts: The future imperfect and human service delivery.
- Author
- Abram
- Abram
- Anthony
- Bernstein
- Blacher
- Blum
- CELDIC REPORT
- Chamberlain
- Char
- Clarke
- Danilowicz
- Darley
- David
- Duhl
- Eisenberg
- Eisendrath
- Foley
- Forssman
- French
- Galdston
- Glueck
- Goldfarb
- Grunebaum
- JOINT COMMISSION ON MENTAL HEALTH OF CHILDREN.
- Kahn
- Kahn
- Kline
- Koller
- Kornfield
- Lazarus
- Leighton
- Lindemann
- Little
- Lourie
- Lunde
- Lurie
- Margolis
- Mcdermott
- Mcdermott
- Mckegney
- Mensh
- Naomi I. Rae-Grant
- Oliver
- Orne
- Pasamanick
- Pavenstedt
- Radin
- Rae-Grant
- Rees
- Rice
- Robins
- Rome
- Rosenthal
- Silver
- Toffler
- Toker
- Vanalstyne
- Westman
- Yahraes
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
- Author
- AISSI Dylan
- AL CHALABI Ammar
- AL KHLEIFAT Ahmad
- ALARCON-RIQUELME Marta E.
- ARSENEAULT Louise
- AWALOFF Yvonne
- BARTUREN Guillermo
- BEEKMAN Marian
- BELL Jordana T.
- BERNARD Manon
- BINDER Elisabeth B.
- BOCK Christoph
- BOLLEPALLI Sailalitha
- BOOMSMA Dorret I.
- BRETHERICK Andrew D.
- BRUNEKREEF Bert
- BURROWS Kimberley
- BUSTAMANTE Mariona
- CARDONA Alexia
- CARNERO-MONTORO Elena
- CASPI Avshalom
- CASTILLO-FERNANDEZ Juan
- CATALA-MOLL Francesc
- CHATURVEDI Nish
- CLARKE Toni Kim
- CONSORTIUM Bios
- CORCORAN David L.
- CUGLIARI Giovanni
- CZAMARA Darina
- DAVEY SMITH George
- DAVIES Gareth E.
- DAY Felix R.
- DE GEUS Eco J. C.
- DEARY Ian J.
- DEKKER Annelot
- DEKKERS Koen F.
- ELLIOTT Hannah R.
- ESKO Tonu
- EVANS Kathryn L.
- FELIX Janine F.
- GAGNON France
- GAUNT Tom R.
- GERMAIN Marine
- GIRALT-STEINHAUER Eva
- GONZALEZ Juan Ramon
- GORRIE-STONE Tyler
- GUARRERA Simonetta
- GUPTA Richa
- HALEY Chris
- HANNON Eilis
- HANSEN Torben
- HEIJMANS Bastiaan T.
- HEMANI Gibran
- HO Karen M.
- HOLLOWAY John W.
- HOTTENGA Jouke Jan
- HUANG Rae Chi
- HUGHES Alun D.
- IACOANGELI Alfredo
- IKRAM M. Arfan
- IOTCHKOVA Valentina
- JADDOE Vincent W. V.
- JIMENEZ-CONDE Jordi
- KAPRIO Jaakko
- KARMAUS Wilfried
- KASELA Silva
- KAZMI Nabila
- KERICK Martin
- KLUGHAMMER Johanna
- KOPPELMAN Gerard H.
- KUMAR Ashish
- KUMARI Meena
- LAHTI Jari
- LAWLOR Deborah A.
- LAWSON Daniel J.
- LERRO Michael
- LIN Tian
- LUCAE Susanne
- LUIJK Rene
- MANDAVIYA Pooja
- MARIONI Riccardo E.
- MARTIN Nicholas G.
- MASON Dan
- MATULLO Giuseppe
- MCARDLE Wendy L.
- MCINTOSH Andrew M.
- MCRAE Allan F.
- MELEN Erik
- MELTON Phillip
- METSPALU Andres
- MILANI Lili
- MILL Jonathan
- MIN Josine L.
- MOFFITT Terrie E.
- MONTGOMERY Grant W.
- MORANGE Pierre Emmanuel
- MORGEN Camilla S.
- MURRAY Alison
- NOHR Ellen A.
- OLLIKAINEN Miina
- ONG Ken K.
- PANICO Salvatore
- PAUS Tomas
- PAUSOVA Zdenka
- PENNELL Craig E.
- PERRY John R. B.
- PERSHAGEN Goran
- POULTON Richie
- RAIKKONEN Katri
- RELTON Caroline L.
- REZWAN Faisal I.
- RICHARDSON Tom G.
- RING Susan M.
- RIVADENEIRA Fernando
- ROQUER Jaume
- RUIZ-ARENAS Carlos
- SACERDOTE Carlotta
- SCHALKWYK Leonard C.
- SCHMOLL Vanessa
- SHARP Gemma
- SHATUNOV Aleksey
- SHAW Chris
- SHIN Jean
- SLAGBOOM P. Eline
- SMART Melissa
- SODERHALL Cilla
- SORENSEN Thorkild I. A.
- SORIANO-TARRAGA Carolina
- SPECTOR Timothy D.
- STARR John M.
- SUDERMAN Matthew
- SUGDEN Karen
- SUNYER Jordi
- TIEMEIER Henning
- TILLIN Therese
- TREGOUET David-Alexandre
- UITTERLINDEN Andre G.
- VAN DONGEN Jenny
- VAN EIJK Kristel
- VAN HEEMST Diana
- VAN IJZENDOORN Marinus H.
- VAN MEURS Joyce
- VELDINK Jan H.
- VIBERTI Clara
- VISSCHER Peter M.
- VONK Judith M.
- WALKER Rosie M.
- WANG Carol
- WAREHAM Nicholas J.
- WILLEMSEN Gonneke
- WRAY Naomi R.
