Who was Greasy Sal? Outlaw Horses and the Spirit of Calgary in the Automobile Age

This article examines the development of the bucking bronc as an icon ofmodernity, business, and tourism promotion through a study of living horses andtheir representation at the Calgary Stampede during the 1920s. It draws upon themanagement records of the rodeo, tourism theory on back stage and front regionperformance, and theory on human-animal relationships. The little known mareGreasy Sal serves as a case study exposing which aspects of their horses’ livesStampede managers sought to keep private in order to mass produce the displaysof bucking central to the bronc ideal for locals and visitors.L’étude de chevaux vivants et de leur représentation au Stampede de Calgarydans les années 1920 permet de traiter de l’émergence du bronco qui rue en tantqu’emblème de la modernité, des affaires et de la promotion du tourisme. Pource faire, l’auteure fait appel aux archives administratives du rodéo, à la théoriedu tourisme concernant le comportement en coulisse et dans l’arène ainsi qu’à lathéorie sur les relations entre l’humain et l’animal. Elle se sert du cas de la jumentpeu connue Greasy Sal pour révéler les aspects de la vie de leurs chevaux que lesdirigeants du Stampede ont tenté d’éviter de divulguer afin de produire en masseles scènes de ruades essentielles à l’idéal du broco aux yeux de la populationlocale et des visiteurs

Characterization of Facies and Permeability Patterns in Carbonate Reservoirs Based in Outcrop Analogs

More than 13 billion barrels (Bbbl) of mobile oil and 17 Bbbl of residual oil will remain in San Andres and Grayburg reservoirs at abandonment under current development practices. Through the development and application of new recovery technology, a large part of this resource can be recovered. This report focuses on research for the development and testing of new techniques for improving the recovery of this resource. Outcrop and subsurface geologic and engineering data are utilized to develop new methodologies through the integration of geologic observations and engineering data for improving numerical models that predict reservoir performance more accurately. Extensive regional mapping of the 14-mile by 1,200-foot San Andres outcrop, located on the Algerita Escarpment, Guadalupe Mountains, New Mexico, demonstrates that the San Andres carbonate-ramp complex is composed of multiple depositional sequences that have significant basinward shifts in reservoir-quality facies tracts occurring across sequence boundaries. Detailed geologic and petrophysical mapping of three reservoir-quality facies tracts demonstrates that the fundamental scale of geologic description for reservoir characterization is the parasequence and its component rock-fabric-based facies. Descriptions of cores from the Seminole San Andres Unit illustrate that the parasequence is also the fundamental geologic scale for reservoir mapping in the subsurface.Bureau of Economic Geolog

Characterization of Reservoir Heterogenity in Carbonate-Ramp Systems, San Andres/Grayburg Permian Basin

This report summarizes research carried out by the Bureau of Economic Geology's San Andres/Grayburg Reservoir Characterization Research Laboratory (RCRL) from September 1988 through September 1990. The goal of the RCRL program was to develop advanced approaches to reservoir characterization for improved recovery of the substantial remaining mobile oil in San Andres and Grayburg reservoirs. Emphasis was placed on developing an outcrop analog for San Andres strata that could be used as (1) a guide to interpreting the regional and local geologic framework of the subsurface reservoirs and (2) a data source illustrating the scales and patterns of variability of rock-fabric facies and petrophysical properties, particularly in lateral dimensions, and on scales that cannot be studied during subsurface reservoir characterization. Areas selected for study were the San Andres exposures of the Algerita Escarpment in the northern Guadalupe Mountains and the Seminole San Andres Unit on the northern margin of the Central Basin Platform. The outcrop-analog research was emphasized because it had received little attention before this study by either industry or academe. Reports in this summary involve (1) outcrop and subsurface geological characterization of the Algerita Escarpment San Andres and the Seminole San Andres Unit (Kerans), (2) correlation of detailed outcrop mapping in order to research cored wells at Lawyer Canyon, Algerita Escarpment (Nance), (3) diagenetic/petrographic analysis of selected upper San Andres facies focusing on the origin of moldic porosity (Hovorka), (4) geologic engineering description of the upper San Andres carbonates at Lawyer Canyon and the upper producing interval at Seminole (Lucia), (5) geostatistical analysis of permeability patterns and stochastic-based finite-difference modeling of the upper San Andres parasequence window (Senger and Fogg), and (6) deterministic finite element modeling of the upper San Andres parasequence window (Kasap). Availability of basic data for these studies is summarized in the appendix.Bureau of Economic Geolog

Association Between Chronic Hepatitis C Virus Infection and Myocardial Infarction Among People Living With HIV in the United States.

