Correlation of mechanical factors and gallbladder pain

Acalculous biliary pain occurs in patients with no gallstones, but is similar to that experienced by patients with gallstones. Surgical removal of the gallbladder (GB) in these patients is only successful in providing relief of symptoms to about half of those operated on, so a reliable pain-prediction model is needed. In this paper, a mechanical model is developed for the human biliary system during the emptying phase, based on a clinical test in which GB volume changes are measured in response to a standard stimulus and a recorded pain profile. The model can describe the bile emptying behaviour, the flow resistance in the biliary ducts, the peak total stress, including the passive and active stresses experienced by the GB during emptying. This model is used to explore the potential link between GB pain and mechanical factors. It is found that the peak total normal stress may be used as an effective pain indicator for GB pain. When this model is applied to clinical data of volume changes due to Cholecystokinin stimulation and pain from 37 patients, it shows a promising success rate of 88.2% in positive pain prediction

A Modified Stratified Randomized Response Techniques

This paper presents a modification of Kim and Warde’s (2004) Stratified Warner’s Randomized Response Technique (SWRRT) and Kim and Elam’s (2007) Stratified Unrelated Question Randomized Response Technique with known distribution (SURRT) using optimal allocation. Our models further reduce the non-response bias by introducing the concept of sub-samples of non-respondent developed by Hansen and Hurwitz (1946) to the above mentioned models. In this paper we perform an empirical practice of our model and we also perform the empirical comparison of our models with both Kim and Warde (2004) and Kim and Elam (2007) models. We discovered a new note in the empirical comparative study of our models. Keywords: Close supervision, Sensitive behavior, Non-respondent, Sub-sample, Randomized response techniques

An NMR-based nanostructure switch for quantum logic

We propose a nanostructure switch based on nuclear magnetic resonance (NMR) which offers reliable quantum gate operation, an essential ingredient for building a quantum computer. The nuclear resonance is controlled by the magic number transitions of a few-electron quantum dot in an external magnetic field.Comment: 4 pages, 2 separate PostScript figures. Minor changes included. One reference adde

Interchannel coupling effects in the spin polarization of energetic photoelectrons

Effects of the interchannel coupling on the spin polarization of energetic photoelectrons emitted from atomic Ne valence subshells are examined. Like previously obtained results for cross sections and angular distributions, the photoelectron spin polarization parameters too are found considerably influenced by the coupling. The result completes a series of studies to finally conclude that the independent particle description is inadequate for the {\em entire} range of photoionization dynamics over the {\em full} spectral energy domainComment: 7 pages, 5 figures, accepted in Phys. Rev.

Non-extremal fractional branes

We construct non-extremal fractional D-brane solutions of type-II string theory at the Z_2 orbifold point of K3. These solutions generalize known extremal fractional-brane solutions and provide further insights into N=2 supersymmetric gauge theories and dual descriptions thereof. In particular, we find that for these solutions the horizon radius cannot exceed the non-extremal enhancon radius. As a consequence, we conclude that a system of non-extremal fractional branes cannot develop into a black brane. This conclusion is in agreement with known dual descriptions of the system.Comment: 29 pages, LaTeX. v2: 30 pages; equation (3.4) corrected; typos fixed; discussion in section 3 streamlined and slightly extended; reference adde