- WRIGHT John
- XU Cheng Jian
- YET Idil
- ZENG Yanni
- ZHANG Hongmei
- ZWAMBORN Ramona
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/09/2021
- Field of study
Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantitative trait locus (mQTL) analyses on 32,851 participants, identifying genetic variants associated with DNAm at 420,509 DNAm sites in blood. We present a database of >270,000 independent mQTLs, of which 8.5% comprise long-range (trans) associations. Identified mQTL associations explain 15–17% of the additive genetic variance of DNAm. We show that the genetic architecture of DNAm levels is highly polygenic. Using shared genetic control between distal DNAm sites, we constructed networks, identifying 405 discrete genomic communities enriched for genomic annotations and complex traits. Shared genetic variants are associated with both DNAm levels and complex diseases, but only in a minority of cases do these associations reflect causal relationships from DNAm to trait or vice versa, indicating a more complex genotype–phenotype map than previously anticipated
Is perioperative COVID-19 really associated with worse surgical outcomes? A nationwide COVIDSurg propensity-matched analysis
- Author
- A Abbas
- A Abouassi
- A Bhavaraju
- A Brown
- A Choudhry
- A Cioci
- A Dehal
- A Dorafshar
- A E Berndtson
- A F Utria
- A Fuson
- A Goldenberg-Sandau
- A Gosain
- A H Sohail
- A J Rios-Diaz
- A Khalil
- A Maiga
- A Meagher
- A Ovaitt
- A R Bhama
- A R Kar
- A Salim
- A Soliman
- A Ssentongo
- A Suri
- A Torquati
- A Volpe
- A Walters
- Abhinav Tiwari
- Abramowicz S
- Adesoji Ademuyiwa
- Ahmad Qureshi
- Ahmad Zarour
- Ahmed Adil
- Aiste Gulla
- Alaa El-Hussuna
- Alexis Arnaud
- Alser O
- Amanpreet Brar
- Amin D
- Ana Danic Hadzibegovic
- Ana Minaya Bravo
- Ana Minaya-Bravo
- Anant Desai
- Andreas Demetriades
- Andrew Schache
- Andrey Litvin
- Aneel Bhangu
- Angelos Kolias
- Antonio Ramos De La Medina
- April Roslani
- Arben Gjata
- Arda Isik
- Argandykov Dias
- Arnav Agarwal
- B A Miles
- B Dennis
- B Galbreath
- B George
- B Hall
- B Juthani
- B Kim
- B Nunez-Garcia
- B Robinson
- B S Karam
- B Till
- B U Okafor
- Babatunde Osinaike
- Bankhead-Kendall B
- Bhangu Aneel
- Bokenkamp Mary
- Brathwaite Cem
- Breen K
- Brett E Dawson
- Brittany Kendall
- C Burlew
- C Chung
- C G Velopulos
- C Gillezeau
- C Jones
- C Marsh
- C P Raut
- C Paranjape
- Cardenas T
- Carlos Jose Perez Rivera
- Chetan Khatri
- Chew Min Hoe
- Christensen M A
- Christina Fotopoulou
- Conor S Jones
- D A Mahvi
- D Brahmbhatt
- D Chen
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- D Deisher
- D Klaristenfeld
- D Moris
- D Nehra
- D Ozgediz
- D Podolsky
- Dakshitha Wickramasinghe
- Dale Vimalchandran
- Daniel Cox
- Daniel Wettstein
- Daoud Chaudhry
- Dejan Radenkovic
- Dennis Mazingi
- Dhruv Ghosh
- Dmitri Nepogodiev
- Dorken-Gallastegi Ander
- E A Hennessy
- E Aigbivbalu
- E Benedetti
- E Cherullo
- E Consorti
- E Dauer
- E Eriksson
- E Giorgakis
- E Gokcen
- E Hernandez
- E Holler
- E Kropf
- E Renza-Stingone
- E S Hwang
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- Elaine Leung
- Elizabeth Li
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- Emmanuel Williams
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- Faustin Ntirenganya
- Felix Aigner
- Francesco Pata
- Frederick Koh Hong Xiang
- G Baltazar
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- G H Davidson
- G Kinnaman
- G Kulkarni
- G Peck
- G Ruiz
- Gabre-Kidan A
- Gabriele Kembuan
- Gabrielle VanRamshorst
- Gaetano Gallo
- Gaitanidis A
- Gebran Anthony
- Georgios Tsoulfas
- Gianluca Pellino
- Glauco Baiocchi
- Grant Stewart
- Gustavo Ataide
- Gustavo Grecinos
- H Abdou
- H Carmichael
- H E Rice
- H Evans
- H H Batjer
- H Hakmi
- H Hirsch
- H Jackson
- H Liu
- H Marwan
- H Ross
- H Sufrin
- Hailu Tamiru
- Hamza Al Naggar
- Hans Lederhuber
- Harvinder Mann
- Hassan Mashbari
- Haynes A B
- Haytham Kaafarani
- Helen M Mohan
- Hemmila M
- Heron C
- Hill C E
- Hugo Gomez
- I Ganly
- I Kent
- I Sharma
- Ian Ganly
- Igor Buarque
- Ildar R Fakhradiyev
- Ionut Negoi
- Irene Santos
- Irida Dajti
- Irmgard Kronberger
- Ismail Lawani
- Isobel M Trout
- J Caruso
- J Chan
- J Clark
- J Coleman
- J Cuschieri
- J Diaz
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- J Dunn
- J Eid
- J Engel
- J Fleming
- J Gigliotti
- J H Levin
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- J Hazelton
- J Laryea
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- J Maines
- J Myers
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- J Ourieff
- J P Kronenfeld
- J Poggio
- J Rapp
- J S Jolissaint
- J S Oh
- J Sewards
- J Sundaresan
- Jakov Mihanovic
- James C Glasbey
- James M Keatley
- James Ngu Chi Yong
- Janet Martin
- Jaroslav Klat
- Jenny H
- Joana F F Simoes
- Joana F F Simoes
- Johanna Laukkarinen
- John G Edwards
- Jonathan P Evans
- Joonas Kauppila
- Jose Calvache
- José Azevedo
- Justina Seyi-Olajide
- K Fretwell
