Promoting prosociality in Colombia: Is music more effective than other cultural interventions?

This article reports a two-part study into the prosocial impacts of third sector cultural activities with children and adolescents in impoverished and violence-stricken urban neighbourhoods in Cali, Colombia. First, a year-long field study set out to compare a pre-existing music-training programme with a dance-training programme and a football-training programme with 9–14 year olds, to determine the extent to which each affords the development of empathic attitudes and prosocial behaviours. The music and dance programmes produced few significant changes in participants’ empathy or prosociality, and there were few significant differences between the empathy and prosociality of the participants in the two groups. Participant dropout prevented comparison with the football-training programme. Second, an interview study was used to understand the place of prosociality in the aims and work of policymakers, funders and third-sector practitioners running cultural activities for social impacts in the Cali region. The study revealed that the organisations aimed to achieve individual and social transformation by creating the conditions for transformation, evidenced as positive outcomes. Neither the measures used by the organisations themselves nor the psychosocial constructs of prosociality and empathy used by the researchers adequately evidenced some of the intended outcomes, such as enabling individuals to build a life project, practising and sustaining social inclusion and transforming communities, nor a path from individual to social transformation. Differences between the structure of cultural activities and their associated values meant that different activities were believed to lend themselves to social transformation more or less well. This highlights the need for critically reflective, co-constructed research using a fuller range of constructs that can capture the outcomes of these programmes for both individuals and groups

The role of embodied simulation and visual imagery in emotional contagion with music

Emotional contagion has been explained as arising from embodied simulation. The two most accepted theories of music-induced emotions presume a mechanism of internal mimicry: the BRECVEMA framework proposes that the melodic aspect of music elicits internal mimicry leading to the induction of basic emotions in the listener, and the Multifactorial Process Model proposes that the observation or imagination of motor expressions of the musicians elicits muscular and neural mimicry, and emotional contagion. Two behavioral studies investigated whether, and to what extent, mimicry is responsible for emotion contagion, and second, to what extent context for affective responses in the form of visual imagery moderates emotional responses. Experiment 1 tested whether emotional contagion is influenced by mimicry by manipulating explicit vocal and motor mimicry. In one condition, participants engaged in mimicry of the melodic aspects of the music by singing along with the music, and in another, participants engaged in mimicry of the musician’s gestures when producing the music, by playing along (“air guitar”-style). The experiment did not find confirmatory evidence for either hypothesized simulation mechanism, but it did provide evidence of spontaneous visual imagery consistent with the induced and perceived emotions. Experiment 2 used imagined rather than performed mimicry, but found no association between imagined motor simulation and emotional intensity. Emotional descriptions read prior to hearing the music influenced the type of perceived and induced emotions and support the prediction that visual imagery and associated semantic knowledge shape listeners’ affective experiences with music. The lack of evidence for the causal role of embodied simulation suggests that current theorization of emotion contagion by music needs refinement to reduce the role of simulation relative to other mechanisms. Evidence for induction of affective states that can be modulated by contextual and semantic associations suggests a model of emotion induction consistent with constructionist accounts

Important Teacher Qualities for Integrating Blended Learning in Higher Education

Blended learning is widely accepted in Peruvian higher education for a number of reasons, including the fact that it allows students more leeway to accommodate their own unique schedule and learning needs. The present qualitative research investigates the qualities of effective teachers that are crucial to the successful implementation of blended learning from the vantage point of experts, who can gain valuable insight into the causes of organizational problems and the best strategies for resolving them. There are seven positive characteristics of blended learning teachers, such as the ability to recognize the need for pedagogical change or the confidence to incorporate technology into learning processes, and four negative characteristics, such as a lack of familiarity with blended learning or anxiety about students use of technology. Blended learning in higher education is investigated here to identify the factors that influence it

G-TRACE: rapid Gal4-based cell lineage analysis in Drosophila.

