2,461 research outputs found
Spinoza
"Spinoza", second edition.
Encyclopedia entry for the Springer Encyclopedia of EM Phil and the Sciences, ed. D. Jalobeanu and C. T. Wolfe
Random Walks on a Fluctuating Lattice: A Renormalization Group Approach Applied in One Dimension
We study the problem of a random walk on a lattice in which bonds connecting
nearest neighbor sites open and close randomly in time, a situation often
encountered in fluctuating media. We present a simple renormalization group
technique to solve for the effective diffusive behavior at long times. For
one-dimensional lattices we obtain better quantitative agreement with
simulation data than earlier effective medium results. Our technique works in
principle in any dimension, although the amount of computation required rises
with dimensionality of the lattice.Comment: PostScript file including 2 figures, total 15 pages, 8 other figures
obtainable by mail from D.L. Stei
A categorification of Morelli's theorem
We prove a theorem relating torus-equivariant coherent sheaves on toric
varieties to polyhedrally-constructible sheaves on a vector space. At the level
of K-theory, the theorem recovers Morelli's description of the K-theory of a
smooth projective toric variety. Specifically, let be a proper toric
variety of dimension and let M_\bR = \mathrm{Lie}(T_\bR^\vee)\cong \bR^n
be the Lie algebra of the compact dual (real) torus T_\bR^\vee\cong U(1)^n.
Then there is a corresponding conical Lagrangian \Lambda \subset T^*M_\bR and
an equivalence of triangulated dg categories \Perf_T(X) \cong
\Sh_{cc}(M_\bR;\Lambda), where \Perf_T(X) is the triangulated dg category of
perfect complexes of torus-equivariant coherent sheaves on and
\Sh_{cc}(M_\bR;\Lambda) is the triangulated dg category of complex of sheaves
on M_\bR with compactly supported, constructible cohomology whose singular
support lies in . This equivalence is monoidal---it intertwines the
tensor product of coherent sheaves on with the convolution product of
constructible sheaves on M_\bR.Comment: 20 pages. This is a strengthened version of the first half of
arXiv:0811.1228v3, with new results; the second half becomes
arXiv:0811.1228v
Heat Conduction and Entropy Production in a One-Dimensional Hard-Particle Gas
We present large scale simulations for a one-dimensional chain of hard-point
particles with alternating masses. We correct several claims in the recent
literature based on much smaller simulations. Both for boundary conditions with
two heat baths at different temperatures at both ends and from heat current
autocorrelations in equilibrium we find heat conductivities kappa to diverge
with the number N of particles. These depended very strongly on the mass
ratios, and extrapolation to N -> infty resp. t -> infty is difficult due to
very large finite-size and finite-time corrections. Nevertheless, our data seem
compatible with a universal power law kappa ~ N^alpha with alpha approx 0.33.
This suggests a relation to the Kardar-Parisi-Zhang model. We finally show that
the hard-point gas with periodic boundary conditions is not chaotic in the
usual sense and discuss why the system, when kept out of equilibrium, leads
nevertheless to energy dissipation and entropy production.Comment: 4 pages (incl. 5 figures), RevTe
Molecular Phylogenetics and Diagnosis of \u3ci\u3eAnisakis\u3c/i\u3e, \u3ci\u3ePseudoterranova\u3c/i\u3e, and \u3ci\u3eContracaecum\u3c/i\u3e from Northern Pacific Marine Mammals
Individual specimens of Anisakis, Pseudoterranova, and Contracaecum collected from marine mammals inhabiting northern Pacific waters were used for comparative diagnostic and molecular phylogenetic analyses. Forty-eight new sequences were obtained for this study of 14 Anisakis taxa, 8 Pseudoterranova taxa, 4 Contracaecum taxa, and 4 outgroup species. Partial 28S (LSU) and complete internal transcribed spacer (ITS-1, 5.8S, ITS-2) ribosomal DNA was amplified by the polymerase chain reaction and sequenced. Sequences of ITS indicated that Pseudoterranova specimens from Zalophus californianus (California sea lion), Mirounga angustirostris (northern elephant seal), Phoca vitulina (harbor seal), Enhydra lutris (sea otter), and Eumetopias jubatus (Steller’s sea lion) exactly matched P. decipiens s. str., extending the host and geographic range of this species. Anisakis from northern Pacific marine mammals were most closely related to members of the A. simplex species complex. Comparison of Anisakis ITS sequences diagnosed the presence of A. simplex C in 2 M. angustirostris hosts, which is a new host record. Anisakis specimens from Phocoena phocoena (harbor porpoise), Lissodelphis borealis (Pacific rightwhale porpoise), and E. jubatus included 3 ITS sequences that did not match any known species. Contracaecum adults obtained from Z. californianus were most closely related to C. ogmorhini s.l. and C. rudolphii, but ITS sequences of these Contracaecum specimens did not match C. ogmorhini s. str. or C. margolisi. These novel Anisakis and Contracaecum ITS sequences may represent previously uncharacterized species. Phylogenetic analysis of LSU sequences revealed strong support for the monophyly of Anisakinae, Contracaecum plus Phocascaris, Pseudoterranova, and Anisakis. Phylogenetic trees inferred from ITS sequences yielded robustly supported relationships for Pseudoterranova and Anisakis species that are primarily consistent with previously published phenograms based on multilocus electrophoretic data
When the world collapses : Changed worldview and social reconstruction in a traumatized community
Background: Traumatic experience can affect the individual’s basic beliefs about the world as a predictable and safe place. One of the cornerstones in recovery from trauma is reestablishment of safety, connectedness, and the shattered schema of a worldview.
