Inflammatory response induced by Helicobacter pylori infection in lung

Helicobacter pylori is a microorganism that in the last years has been associated with extragastric disorders such as respiratory diseases, however, its impact on lung is partially understood. The aim of this work was to study infection impact of H. pylori on the inflammatory markers expression at the pulmonary level using an animal model. Infection was performed by BALB/c wild type (WT) mice orotracheal instillation with 20 μl of 1 × 108 H. pylori reference strain suspension once per day throughout 3 days. Inflammatory response was evaluated at 3, 7, 14, 21 and 30 days post infection. Lung was aseptically removed and pulmonary edema index values showed a significant change at 30 days of infection. Hematoxylin-Eosin (H-E) stain allowed to visualizing H. pylori presence in lung samples at 3 days of infection near the phagocytic cells or in the alveoli lumen. Bronchoalveolar lavage (BAL) was used for inflammatory response evaluation. Lactate dehydrogenase values showed a gradual increase in infected animals along infection time. Protein concentrations in mg/ml from BAL increased significantly at 7 days in infected animals. Macrophages viability obtained from BAL, decreased at the first moment of infection, maintaining constant values along contamination time. Results obtained demonstrate an inflammatory response in lung after orotracheal H. pylori infection and suggest that the pathogenic mechanism is strongly evidenced by tissue damage, endothelial dysfunction inflammatory mediators and markers expression at the pulmonary level.Fil: Arismendi Sosa, Andrea Celeste. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Salinas Ibáñez, A.G.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Pérez Chaca, M.V.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Penissi, Alicia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Gómez, N.N.. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Investigaciones Biológicas - San Luis; ArgentinaFil: Vega, A.E.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentin

Pion radiative weak decays in nonlocal chiral quark models

We analyze the radiative pion decay pi+ -> e+ nu_e gamma within nonlocal chiral quark models that include wave function renormalization. In this framework we calculate the vector and axial-vector form factors FV and FA at q^2=0 --where q^2 is the (e+ \nu_e) squared invariant mass-- and the slope a of FV(q^2) at q^2 -> 0. The calculations are carried out considering different nonlocal form factors, in particular those taken from lattice QCD evaluations, showing a reasonable agreement with the corresponding experimental data. The comparison of our results with those obtained in the (local) NJL model and the relation of FV and a with the form factor in pi^0 -> gamma* gamma decays are discussed.Comment: 14 pages, 1 figure, minor changes in text introduce

Electromagnetic and weak hyperon properties in the Skyrme model

We report on the result of some investigations concerning the radiative decays of decuplet baryons and the non-leptonic weak decays of the octet baryons in the context of topological chiral soliton models. Our results are compared with those of alternative baryon models. For the radiative decays we find that the predictions are similar to those of quark models. In the case of the non-leptonic weak decays, we find that although the predicted S-wave amplitudes are in rather good agreement with the observed values, the model is not able to reproduce the empirical P-wave amplitudes. Thus, in contrast to previous expectations, the Skyrme model does not seem to provide a solution to the long-standing 'S-wave/P-wave puzzle'.Comment: 7 pages, 1 fig. Cont. to the Proc. of the "School on Electromagnetic probes and the structure of hadrons and nuclei". Erice, Italy. September 17- 24, 1999 to be published in Progress in Particle and Nuclear Physic

Configuring the neighbourhood effect in irregular cellular automata based models

Cellular automata (CA) models have been widely employed to simulate urban growth and land use change. In order to represent urban space more realistically, new approaches to CA models have explored the use of vector data instead of traditional regular grids. However, the use of irregular CA-based models brings new challenges as well as opportunities. The most strongly affected factor when using an irregular space is neighbourhood. Although neighbourhood definition in an irregular environment has been reported in the literature, the question of how to model the neighbourhood effect remains largely unexplored. In order to shed light on this question, this paper proposed the use of spatial metrics to characterise and measure the neighbourhood effect in irregular CA-based models. These metrics, originally developed for raster environments, namely the enrichment factor and the neighbourhood index, were adapted and applied in the irregular space employed by the model. Using the results of these metrics, distance-decay functions were calculated to reproduce the push-and-pull effect between the simulated land uses. The outcomes of a total of 55 simulations (five sets of different distance functions and eleven different neighbourhood definition distances) were compared with observed changes in the study area during the calibration period. Our results demonstrate that the proposed methodology improves the outcomes of the urban growth simulation model tested and could be applied to other irregular CA-based models

Strongly interacting matter under external magnetic fields within nonlocal NJL-type models

We study the behavior of strongly interacting matter under an external magnetic field in the context of nonlocal Nambu–Jona-Lasinio (NJL) -like models. We find that at zero temperature the condensates display the well-known Magnetic Catalysis effect, showing a good quantitative agreement with lattice QCD (LQCD) results. Moreover, when extended to finite temperature we find that (contrary to what happens in the local NJL model) the Inverse Magnetic Catalysis (IMC) effect is naturally incorporated. We also analyze the magnetic susceptibility of the QCD vacuum in the limit of small magnetic field, considering two different model parametrizations, and compare our numerical results to those obtained in other theoretical approaches and in LQCD calculations

Strong magnetic fields in a nonlocal Polyakov chiral quark model

We study the behavior of strongly interacting matter under an external constant magnetic field in the context of nonlocal chiral quark models that incorporate a coupling to the Polyakov loop. We find that at zero temperature the behavior of the quark condensates shows the expected magnetic catalysis effect, our predictions being in good quantitative agreement with lattice QCD results. On the other hand when the analysis is extended to the case of finite temperature our results show that nonlocal models naturally lead to the Inverse Magnetic Catalysis effect for both the chiral restoration and deconfinement transition temperatures

Track D Social Science, Human Rights and Political Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138414/1/jia218442.pd