Legal Malpractice in Ohio

This article will discuss the fundamentals of a legal malpractice case, specifically addressing two areas. The first involves the elements of a legal malpractice case. This discussion will expose two problems that continually appear in legal malpractice litigation: (1) expanding the liability of an attorney to third parties, and (2) determining whether the alleged malpractice was the proximate cause of the plaintiff\u27s injuries. The second area of discussion will focus on the time limitations imposed for bringing a legal malpractice action. Additionally, in order to better understand the current state of the law, a brief discussion illustrating the historical development of the applicable statute of limitations will be instructive

A simple morphodynamic model for sand banks and large-scale sand pits subject to asymetrical tides

We extend existing knowledge on theoretical growth characteristics of tidal sand banks by including asymmetrical tides with an M0, M2 and M4-constituent, thus allowing for migration. Furthermore, in the context of the continuously increasing demand on the Dutch sand market, we show that creating a large-scale offshore sand pit has long-term morphological implications, both for the pit itself and the surrounding area. The pit deepens, while around it a sand bank pattern emerges, spreading at a constant rate of the order of tens to hundred metres per year

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

Iron overload is the hallmark of hereditary hemochromatosis and a complication of iron-loading anemias such as β-thalassemia. Treatment can be burdensome and have significant side effects, and new therapeutic options are needed. Iron overload in hereditary hemochromatosis and β-thalassemia intermedia is caused by hepcidin deficiency. Although transgenic hepcidin replacement in mouse models of these diseases prevents iron overload or decreases its potential toxicity, natural hepcidin is prohibitively expensive for human application and has unfavorable pharmacologic properties. Here, we report the rational design of hepcidin agonists based on the mutagenesis of hepcidin and the hepcidin-binding region of ferroportin and computer modeling of their docking. We identified specific hydrophobic/aromatic residues required for hepcidin-ferroportin binding and obtained evidence in vitro that a thiol-disulfide interaction between ferroportin C326 and the hepcidin disulfide cage may stabilize binding. Guided by this model, we showed that 7–9 N-terminal amino acids of hepcidin, including a single thiol cysteine, comprised the minimal structure that retained hepcidin activity, as shown by the induction of ferroportin degradation in reporter cells. Further modifications to increase resistance to proteolysis and oral bioavailability yielded minihepcidins that, after parenteral or oral administration to mice, lowered serum iron levels comparably to those after parenteral native hepcidin. Moreover, liver iron concentrations were lower in mice chronically treated with minihepcidins than those in mice treated with solvent alone. Minihepcidins may be useful for the treatment of iron overload disorders

Revised Coordinates and Proper Motions of the Stars in the Luyten Half-Second Catalogue

We present refined coordinates and proper motion data for the high proper motion (HPM) stars in the Luyten Half-Second (LHS) catalogue. The positional uncertainty in the original Luyten catalogue is typically >10" and is often >30". We have used the digital scans of the Palomar Observatory Sky Survey (POSS) I and POSS II plates to derive more accurate positions and proper motions of the objects. Out of the 4470 candidates in the LHS catalogue, 4323 objects were manually re-identified in the POSS I and POSS II scans. A small fraction of the stars were not found due to the lack of finder charts and digitized POSS II scans. The uncertainties in the revised positions are typically ~2", but can be as high as ~8" in a few cases; this is a large improvement over the original data. Cross-correlation with the Tycho-2 and Hipparcos catalogues yielded 819 candidates (with m_R < 12). For these brighter sources, the position and proper motion data have been replaced with the more accurate Tycho/Hipparcos data. In total, we have revised proper motion measurements and coordinates for 4040 stars and revised coordinates for 4330 stars, which are presented here.Comment: 108 pages. Accepted for Publication in ApJ Suppl. Some errors caused by the transcription errors in the original LHS catalogue have been corrected in this resubmission. The most current version of the catalogue is also available online at http://www.stsci.edu/~ksahu/lh

Particle Approximations of the Score and Observed Information Matrix for Parameter Estimation in State Space Models With Linear Computational Cost

Poyiadjis et al. (2011) show how particle methods can be used to estimate both the score and the observed information matrix for state space models. These methods either suffer from a computational cost that is quadratic in the number of particles, or produce estimates whose variance increases quadratically with the amount of data. This paper introduces an alternative approach for estimating these terms at a computational cost that is linear in the number of particles. The method is derived using a combination of kernel density estimation, to avoid the particle degeneracy that causes the quadratically increasing variance, and Rao-Blackwellisation. Crucially, we show the method is robust to the choice of bandwidth within the kernel density estimation, as it has good asymptotic properties regardless of this choice. Our estimates of the score and observed information matrix can be used within both online and batch procedures for estimating parameters for state space models. Empirical results show improved parameter estimates compared to existing methods at a significantly reduced computational cost. Supplementary materials including code are available

Picoliter-volume inkjet printing into planar microdevice reservoirs for low-waste, high-capacity drug loading.

