1,164 research outputs found
Biotransformation of explosives by the old yellow enzyme family of flavoproteins
Several independent studies of bacterial degradation of nitrate ester explosives have demonstrated the involvement of flavin-dependent oxidoreductases related to the old yellow enzyme (OYE) of yeast. Some of these enzymes also transform the nitroaromatic explosive 2,4,6-trinitrotoluene (TNT). In this work, catalytic capabilities of five members of the OYE family were compared, with a view to correlating structure and function. The activity profiles of the five enzymes differed substantially; no one compound proved to be a good substrate for all five enzymes. TNT is reduced, albeit slowly, by all five enzymes. The nature of the transformation products differed, with three of the five enzymes yielding products indicative of reduction of the aromatic ring. Our findings suggest two distinct pathways of TNT transformation, with the initial reduction of TNT being the key point of difference between the enzymes. Characterization of an active site mutant of one of the enzymes suggests a structural basis for this difference
The future of the subsurface chlorophyll-a maximum in the Canada Basin-A model intercomparison
Six Earth system models and three ocean-ice-ecosystem models are analyzed to evaluate magnitude and depth of the subsurface Chl-a maximum (SCM) in the Canada Basin and ratio of surface to subsurface Chl-a in a future climate scenario. Differences in simulated Chl-a are caused by large intermodel differences in available nitrate in the Arctic Ocean and to some extent by ecosystem complexity. Most models reproduce the observed SCM and nitracline deepening and indicate a continued deepening in the future until the models reach a new state with seasonal ice-free waters. Models not representing a SCM show either too much nitrate and hence no surface limitation or too little nitrate with limited surface growth only. The models suggest that suppression of the nitracline and deepening of the SCM are caused by enhanced stratification, likely driven by enhanced Ekman convergence and freshwater contributions with primarily large-scale atmospheric driving mechanisms. The simulated ratio of near-surface Chl-a to depth-integrated Chl-a is slightly decreasing in most areas of the Arctic Ocean due to enhanced contributions of subsurface Chl-a. Exceptions are some shelf areas and regions where the continued ice thinning leaves winter ice too thin to provide a barrier to momentum fluxes, allowing winter mixing to break up the strong stratification. Results confirm that algorithms determining vertically integrated Chl-a from surface Chl-a need to be tuned to Arctic conditions, but likely require little or no adjustments in the future
Addressing the clumsiness loophole in a Leggett-Garg test of macrorealism
The rise of quantum information theory has lent new relevance to experimental
tests for non-classicality, particularly in controversial cases such as
adiabatic quantum computing superconducting circuits. The Leggett-Garg
inequality is a "Bell inequality in time" designed to indicate whether a single
quantum system behaves in a macrorealistic fashion. Unfortunately, a violation
of the inequality can only show that the system is either (i)
non-macrorealistic or (ii) macrorealistic but subjected to a measurement
technique that happens to disturb the system. The "clumsiness" loophole (ii)
provides reliable refuge for the stubborn macrorealist, who can invoke it to
brand recent experimental and theoretical work on the Leggett-Garg test
inconclusive. Here, we present a revised Leggett-Garg protocol that permits one
to conclude that a system is either (i) non-macrorealistic or (ii)
macrorealistic but with the property that two seemingly non-invasive
measurements can somehow collude and strongly disturb the system. By providing
an explicit check of the invasiveness of the measurements, the protocol
replaces the clumsiness loophole with a significantly smaller "collusion"
loophole.Comment: 7 pages, 3 figure
Viscoelasticity of crystal- and bubble-bearing rhyolite melts
The effect of non-deformable inclusions on the frequency-dependent rheology of a rhyolite melt plus crystals has been investigated using a sinusoidal torsion deformation device for measurements of shear viscosity and modulus in the frequency range of 5 mHz to 20 Hz at temperatures of 750â1050°C. The relaxed shear viscosity and unrelaxed shear modulus of rhyolite magma (rhyolite melt plus crystals plus bubbles) decreases with increasing bubble content and increases with the addition of crystals. At a crystal concentration of about 45% a relaxed value of the shear viscosity is not attainable. The presence of rigid inclusions results in an imaginary component of the shear modulus that becomes more symmetrical and shifted to the low-frequencyâhigh-temperature range with respect to that for a crystal-free melt. The slope of log(Qâ1) (internal friction) as a function of the dimensionless variable log(ÏÏ), is unaffected in the low-temperatureâhigh-frequency range of crystals, with Qâ1 â 1/(ÏÏ)0.5 (the same as for bubble- and crystal-free rhyolite). For the present type of suspension, the internal friction is practically constant and independent of log(ÏÏ) in the high-temperatureâlow-frequency limit (ÏÏ 1). The shape of the Cole-Cole diagram becomes symmetrical and can be described as a Caputo body with parameter Îł â 0.45, whereas for bubble-bearing and inclusion-free rhyolite melts the shape of diagram relates to the ÎČ-relaxation exponent with ÎČ â 0.5. The present work demonstrates that magma may or may not follow a power-law rheology depending on the relative volume proportion between crystals and bubbles