Multi-touch Technology in Early Childhood: Current Trends and Future Challenges

© ACM 2015. This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in Interacción '15 Proceedings of the XVI International Conference on Human Computer Interactionhttp://dx.doi.org/10.1145/{10.1145/2829875.2829887The advantages of the direct manipulation style make the multi-touch technology an ideal mechanism to support learning activities for children. Moreover, although pre-kindergarten children are becoming frequent users of the technology little work has been done in the area to assess their actual abilities. This paper goes over the state of the art of multi-touch technology targeting pre-kindergarten children and its use for educational purposes. In addition, in this work we present future challenges that should be faced in the area in the near future to establish the basis on which designers will develop educational applications for children that fully exploit the multi-touch technology according to the actual abilities of pre-kindergarten children.Work supported by the MINECO (grants TIN2010-20488 and TIN2014-60077-R) and from GVA (ACIF/2015/075).Nácher-Soler, VE.; Jaén Martínez, FJ. (2015). Multi-touch Technology in Early Childhood: Current Trends and Future Challenges. ACM. https://doi.org/10.1145/2829875.2829887SAbdul Aziz, N.A., Batmaz, F., Stone, R., and Paul, C. Selection of touch gestures for children's applications. Proc. of SIC'13, 721--726.Abdul Aziz, N.A., Mat, N.S., Batmaz, F., Stone, R., and Paul, C. Selection of Touch Gestures for Children's Applications: Repeated Experiment to Increase Reliability. International Journal of Advanced Computer Science and Applications 5, 4 (2014), 97--102.Baloian, N., Pino, J. a., and Vargas, R. Tablet gestures as a motivating factor for learning. Proc. of ChileCHI'13, 98--103.Bebell, D., Dorris, S., and Muir, M. Emerging Results From The Nation's First Kindergarten Implementation of iPads. Auburn, 2012.Buxton, B. Multi-touch systems that I have known and loved. 2013. http://billbuxton.com/multitouchOverview.html.Chiong, C. and Shuler, C. Learning: Is there an app for that? Investigations of young children's usage and learning with mobile devices and apps. New York, 2010.Common Sense Media. Zero to Eight: Childrens Media Use in America 2013. 2013.Egloff, T.H. Edutainment: a case study of interactive cd-rom playsets. Computers in Entertainment 2, 1 (2004), 13.Hinrichs, U. and Carpendale, S. Gestures in the wild: studying multi-touch gesture sequences on interactive tabletop exhibits. Proc. of CHI'11, 3023--3032.Hourcade, J.P. Interaction Design and Children. Foundations and Trends® in Human-Computer Interaction 1, 4 (2007), 277--392.Ingram, A., Wang, X., and Ribarsky, W. Towards the establishment of a framework for intuitive multi-touch interaction design. Proc. of AVI'12, 66--73.Johnson, L., Adams, S., and Cummins, M. The NMC Horizon Report: 2012 K-12. The New Media Consortium, Austin, Texas, 2012.Kammer, D., Dang, R., Steinhauf, J., and Groh, R. Investigating interaction with tabletops in kindergarten environments. Proc. of IDC'14, 57--66.Knoche, H., Rasmussen, N.A., and Boldreel, K. Do Interactions Speak Louder than Words? Dialogic Reading of an Interactive Tablet-based E-book with Children between 16 Months and Three Years of Age. Proc. of IDC'14, 285--288.Kremer, K.E. Conducting Game User Experience Research with Preschoolers. Workshop on Games User Research: practice, methods, and applications (collocated to CHI'12).Nacher, V., Jaen, J., Catala, A., Navarro, E., and Gonzalez, P. Improving Pre-Kindergarten Touch Performance. Proc. of ITS '14, 163--166.Nacher, V., Jaen, J., and Catala, A. Exploring Visual Cues for Intuitive Communicability of Touch Gestures to Pre-kindergarten Children. Proc. of ITS '14, 159--162.Nacher, V., Jaen, J., Navarro, E., Catala, A., and González, P. Multi-touch gestures for pre-kindergarten children. International Journal of Human-Computer Studies 73, (2015), 37--51.Piaget, J.The Child and Reality. Grossman, New York, 1973.Rushton, S. and Juola-Rushton, A. Classroom Learning Environment, Brain Research and The No Child Left Behind Initiative: 6 years Later. Early Childhood Education Journal 36, 1 (2008), 87--92.Shneiderman, B., Plaisant, C., Cohen, M., and Jacobs, S. Designing the User Interface: Strategies for Effective Human-Computer Interaction. Prentice Hall, 2009.Shuler, C. iLearn II: An Analysis of the Education Category of the iTunes App Store. The Joan Ganz Cooney Center at Sesame Workshop, New York, 2012.Smith, S.P., Burd, E., and Rick, J. Developing, evaluating and deploying multi-touch systems. International Journal of Human-Computer Studies 70, 10 (2012), 653--656.Vatavu, R., Cramariuc, G., and Schipor, D.M. Touch interaction for children aged 3 to 6 years: Experimental findings and relationship to motor skills. International Journal of Human-Computer Studies 74, (2015), 54--76.Wakefield, J. and Smith, D. From Socrates to Satellites: iPad Learning in an Undergraduate Course. Creative Education 03, 05 (2012), 643--648.Wolock, E., Ann Orr, E.D., and Buckleitner, W. Child development 101 for the developers of interactive media. Active Learning Associates, Inc., 2006.Zaranis, N., Kalogiannakis, M., and Papadakis, S. Using Mobile Devices for Teaching Realistic Mathematics in Kindergarten Education. Creative Education 04, 07 (2013), 1--10

Deciphering the Link between Doubly Uniparental Inheritance of mtDNA and Sex Determination in Bivalves: Clues from Comparative Transcriptomics