We combined Gal4-UAS and the FLP recombinase-FRT and fluorescent reporters to generate cell clones that provide spatial, temporal and genetic information about the origins of individual cells in Drosophila melanogaster. We named this combination the Gal4 technique for real-time and clonal expression (G-TRACE). The approach should allow for screening and the identification of real-time and lineage-traced expression patterns on a genomic scale

Evidence for inhibition of exodus of small neutral amino acids from non-brain tissues in hyperphenylalaninaemic rats

The mechanism of the depletion of several plasma amino acids in PKU has remained unexplained. In the present study, a statistically significant decrease in the plasma concentration of several amino acids was observed 2 h after the intraperitoneal injection of Phe to weanling rats. The pattern was very similar to the one observed in PKU patients. Statistically significant increases in the distribution ratios liver/plasma and, mainly, muscle/plasma ratios accompanied in most of the cases the corresponding decreases in plasma concentrations. Equimolar injection under the same conditions of the non-insulinogenic transport system L analogue, the a(±) isomer of the 2-amino-norbornane-2-carboxylic acid, produced, in a parallel effect to Phe, statistically significant increases in the distribution ratios of Ala and Gly, and probably of Pro in muscle, as well as of Ala in liver. These results seem to indicate that the high intracellular Phe attained inhibits the exodus of small neutral amino acids through system L, causing their depletion in plasma and ultimately in the brain. This effect may be additive to the inhibition by Phe of the entry of bulky neutral amino acids at the level of the blood-brain barrier. Further study is needed to assess the relevance of these effects to PKU.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42494/1/10545_2005_Article_BF01800722.pd

Anisotropic fractal magnetic domain pattern in bulk Mn1.4PtSn

The tetragonal compound Mn1.4PtSn with D2d symmetry recently attracted attention as the first known material that hosts magnetic antiskyrmions, which differ from the skyrmions known so far by their internal structure. The latter have been found in a number of magnets with the chiral crystal structure. In previous works, the existence of antiskyrmions in Mn1.4PtSn was unambiguously demonstrated in real space by means of Lorentz transmission electron microscopy on thin-plate samples (∼100 nm thick). In the present study, we used small-angle neutron scattering and magnetic force microscopy to perform reciprocal- and real-space imaging of the magnetic texture of bulk Mn1.4PtSn single crystals at different temperatures and in applied magnetic field. We found that the magnetic texture in the bulk differs significantly from that of thin-plate samples. Instead of spin helices or an antiskyrmion lattice, we observe an anisotropic fractal magnetic pattern of closure domains in zero field above the spin-reorientation transition temperature, which transforms into a set of bubble domains in high field. Below the spin-reorientation transition temperature the strong in-plane anisotropy as well as the fractal self-affinity in zero field is gradually lost, while the formation of bubble domains in high field remains robust. The results of our study highlight the importance of dipole-dipole interactions in thin-plate samples for the stabilization of antiskyrmions and identify criteria which should guide the search for potential (anti)skyrmion host materials. Moreover, they provide consistent interpretations of the previously reported magnetotransport anomalies of the bulk crystals. © 2020 authors. Published by the American Physical Society. Published by the American Physical Society under the terms of the "https://creativecommons.org/licenses/by/4.0/"Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Open access publication funded by the Max Planck Society

Genetic and epigenetic analyses of MBD3 in colon and lung cancer

MBD3: is a member of the methyl-CpG-binding domain family and is located on chromosome 19p13.3, a region of loss of heterozygosity in colon and lung cancers. We therefore screened samples for abnormalities in MBD3. Our results indicate that MBD3 is not a major target of genetic and epigenetic alteration in these cancers.Publisher PDFPeer reviewe