Objective: This study explored the role of negatively changed worldview in the relationship between war-related traumatization and readiness for social reconstruction of intergroup relations in a post-conflict community measured by three processes: intergroup rapprochement, rebuilding trust, and need for apology. It was hypothesized that more traumatized people are less supportive of social reconstruction and that this relationship is mediated by the changed worldview.
Method: The study included a community random sample of 333 adults in the city of Vukovar, Croatia, that was most devastated during the 1991–1995 war. Six instruments were administered: Stressful Events Scale, Impact of Event Scale-Revised, Changed Worldview Scale, and three scales measuring the post-conflict social reconstruction processes: Intergroup Rapprochement, Intergroup Trust and Need for Apology.
Results: Mediation analyses showed that the worldview change fully mediated between traumatization and all three aspects of social reconstruction.
Conclusions: In a population exposed to war traumatization the worldview change mediates post-conflict social recovery of community relations
Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications
12-lipoxygenase (12-LOX) is one of several enzyme isoforms responsible for the metabolism of arachidonic acid and other poly-unsaturated fatty acids to both pro- and anti-inflammatory lipid mediators. Mounting evidence has shown that 12-LOX plays a critical role in the modulation of inflammation at multiple checkpoints during diabetes development. Due to this, interventions to limit pro-inflammatory 12-LOX metabolites either by isoform-specific 12-LOX inhibition, or by providing specific fatty acid substrates via dietary intervention, has the potential to significantly and positively impact health outcomes of patients living with both type 1 and type 2 diabetes. To date, the development of truly specific and efficacious inhibitors has been hampered by homology of LOX family members; however, improvements in high throughput screening have improved the inhibitor landscape. Here, we describe the function and role of human 12-LOX, and mouse 12-LOX and 12/15-LOX, in the development of diabetes and diabetes-related complications, and describe promise in the development of strategies to limit pro-inflammatory metabolites, primarily via new small molecule 12-LOX inhibitors
Amelioration of type 1 diabetes following treatment of non-obese diabetic mice with INGAP and lisofylline
Type 1 diabetes mellitus results from the autoimmune and inflammatory destruction of insulin-producing islet β cells, rendering individuals devoid of insulin production. Recent studies suggest that combination therapies consisting of anti-inflammatory agents and islet growth-promoting factors have the potential to cause sustained recovery of β cell mass, leading to amelioration or reversal of type 1 diabetes in mouse models. In this study, we hypothesized that the combination of the anti-inflammatory agent lisofylline (LSF) with an active peptide fragment of islet neogenesis associated protein (INGAP peptide) would lead to remission of type 1 diabetes in the non-obese diabetic (NOD) mouse. We treated groups of spontaneously diabetic NOD mice with combinations of LSF, INGAP peptide, or control saline parenterally for up to 6 weeks. Our results demonstrate that the mice receiving combined treatment with LSF and INGAP peptide exhibited partial remission of diabetes with increased plasma insulin levels. Histologic assessment of pancreata in mice receiving combined therapy revealed the presence of islet insulin staining, increased β cell replication, and evidence of Pdx1-positivity in ductal cells. By contrast, diabetic animals showed severe insulitis with no detectible insulin or Pdx1 staining. We conclude that the novel combination treatment with LSF and INGAP peptide has the potential to ameliorate hyperglycemia in the setting of established type 1 diabetes via the recovery of endogenous β cells and warrant further studies
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