Bivalves exhibit an astonishing diversity of sexual systems and sex-determining mechanisms. They can be gonochoric, hermaphroditic or androgenetic, with both genetic and environmental factors known to determine or influence sex. One unique sex-determining system involving the mitochondrial genome has also been hypothesized to exist in bivalves with doubly uniparental inheritance (DUI) of mtDNA. However, the link between DUI and sex determination remains obscure. In this study, we performed a comparative gonad transcriptomics analysis for two DUI-possessing freshwater mussel species to better understand the mechanisms underlying sex determination and DUI in these bivalves. We used a BLAST reciprocal analysis to identify orthologs between Venustaconcha ellipsiformis and Utterbackia peninsularis and compared our results with previously published sex-specific bivalve transcriptomes to identify conserved sex-determining genes. We also compared our data with other DUI species to identify candidate genes possibly involved in the regulation of DUI. A total of 3c12,000 orthologous relationships were found, with 2,583 genes differentially expressed in both species. Among these genes, key sex-determining factors previously reported in vertebrates and in bivalves (e.g., Sry, Dmrt1, Foxl2) were identified, suggesting that some steps of the sex-determination pathway may be deeply conserved in metazoans. Our results also support the hypothesis that a modified ubiquitination mechanism could be responsible for the retention of the paternal mtDNA in male bivalves, and revealed that DNA methylation could also be involved in the regulation of DUI. Globally, our results suggest that sets of genes associated with sex determination and DUI are similar in distantly-related DUI species

Louse (Insecta : Phthiraptera) mitochondrial 12S rRNA secondary structure is highly variable

Lice are ectoparasitic insects hosted by birds and mammals. Mitochondrial 12S rRNA sequences obtained from lice show considerable length variation and are very difficult to align. We show that the louse 12S rRNA domain III secondary structure displays considerable variation compared to other insects, in both the shape and number of stems and loops. Phylogenetic trees constructed from tree edit distances between louse 12S rRNA structures do not closely resemble trees constructed from sequence data, suggesting that at least some of this structural variation has arisen independently in different louse lineages. Taken together with previous work on mitochondrial gene order and elevated rates of substitution in louse mitochondrial sequences, the structural variation in louse 12S rRNA confirms the highly distinctive nature of molecular evolution in these insects

Two-temperature relaxation and melting after absorption of femtosecond laser pulse

The theory and experiments concerned with the electron-ion thermal relaxation and melting of overheated crystal lattice constitute the subject of this paper. The physical model includes two-temperature equation of state, many-body interatomic potential, the electron-ion energy exchange, electron thermal conductivity, and optical properties of solid, liquid, and two phase solid-liquid mixture. Two-temperature hydrodynamics and molecular dynamics codes are used. An experimental setup with pump-probe technique is used to follow evolution of an irradiated target with a short time step 100 fs between the probe femtosecond laser pulses. Accuracy of measurements of reflection coefficient and phase of reflected probe light are ~1% and \sim 1\un{nm}, respectively. It is found that, {\it firstly}, the electron-electron collisions make a minor contribution to a light absorbtion in solid Al at moderate intensities; {\it secondly}, the phase shift of a reflected probe results from heating of ion subsystem and kinetics of melting of Al crystal during 0 where $t$ is time delay between the pump and probe pulses measured from the maximum of the pump; {\it thirdly} the optical response of Au to a pump shows a marked contrast to that of Al on account of excitation of \textit{d}-electronsComment: 6th International Conference on Photo-Excited Processes and Applications 9-12 Sep 2008, Sapporo, Japan, http://www.icpepa6.com, the contributed paper will be published in Applied Surface Science(2009

From Social Data Mining to Forecasting Socio-Economic Crisis

Socio-economic data mining has a great potential in terms of gaining a better understanding of problems that our economy and society are facing, such as financial instability, shortages of resources, or conflicts. Without large-scale data mining, progress in these areas seems hard or impossible. Therefore, a suitable, distributed data mining infrastructure and research centers should be built in Europe. It also appears appropriate to build a network of Crisis Observatories. They can be imagined as laboratories devoted to the gathering and processing of enormous volumes of data on both natural systems such as the Earth and its ecosystem, as well as on human techno-socio-economic systems, so as to gain early warnings of impending events. Reality mining provides the chance to adapt more quickly and more accurately to changing situations. Further opportunities arise by individually customized services, which however should be provided in a privacy-respecting way. This requires the development of novel ICT (such as a self- organizing Web), but most likely new legal regulations and suitable institutions as well. As long as such regulations are lacking on a world-wide scale, it is in the public interest that scientists explore what can be done with the huge data available. Big data do have the potential to change or even threaten democratic societies. The same applies to sudden and large-scale failures of ICT systems. Therefore, dealing with data must be done with a large degree of responsibility and care. Self-interests of individuals, companies or institutions have limits, where the public interest is affected, and public interest is not a sufficient justification to violate human rights of individuals. Privacy is a high good, as confidentiality is, and damaging it would have serious side effects for society.Comment: 65 pages, 1 figure, Visioneer White Paper, see http://www.visioneer.ethz.c