Hernioplastias en pacientes añosos

La hernia inguinal constituye una patología frecuente en los pacientes añosos y laedad no constituye por sí sola un factor que contraindique el tratamiento quirúrgico con técnicaslibres de tensión en este grupo etario, a pesar que con frecuencia se asocian con patologíasasociadas, en su mayoría estabilizadas. La intervención quirúrgica de este grupo de pacientes encondiciones de urgencia sí podría significar un aumento de la morbi-mortalidad. Objetivo: describirlos resultados del tratamiento quirúrgico de la hernia inguinal con técnicas libres de tensión enpacientes añosos. Material y métodos: Estudio observacional descriptivo, longitudinal en 250pacientes mayores a 60 años, portadores de hernia inguinal, sometidos a tratamiento quirúrgicocon técnica libre de tensión de manera electiva o de urgencia en el departamento de paredabdominal de la Segunda Cátedra de Clínica Quirúrgica de la Facultad de Ciencias Médicas,Universidad Nacional de Asunción, desde enero de 1998 a diciembre del 2010. Variables: edad,sexo, tipo de hernia, forma de presentación, patologías asociadas, clasificación de Gilbert,anestesia empleada, estancia hospitalaria, complicaciones locales y seguimiento a 24 meses.Resultados: Fueron operados 250 pacientes, predominantemente del sexo masculino, con edadesentre 60 y 90 años (promedio 75 años), con patologías asociadas en 53 (21%),predominantemente afecciones cardíacas como patología de base. 220 (88%) fueron herniasprimarias y 30 (12%) fueron recurrentes. En cuanto a la forma de presentación 218 pacientes(87,2%) se presentaron sin complicación herniaria, 18 (7,2%) presentaban encarcelamiento y 14(5,6%) presentaron estrangulación. Según la clasificación de Gilbert, la del tipo III fue la másfrecuente en el 51,6% (129 pacientes). La estancia media hospitalaria fue de 21,4 horas concomplicaciones locales en 12 pacientes (4,8%). Se realizó seguimiento satisfactorio a 19 meses enel 60% de los casos sin evidenciar recurrencia ni mortalidad. Conclusión: El empleo de técnicaslibres de tensión para tratar quirúrgicamente a pacientes añosos portadores de hernia inguinalofrece resultados similares en cuanto a complicaciones locales y recidiva que en otros gruposetarios

2,6-Di(pyrazol-1-yl)pyridine-4-carboxylate Esters with Alkyl Chain Substituents, and their Iron(II) Complexes

Two series of 4-(alkoxyphenyl) 2,6-bis{pyrazol-1-yl}pyridine-4-carboxyate (L3R) or alkyl 2,6-bis{pyrazol-1-yl}pyridine-4-carboxyate (L4R) esters have been synthesized and complexed to iron(II), where R = CnH2n+1 (n = 6, 12, 14, 16, 18); two other derivatives related to L3R are also reported. While the solid [Fe(L4R)2][BF4]2 compounds are isostructural by powder diffraction and show similar spin state behaviors, the [Fe(L3R)2][BF4]2 series shows more varied structures and magnetic properties. This was confirmed by solvated crystal structures of [Fe(L3R)2][BF4]2 with n = 6, 14, 16, which all adopt the P1̅ space group but show significantly different side-chain conformations and/or crystal packing. The solid complexes are mostly low spin at room temperature, with many exhibiting the onset of thermal spin crossover (SCO) upon warming. Heating the complexes with n ≥ 14 significantly above their SCO temperature transforms them irreversibly into a predominantly high spin state, which is accompanied by structure changes and loss of crystallinity by powder diffraction. These transformations do not coincide with lattice solvent loss and may reflect melting and refreezing of their alkyl chain conformations during the thermal cycle. Four of the complexes exhibit SCO in CD3CN solution with T1/2 = 273–277 K, which is apparently unaffected by their alkyl chain substituents

Correction: Heteroleptic iron(ii) complexes of chiral 2,6-bis(oxazolin-2-yl)-pyridine (PyBox) and 2,6-bis(thiazolin-2-yl)pyridine ligands – the interplay of two different ligands on the metal ion spin state

Correction for ‘Heteroleptic iron(II) complexes of chiral 2,6-bis(oxazolin-2-yl)-pyridine (PyBox) and 2,6-bis(thiazolin-2-yl)pyridine ligands – the interplay of two different ligands on the metal ion spin state’ by Namrah Shahid et al., Dalton Trans., 2022, 51, 4262–4274, DOI: 10.1039/d2dt00393g