- K Huynh
- K Kalkwarf
- K Kieran
- K Nicholson
- K P Colling
- K Rakoczy
- K Rodkey
- K Rubin
- K Sanserino
- K Schaffer
- K Sexton
- Kaafarani H
- Kaafarani Haytham M A
- Kamral Hossain
- Kapoen C
- Katie Shaw
- Keith Roberts
- Kenneth A Mclean
- Kent A
- Kerry Breen
- Knut Magne Augestad
- Kwabena Siaw-Acheampong
- L A O'Banion
- L Brown
- L Burdine
- L Camp
- L Hansen
- L O'Meara
- L Rae
- L Z Kornblith
- L Zier
- Ladd M R
- Langeveld K
- Laura Martinez
- Leah Argus
- Leede E
- Lisa Norman
- Long C
- Luis Boccalatte
- M Abdallah
- M Allen
- M Allen
- M Almasri
- M Boeck
- M El Moheb
- M Garner
- M H Haqqani
- M J Hill
- M K Abel
- M Kimbrough
- M Kost
- M L Hibbard
- M Lallemand
- M M Carrick
- M Masrur
- M Mehdi
- M Metro
- M P Callahan
- M Philp
- M Quintana
- M Richmond
- M Roberts
- M Rosengart
- M San Andrés
- M Schellenberg
- M Sion
- M Ujiki
- Malapati H
- Malin Sund
- Manning D
- Marco Fiore
- Margalit A
- Maria Aguilera Lorena
- Maria Marta Modolo
- Maria Picciochi
- MariaMarta Modolo
- Maricarmen Olivos
- Marie Dione Parreno-Sacdalan
- Markus Albertsmeiers
- Markus Loffler
- Martin Rcg
- Martin Rutegård
- Mary L Venn
- Mashbari H
- Masoud Mozafari
- Maurer L R
- McElhinney K
- McKenzie K
- McNelis P
- Mengistu Gebreyohanes Mengesha
- Michael D Jenkinson
- Miguel Cunha
- Mihail Slavchev
- Milou Noltes
- Mohammad Chaar
- Mohammad Jamal
- Mohammad Khosravi
- Mohammed Elmujtaba
- Moises Cukier
- Mokhtari A
- Monson Jrt
- Muhammad Gohar
- Muhammed Elhadi
- Mustafa Abu Mohsen Daraghmeh
- N Alpert
- N Bhutiani
- N Glass
- N Goel
- N Gusani
- N Hanna
- N L Coleman
- N M Ruzgar
- N Post
- N Talathoti
- Naar L
- Naomi Wright
- Napolitano L
- Ncamsile Nhlabathi
- Neil Smart
- Nepogodiev Dmitri
- O Merzlikin
- Oded Zmora
- Olson K A
- Osaid Alser
- Oumaima Outani
- P Giulianotti
- P Javid
- P N Martins
- P Park
- P Petrone
- P Ssentongo
- Pascal Jonker
- Pazionis T
- Peiman Brouk
- Perkins R
- Peter Christensen
- Peter Hutchinson
- Peter Pockney
- Petrov R
- Philip Townend
- Pieter Steinkamp
- Piotr Major
- Proaño-Zamudio Jefferson A
- R C McIntyre Jr
- R Callcut
- R Choron
- R Cosker
- R Dirks
- R Gonzalez
- R Grolman
- R Hassan
- R Heckburn
- R Kennedy
- R Kwan-Feinberg
- R Lamm
- R Lewit
- R M Nygaard
- R Morris
- R Rattan
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- Rachel Moore
- Raza Sayyed
- Rehman S
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- René Novysedlak
- Richard J W Wilkin
- Richard Shaw
- Riinu Ots
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- Rohan R Gujjuri
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- Ruth Blanco Colino
- S A Hirji
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- S Averbach
- S D Wexner
- S E Rice-Townsend
- S Eckhouse
- S G Aoun
- S Horvath
- S J Ullrich
- S Merola
- S Nicholson
- S Rehman
- S Seegert
- S Urban
- Sadi Abukhalaf
- Sameh H Emile
- Samuel Ford
- Samuel Hailu
- Samuel Lawday
- Sattar Alshryda
- Schelto Kruijff
- Sebastian Shu
- Sergey Efetov
- Sezai Leventoğlu
- Siobhan McKay
- Sivesh K Kamarajah
- Sofija Pejkova
- Sohei Satoi
- Sohini Chakrabortee
- Stephen Knight
- Stephen Tabiri
- Stevens K
- Sudha Sundar
- Sylvia Batista
- Symeon Metallidis
- T Curry
- T J Schroeppel
- T Jamil
- T Liu
- T Price
- T Rostkowski
- Tabassum Khan
- Tamas Mersich
- Teixeira P G
- Thomas D Drake
- Thompson K
- Thornhill M
- Tom E F Abbott
- Tomislav Kopjar
- Trust M D
- Tsai L
- Umesh Jayarajah
- V Hart
- V Roxo
- V S Ban
- Velmahos G
- Vervoort D
- Vidya Raghavan
- W Biffl
- W Marx
- W Nugent 3rd
- W Pavlis
- Willemijn van der Plas
- William Jebril
- Wong J J
- Ximena Vasquez
- Y Ying
- Yesantharao L
- Yesantharao P
- Z Cooper
- Zainab Al Balushi
- Publication venue
- place:TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
- Publication date
- 01/01/2023
- Field of study
BACKGROUND: Patients undergoing surgery with perioperative COVID-19 are suggested to have worse outcomes, but whether this is COVID-related or due to selection bias remains unclear. We aimed to compare the postoperative outcomes of patients with and without perioperative COVID-19. METHODS: Patients with perioperative COVID-19 diagnosed within 7 days before or 30 days after surgery between February and July 2020 from 68 US hospitals in COVIDSurg, an international multicenter database, were 1:1 propensity score matched to patients without COVID-19 undergoing similar procedures in the 2012 American College of Surgeons National Surgical Quality Improvement Program database. The matching criteria included demographics (e.g., age, sex), comorbidities (e.g., diabetes, chronic obstructive pulmonary disease, chronic kidney disease), and operation characteristics (e.g., type, urgency, complexity). The primary outcome was 30-day hospital mortality. Secondary outcomes included hospital length of stay and 13 postoperative complications (e.g., pneumonia, renal failure, surgical site infection). RESULTS: A total of 97,936 patients