Hepatitis C virus (HCV) infection is common among people living with human immunodeficiency virus (PLWH). Extrahepatic manifestations of HCV, including myocardial infarction (MI), are a topic of active research. MI is classified into types, predominantly atheroembolic type 1 MI (T1MI) and supply-demand mismatch type 2 MI (T2MI). We examined the association between HCV and MI among patients in the Centers for AIDS Research (CFAR) Network of Integrated Clinical Systems, a US multicenter clinical cohort of PLWH. MIs were centrally adjudicated and categorized by type using the Third Universal Definition of Myocardial Infarction. We estimated the association between chronic HCV (RNA+) and time to MI while adjusting for demographic characteristics, cardiovascular risk factors, clinical characteristics, and history of injecting drug use. Among 23,407 PLWH aged ≥18 years, there were 336 T1MIs and 330 T2MIs during a median of 4.7 years of follow-up between 1998 and 2016. HCV was associated with a 46% greater risk of T2MI (adjusted hazard ratio (aHR) = 1.46, 95% confidence interval (CI): 1.09, 1.97) but not T1MI (aHR = 0.87, 95% CI: 0.58, 1.29). In an exploratory cause-specific analysis of T2MI, HCV was associated with a 2-fold greater risk of T2MI attributed to sepsis (aHR = 2.01, 95% CI: 1.25, 3.24). Extrahepatic manifestations of HCV in this high-risk population are an important area for continued research

Motor phenotype of LRRK2 G2019S carriers in early-onset Parkinson disease

Objective: To determine the motor phenotype of LRRK2 G2019S mutation carriers. LRRK2 mutation carriers were previously reported to manifest the tremor dominant motor phenotype, which has been associated with slower motor progression and less cognitive impairment compared with the postural instability and gait difficulty (PIGD) phenotype. Design: Cross-sectional observational study. Setting: Thirteen movement disorders centers. Participants: Nine hundred twenty-five early-onset Parkinson disease cases defined as age at onset younger than 51 years. Main Outcome Measures: LRRK2 mutation status and Parkinson disease motor phenotype: tremor dominant or PIGD. Demographic information, family history of Parkinson disease, and the Unified Parkinson's Disease Rating Scale score were collected on all participants. DNA samples were genotyped for LRRK2 mutations (G2019S, I2020T, R1441C, and Y1699C). Logistic regression was used to examine associations of G2019S mutation status with motor phenotype adjusting for disease duration, Ashkenazi Jewish ancestry, levodopa dose, and family history of Parkinson disease. Results: Thirty-four cases (3.7%) (14 previously reported) were G2019S carriers. No other mutations were found. Carriers were more likely to be Ashkenazi Jewish (55.9% vs 11.9%; P < .001) but did not significantly differ in any other demographic or disease characteristics. Carriers had a lower tremor score (P = .03) and were more likely to have a PIGD phenotype (92.3% vs 58.9%; P = .003). The association of the G2019S mutation with PIGD phenotype remained after controlling for disease duration and Ashkenazi Jewish ancestry (odds ratio, 17.7; P < .001). Conclusion: Early-onset Parkinson disease G2019S LRRK2 carriers are more likely to manifest the PIGD phenotype, which may have implications for disease course

Adaptations of Avian Flu Virus Are a Cause for Concern

We are in the midst of a revolutionary period in the life sciences. Technological capabilities have dramatically expanded, we have a much improved understanding of the complex biology of selected microorganisms, and we have a much improved ability to manipulate microbial genomes. With this has come unprecedented potential for better control of infectious diseases and significant societal benefit. However, there is also a growing risk that the same science will be deliberately misused and that the consequences could be catastrophic. Efforts to describe or define life-sciences research of particular concern have focused on the possibility that knowledge or products derived from such research, or new technologies, could be directly misapplied with a sufficiently broad scope to affect national or global security. Research that might greatly enhance the harm caused by microbial pathogens has been of special concern (1–3). Until now, these efforts have suffered from a lack of specificity and a paucity of concrete examples of “dual use research of concern” (3). Dual use is defined as research that could be used for good or bad purposes. We are now confronted by a potent, real-world example

Assessing and Refining Myocardial Infarction Risk Estimation Among Patients With Human Immunodeficiency Virus: A Study by the Centers for AIDS Research Network of Integrated Clinical Systems

Persons with human immunodeficiency virus (HIV) treated with antiretroviral therapy (ART) have improved longevity but are at elevated risk for myocardial infarction (MI) due to common MI risk factors and HIV-specific factors. Despite these elevated MI rates, optimal methods to predict MI risks for HIV-infected persons remain unclear

Tissue specific mutagenic and carcinogenic responses in NER defective mouse models.

Several mouse models with defects in genes encoding components of the nucleotide excision repair (NER) pathway have been developed. In NER two different sub-pathways are known, i.e. transcription-coupled repair (TC-NER) and global-genome repair (GG-NER). A defect in one particular NER protein can lead to a (partial) defect in GG-NER, TC-NER or both. GG-NER defects in mice predispose to cancer, both spontaneous as well as UV-induced. As such these models (Xpa, Xpc and Xpe) recapitulate the human xeroderma pigmentosum (XP) syndrome. Defects in TC-NER in humans are associated with Cockayne syndrome (CS), a disease not linked to tumor development. Mice with TC-NER defects (Csa and Csb) are - except for the skin - not susceptible to develop (carcinogen-induced) tumors. Some NER factors, i.e. XPB, XPD, XPF, XPG and ERCC1 have functions outside NER, like transcription initiation and inter-strand crosslink repair. Deficiencies in these processes in mice lead to very severe phenotypes, like trichothiodystrophy (TTD) or a combination of XP and CS. In most cases these animals have a (very) short life span, display segmental progeria, but do not develop tumors. Here we will overview the available NER-related mouse models and will discuss their phenotypes in terms of (chemical-induced) tissue-specific tumor development, mutagenesis and premature aging features