Standard and Null Weak Values
Weak value (WV) is a quantum mechanical measurement protocol, proposed by
Aharonov, Albert, and Vaidman. It consists of a weak measurement, which is
weighed in, conditional on the outcome of a later, strong measurement. Here we
define another two-step measurement protocol, null weak value (NVW), and point
out its advantages as compared to WV. We present two alternative derivations of
NWVs and compare them to the corresponding derivations of WVs.Comment: 11 pages, 2 figures. To appear in Quantum Theory: A Two-Time Success
Story: Yakir Aharonov Festschrif
Anisotropic splitting of intersubband spin plasmons in quantum wells with bulk and structural inversion asymmetry
In semiconductor heterostructures, bulk and structural inversion asymmetry
and spin-orbit coupling induce a k-dependent spin splitting of valence and
conduction subbands, which can be viewed as being caused by momentum-dependent
crystal magnetic fields. This paper studies the influence of these effective
magnetic fields on the intersubband spin dynamics in an asymmetric n-type
GaAs/AlGaAs quantum well. We calculate the dispersions of intersubband spin
plasmons using linear response theory. The so-called D'yakonov-Perel'
decoherence mechanism is inactive for collective intersubband excitations,
i.e., crystal magnetic fields do not lead to decoherence of spin plasmons.
Instead, we predict that the main signature of bulk and structural inversion
asymmetry in intersubband spin dynamics is a three-fold, anisotropic splitting
of the spin plasmon dispersion. The importance of many-body effects is pointed
out, and conditions for experimental observation with inelastic light
scattering are discussed.Comment: 8 pages, 6 figure
âIt Should Have Been Given Sooner, and We Should Not Have to Fight for Itâ: A Mixed-Methods Study of the Experience of Diagnosis and Early Management of Cerebral Palsy
Listening to the family experience is integral to identifying areas of strength and for im-provement in health service delivery around diagnosis and early management of cerebral palsy (CP). Families of children with a diagnosis of CP were invited to complete a purpose-developed electronic survey that included items around the timing of diagnosis, their experiences and satisfaction. It also allowed families to expand on their experiences through free text. Of the 57 families responding, 49% of children functioned at Gross Motor Function Classification System (GMFCS) levels I or II, 8% at GMFCS level III and 23% at GMFCS levels IV or V. 51% of participants were satisfied or very satisfied with the diagnosis experience, 18% were neutral about the experience and 31% were dissatisfied or very dissatisfied. Though the findings of this study may be subject to selection bias, perceived delays in the receipt of diagnosis of CP appeared common with 60% of participants indicating concerns about their child by <6 months of age but only 21% provided with a diagnosis of CP <6 months of age. Approximately 18% of families experienced a delay of more than 12 months. Thirty-four (61%) participants noted a delay between referrals to a service and receipt of service management/therapy. Common themes impacting on familiesâ experience in the diagnosis and health service delivery journey related to provision of information, and the style of communication, with both direct and ongoing communication styles common for greater family satisfaction. Overall, families desired the diagnosis experience to be informative and timely, with early follow up support and assistance with health sector navigation
Intersubband spin-density excitations in quantum wells with Rashba spin splitting
In inversion-asymmetric semiconductors, spin-orbit coupling induces a
k-dependent spin splitting of valence and conduction bands, which is a
well-known cause for spin decoherence in bulk and heterostructures.
Manipulating nonequilibrium spin coherence in device applications thus requires
understanding how valence and conduction band spin splitting affects carrier
spin dynamics. This paper studies the relevance of this decoherence mechanism
for collective intersubband spin-density excitations (SDEs) in quantum wells. A
density-functional formalism for the linear spin-density matrix response is
presented that describes SDEs in the conduction band of quantum wells with
subbands that may be non-parabolic and spin-split due to bulk or structural
inversion asymmetry (Rashba effect). As an example, we consider a 40 nm
GaAs/AlGaAs quantum well, including Rashba spin splitting of the conduction
subbands. We find a coupling and wavevector-dependent splitting of the
longitudinal and transverse SDEs. However, decoherence of the SDEs is not
determined by subband spin splitting, due to collective effects arising from
dynamical exchange and correlation.Comment: 10 pages, 4 figure
Pre-analytical and analytical variables affecting the measurement of plasma-derived microparticle tissue factor activity
Elevated levels of tissue factor positive (TF+) microparticles (MPs) are observed in plasma from a variety of patients with an increased risk of thrombosis. We and others have described the measurement of TF activity in MPs isolated from plasma. The aim of this study was to investigate the effects of pre-analytical and analytical variables on TF activity of MPs isolated from blood of healthy volunteers treated ex vivo with or without bacterial lipopolysaccharide
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