were included, 1,054 with and 96,882 without COVID-19. Prematching, COVID-19 patients more often underwent emergency surgery (76.1% vs. 10.3%, p < 0.001). A total of 843 COVID-19 and 843 non-COVID-19 patients were successfully matched based on demographics, comorbidities, and operative characteristics. Postmatching, COVID-19 patients had a higher mortality (12.0% vs. 8.1%, p = 0.007), longer length of stay (6 [2-15] vs. 5 [1-12] days), and higher rates of acute renal failure (19.3% vs. 3.0%, p < 0.001), sepsis (13.5% vs. 9.0%, p = 0.003), and septic shock (11.8% vs. 6.0%, p < 0.001). They also had higher rates of thromboembolic complications such as deep vein thrombosis (4.4% vs. 1.5%, p < 0.001) and pulmonary embolism (2.5% vs. 0.4%, p < 0.001) but lower rates of bleeding (11.6% vs. 26.1%, p < 0.001). CONCLUSION: Patients undergoing surgery with perioperative COVID-19 have higher rates of 30-day mortality and postoperative complications, especially thromboembolic, compared with similar patients without COVID-19 undergoing similar surgeries. Such information is crucial for the complex surgical decision making and counseling of these patients. (J Trauma Acute Care Surg. 2023;94: 513-524. Copyright (C) 2023 American Association for the Surgery of Trauma.)LEVEL OF EVIDENCE: Prognostic and Epidemiologic; Level IV
Utilisation of an operative difficulty grading scale for laparoscopic cholecystectomy (vol 33, pg 110, 2019)
- Author
- Aawsaj Yousif
- Abayomi Michael
- Acharya Vikas
- Aggarwal Smeer Kumar
- Ahmad Anwar
- Ahmed Irfan
- Ahmed Jamil
- Ahmed Javed
- Ahmed Talat
- Ainley Paul
- Akhtar Mansoor
- Al-Abed Yahya A.
- Al-Akash Musallam
- Al-Bahrani Ahmed Z.
- Al-Khyatt Waleed
- Al-Muhktar Ahmed
- Al-Sarireh Bilal
- Al-Taan Omer
- Alagaratnam Swethan
- Alam Imran
- Alberts Justin
- Alderson Derek
- Aldridge Roland C.
- Aleksandrov Danail
- Ali Haythem
- Ali Shahda
- Amari Khalid Al
- Amin Khalid
- Andrew David R.
- Angharad Jones M.
- Appleton Shaun
- Arhi Chanpreet
- Aroori Somaiah
- Aryal Kamal
- Asad Mehek
- Aseem Rabiya
- Asprou Fotini M.
- Awan Altaf
- Ayaani Soofiyah
- Aymon Null
- Babu Benoy I.
- Bajwa Dalvir S.
- Bajwa Farrukh M.
- Baker Andrew L.
- Balfe Paul
- Ball William R.
- Ballance Laura
- Banwell Victoria
- Barnes James
- Barrie Jenifer
- Bartlett Francis
- Basheer Mohammed
- Bashir Gareth
- Basra Melvinder
- Basu Sanjoy
- Basynat Pradeep
- Batt Jeremy
- Bausbacher Harald
- Bawa Sadiq
- Beasley William D.
- Belding Rowena
- Bellini Maria Irene
- Bennett Stephen P.
- Bhandari Christopher Taylor Santosh
- Bhattacharya Vish
- Blane Christine
- Blazeby Jane M.
- Boal Matthew
- Boddy Alexander
- Boland Michael
- Bond-Smith Giles
- Booth Michael I.
- Borowski David W.
- Bowen Laura
- Boyce Kathryn M.
- Boyd Alan T.
- Bradley Donal
- Bradley Neil
- Brennan Stephen
- Brett Daniel
- Broadhurst Jack
- Brooke Eleanor
- Brown Timothy H.
- Bryant Alice
- Buchan Joanna
- Bullen Naomi
- Bunnell Catherine
- Bunting David M.
- Burke Paul
- Byrne James P.
- Byrnes Colman K.
- Campbell William
- Carney Kate
- Carney Kate
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- Carter Nicholas C.
- Carty Nick
- Cassidy John T.
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- Chambers Alice
- Chan Wei Ming
- Chang Jessica
- Charalabopoulos Alexandros
- Chauhan Neal
- Cheung Melanie
- Chishti Imran A.
- Chitre Vivek
- Choy Alfred
- Cieplucha Krzysztos
- Clements Joshua M.
- Coats Maria
- Cockbain Andrew J.
- Coe Peter O.
- Connelly Martin
- Cooke Fiachra
- Courtney Michael J.
- Cowley Jonathan B.
- Cross Keith S.
- Cuming Tamzin
- Cunha Pedro
- D\u2019Costa Conrad
- Dalgaty Faith
- Dar Farooq
- Date Ravindra
- Dave Rajiv V.
- Davey Phil
- Davies James
- Dawson Suzanne
- De Marchi Joshua A.
- de Siqueira Jonathan
- Deguara Jean
- Delisle Theo G.
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- Derbyshire Laura
- Devoto Laurence
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- Dorrian Emmet
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- Downing Justine
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- Driscoll Peter J.
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- Durkin Damien
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- Janeczko Adam
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- Kimble Adam
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- Knight Benjamin
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- Kourkulos Michail
- Krysztopik Richard
- Kumar Pradeep
- Kynaston James
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- Lalla Kushik
- Lambert Joel
- Lane Risha
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- Tutton Matthew G.
- Ullah Muhammad Fahad
- Upchurch Emma A.
- Urbonas Tomas
- Varghase Joseph
- Vass David G.
- Vaughan Elizabeth M.
- Vijay Vardhini
- Vijayan Deepak
- Vijayanand Dhakshinamoorthy
- Villatoro Eduardo
- Virupaksha Suvi
- Vitone Louis J.
- Vohra Ravi S.
- Vohra Ravinder S.
