A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes.

BACKGROUND: Fat infiltration of the liver, muscle and pancreas is associated with insulin resistance and risk of diabetes. Weight loss reduces ectopic fat deposition and risk of diabetes, but is difficult to sustain to due to compensatory increases in appetite. Fermentable carbohydrates have been shown to decrease appetite and food intake, and promote weight loss in overweight subjects. In animal studies, fermentable carbohydrate reduces ectopic fat independent of weight loss. We aimed to investigate the effect of the fermentable carbohydrate inulin on weight maintenance, appetite and ectopic fat in subjects with prediabetes. METHODS: Forty-four subjects with prediabetes were randomized to 18 weeks' inulin or cellulose supplementation. During weeks 1-9 (weight loss phase) all subjects had four visits with a dietitian to guide them towards a 5 % weight loss. During weeks 10-18 (weight maintenance phase) subjects continued taking their assigned supplementation and were asked to maintain the weight they had lost but were offered no further support. All subjects attended study sessions at baseline, 9 and 18 weeks for measurement of weight; assessment of adipose tissue and ectopic fat content by magnetic resonance imaging and magnetic resonance spectroscopy; glucose, insulin and GLP-1 levels following a meal tolerance test; and appetite by ad libitum meal test and visual analogue scales. RESULTS: Both groups lost approximately 5 % of their body weight by week nine (-5.3 ± 0.1 % vs -4.3 ± 0.4 %, p = 0.13, but the inulin group lost significantly more weight between 9 and 18 weeks (-2.3 ± 0.5 % vs -0.6 ± 0.4 %, p = 0.012). Subjects taking inulin had lower hepatic (p = 0.02) and soleus muscle (p < 0.05) fat content at 18 weeks compared to control even after controlling for weight loss and consumed less at the ad libitum meal test (p = 0.027). Fasting glucose significantly decreased at week nine only (p = 0.005), insulin concentrations did not change, and there was a significant increase in GLP-1 in the cellulose group at 9 and 18 weeks (p < 0.03, p < 0.00001). CONCLUSION: Inulin may have a two-pronged effect on the risk of diabetes by 1) promoting weight loss 2) reducing intrahepatocellular and intramyocellular lipid in people with prediabetes independent of weight loss

Spectroscopy of 13B via the 13C(t,3He) reaction at 115 AMeV

Gamow-Teller and dipole transitions to final states in 13B were studied via the 13C(t,3He) reaction at Et = 115 AMeV. Besides the strong Gamow-Teller transition to the 13B ground state, a weaker Gamow-Teller transition to a state at 3.6 MeV was found. This state was assigned a spin-parity of 3/2- by comparison with shell-model calculations using the WBP and WBT interactions which were modified to allow for mixing between nhw and (n+2)hw configurations. This assignment agrees with a recent result from a lifetime measurement of excited states in 13B. The shell-model calculations also explained the relatively large spectroscopic strength measured for a low-lying 1/2+ state at 4.83 MeV in 13B. The cross sections for dipole transitions up to Ex(13B)= 20 MeV excited via the 13C(t,3He) reaction were also compared with the shell-model calculations. The theoretical cross sections exceeded the data by a factor of about 1.8, which might indicate that the dipole excitations are "quenched". Uncertainties in the reaction calculations complicate that interpretation.Comment: 11 pages, 6 figure

Rethinking globalised resistance : feminist activism and critical theorising in international relations

This article argues that a feminist approach to the 'politics of resistance' offers a number of important empirical insights which, in turn, open up lines of theoretical inquiry which critical theorists in IR would do well to explore. Concretely, we draw on our ongoing research into feminist 'anti-globalisation' activism to rethink the nature of the subject of the politics of resistance, the conditions under which resistance emerges and how resistance is enacted and expressed. We begin by discussing the relationship of feminism to critical IR theory as a way of situating and explaining the focus and approach of our research project. We then summarise our key empirical arguments regarding the emergence, structure, beliefs, identities and practices of feminist 'anti-globalisation' activism before exploring the implications of these for a renewed critical theoretical agenda in IR

Nuclear matrix element for two neutrino double beta decay from 136Xe

The nuclear matrix element for the two neutrino double beta decay (DBD) of 136Xe was evaluated by FSQP (Fermi Surface Quasi Particle model), where experimental GT strengths measured by the charge exchange reaction and those by the beta decay rates were used. The 2 neutrino DBD matrix element is given by the sum of products of the single beta matrix elements via low-lying (Fermi Surface) quasi-particle states in the intermediate nucleus. 136Xe is the semi-magic nucleus with the closed neutron-shell, and the beta + transitions are almost blocked. Thus the 2 neutrino DBD is much suppressed. The evaluated 2 neutrino DBD matrix element is consistent with the observed value.Comment: 7 pages 6 figure

Spectroscopy of 24Al and extraction of Gamow-Teller strengths with the 24Mg(3He,t) reaction at 420 MeV

The 24Mg(3He,t)24Al reaction has been studied at E(3He)=420 MeV. An energy resolution of 35 keV was achieved. Gamow-Teller strengths to discrete levels in 24Al are extracted by using a recently developed empirical relationship for the proportionality between Gamow-Teller strengths and differential cross sections at zero momentum transfer. Except for small discrepancies for a few weak excitations, good agreement with previous 24Mg(p,n) data and nuclear-structure calculations using the USDA/B interactions in the sd shell-model space is found. The excitation energy of several levels in 24Al of significance for determination of the 23Mg(p,gamma)24Al thermonuclear reaction rate were measured. Results are consistent with two of the three previous (3He,t) measurements, performed at much lower beam energies. However, a new state at Ex(24Al)=2.605(10) MeV was found and is the third state above the proton separation energy.Comment: 6 pages, 4 figure

