Preliminary evaluation of a thin organic film coating Final report

High temperature and humidity resistance of thin siloxane films on metal substrate

Priority setting for new technologies in medicine: A transdisciplinary study

BACKGROUND: Decision makers in health care organizations struggle with how to set priorities for new technologies in medicine. Traditional approaches to priority setting for new technologies in medicine are insufficient and there is no widely accepted model that can guide decision makers. DISCUSSION: Daniels and Sabin have developed an ethically based account about how priority setting decisions should be made. We have developed an empirically based account of how priority setting decisions are made. In this paper, we integrate these two accounts into a transdisciplinary model of priority setting for new technologies in medicine that is both ethically and empirically based. SUMMARY: We have developed a transdisciplinary model of priority setting that provides guidance to decision makers that they can operationalize to help address priority setting problems in their institution

Stem Of The Arts: Incorporating Art Into Stem Fields

Sherri MartinieThroughout this research project, we explored how arts can be intertwined into the STEM field. Collectively, we planned, created and facilitated three activities that centered around different styles of art-specifically the areas of art, music and dance. Our goal was to express to students how art and STEM can be used together and prove STEM is needed in areas of art. We conducted this research at Woodrow Wilson Elementary and various STEAM nights throughout the USD 383 school district. At the beginning of each activity, students were given a survey asking, “What is STEM?” and “Could art be a part of Stem?” Students recorded their responses before beginning the activities. The first activity we facilitated focused on incorporating art into STEM. Fourth-grade students were given the opportunity to let their imaginations run wild by using static electricity to make their creations come to life. Students were given a variety of materials (cardboard, tissue paper, markers and glue) to construct a “movable” project. After they finished, they were given balloons to explore how static electricity could make their art alive. The second activity we implemented centered around integrating music into STEM. Fifth-grade students used iPads to explore the Tynker App and create choreographed dances. Students activated their prior knowledge of coding to design a character and code it to create a dance. The third activity we conducted focused on incorporating music into STEM. Sixth-grade students were given a Makey Makey and asked to create a song utilizing their understanding of circuits. Using alligator clips, students were able to connect to a conductive material (bananas) and control their circuit boards. They were able to investigate how closed circuits worked in order to appropriately make the Makey Makey work. After each activity, we gave the students another short survey with the following two questions, “Could art be a part of STEM?” and “If so, how?” Before the activities, 80% of students stated that they could see art being a part of STEM. After facilitating each activity 90% of the students said they thought art was a part of STEM

Semiflexible polymers: Dependence on ensemble and boundary orientations

We show that the mechanical properties of a worm-like-chain (WLC) polymer, of contour length $L$ and persistence length \l such that t=L/\l\sim{\cal O}(1), depend both on the ensemble and the constraint on end-orientations. In the Helmholtz ensemble, multiple minima in free energy near $t=4$ persists for all kinds of orientational boundary conditions. The qualitative features of projected probability distribution of end to end vector depend crucially on the embedding dimensions. A mapping of the WLC model, to a quantum particle moving on the surface of an unit sphere, is used to obtain the statistical and mechanical properties of the polymer under various boundary conditions and ensembles. The results show excellent agreement with Monte-Carlo simulations.Comment: 15 pages, 15 figures; version accepted for publication in Phys. Rev. E; one new figure and discussions adde

Therapeutic depletion of natural killer cells controls persistent infection

Persistent viral infections are associated with host and viral factors that impair effective antiviral immunity. Natural killer (NK) cells contribute to establishment of persistent lymphocytic choriomeningitis virus (LCMV) infection in mice through suppression of virus-specific T cell responses during the first few days of infection, but NK cell depletion during those early time points can enable severe T cell-mediated immune pathology and death of the host. Here we show that long after their peak in cytolytic activation, NK cells continue to support viral persistence at later times of infection. Delayed depletion of NK cells, 2 to 3 weeks after infection, enhanced virus-specific T cell responses and viral control. This enhancing effect of delayed NK cell depletion on antiviral immunity, in contrast to early NK cell depletion, was not associated with increased morbidity and mortality, and mice quickly regained weight after treatment. The efficacy of the depletion depended in part upon the size of the original virus inoculum, the viral load at the time of depletion, and the presence of CD4 T cells. Each of these factors is an important contributor to the degree of CD8 T cell dysfunction during viral persistence. Thus, NK cells may continuously contribute to exhaustion of virus-specific T cells during chronic infection, possibly by depleting CD4 T cells. Targeting of NK cells could thus be considered in combination with blockade of other immunosuppressive pathways, such as the interleukin-10 (IL-10) and programmed death 1 (PD-1) pathways, as a therapy to cure chronic human infections, including those with HIV or hepatitis C virus. IMPORTANCE: Persistent virus infections are a major threat to global human health. The capacity of viruses, including HIV and hepatitis C virus, to overwhelm or subvert host immune responses contributes to a prolonged state of dampened antiviral immune functionality, which in turn facilitates viral persistence. Recent efforts have focused on therapeutics that can restore the effector functions of these functionally exhausted virus-specific T cells in order to expedite viral clearance. Here we establish that natural killer (NK) cells actively contribute to immune dysfunction and viral persistence at later stages of infection. This previously undescribed mechanism of immune suppression during chronic infection provides a vital clue for the design of novel therapeutic strategies targeting NK cell immunosuppressive activity in order to restore immune function and enhance viral control in chronically infected individuals