- Wadley Martin
- Wainwright Denise
- Wajed Saj
- Wallace Tom
- Wardle Stacy
- Warren Conor
- Watkin Helen
- Watson Angus J. M.
- Watson Nicholas F.
- Wayman John
- Weaver Simon
- Weber Beatrix
- Weber Beatrix
- Weerasinghe Chamindri
- Welbourn Hannah
- Wheatley Kevin
- White Timothy J.
- Wijetunga Imeshi
- Wild Jonathan R. L.
- Wilkinson Marc D.
- Williams Sophie V.
- Williamson Tracey K.
- Willson Peter D.
- Wilson Michael S. J.
- Wilson Timothy R.
- Winter Des C.
- Winter Hannah
- Wood Christopher P. J.
- Wood Peter
- Wood Simon
- Woodman Thomas
- Yahya Salama
- Yao Caroline
- Yeldham Geoffrey
- Yoganathan Thusidaran
- Youssef Haney
- Zafar Sara
- Zafrani Zakhi
- Zarsadias Prizzi
- Zeeshan Saquib
- Zhang Catherine
- Zino Samer
- Ziprin Paul
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Outcomes and Their State-level Variation in Patients Undergoing Surgery With Perioperative SARS-CoV-2 Infection in the USA. A Prospective Multicenter Study
- Author
- A Abbas
- A Abouassi
- A B Haynes
- A Bhavaraju
- A Brown
- A Choudhry
- A Cioci
- A Dehal
- A Dorafshar
- A E Berndtson
- A F Utria
- A Fuson
- A Gabre-Kidan
- A Gaitanidis
- A Goldenberg-Sandau
- A Gosain
- A H Sohail
- A J Rios-Diaz
- A Kent
- A Khalil
- A Maiga
- A Margalit
- A Meagher
- A Mokhtari
- A Ovaitt
- A R Bhama
- A R Kar
- A Salim
- A Soliman
- A Ssentongo
- A Suri
- A Torquati
- A Volpe
- A Walters
- Abd'Rashid Nashidengo
- Abdourahmane Ndong
- Abel Huang
- Abhinav Tiwari
- Adesoji Ademuyiwa
- Ahmad Qureshi
- Ahmad Zarour
- Ahmed Adil
- Ahmed Elgun
- Aiste Gulla
- Alaa El-Hussuna
- Alemayehu Ginbo Bedada
- Alexis Arnaud
- Alistair Denniston
- Amanpreet Brar
- Amer Alderazi
- Ana Danic Hadzibegovic
- Ana Minaya Bravo
- Anant Desai
- Ander Dorken Gallastegi
- Andreas A Schnitzbauer
- Andreas Demetriades
- Andrew Schache
- Andrey Litvin
- Aneel Bhangu
- Aneel Bhangu
- Angelos Kolias
- Anthony Gebran
- Antonio Ramos De La Medina
- Anvar Beisembaev
- Apostolos Gaitanidis
- April Roslani
- Arben Gjata
- Arda Isik
- Arnav Agarwal
- Arpad Panyko
- Ashish Lal Shrestha
- Atul Suroy
- B A Miles
- B Bankhead-Kendall
- B Dennis
- B Galbreath
- B George
- B Hall
- B Juthani
- B Kim
- B Nunez-Garcia
- B Robinson
- B S Karam
- B Till
- B U Okafor
- Babatunde Osinaike
- Ben Mbwele
- Bernard Ofori Appiah
- Brett E Dawson
- Brittany Bankhead-Kendall
- Brittany Kendall
- C Burlew
- C Chung
- C E Hill
- C E M Brathwaite
- C G Velopulos
- C Gillezeau
- C Heron
- C Jones
- C Kapoen
- C Long
- C Marsh
- C P Raut
- C Paranjape
- C Reinke
- C Riley
- Carlos Jose Perez Rivera
- Cerovac Anis
- Charu Paranjape
- Chetan Khatri
- Chew Min Hoe
- Chris Munguas
- Chris Varghese
- Christina Fotopoulou
- Chukwuemeka Nwegbu
- Conor S Jones
- D A Mahvi
- D Amin
- D Brahmbhatt
- D Chen
- D Dehart
- D Deisher
- D Klaristenfeld
- D Manning
- D Moris
- D Nehra
- D Ozgediz
- D Podolsky
- D Vervoort
- Dakshitha Wickramasinghe
- Dale Vimalchandran
- Daniel Acquah
- Daniel Cox
- Daniel Wettstein
- Danilo Alfonso Arévalo Sandoval
- Daoud Chaudhry
- Deborah Wright
- Dejan Radenkovic
- Dennis Mazingi
- Dhruv Ghosh
- Dmitri Nepogodiev
- Dmitri Nepogodiev
- Dong-Lin Ren
- Duane Wedderburn
- E A Hennessy
- E Aigbivbalu
- E Benedetti
- E Cherullo
- E Consorti
- E Eriksson
- E Etchill
- E Giorgakis
- E Gokcen
- E Hernandez
- E Holler
- E Kropf
- E Leede
- E Renza-Stingone
- E S Hwang
- E T Colonna
- E Taioli
- E Urrechaga
- Ed Caruna
- Eddy Lincango
- Eduard-Alexandru Bonci
- Ehab AlAmeer
- Elaine Leung
- Eleftherios Gialamas
- Elizabeth Li
- Ella J Marson
- Elliott H Taylor
- Emmanuel Williams
- Enver Fekaj
- Ewen Griffiths
- F L Wright
- F Palazzo
- F Soliman
- F T Drake
- F W Endorf
- F Zheng
- Faris Ayasra
- Faustin Ntirenganya
- Felix Aigner
- Fernando Bonilla
- Francesco Pata
- Frederick Koh Hong Xiang
- G Baltazar
- G Chang
- G Gilna
- G H Davidson
- G Kinnaman
- G Kulkarni
- G Peck
- G Ruiz
- G Velmahos
- Gabriele Kembuan
- Gabrielle VanRamshorst
- Gallo G
- George C Velmahos
- Georgios Tsoulfas
- Gianluca Pellino
- Glauco Baiocchi
- Grant Stewart
- Greg Padmore
- Gustavo Ataide
- Gustavo Grecinos
- H Abdou
- H Carmichael
- H E Rice
- H Evans
- H H Batjer
- H Hakmi
- H Hirsch
- H Jackson