The 150^{150}Nd(3^3He,tt) and 150^{150}Sm(tt,3^3He) reactions with applications to ββ\beta\beta decay of 150^{150}Nd

The $^{150}$Nd($^3$He,$t$) reaction at 140 MeV/u and $^{150}$Sm($t$,$^3$He) reaction at 115 MeV/u were measured, populating excited states in $^{150}$Pm. The transitions studied populate intermediate states of importance for the (neutrinoless) $\beta\beta$ decay of $^{150}$Nd to $^{150}$Sm. Monopole and dipole contributions to the measured excitation-energy spectra were extracted by using multipole decomposition analyses. The experimental results were compared with theoretical calculations obtained within the framework of Quasiparticle Random-Phase Approximation (QRPA), which is one of the main methods employed for estimating the half-life of the neutrinoless $\beta\beta$ decay ($0\nu\beta\beta$) of $^{150}$Nd. The present results thus provide useful information on the neutrino responses for evaluating the $0\nu\beta\beta$ and $2\nu\beta\beta$ matrix elements. The $2\nu\beta\beta$ matrix element calculated from the Gamow-Teller transitions through the lowest $1^{+}$ state in the intermediate nucleus is maximally about half of that deduced from the half-life measured in $2\nu\beta\beta$ direct counting experiments and at least several transitions through $1^{+}$ intermediate states in $^{150}$Pm are required to explain the $2\nu\beta\beta$ half-life. Because Gamow-Teller transitions in the $^{150}$Sm($t$,$^3$He) experiment are strongly Pauli-blocked, the extraction of Gamow-Teller strengths was complicated by the excitation of the $2\hbar\omega$, $\Delta L=0$, $\Delta S=1$ isovector spin-flip giant monopole resonance (IVSGMR). However, the near absence of Gamow-Teller transition strength made it possible to cleanly identify this resonance, and the strength observed is consistent with the full exhaustion of the non-energy-weighted sum rule for the IVSGMR.Comment: 18 pages, 13 figures, 2 table

Beta-delayed proton emission in the 100Sn region

Beta-delayed proton emission from nuclides in the neighborhood of 100Sn was studied at the National Superconducting Cyclotron Laboratory. The nuclei were produced by fragmentation of a 120 MeV/nucleon 112Sn primary beam on a Be target. Beam purification was provided by the A1900 Fragment Separator and the Radio Frequency Fragment Separator. The fragments of interest were identified and their decay was studied with the NSCL Beta Counting System (BCS) in conjunction with the Segmented Germanium Array (SeGA). The nuclei 96Cd, 98Ing, 98Inm and 99In were identified as beta-delayed proton emitters, with branching ratios bp = 5.5(40)%, 5.5+3 -2%, 19(2)% and 0.9(4)%, respectively. The bp for 89Ru, 91,92Rh, 93Pd and 95Ag were deduced for the first time with bp = 3+1.9 -1.7%, 1.3(5)%, 1.9(1)%, 7.5(5)% and 2.5(3)%, respectively. The bp = 22(1)% for 101Sn was deduced with higher precision than previously reported. The impact of the newly measured bp values on the composition of the type-I X-ray burst ashes was studied.Comment: 15 pages, 14 Figures, 4 Table

Editorial: Implausible discussions in saturated fat 'research'; definitive solutions won't come from another million editorials (or a million views of one).

The British Journal of Sports Medicine published an opinion editorial advocating a revision of public health guidance on saturated fat.1 Here, we offer a rebuttal, incorporating evidence-based principles absent in the original editorial, focusing on the quality of the evidence presented and we discuss contradictory evidence in relation to saturated fat, low-density lipoprotein cholesterol (LDL-C), specific dietary interventions and cardiovascular disease (CVD) alongside future directions

On the extraction of weak transition strengths via the (3He,t) reaction at 420 MeV

Differential cross sections for transitions of known weak strength were measured with the (3He,t) reaction at 420 MeV on targets of 12C, 13C, 18O, 26Mg, 58Ni, 60Ni, 90Zr, 118Sn, 120Sn and 208Pb. Using this data, it is shown the proportionalities between strengths and cross sections for this probe follow simple trends as a function of mass number. These trends can be used to confidently determine Gamow-Teller strength distributions in nuclei for which the proportionality cannot be calibrated via beta-decay strengths. Although theoretical calculations in distorted-wave Born approximation overestimate the data, they allow one to understand the main experimental features and to predict deviations from the simple trends observed in some of the transitions.Comment: 4 pages, 2 figure

Analysis of School Discipline Policies at a Title I High School in Texas

Discipline referrals and suspensions are used as a last resort to address inappropriate student behavior in schools. The problem investigated in this study was the inconsistent trend in the number of discipline referrals and suspensions during implementation of three different discipline policies (zero tolerance, progressive discipline, and restorative practice) at a local Title I high school in north Texas from 2013 to 2019. Guided by Skinner’s theory of behaviorism, the purpose of this quantitative, ex post facto study was to determine if significant differences in the total number of disciplinary referrals and suspensions existed between the 2-year implementation period of each discipline policy. Using the census of school-wide discipline data, differences in total number of discipline referrals and suspensions during implementation of each of the three different discipline policies were tested while controlling for students’ GPA. ANCOVA analyses revealed that differences in discipline referrals were not significant (p = .403). For suspensions, significant differences were found for zero tolerance compared to progressive discipline and restorative practice (p = .000); however, these results need to be interpreted with caution due to violations of assumptions. Findings suggest that continuous monitoring of discipline data should be conducted as a necessary step toward refining discipline policy and practice at the school level. With enhancement of discipline data monitoring, positive social change may occur by fostering better-quality school discipline policy and practice, which may have a positive influence on student achievement, social-emotional wellbeing, and campus climate over time