Simulation of DC dual-laterolog measurements in complex formations: A Fourier-series approach with nonorthogonal coordinates and self-adapting finite elements

Dual laterolog (DLL) makes use of a galvanic conduction principle to focus electrical currents into rock formations, thereby minimizing shoulder and borehole effects in the measurement of formation resistivity. The tool includes two separate focusing systems: deep-sensing (LLd) and shallow-sensing modes (LLs). Laterolog current-focusing systems were designed for operation primarily in vertical boreholes penetrating horizontal layers; only recently their design has been revised for operation in deviated wells in the presence of electrical anisotropy. We simulated three-dimensional (3D) DLL measurements in dipping, invaded, and electrically anisotropic formations and appraised the corresponding effects on apparent resistivity logs. Simulations were performed by combining the use of a Fourier-series expansion in a nonorthogonal system of coordinates with an existing 2D goal-oriented, higher-order, and self-adaptive finite-element method. This numerical algorithm yields accurate solutions in limited CPU time because only a few Fourier modes are needed to simulate practical applications. For the calculation of focused currents, we introduced an embedded postprocessing method that incorporates a synthetic focusing principle to compute current intensities at each iterative step of optimal mesh refinements. Our numerical method accurately simulates 3D DLL measurements in rock formations that exhibit extreme contrasts of electrical resistivity. Simulations indicate that LLs resistivity logs are more sensitive to both invaded and anisotropic layers than LLd resistivity logs. In deviated wells, shoulder-bed effects on apparent resistivity logs increase with an increase of dip angle, and are emphasized across thin conductive layers. Electrical anisotropy effects on apparent resistivity logs increase substantially with dip angle. © 2009 Society of Exploration Geophysicists. All rights reserved

Agriculture Diversification in the Mekong Delta: Farmers' Motives and Contributions to Livelihoods

Although specialization is the global trend in agriculture, integrated farming systems have emerged in Vietnam. An important motive was the desire to improve the livelihoods and the diet of the nuclear families; this was evident in the analysis using the household life cycle of five phases. Off-farm diversification was especially important for a new household. At the onset of expansion, the new mothers replaced off-farm with homebound activities. During expansion the farmers increased virtual farm size by keeping more livestock; during accumulation, they invested in land or education, and during consolidation old couples adjusted farm activities to their labor capacity. Livestock, including fish, was essential for livelihood. The distribution of goats instead of cattle by credit or by "passing-on-the-gift " was far more effective for poverty alleviation. Technological innovations on the cultivation of rice and fruits, and the breeding of fish were essential for change. The improved food security and reduced cash income from rice after the 1986 reforms pushed farmers to take risks. The farm area and number of component farm activities providing cash determined the level of cash income from agriculture. Farms with at least four flows of biomass between components earned more, demonstrating that real integration improved profits. A minimum area of land in, or close to, the homestead, and know-how are required for an effective integration of components.Mekong Delta, agricultural diversification

Simulation of marine controlled source electromagnetic measurements using a parallel fourier hp-finite element method

We introduce a new numerical method to simulate geophysical marine controlled source electromagnetic (CSEM) measurements for the case of 2D structures and finite 3D sources of electromagnetic (EM) excitation. The method of solution is based on a spatial discretization that combines a 1D Fourier transform with a 2D self-adaptive, goal-oriented, hp-Finite element method. It enables fast and accurate simulations for a variety of important, challenging and practical cases of marine CSEM acquisition. Numerical results confirm the high accuracy of the method as well as some of the main physical properties of marine CSEM measurements such as high measurement sensitivity to oil-bearing layers in the subsurface. In our model, numerical results indicate that measurements could be affected by the finite oil-bearing layer by as much as 104% (relative difference). While the emphasis of this paper is on EM simulations, the method can be used to simulate different physical phenomena such as seismic measurements

Solid‐Phase Synthesis of Branched Oligonucleotides

Branched nucleic acids (bNAs) have been of particular interest since the discovery of RNA forks and lariats as intermediates of nuclear mRNA splicing, as well as multicopy, single‐stranded DNA (msDNA). Such molecules contain the inherent trait of vicinal 2′,5′‐ and 3′,5′‐phosphodiester linkages. bNAs have many potential applications in nucleic acid biochemistry, particularly as tools for studying the substrate specificity of lariat debranching enzymes, and as biological probes for the investigation of branch recognition during pre‐mRNA splicing. The protocols described herein allow for the facile solid‐phase synthesis of branched DNA and/or RNA oligonucleotides of varying chain length, containing symmetrical or asymmetrical sequences immediate to an RNA branch point. The synthetic methodology utilizes widely adopted phosphoramidite chemistry. Methods for efficient purification of bNAs via anion‐exchange HPLC and PAGE are also illustrated.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/143634/1/cpnc0414.pd

