Application of Salagean and Ruscheweyh Operators on Univalent Holomorphic Functions with Finitely many Coefficients

MSC 2010: 30C45, 30C50The purpose of the present paper is to introduce a new subclass of holomorphic univalent functions with negative and fixed finitely coefficient based on Salagean and Ruscheweyh differential operators. The various results investigated in this paper include coefficient estimates, extreme points and Radii properties

The use of isolated peripheral lymphocytes and human whole blood in the comet assay

YesThe comet assay is a sensitive method used to detect DNA damage, measuring DNA breaks and alkali labile lesions in eukaryotic cells. Here, the use of whole blood in the alkaline gel electrophoresis method is described. Two hundred and seventy blood samples from individuals were examined: 120 healthy individuals, 65 suspected or pre-cancerous individuals and 85 cancer patients. Each sample was divided into two identical volumes in different falcon tubes. The blood was prepared and stored by adding the same amount of RPMI medium and 10% DMSO. Using the Student’s t-Test, the data showed a p value = 0.59 for Olive tail moment (OTM) and 0.16 for % tail DNA, and no statistically significant differences between the two methods, with or without treatment. In conclusion, using whole blood instead of isolated lymphocytes saves time, is still very sensitive and requires less than 20 µL of blood from each individual

Scour Propagation Rates around Offshore Pipelines Exposed to Currents by Applying Data-Driven Models

Offshore pipelines are occasionally exposed to scouring processes; detrimental impacts on their safety are inevitable. The process of scouring propagation around offshore pipelines is naturally complex and is mainly due to currents and/or waves. There is a considerable demand for the safe design of offshore pipelines exposed to scouring phenomena. Therefore, scouring propagation patterns must be focused on. In the present research, machine learning (ML) models are applied to achieve equations for the prediction of the scouring propagation rate around pipelines due to currents. The approaching flow Froude number, the ratio of embedment depth to pipeline diameter, the Shields parameter, and the current angle of attack to the pipeline were considered the main dimensionless factors from the reliable literature. ML models were developed based on various setting parameters and optimization strategies coming from evolutionary and classification contents. Moreover, the explicit equations yielded from ML models were used to demonstrate how the proposed approaches are in harmony with experimental observations. The performance of ML models was assessed utilizing statistical benchmarks. The results revealed that the equations given by ML models provided reliable and physically consistent predictions of scouring propagation rates regarding their comparison with scouring tests

PROPERTIES OF A NEW SUBCLASS OF ANALYTIC FUNCTIONS ASSOCIATED TO RAFID - OPERATOR AND q-DERIVATIVE

In this article, we introduce a new subclass of analytic functions, using the exponent operators of Rafid and $q$-derivative. The coefficient estimates, extreme points, convex linear combination, radii of starlikeness, convexity, and finally integral are investigated

The effect of adding inhaled corticosteroids to tiotropium and long-acting beta(2)-agonists for chronic obstructive pulmonary disease (Review)

BackgroundLong-acting bronchodilators comprising long-acting beta(2)-agonists and the anticholinergic agent tiotropiumare commonly used, either on their own or in combination, for managing persistent symptoms of chronic obstructive pulmonary disease. Patients with severe chronic obstructive pulmonary disease who are symptomatic and who suffer repeated exacerbations are recommended to add inhaled corticosteroids to their bronchodilator treatment. However, the benefits and risks of adding inhaled corticosteroid to tiotropium and long-acting beta2-agonists for the treatment of chronic obstructive pulmonary disease are unclear.ObjectivesTo assess the relative effects of adding inhaled corticosteroids to tiotropium and long-acting beta2-agonists treatment in patients with chronic obstructive pulmonary disease.Search strategyWe searched the Cochrane Airways Group Specialised Register of trials (February 2011) and reference lists of articles.Selection criteriaWe included parallel group, randomised controlled trials of three months or longer comparing inhaled corticosteroid and long-acting beta(2)-agonist combination therapy in addition to inhaled tiotropium against tiotropium and long-acting beta2-agonist treatment for patients with chronic obstructive pulmonary disease (COPD).Data collection and analysisTwo review authors independently assessed trials for inclusion and then extracted data on trial quality and the outcome results. We contacted study authors for additional information. We collected information on adverse effects from the trials.Main resultsOne trial (293 patients) was identified comparing tiotropium in addition to inhaled corticosteroid and long-acting beta(2)-agonist combination therapy to tiotropium plus long-acting beta2-agonist. The study was of good methodological quality, however it suffered from high and uneven withdrawal rates between the treatment arms. There is currently insufficient evidence to know how much difference the addition of inhaled corticosteroids makes to people who are taking tiotropium and a long-acting beta(2)-agonist for COPD.Authors' conclusionsThe relative efficacy and safety of adding inhaled corticosteroid to tiotropium and a long-acting beta(2)-agonist for chronic obstructive pulmonary disease patients remains uncertain and additional trials are required to answer this question