Oral delivery of therapeutics is the preferred route for systemic drug administration due to ease of access and improved patient compliance. However, many therapeutics suffer from low oral bioavailability due to low pH and enzymatic conditions, poor cellular permeability, and low residence time. Microfabrication techniques have been used to create planar, asymmetric microdevices for oral drug delivery to address these limitations. The geometry of these microdevices facilitates prolonged drug exposure with unidirectional release of drug toward gastrointestinal epithelium. While these devices have significantly enhanced drug permeability in vitro and in vivo, loading drug into the micron-scale reservoirs of the devices in a low-waste, high-capacity manner remains challenging. Here, we use picoliter-volume inkjet printing to load topotecan and insulin into planar microdevices efficiently. Following a simple surface functionalization step, drug solution can be spotted into the microdevice reservoir. We show that relatively high capacities of both topotecan and insulin can be loaded into microdevices in a rapid, automated process with little to no drug waste

KIC7668647: a 14 day beaming sdB+WD binary with a pulsating subdwarf

The recently discovered subdwarf B (sdB) pulsator KIC7668647 is one of the 18 pulsating sdB stars detected in the Kepler field. It features a rich g-mode frequency spectrum, with a few low-amplitude p-modes at short periods. We use new ground-based low-resolution spectroscopy, and the near-continuous 2.88 year Kepler lightcurve, to reveal that KIC7668647 consists of a subdwarf B star with an unseen white-dwarf companion with an orbital period of 14.2d. An orbit with a radial-velocity amplitude of 39km/s is consistently determined from the spectra, from the orbital Doppler beaming seen by Kepler at 163ppm, and from measuring the orbital light-travel delay of 27 by timing of the many pulsations seen in the Kepler lightcurve. The white dwarf has a minimum mass of 0.40 M_sun. We use our high signal-to-noise average spectra to study the atmospheric parameters of the sdB star, and find that nitrogen and iron have abundances close to solar values, while helium, carbon, oxygen and silicon are underabundant relative to the solar mixture. We use the full Kepler Q06--Q17 lightcurve to extract 132 significant pulsation frequencies. Period-spacing relations and multiplet splittings allow us to identify the modal degree L for the majority of the modes. Using the g-mode multiplet splittings we constrain the internal rotation period at the base of the envelope to 46-48d as a first seismic result for this star. The few p-mode splittings may point at a slightly longer rotation period further out in the envelope of the star. From mode-visibility considerations we derive that the inclination of the rotation axis of the sdB in KIC7668647 must be around ~60 degrees. Furthermore, we find strong evidence for a few multiplets indicative of degree 3 <= L <= 8, which is another novelty in sdB-star observations made possible by Kepler.Comment: arXiv admin note: text overlap with arXiv:1206.387

On the off-axis tensile test for unidirectional composites

The off axis tensile test was examined experimentally to obtain actual displacement fields over the surface of graphite polyimide coupon specimens. The experimental results were compared with approximate analytical solutions and generated finite element results. An optical method of high sensitivity moire interferometry was used to determine the actual displacements to high precision. The approximate analytical solution and the finite element results compare very favorably with the measured centerline displacements in the test section, and the finite element displacement fields provide excellent agreement with the moire displacements throughout the specimen. A 15 degree fiber orientation and coupon aspect ratios of 5 and 15 are presented

Effect of Boundary Conditions on the Axial Compression Buckling of Homogeneous Orthotropic Composite Cylinders in the Long Column Range

Buckling loads for long isotropic and laminated cylinders are calculated based on Euler, Fluegge and Donnell's equations. Results from these methods are presented using simple parameters useful for fundamental design work. Buckling loads for two types of simply supported boundary conditions are calculated using finite element methods for comparison to select cases of the closed form solution. Results indicate that relying on Donnell theory can result in an over-prediction of buckling loads by as much as 40% in isotropic materials