- H Jenny
- H Kaafarani
- H Liu
- H Malapati
- H Marwan
- H Mashbari
- H Ross
- H Sufrin
- Hailu Tamiru
- Haithem Jlassi
- Hamza Al Naggar
- Hans Lederhuber
- Harvinder Mann
- Hassan Ali
- Hassan Mashbari
- Hassan Mashbari
- Haytham Kaafarani
- Haytham M A Kaafarani
- Helen M Mohan
- Herman Lule
- Hugo Gomez
- I Ganly
- I Kent
- I Sharma
- Ian Ganly
- Ibrahim Sesay
- Igor Buarque
- Ildar R Fakhradiyev
- Intisar Hisham
- Ionut Negoi
- Iran Irani Duran Sanchez
- Irene Santos
- Irida Dajti
- Irmgard Kronberger
- Ismail Lawani
- Isobel M Trout
- Israël Feraudy
- J Caruso
- J Chan
- J Clark
- J Coleman
- J Cuschieri
- J Diaz
- J Diaz
- J Dunn
- J Eid
- J Engel
- J Fleming
- J Gigliotti
- J H Levin
- J Hauptman
- J Hazelton
- J J Wong
- J Laryea
- J Lilienstein
- J Maines
- J Myers
- J Nunez
- J Ourieff
- J P Kronenfeld
- J Poggio
- J R T Monson
- J Rapp
- J Rose
- J S Jolissaint
- J S Oh
- J Sewards
- J Sundaresan
- Jade Nunez
- Jakov Mihanovic
- James C Glasbey
- James M Keatley
- James Ngu Chi Yong
- Janet Martin
- Jaroslav Klat
- Jean Marie Vianney Butoyi
- Jin-Young Jang
- Joana F F Simoes
- Joana F F Simoes
- Johanna Laukkarinen
- John G Edwards
- Jonathan P Evans
- Joonas Kauppila
- Jorge Neira
- Jose Calvache
- José Azevedo
- Jupsi Neny
- Jurij Kosir
- Justina Seyi-Olajide
- K A Olson
- K Breen
- K Fretwell
- K Huynh
- K Kalkwarf
- K Kieran
- K Langeveld
- K McElhinney
- K McKenzie
- K Nicholson
- K P Colling
- K Rakoczy
- K Rodkey
- K Rubin
- K Sanserino
- K Schaffer
- K Sexton
- K Stevens
- K Thompson
- Kamral Hossain
- Karoline Horisberger
- Katie Shaw
- Kebba Marenah
- Keith Roberts
- Kenneth A Mclean
- Kerry Breen
- Kerry Breen
- Kjetil Soreide
- Knut Magne Augestad
- Kwabena Siaw-Acheampong
- L A O'Banion
- L Brown
- L Burdine
- L Camp
- L Hansen
- L Naar
- L Napolitano
- L O'Meara
- L R Maurer
- L Rae
- L Tsai
- L Yesantharao
- L Z Kornblith
- L Zier
- Laura Martinez Perez Maldonado
- Leah Argus
- Lekuya Herve
- Lekuya Monka
- Leon Naar
- Lisa Norman
- Luc Samison
- Luis Boccalatte
- Lydia R Maurer
- M A Christensen
- M Abdallah
- M Allen
- M Allen
- M Almasri
- M Boeck
- M D Dauer
- M D Trust
- M El Hechi
- M El Moheb
- M El Moheb
- M Garner
- M H Haqqani
- M Hemmila
- M J Hill
- M K Abel
- M Kimbrough
- M Kost
- M L Hibbard
- M Lallemand
- M M Carrick
- M Masrur
- M Mehdi
- M Metro
- M P Callahan
- M Philp
- M Quintana
- M R Ladd
- M Richmond
- M Roberts
- M Rosengart
- M San Andrés
- M Schellenberg
- M Sion
- M Thornhill
- M Ujiki
- Magdalena Gruendl
- Malin Sund
- Marco Fiore
- Maria Aguilera Lorena
- Maria Marta Modolo
- Maria Marta Modolo
- Maria Picciochi
- Maricarmen Olivos
- Marie Dione Parreno-Sacdalan
- Markus Albertsmeiers
- Markus Loffler
- Martin Rutegård
- Mary L Venn
- Masoud Mozafari
- Mayaba Maimbo
- Mengistu Gebreyohanes Mengesha
- Michael D Jenkinson
- Michel Adamina
- Miguel Cunha
- Mihail Slavchev
- Milou Noltes
- Mohamad El Moheb
- Mohammad Chaar
- Mohammad Jamal
- Mohammad Khosravi
- Mohammed Elmujtaba
- Moises Cukier
- Muhammad Alshaar
- Muhammad Gohar
- Muhammed Elhadi
- Mustafa Abu Mohsen Daraghmeh
- N Alpert
- N Bhutiani
- N Glass
- N Goel
- N Gusani
- N Hanna
- N L Coleman
- N M Ruzgar
- N Post
- N Talathoti
- Naomi Wright
- Naoto Kuroda
- Ncamsile Nhlabathi
- Neil Smart
- Nicolas Amisi
- Nikolaos Gouvas
- O Alser
- O Merzlikin
- Oded Zmora
- Osaid Alser
- Osaid Alser
- Oumaima Outani
- Oussama Kacimi
- P G Teixeira
- P Giulianotti
- P Javid
- P McNelis
- P N Martins
- P Park
- P Petrone
- P Ssentongo
- P Yesantharao
- Pablo Avilés
- Palesa Chisala
- Pascal Jonker
- Peiman Brouk
- Peter Christensen
- Peter Hutchinson
- Peter Pockney
- Philip Townend
- Pieter Steinkamp
- Piotr Major
- Pranay Pawar
- R C G Martin
- R C McIntyre Jr
- R Callcut
- R Choron
- R Cosker
- R Dirks
- R Gonzalez
- R Grolman
- R Hassan
- R Heckburn
- R Kennedy
- R Kwan-Feinberg
- R Lamm
- R Lewit
- R M Nygaard
- R Morris
- R Perkins
- R Petrov
- R Rattan
- R Robertson
- R Saberi
- R Verma
- Rachel Moore
- Rakesh Shah
- Raza Sayyed
- René Novysedlak
- Richard J W Wilkin
- Richard Shaw
- Riinu Ots
- Robert D Sinyard
- Rohan R Gujjuri
- Roumanatou Bankole Sapin
- Ruth Benson
- Ruth Blanco Colino
- S A Hirji
