Design of F-16 Airfoil Mock-ups for Supersonic Wind Tunnel: Study, Production, Testing and Validation

This research paper presents a comprehensive investigation into the behavior of viscous supersonic laminar flow and the Shock Wave- Laminar Boundary Layer Interaction (SWBLI) around the F-16 laminar NACA 6-series airfoil NACA 64A204. The study aims to establish and compare different methods for accurately describing these complex phenomena, which are of significant importance in the development of advanced aerospace technologies. To achieve this objective, a unique approach was adopted, involving the design and production of a mock-up F-16 airfoil equipped with pressure taps for use in the supersonic burst wind tunnel AF300. The mock-up was then experimentally tested, and the obtained data were analysed using numerical simulations with Ansys Fluent and a theoretical model based on a previously established analytical SWBLI model. The results obtained from the experimental, numerical, and analytical analyses validate the designed NACA 64A204 mock-up to a great extent. The study provides valuable insights into the physics of viscous supersonic laminar flow and SWBLI, contributing to a better understanding of these phenomena. The findings of this study will have important applications in the design of high-speed aircraft and other advanced aerospace technologies.Comment: 14 pages, 17 figures, 5 tables, submitted to Jounral of Applied Fluid Mechanic

The Coastal Data Information Program, a Successful Federal, State and University Cooperation

International audienceThermal management and heat prediction are essential to improve the Li-ion battery operation life and performance, especially in Energy Storage System (ESS) for electric vehicles. Variation of cells temperatures of a battery pack can cause damage if not managed. In this paper, an electrochemical-thermal battery pack of three parallel-connected cylindrical Li-ion cells is modelled using COMSOL Multi-physics. The battery pack is cooled using air cooling approach with different inlet velocity to investigate its impact on the model temperature evolution , and the developed thermal model was then, charged/discharge at different temperatures to generate the essential data needed to model an electric-thermal model and identify its parameters in Matlab/Simulink software

Adenosine metabolic signature in circulating CD4+ T cells predicts remission in rheumatoid arthritis

\ua9 Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.Objectives Long-term outcomes in rheumatoid arthritis (RA) depend on early and effective disease control. Methotrexate (MTX) remains the first-line disease modifying therapy, however there are no biomarkers with which to identify those most likely to achieve remission. To address this unmet need we explored metabolic pathways involved in MTX mechanism of action within circulating CD4+T cells in a cohort of treatment naive patients with early RA. Methods Purified CD4+T cells were isolated from peripheral blood of 68 patients with early RA commencing MTX. The expression of a range of putative MTX metabolism and mechanism of action targets were explored by flow-cytometry and transcriptional analysis. From these data significant predictors of Disease Activity Score 28-C reactive protein (DAS28-CRP) remission (<2.4 at 6 months) were determined by logistic regression (clinical; flow-cytometry data) and linear modelling (gene expression data). Results Low baseline DAS28-CRP was associated with remission at 6 months (p=0.02). Expression of the ectonucleotidase CD39, involved in ATP-ADP conversion during adenosine synthesis, was higher on CD4+CD25 High regulatory T cells at baseline in those achieving remission (molecules of equivalent fluorescence 1264 vs 847; p=0.007). Expression of other adenosine signalling elements in CD4+T cells were also upregulated at baseline in patients achieving remission: AMPD1 (p<0.001), ADORA2b (p=0.039) and ADORA3 (p=0.047). When combined into a single predictive metric, a combination of these variables outperformed baseline DAS28-CRP in prediction of early remission (area under the curve 0.92 vs 0.67, p=0.001) Conclusions Adenosine signalling is important in the achievement of early remission with MTX in RA and biomarkers of adenosine activity may hold utility for the stratification of therapy in early disease

The Application of Genetic Risk Scores in Rheumatic Diseases: A Perspective

\ua9 2023 by the authors.Modest effect sizes have limited the clinical applicability of genetic associations with rheumatic diseases. Genetic risk scores (GRSs) have emerged as a promising solution to translate genetics into useful tools. In this review, we provide an overview of the recent literature on GRSs in rheumatic diseases. We describe six categories for which GRSs are used: (a) disease (outcome) prediction, (b) genetic commonalities between diseases, (c) disease differentiation, (d) interplay between genetics and environmental factors, (e) heritability and transferability, and (f) detecting causal relationships between traits. In our review of the literature, we identified current lacunas and opportunities for future work. First, the shortage of non-European genetic data restricts the application of many GRSs to European populations. Next, many GRSs are tested in settings enriched for cases that limit the transferability to real life. If intended for clinical application, GRSs are ideally tested in the relevant setting. Finally, there is much to elucidate regarding the co-occurrence of clinical traits to identify shared causal paths and elucidate relationships between the diseases. GRSs are useful instruments for this. Overall, the ever-continuing research on GRSs gives a hopeful outlook into the future of GRSs and indicates significant progress in their potential applications

