934 research outputs found
YAC contigs of the Rab1 and wobbler (wr) spinal muscular atrophy gene region on proximal mouse chromosome 11 and of the homologous region on human chromosome 2p
powerful tool to advance the identi®cation of gene com-Despite rapid progress in the physical characteriza- plexes and of disease genes. In this respect, the analysis tion of murine and human genomes, little molecular in- of human chromosomes 16 and 19 (Nowak, 1995) and formation is available on certain regions, e.g., proximal mouse chromosomes 1 (Hunter et al., 1994) and 17 (Cox mouse chromosome 11 (Chr 11) and human chromosome et al., 1993) as well as of human and murine X chromo-2p (Chr 2p). We have localized the wobbler spinal atrophy somes is particularly far advanced (Hamvas et al., 1993). gene wr to proximal mouse Chr 11, tightly linked toRab1, On the other hand, such extensive information is not a gene coding for a small GTP-binding protein, and Glns- available for mouse proximal chromosome 11 (Chr 11) ps1, an intronless pseudogene of the glutamine synthe- and human chromosome 2p (Chr 2p) (Fig. 1; cf. Berry et tase gene. We have now used these markers to construct al., 1995; Nowak, 1995), known to share at least the genesa 1.3-Mb yeast arti®cial chromosome (YAC) contig of the for the reticuloendotheliosis oncogene (Brownell et al.,Rab1 region on mouse Chr 11. Four YAC clones isolated 1985), for a brain-speci®cb-spectrin isoform (Bloom et al.,from two independent YAC libraries were characterized 1992), and for cytoplasmic malate dehydrogenase (Ball etby rare-cutting analysis, ¯uorescence in situ hybridiza-al., 1994). However, comparing the segregation map oftion (FISH), and sequence-tagged site (STS) isolation and the mouse with the human cytogenetic map, a colinearmapping. Rab1 and Glns-ps1 were found to be only 20
Impact of granulation effects on the use of Balmer lines as temperature indicators
Balmer lines serve as important indicators of stellar effective temperatures
in late-type stellar spectra. One of their modelling uncertainties is the
influence of convective flows on their shape. We aim to characterize the
influence of convection on the wings of Balmer lines. We perform a differential
comparison of synthetic Balmer line profiles obtained from 3D hydrodynamical
model atmospheres and 1D hydrostatic standard ones. The model parameters are
appropriate for F,G,K dwarf and subgiant stars of metallicity ranging from
solar to 1/1000 solar. The shape of the Balmer lines predicted by 3D models can
never be exactly reproduced by a 1D model, irrespective of its effective
temperature. We introduce the concept of a 3D temperature correction, as the
effective temperature difference between a 3D model and a 1D model which
provides the closest match to the 3D profile. The temperature correction is
different for the different members of the Balmer series and depends on the
adopted mixing-length parameter in the 1D model. Among the investigated models,
the 3D correction ranges from -300K to +300K. Horizontal temperature
fluctuations tend to reduce the 3D correction. Accurate effective temperatures
cannot be derived from the wings of Balmer lines, unless the effects of
convection are properly accounted for. The 3D models offer a physically well
justified way of doing so. The use of 1D models treating convection with the
mixing-length theory do not appear to be suitable for this purpose. In
particular, there are indications that it is not possible to determine a single
value of the mixing-length parameter which will optimally reproduce the Balmer
lines for any choice of atmospheric parameters.Comment: 6 pages, 3 figures, accepted for publication in A&
CRANKITE: a fast polypeptide backbone conformation sampler
Background: CRANKITE is a suite of programs for simulating backbone conformations of polypeptides and proteins. The core of the suite is an efficient Metropolis Monte Carlo sampler of backbone conformations in continuous three-dimensional space in atomic details.
Methods: In contrast to other programs relying on local Metropolis moves in the space of dihedral angles, our sampler utilizes local crankshaft rotations of rigid peptide bonds in Cartesian space.