- S A Olson
- S Abramowicz
- S Al-Embideen
- S Averbach
- S D Wexner
- S E Rice-Townsend
- S Eckhouse
- S G Aoun
- S Horvath
- S J Ullrich
- S M Roser
- S Merola
- S Nicholson
- S Rehman
- S Rehman
- S Ross
- S Roward
- S Seegert
- S Urban
- Sadi Abukhalaf
- Sameh H Emile
- Samir Delibegovic
- Samuel Ford
- Samuel Hailu
- Samuel Lawday
- Sattar Alshryda
- Schelto Kruijff
- Sebastian Shu
- Sergey Efetov
- Sezai Leventoğlu
- Shane Charles
- Siobhan McKay
- Sivesh K Kamarajah
- Slava Kopetskiy
- Sofija Pejkova
- Sohei Satoi
- Sohini Chakrabortee
- Sonam Dargay
- Stephen Knight
- Stephen Tabiri
- Sudha Sundar
- Sylvia Batista
- Symeon Metallidis
- T Cardenas
- T Curry
- T J Schroeppel
- T Jamil
- T Liu
- T Pazionis
- T Price
- T Rostkowski
- Tabassum Khan
- Tamas Mersich
- Thomas D Drake
- Tom E F Abbott
- Tomislav Kopjar
- Umesh Jayarajah
- Uros Bele
- V Hart
- V Roxo
- V S Ban
- Varut Lohsiriwat
- Vidya Raghavan
- W Biffl
- W Marx
- W Nugent 3rd
- W Pavlis
- Wenhui Lou
- Willemijn van der Plas
- William Jebril
- Xiao Liu
- Ximena Vasquez
- Y Ying
- Yuki Fujimoto
- Z Cooper
- Zainab Al Balushi
- Zaza Demetrashvili
- Publication venue
- Wolters Kluwer Health
- Publication date
- 01/01/2022
- Field of study
Objective: To report the 30-day outcomes of patients with perioperative SARS-CoV-2 infection undergoing surgery in the USA.
Background: Uncertainty regarding the postoperative risks of patients with SARS-CoV-2 exists.
Methods: As part of the COVIDSurg multicenter study, all patients aged ≥17 years undergoing surgery between January 1 and June 30, 2020 with perioperative SARS-CoV-2 infection in 70 hospitals across 27 states were included. The primary outcomes were 30-day mortality and pulmonary complications. Multivariable analyses (adjusting for demographics, comorbidities, and procedure characteristics) were performed to identify predictors of mortality.
Results: A total of 1581 patients were included; more than half of them were males (n = 822, 52.0%) and older than 50 years (n = 835, 52.8%). Most procedures (n = 1261, 79.8%) were emergent, and laparotomies (n = 538, 34.1%). The mortality and pulmonary complication rates were 11.0 and 39.5%, respectively. Independent predictors of mortality included age ≥70 years (odds ratio 2.46, 95% confidence interval [1.65-3.69]), male sex (2.26 [1.53-3.35]), ASA grades 3-5 (3.08 [1.60-5.95]), emergent surgery (2.44 [1.31-4.54]), malignancy (2.97 [1.58-5.57]), respiratory comorbidities (2.08 [1.30-3.32]), and higher Revised Cardiac Risk Index (1.20 [1.02-1.41]). While statewide elective cancelation orders were not associated with a lower mortality, a sub-analysis showed it to be associated with lower mortality in those who underwent elective surgery (0.14 [0.03-0.61]).
Conclusions: Patients with perioperative SARS-CoV-2 infection have a significantly high risk for postoperative complications, especially elderly males. Postponing elective surgery and adopting non-operative management, when reasonable, should be considered in the USA during the pandemic peaks
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort (Nature, (2020), 583, 7814, (90-95), 10.1038/s41586-020-2265-1)
- Author
- Abbs Stephen
- Adhya Zoe
- Adlard Julian
- Afzal Maryam
- Ahmed Irshad
- Ahmed Munaza
- Ahmed Saeed
- Aitman Timothy J.
- Alachkar Hana
- Alamelu Jayanthi
- Alikhan Raza
- Allen Carl E.
- Allen Louise
- Allsup David J.
- Alvi Arif
- Ambegaonkar Gautam
- Anantharachagan Ariharan
- Ancliff Philip
- Anderson Julie
- Antrobus Richard
- Armstrong Ruth
- Arno Gavin
- Arumugakani Gururaj
- Arya Rita
- Ashford Sofie
- Astle William J.
- Attwood Anthony
- Austin Steve
- Aydinok Yesim
- Ayub Waqar
- Babbs Christian
- Bacchelli Chiara
- Baglin Trevor
- Bakchoul Tamam
- Bariana Tadbir K.
- Barratt Jonathan
- Barwell Julian
- Baski John
- Bates Rachel W.
- Batista Joana
- Baxendale Helen E.
- Baxendale Helen E.
- Baynam Gareth
- Bennett David L.
- Bethune Claire
- Bhatnagar Neha
- Bibi Shahnaz
- Bierzynska Agnieszka
- Biss Tina
- Bitner-Glindzicz Maria A.K.
- Bleda Marta
- Blesneac Iulia
- Boardman Barbara
- Boddana Preetham
- Bogaard Harm J.
- Booth Claire
- Boschann Felix
- Boyce Sara
- Bradley John R.