Decoupled models for vehicle dynamics and estimation of coupling terms

International audienceThis paper presents different dynamic models of vehicles to compare their dynamics. The main objective is to appreciate the couplings between the different model blocks after splitting systems to five sub models. The passivity approach is used and illustrated by simulation results obtained by the proposed simulator SimK106N

Traitement Expérimental Par Coagulation Floculation Des Effluents Brutes D’une Industrie Aéronautique À Casablanca (Maroc)

Les effluents de l’industrie de traitement de surface présentent souvent une forte charge en produits chimiques très toxiques qui doivent être traités conformément à une réglementation de plus en plus stricte. Dans ce travail, nous avons effectué une caractérisation des effluents liquides d’une unité de traitement de surface au Maroc qui a révélé une forte pollution colloïdale (Turbidité=131 NTU), une charge en matière oxydable élevée (DCO = 960 mg/l) et en éléments métalliques (Fer, cuivre, zinc, nickel, aluminium, chrome et cyanure). L’objectif de cette étude expérimentale consiste à appliquer un traitement physico-chique par coagulation-floculation à ces eaux uses industrielles toxiques en vue de les conformer aux normes de rejet dans le réseau d’assainissement local. En effet, ce traitement, précédé d’un ajustement du pH, une oxydation des cyanures et d’une réduction du chrome hexavalent, a abouti à une réduction très satisfaisante de la toxicité de ces effluents avec des taux d’abattement de 94% pour la DCO et jusqu'à 99 % pour la turbidité et charge métallique. Effluents from the surface treatment industry often have a high load o f highly toxic chemicals that need to be treated in accordance with increasing ly stringent regulations. In this work, we performed a characterization of liqu id effluents from a surface treatment unit in Morocco that revealed high collo idal pollution (Turbidity=131 NTU), high stainless material (COD=960 mg/l ) and metal elements (Iron, copper, zinc, nickel, aluminum, chromium and cy anide). The objective of this experimental study is to apply a physico-chemical treatment by coagulation-flocculation to these toxic industrial wastewater in order to comply with the discharge standards in the local sewage system. This treatment, preceded by pH adjustment, cyanide oxidation and reduction of hexavalent chromium, resulted in a very satisfactory reduction in toxicity of these effluents with abatement rates of 94% for COD and up to 99% for turbidity and metal load

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

The first genome-scale DNA methylation study on pancreatic islets from type 2 diabetic patients identifies disease-associated DNA methylation pattern that translate into aberrant gene expression in novel factors relevant for β-cell function and survival

EuroDia: a beta-cell gene expression resource

Type 2 diabetes mellitus (T2DM) is a major disease affecting nearly 280 million people worldwide. Whilst the pathophysiological mechanisms leading to disease are poorly understood, dysfunction of the insulin-producing pancreatic beta-cells is key event for disease development. Monitoring the gene expression profiles of pancreatic beta-cells under several genetic or chemical perturbations has shed light on genes and pathways involved in T2DM. The EuroDia database has been established to build a unique collection of gene expression measurements performed on beta-cells of three organisms, namely human, mouse and rat. The Gene Expression Data Analysis Interface (GEDAI) has been developed to support this database. The quality of each dataset is assessed by a series of quality control procedures to detect putative hybridization outliers. The system integrates a web interface to several standard analysis functions from R/Bioconductor to identify differentially expressed genes and pathways. It also allows the combination of multiple experiments performed on different array platforms of the same technology. The design of this system enables each user to rapidly design a custom analysis pipeline and thus produce their own list of genes and pathways. Raw and normalized data can be downloaded for each experiment. The flexible engine of this database (GEDAI) is currently used to handle gene expression data from several laboratory-run projects dealing with different organisms and platforms

Nushus Al–Waridah Fil Miqdar Al–Muharram Minarridha': Dirasah Tahliliah

This study explaines about views of Muslim jurists on the amount of breast milk that establishes fosterage and prohibits marriage based on the differences in the relevant legal texts. This research, critically, examines those texts, especially those that require five counts of breastfeeding. The methodology is based on critical examination of all the texts to establish their authenticity and relevance. The Researcher argued For safety, it is recommended to consider any amount of breastfeeding as a cause of fostering and prohibition. It concluded that there is doubt about the authenticity of those texts require five counts of breastfeeding

The use of Carbide Silicon transistors in a switch-mode power supply

International audienceIn this paper, we propose a switch mode power supply using carbide silicon transistors in a Full Bridge DC/DC converter structure controlled by an analog control, designed during this work. This solution shows several advantages: simple implementation, compactness with satisfactory performance. The simulation results achieved are compared with those obtained by using a Texas Instrument digital controller UCC28950. It is shown that the designed power supply with an analog control shows an efficiency of more than 90%