Results: The sampler allows fast simulation and analysis of secondary structure formation and conformational changes for proteins of average length
Main-Sequence and sub-giant stars in the Globular Cluster NGC6397: The complex evolution of the lithium abundance
Thanks to the high multiplex and efficiency of Giraffe at the VLT we have
been able for the first time to observe the Li I doublet in the Main Sequence
(MS) stars of a Globular Cluster. At the same time we observed Li in a sample
of Sub-Giant (SG) stars of the same B-V colour. Our final sample is composed of
84 SG stars and 79 MS stars. In spite of the fact that SG and MS span the same
temperature range we find that the equivalent widths of the Li I doublet in SG
stars are systematically larger than those in MS stars, suggesting a higher Li
content among SG stars. This is confirmed by our quantitative analysis. We
derived the effective temperatures, from H fitting, and NLTE Li
abundances of the stars in our the sample, using 3D and 1D models. We find that
SG stars have a mean Li abundance higher by 0.1dex than MS stars, using both 1D
and 3D models. We also detect a positive slope of Li abundance with effective
temperature. These results provide an unambiguous evidence that the Li
abundance changes with evolutionary status. The physical mechanisms responsible
for this behaviour are not yet clear, and none of the existing models seems to
describe accurately these observations. Based on these conclusions, we believe
that the cosmological lithium problem still remains an open question.Comment: Proceedings of the contributed talk presented at the IAU Symposium
26
Combination of Conservative and Interventional Therapy Strategies for Intra- and Extrahepatic Cholangiocellular Carcinoma: A Retrospective Survival Analysis
Background. Due to the predominantly advanced stage at the time of diagnosis treatment of cholangiocarcinoma is difficult. Apart from surgical resection, interventional treatment strategies are increasingly used in advanced stage tumours. The aim of the study was a retrospective comparison of the effect of the various forms of treatment on morbidity and mortality. Method. A total of 195 patients, received either chemotherapy or a combination of photodynamic therapy (PDT) or transarterial chemoembolization (TACE) and chemotherapy. Results. The median survival rate for all patients was 15.6 months, 50.8% were still alive 1 year after diagnosis. Patients, who had previously undergone surgery, survived 17.1 months longer than those without surgical treatment (P < .01). Chemotherapy prolonged the survival by 9.2 months (P = .47). Palliative patients under combination of chemotherapy and PDT survived on average 1.8 months longer (P = .28), with chemotherapy and TACE 9.8 months longer (P = .04) compared to chemotherapy alone. Conclusions. It appears that surgical treatment and chemotherapy combined with PDT or TACE may prolong survival
On the Formation Height of the SDO/HMI Fe 6173 Doppler Signal
The Helioseismic and Magnetic Imager (HMI) onboard the Solar Dynamics
Observatory (SDO) is designed to study oscillations and the mag- netic field in
the solar photosphere. It observes the full solar disk in the Fe I absorption
line at 6173\AA . We use the output of a high-resolution 3D, time- dependent,
radiation-hydrodynamic simulation based on the CO5BOLD code to calculate
profiles F({\lambda},x,y,t) for the Fe I 6173{\AA} line. The emerging profiles
F({\lambda},x,y,t) are multiplied by a representative set of HMI filter
transmission profiles R_i({\lambda},1 \leq i \leq 6) and filtergrams
I_i(x,y,t;1 \leq i \leq 6) are constructed for six wavelengths. Doppler
velocities V_HMI(x,y,t) are determined from these filtergrams using a
simplified version of the HMI pipeline. The Doppler velocities are correlated
with the original velocities in the simulated atmosphere. The cross-
correlation peaks near 100 km, suggesting that the HMI Doppler velocity signal
is formed rather low in the solar atmosphere. The same analysis is performed
for the SOHO/MDI Ni I line at 6768\AA . The MDI Doppler signal is formed
slightly higher at around 125 km. Taking into account the limited spatial
resolution of the instruments, the apparent formation height of both the HMI
and MDI Doppler signal increases by 40 to 50 km. We also study how
uncertainties in the HMI filter-transmission profiles affect the calculated
velocities.Comment: 15 pages, 11 Figure
The solar photospheric abundance of hafnium and thorium. Results from CO5BOLD 3D hydrodynamic model atmospheres
Context: The stable element hafnium (Hf) and the radioactive element thorium
(Th) were recently suggested as a suitable pair for radioactive dating of
stars. The applicability of this elemental pair needs to be established for
stellar spectroscopy. Aims: We aim at a spectroscopic determination of the
abundance of Hf and Th in the solar photosphere based on a \cobold 3D
hydrodynamical model atmosphere. We put this into a wider context by
investigating 3D abundance corrections for a set of G- and F-type dwarfs.