- Brady Angela
- Breen Gerome
- Brennan Paul
- Brewer Carole
- Briley Annette
- Brod Naomi Clements
- Brown Matthew
- Brown Matthew
- Brown Richard
- Browning Michael J.
- Brownlie Mary
- Bryson Christine J.
- Buchan Rachel J.
- Buck Jackie
- Buckland Matthew S.
- Buckland Matthew S.
- Bueser Teofila
- Burns Siobhan O.
- Burns Siobhan O.
- Burren Oliver S.
- Burren Oliver S.
- Calleja Paul
- Carmichael Jenny
- Carr-White Gerald
- Carss Keren J.
- Casey Ruth
- Castello Ignacio Medina
- Chalmers Elizabeth
- Chambers Jenny
- Chambers John
- Chan Melanie M.Y.
- Chan Melissa V.
- Chandra Anita
- Chandra Anita
- Cheng Floria
- Chinn Ivan K.
- Chinnery Patrick F.
- Chitre Manali
- Chong Sam
- Christian Martin T.
- Church Colin
- Clement Emma M.
- Clifford Hayley
- Clowes Virginia E.
- Coghlan Gerry
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- Cole Trevor R.P.
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- Condliffe Robin
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- Cooper Nichola
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- Corris Paul A.
- Creaser-Myers Amanda
- Crisp-Hihn Abigail
- Curry Nicola S.
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- Diz Carmen Bugarin
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- Drazyk Anna M.
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- Duarte Daniel
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- El-Shanawany Tariq
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- Emmerson Ingrid
- Erber Wendy N.
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- Estiu Maria C.
- Evans Dafydd Gareth
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- Everington Tamara
- Eyries Mélanie
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- Hague Rosie
- Hague William M.
- Haimel Matthias
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- Halmagyi Csaba
- Hammerton Tracey
- Hanson Helen L.
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- Harper Andrew R.
- Harper Lorraine
- Harris Claire
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- Hart Daniel
- Hassan Ahamad
- Hayman Grant
- Heemskerk Johan W.M.
- Hegde Shivaram
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- Hensiek Anke
- Henskens Yvonne M.C.
- Herwadkar Archana
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- MacLaren Robert
- Madan Bella
- Magee Laura
- Mahdi-Rogers Mohamed
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- Makris Mike
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- Manson Ania
- Manzur Adnan
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- Mark Patrick B.
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- Markus Hugh S.
- Marschall Hanns Ulrich
- Marshall Andrew
- Martin Jennifer M.
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- Matser Vera
- Matthews Emma L.
- Maw Anna
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- McAlinden Paul
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- McJannet Coleen
- McKinney Harriet
- Meacham Stuart
- Mead Adam J.
- Meehan Sharon
- Megy Karyn
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- Mehta Sarju
- Mercer Catherine L.
- Michaelides Michel
- Michell Anna C.
- Milford David
- Millar Carolyn M.
- Millar Hazel
- Mistry Anoop
- Moenen Floor
- Moledina Shahin
- Montani David
- Moore Anthony T.
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- 06/08/2020
- Field of study
An amendment to this paper has been published and can be accessed via a link at the top of the paper
Preoperative risk factors for conversion from laparoscopic to open cholecystectomy: a validated risk score derived from a prospective U.K. database of 8820 patients
- Author
- Abbas Kadhim
- Abdalla Eisawi
- Abdulzahra A. Hussain
- Abheesh R. Prasad
- Abhilasha Patel
- Abi Mawhinney
- Abraham Joel
- Adam Chambers
- Adam Janeczko
- Adam Kimble
- Adeshina S. Fawole
- Adnan Hussain
- Adrian W. O'Sullivan
- Ahmad H. Nassar
- Ahmed Al-Muhktar
- Ahmed K. Mirza
- Ahmed M. Khalil
- Ahmed Z. Al-Bahrani
- Alan J. Grant
- Alan T. Boyd
- Alex Hrycaiczuk
- Alexander E.J. Trevatt
- Alexandros Charalabopoulos
- Alfred Choy
- Ali Majeed
- Alice Bryant
- Alice Chambers
- Alice Chambers
- Alicja Psica
- Alison Kinghorn
- Alistair R. Dennison
- Alistair Reid
- Alok Chhabra
- Alponat
- Altaf Awan
- Amanda Roebuck
- Amarah Khan
- Ambareen Kausar
- Amir Forouzanfar
- Amir Khawaja
- Ana C. Pinho-Gomes
- Andrea R.G. Sheel
- Andreas Luhmann
- Andrew Harris
- Andrew J. Cockbain
- Andrew Jackson
- Andrew L. Baker
- Andrew Macdonald
- Andrew McClarey
- Andrew Tsang
- Andrzej Goscimski
- Angharad Jones
- Angus G.K. McNair
- Angus J.M. Watson
- Anisha Sukha
- Anita Hargreaves
- Ansar Farooq
- Anthony J. Rate
- Antonio Manzelli
- Anwar Ahmad
- Anwar Hussain
- April Nilsen-Nunn
- Arikoge Ogedegbe
- Arnold D.K. Hill
- Arnold D.K. Hill
- Arslan Pannu
- Ashish K. Shrestha
- Ashvina Segaran
- Avgerinos
- Babu Karavadra
- Ballal
- Barry McAree
- Beatrix Weber
- Benjamin Drake
- Benjamin Knight
- Benjamin Z. Starmer
- Benoy I. Babu
- Bhavani S. Mothe
- Brendan L. Skelly
- Brian Dobbins
- Bryony Lovett
- Carla Rengifo
- Caroline Hindley
- Caroline Yao
- Catherine Bunnell
- Catherine Zhang
- Cathy Malcolm
- Chamindri Weerasinghe
- Chanpreet Arhi
- Cherith M.L.R. Sutton
- Cheuk-Bong Tang
- CholeS Study Group
- Chris Kendal
- Christina A.W. Macano
- Christine Blane
- Christopher P.J. Wood
- Christopher R. Nicolay
- Christopher Taylor Santosh Bhandari
- Ciny P. Parappally
- Claire Hall
- Claire Jackson
- Claire Jones
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- Fried
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