Analysis of fuzzy logic controller based bi-directional DC-DC converter for battery energy management in hybrid solar/wind micro grid system

This paper proposes a fuzzy logic-based battery energy management system in hybrid renewable system. The novel topology consists of solar and wind energy system-based input sources and a battery bank to store the energy when in excess. The PV-Wind source is equipped with unidirectional boost converter whereas, the battery storage system is connected to the system with a bi-directional DC/DC converter. The main novelty of this research is the fuzzy logic-based battery management system which charges and discharges into the DC bus system based on the supply-load demand. The fuzzy logic controller (FLC) based maximum power point tracking (MPPT) is used in the PV and wind energy conversion system (WECS) to track the maximum available power for the different irradiance and wind velocity respectively. The obtained results are compared to conventional P&O MPPT control algorithm to find the effectiveness of the system. A 500 W PV system and a 500 W Permanent magnet synchronous generator (PMSG) based WECS is implemented for its simplicity and high efficiency. The proposed control topology is designed and tested using MATLAB/Simulin

A study to evaluate safety and efficacy of immediate postpartum postplacental IUCD insertion

Background: The postpartum period is an important time in a woman’s life to promote the health of the newborn and the mother. In INDIA, the unmet need for contraception in the first year postpartum is as high as 65%. Hence, this study aims to evaluate the safety and efficacy of immediate postpartum intrauterine contraceptive device (PPIUCD) as a method of contraception.Methods: The study was undertaken in KIMS Hospital and Research Centre, Bangalore. A total of 60 patients were recruited following complete evaluation. 30 patients had immediate postpartum post placental insertion and 30 patients had intracesarean insertion of Cu T 380A.Results: The patients who accepted PPIUCD mostly belonged to the age group 19-24 years, multigravida with one living issue. Insertion of IUCD was easy in 96.7% of the patients. Only 8.3% of the patients were anxious post insertion. 20% of the patients had minor complications, most commonly, bleeding and pain. There was only one case (1.7%) of infection (vaginitis). There were 23.3% of cases with missing strings but in all these cases IUCD was found in-situ on ultrasonography. Removal rate and expulsion rate were 6.7% and 5% respectively. Continuation rate was 88.3%.Conclusions: We can conclude from this study, that immediate PPIUCD is an effective and inexpensive contraceptive for all delivered women, as it can be easily provided by trained midwives due to its ease of insertion, high continuation rate and no major complications. Thus, we can prevent unwanted pregnancies, abortions and its untoward effects

Chemical marker compounds and their essential role in quality control of herbal medicines

Abstract Many countries are registering their standardized herbal drugs with proven clinical efficacy, safety and as dietary supplements. But India is unable to exploit the World market due to unsatisfactory system of quality control which necessitates the establishment of standards for herbal single drugs and compound formulations. In order to ensure international community to use AYUSH drugs with confidence and without compunction, developing acceptable quality control standards of herbal medicines aims to ensure their consistency, safety and efficacy with good manufacturing practices is very much essential. Study of chemical markers is applicable to many research areas, including authentication of genuine species, search for new resources or substitutes of raw materials, optimization of extraction and purification methods, structure elucidation and purity determination. Systematic investigations using chemical markers may lead to discoveries and development of new drugs

Synthesis of ethyl 4-methyl-2, 10-dioxo-7,10-dihydro-2H-[1]pyrano-[2,3-f]quinoline-9-carboxylate from 7-amino-4-methylcoumarin

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Catecholaminergic signalling through thymic nerve fibres, thymocytes and stromal cells is dependent on both circulating and locally synthesized glucocorticoids

Glucocorticoids have been shown to modulate the expression of noradrenaline metabolizing enzymes and beta(2)- and alpha(1B)-adrenoceptors in a tissue- and cell- specific manner. In the thymus, apart from extensive sympathetic innervation, a regulatory network has been identified that encompasses catecholamine-containing non-lymphoid and lymphoid cells. We examined a putative role of adrenal- and thymus-derived glucocorticoids in modulation of rat thymic noradrenaline levels and adrenoceptor expression. Seven days postadrenalectomy, the thymic levels of mRNAs encoding tyrosine hydroxylase, dopamine beta-hydroxylase, monoamine oxidase-A and, consequently, noradrenaline were decreased. Catecholamine content was diminished in autofluorescent nerve fibres (judging by the intensity of fluorescence) and thymocytes (considering HPLC measurements of noradrenaline and the frequency of tyrosine hydroxylase-positive cells), while it remained unaltered in non-lymphoid autofluorescent cells. In addition, adrenalectomy diminished the thymocyte expression of beta(2)- and alpha(1B)-adrenoceptors at both mRNA and protein levels. Administration of ketoconazole (an inhibitor of glucocorticoid synthesis/action; 25 mg kg(-1) day(-1), s.c.) to glucocorticoid-deprived rats increased the thymic levels of tyrosine hydroxylase, dopamine beta-hydroxylase and, consequently, noradrenaline. The increased intensity of the autofluorescent cell fluorescence in ketoconazole-treated rats indicated an increase in their catecholamine content, and suggested differential glucocorticoid-mediated regulation of catecholamines in thymic lymphoid and non-lymphoid cells. In addition, ketoconazole increased the thymocyte expression of alpha(1B)-adrenoceptors. Thus, this study indicates that in the thymus, as in some other tissues, glucocorticoids not only act in concert with cateholamines, but they may modulate catecholamine action by tuning thymic catecholamine metabolism and adrenoceptor expression in a cell-specific manner. Additionally, the study indicates a role of thymus-derived glucocorticoids in this modulation

HIV and HPV infections and ocular surface squamous neoplasia: systematic review and meta-analysis.

BACKGROUND: The frequency of ocular surface squamous neoplasias (OSSNs) has been increasing in populations with a high prevalence of infection with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and infection with human papillomavirus (HPV). We aimed to quantify the association between HIV/AIDS and HPV infection and OSSN, through systematic review and meta-analysis. METHODS: The articles providing data on the association between HIV/AIDS and/or HPV infection and OSSN were identified in MEDLINE, SCOPUS and EMBASE searched up to May 2013, and through backward citation tracking. The DerSimonian and Laird method was used to compute summary relative risk (RR) estimates and 95% confidence intervals (95% CI). Heterogeneity was quantified with the I(2) statistic. RESULTS: HIV/AIDS was strongly associated with an increased risk of OSSN (summary RR=8.06, 95% CI: 5.29-12.30, I(2)=56.0%, 12 studies). The summary RR estimate for the infection with mucosal HPV subtypes was 3.13 (95% CI: 1.72-5.71, I(2)=45.6%, 16 studies). Four studies addressed the association between both cutaneous and mucosal HPV subtypes and OSSN; the summary RR estimates were 3.52 (95% CI: 1.23-10.08, I(2)=21.8%) and 1.08 (95% CI: 0.57-2.05, I(2)=0.0%), respectively. CONCLUSION: Human immunodeficiency virus infection increases the risk of OSSN by nearly eight-fold. Regarding HPV infection, only the cutaneous subtypes seem to be a risk factor

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

Data for: A stereoselective synthesis of (R)-5-hydroxy-3-(4-methoxyphenethyl)cyclohex-2-enone, towards total synthesis of Prelunularin

A first chiral strategy for synthesis of (R)-5-hydroxy-3-(4-methoxyphenethyl) cyclohex-2-enone reported. Key transformation includes Barbier allylation, ionic hydrogenation, Jefferey reaction, Katsuki Sharpless asymmetric epoxidation, reductive opening of epoxide and ring closing metathesi