Method: High-resolution, high signal-to-noise solar spectra were compared to
line synthesis calculations performed on a solar CO5BOLD model. For the other
atmospheres, we compared synthetic spectra of CO5BOLD 3D and associated 1D
models. Results: For Hf we find a photospheric abundance A(Hf)=0.87+-0.04, in
good agreement with a previous analysis, based on 1D model atmospheres. The
weak Th ii 401.9 nm line constitutes the only Th abundance indicator available
in the solar spectrum. It lies in the red wing of an Ni-Fe blend exhibiting a
non-negligible convective asymmetry. Accounting for the asymmetry-related
additional absorption, we obtain A(Th)=0.09+-0.03, consistent with the
meteoritic abundance, and about 0.1 dex lower than obtained in previous
photospheric abundance determinations. Conclusions: Only for the second time,
to our knowledge, has am non-negligible effect of convective line asymmetries
on an abundance derivation been highlighted. Three-dimensional hydrodynamical
simulations should be employed to measure Th abundances in dwarfs if similar
blending is present, as in the solar case. In contrast, 3D effects on Hf
abundances are small in G- to mid F-type dwarfs and sub-giants, and 1D model
atmospheres can be conveniently used.Comment: A&A, in pres
Recommended from our members
Vortex Motions in the Solar Atmosphere: Definitions, Theory, Observations, and Modelling
Vortex flows, related to solar convective turbulent dynamics at granular scales and their interplay with magnetic fields within intergranular lanes, occur abundantly on the solar surface and in the atmosphere above. Their presence is revealed in high-resolution and high-cadence solar observations from the ground and from space and with state-of-the-art magnetoconvection simulations. Vortical flows exhibit complex characteristics and dynamics, excite a wide range of different waves, and couple different layers of the solar atmosphere, which facilitates the channeling and transfer of mass, momentum and energy from the solar surface up to the low corona. Here we provide a comprehensive review of documented research and new developments in theory, observations, and modelling of vortices over the past couple of decades after their observational discovery, including recent observations in Hα, innovative detection techniques, diverse hydrostatic modelling of waves and forefront magnetohydrodynamic simulations incorporating effects of a non-ideal plasma. It is the first systematic overview of solar vortex flows at granular scales, a field with a plethora of names for phenomena that exhibit similarities and differences and often interconnect and rely on the same physics. With the advent of the 4-m Daniel K. Inouye Solar Telescope and the forthcoming European Solar Telescope, the ongoing Solar Orbiter mission, and the development of cutting-edge simulations, this review timely addresses the state-of-the-art on vortex flows and outlines both theoretical and observational future research directions
Observing the Sun with Atacama Large Millimeter/submillimeter Array (ALMA): High Resolution Interferometric Imaging
Observations of the Sun at millimeter and submillimeter wavelengths offer a
unique probe into the structure, dynamics, and heating of the chromosphere; the
structure of sunspots; the formation and eruption of prominences and filaments;
and energetic phenomena such as jets and flares. High-resolution observations
of the Sun at millimeter and submillimeter wavelengths are challenging due to
the intense, extended, low- contrast, and dynamic nature of emission from the
quiet Sun, and the extremely intense and variable nature of emissions
associated with energetic phenomena. The Atacama Large Millimeter/submillimeter
Array (ALMA) was designed with solar observations in mind. The requirements for
solar observations are significantly different from observations of sidereal
sources and special measures are necessary to successfully carry out this type
of observations. We describe the commissioning efforts that enable the use of
two frequency bands, the 3 mm band (Band 3) and the 1.25 mm band (Band 6), for
continuum interferometric-imaging observations of the Sun with ALMA. Examples
of high-resolution synthesized images obtained using the newly commissioned
modes during the solar commissioning campaign held in December 2015 are
presented. Although only 30 of the eventual 66 ALMA antennas were used for the
campaign, the solar images synthesized from the ALMA commissioning data reveal
new features of the solar atmosphere that demonstrate the potential power of
ALMA solar observations. The ongoing expansion of ALMA and solar-commissioning
efforts will continue to enable new and unique solar observing capabilities.Comment: 22 pages, 12 figures, accepted for publication in Solar Physic
Magnetic Coupling in the Quiet Solar Atmosphere
Three kinds of magnetic couplings in the quiet solar atmosphere are
highlighted and discussed, all fundamentally connected to the Lorentz force.
First the coupling of the convecting and overshooting fluid in the surface
layers of the Sun with the magnetic field. Here, the plasma motion provides the
dominant force, which shapes the magnetic field and drives the surface dynamo.
Progress in the understanding of the horizontal magnetic field is summarized
and discussed. Second, the coupling between acoustic waves and the magnetic
field, in particular the phenomenon of wave conversion and wave refraction. It
is described how measurements of wave travel times in the atmosphere can
provide information about the topography of the wave conversion zone, i.e., the
surface of equal Alfv\'en and sound speed. In quiet regions, this surface
separates a highly dynamic magnetic field with fast moving magnetosonic waves
and shocks around and above it from the more slowly evolving field of high-beta
plasma below it. Third, the magnetic field also couples to the radiation field,
which leads to radiative flux channeling and increased anisotropy in the
radiation field. It is shown how faculae can be understood in terms of this
effect. The article starts with an introduction to the magnetic field of the
quiet Sun in the light of new results from the Hinode space observatory and
with a brief survey of measurements of the turbulent magnetic field with the
help of the Hanle effect.Comment: To appear in "Magnetic Coupling between the Interior and the
Atmosphere of the Sun", eds. S.S. Hasan and R.J. Rutten, Astrophysics and
Space Science Proceedings, Springer-Verlag, Heidelberg, Berlin, 200
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