Drug delivery nanosystems for the localized treatment of glioblastoma multiforme

[EN] Glioblastoma multiforme is one of the most prevalent and malignant forms of central nervous system tumors. The treatment of glioblastoma remains a great challenge due to its location in the intracranial space and the presence of the blood-brain tumor barrier. There is an urgent need to develop novel therapy approaches for this tumor, to improve the clinical outcomes, and to reduce the rate of recurrence and adverse effects associated with present options. The formulation of therapeutic agents in nanostructures is one of the most promising approaches to treat glioblastoma due to the increased availability at the target site, and the possibility to co-deliver a range of drugs and diagnostic agents. Moreover, the local administration of nanostructures presents significant additional advantages, since it overcomes blood-brain barrier penetration issues to reach higher concentrations of therapeutic agents in the tumor area with minimal side effects. In this paper, we aim to review the attempts to develop nanostructures as local drug delivery systems able to deliver multiple agents for both therapeutic and diagnostic functions for the management of glioblastoma.This research was funded by an Ussher start-up funding award (School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin) and the European Union’s Horizon 2020 research and innovation program under Grant agreement No. 708036.Nam, L.; Coll Merino, MC.; Erthal, L.; De La Torre-Paredes, C.; Serrano, D.; Martínez-Máñez, R.; Santos-Martinez, M.... (2018). Drug delivery nanosystems for the localized treatment of glioblastoma multiforme. Materials. 11(5). https://doi.org/10.3390/ma11050779S115Goodenberger, M. L., & Jenkins, R. B. (2012). Genetics of adult glioma. Cancer Genetics, 205(12), 613-621. doi:10.1016/j.cancergen.2012.10.009Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., … Kleihues, P. (2007). 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A determination of the pairing interaction in the high Tc cuprate superconductor Tl2Ba2CaCu2O8 (Tl2212)

We have measured the near-normal reflectance of Tl2Ba2CaCu2O8 (Tl2212) for energies from 0.1 to 4.0 eV at room temperature and used a Kramers-Kronig analysis to find the complex, frequency dependent dielectric function, from which the optical conductivity was determined. Using Thermal-Difference-Reflectance (TDR) Spectroscopy the reflectance of the sample in the normal state just above the superconducting transition, and in the superconducting state were then obtained. From these data we determined the ratio of the superconducting- to normal-state optical conductivities. Mattis and Bardeen had calculated this function within the BCS theory, where the gap is a fixed energy-independent quantity. Taking into account the retarded nature of the electron-phonon coupling results in a complex, energy dependent gap causing deviations from the Mattis-Bardeen plot at energies where the phonon coupling function is large. We find a typical deviation near the phonon energies in Tl2212, and in addition, at 1.2 and 1.7eV. The phonon, and these electronic terms can each be described by a coupling constant. None of which by itself gives rise to a high transition temperature, but the combination does. Using Resonant Inelastic X-Ray Scattering (RIXS) we find that the d-to-d excitations of the cuprate ion in Tl2212 fall at the same energies as the dips in the Mattis-Bardeen plot. We conclude that the high superconducting transition temperature of the cuprates is due to the sum of the phonon interaction, and interactions with the Cu-ion d-shell.Comment: Preprint submitted to Physica C. Paper presented at M2S-HTSC-VIII, Dresden, Germany, July 9-14,200

Photoproduction of K∗K^* for the study of Λ(1405)\Lambda(1405)

The photo-induced $K^*$ vector meson production is investigated for the study of the $\Lambda(1405)$ resonance. This reaction is particularly suited to the isolation of the second pole in the $\Lambda(1405)$ region which couples dominantly to the $\bar K N$ channel. We obtain the mass distribution of the $\Lambda(1405)$ which peaks at 1420 MeV, and differs from the nominal one. Combined with several other reactions, like the $\pi^- p \to K^0 \pi \Sigma$ which favours the first pole, this detailed study will reveal a novel structure of the $\Lambda(1405)$ state.Comment: 13 pages, 8 figures, 2 table

Z^* Resonances: Phenomenology and Models

We explore the phenomenology of, and models for, the Z^* resonances, the lowest of which is now well established, and called the Theta. We provide an overview of three models which have been proposed to explain its existence and/or its small width, and point out other relevant predictions, and potential problems, for each. The relation to what is known about KN scattering, including possible resonance signals in other channels, is also discussed.Comment: 29 pages, uses RevTeX4; expanded version (published form

The compressive behavior of the human glenoid labrum may explain the common patterns of SLAP lesions.

Accepted versio

Experimental investigation of the detection mechanism in WSi nanowire superconducting single photon detectors

Quantum Matter and Optic