Giving Community Psychology Away: A case for open access publishing

Amidst increased pressure for transparency in science, researchers and community members are calling for open access to study stimuli and measures, data, and results. These arguments coincidentally align with calls within community psychology to find innovative ways to support communities and increase the prominence of our field. This paper aims to (1) define the current context for community psychologists in open access publishing, (2) illustrate the alignment between open access publishing and community psychology principles, and (3) demonstrate how to engage in open access publishing using community psychology values. Currently, there are several facilitators (e.g. an increasing number of open access journals, the proliferation of blogs, and social media) and barriers (e.g. Article Processing Charges (APCs), predatory journals) to publishing in open access venues. Openly sharing our research findings aligns with our values of (1) citizen participation, (2) social justice, and (3) collaboration and community strengths. Community psychologists desiring to engage in open access publishing can ask journals to waive APCs, publish pre-prints, use blogs and social media to share results, and push for systemic change in a publishing system that disenfranchises researchers, students, and community members

Giving Community Psychology Away: A case for open access publishing

Amidst increased pressure for transparency in science, researchers and community members are calling for open access to study stimuli and measures, data, and results. These arguments coincidentally align with calls within community psychology to find innovative ways to support communities and increase the prominence of our field. This paper aims to (1) define the current context for community psychologists in open access publishing, (2) illustrate the alignment between open access publishing and community psychology principles, and (3) demonstrate how to engage in open access publishing using community psychology values. Currently, there are several facilitators (e.g. an increasing number of open access journals, the proliferation of blogs, and social media) and barriers (e.g. Article Processing Charges (APCs), predatory journals) to publishing in open access venues. Openly sharing our research findings aligns with our values of (1) citizen participation, (2) social justice, and (3) collaboration and community strengths. Community psychologists desiring to engage in open access publishing can ask journals to waive APCs, publish pre-prints, use blogs and social media to share results, and push for systemic change in a publishing system that disenfranchises researchers, students, and community members

Power-law carrier dynamics in semiconductor nanocrystals at nanosecond time scales

We report the observation of power law dynamics on nanosecond to microsecond time scales in the fluorescence decay from semiconductor nanocrystals, and draw a comparison between this behavior and power-law fluorescence blinking from single nanocrystals. The link is supported by comparison of blinking and lifetime data measured simultaneously from the same nanocrystal. Our results reveal that the power law coefficient changes little over the nine decades in time from 10 ns to 10 s, in contrast with the predictions of some diffusion based models of power law behavior.Comment: 3 pages, 2 figures, compressed for submission to Applied Physics Letter

New Discoveries from the Arecibo 327 MHz Drift Pulsar Survey Radio Transient Search

We present Clusterrank, a new algorithm for identifying dispersed astrophysical pulses. Such pulses are commonly detected from Galactic pulsars and rotating radio transients (RRATs), which are neutron stars with sporadic radio emission. More recently, isolated, highly dispersed pulses dubbed fast radio bursts (FRBs) have been identified as the potential signature of an extragalactic cataclysmic radio source distinct from pulsars and RRATs. Clusterrank helped us discover 14 pulsars and 8 RRATs in data from the Arecibo 327 MHz Drift Pulsar Survey (AO327). The new RRATs have DMs in the range $23.5 - 86.6$ pc cm$^{-3}$ and periods in the range $0.172 - 3.901$ s. The new pulsars have DMs in the range $23.6 - 133.3$ pc cm$^{-3}$ and periods in the range $1.249 - 5.012$ s, and include two nullers and a mode-switching object. We estimate an upper limit on the all-sky FRB rate of $10^5$ day$^{-1}$ for bursts with a width of 10 ms and flux density $\gtrsim 83$ mJy. The DMs of all new discoveries are consistent with a Galactic origin. In comparing statistics of the new RRATs with sources from the RRATalog, we find that both sets are drawn from the same period distribution. In contrast, we find that the period distribution of the new pulsars is different from the period distributions of canonical pulsars in the ATNF catalog or pulsars found in AO327 data by a periodicity search. This indicates that Clusterrank is a powerful complement to periodicity searches and uncovers a subset of the pulsar population that has so far been underrepresented in survey results and therefore in Galactic pulsar population models.Comment: 41 pages, 16 figures, 4 tables, accepted by ApJ; added minor corrections to final ApJ proo

Neutralisation treatment of AMD at affordable cost

Acid mine drainage (AMD) has for many years been a major environmental challenge associated with the mining industry, especially in the Eastern, Central and Western mining basins of Gauteng. The aims of this article are to: (i) demonstrate the suitability of the sequencing batch reactor (SBR) system for both neutralisation of free acid and removal of iron(II), often the main component in AMD, using limestone, the cheapest alkali, followed by lime treatment for removal of heavy metals, and partial sulphate removal through gypsum crystallisation; (ii) compare the alkali cost of the alternative SBR system where limestone and lime are used for treatment, with conventional lime treatment, and (iii) present the capital cost of the SBR system.The conclusions of this study are that: (i) precipitated calcium carbonate can be used for complete removal of iron(II) in an SBR system within 90 min reaction time; (ii) lime can be used for complete removal of heavy metals after pre-treatment with precipitated calcium carbonate; (iii) the alkali cost for treatment of AMD from the Western Basin will amount to R2.80/m3 in the case of limestone/lime treatment compared to R5.83/m3 if only lime is used; (iv) the alkali cost for treatment of 85 Mℓ/d acid mine water from both the Western and Central Basins will amount to R60 m./a in the case of limestone/lime treatment compared to R136.9 m./a if only lime is used; and (v) the capital cost for the SBR system amounts to R3.5 m. per Mℓ/d.Keywords: Acid mine drainage, sequencing batch reactor, neutralisation, limeston