Yukawa Coupling Structure in Intersecting D-brane Models

The structure of Yukawa coupling matrices is investigated in type IIA T^6/(Z_2 x Z_2) orientifold models with intersecting D-branes. Yukawa coupling matrices are difficult to be realistic in the conventional models in which the generation structure emerges by the multiple intersection of D-branes in the factorized T^6 = T^2 x T^2 x T^2. We study the new type of flavor structure, where Yukawa couplings are dynamically generated, and show this type of models lead to nontrivial structures of Yukawa coupling matrices, which can be realistic.Comment: 9 pages, 2 figure

On 'Light' Fermions and Proton Stability in 'Big Divisor' D3/D7 Swiss Cheese Phenomenology

Building up on our earlier work [1,2], we show the possibility of generating "light" fermion mass scales of MeV-GeV range (possibly related to first two generations of quarks/leptons) as well as eV (possibly related to first two generations of neutrinos) in type IIB string theory compactified on Swiss-Cheese orientifolds in the presence of a mobile space-time filling D3-$brane restricted to (in principle) stacks of fluxed D7-branes wrapping the "big" divisor \Sigma_B. This part of the paper is an expanded version of the latter half of section 3 of a published short invited review [3] written up by one of the authors [AM]. Further, we also show that there are no SUSY GUT-type dimension-five operators corresponding to proton decay, as well as estimate the proton lifetime from a SUSY GUT-type four-fermion dimension-six operator to be 10^{61} years. Based on GLSM calculations in [1] for obtaining the geometric Kaehler potential for the "big divisor", using further the Donaldson's algorithm, we also briefly discuss in the first of the two appendices, obtaining a metric for the Swiss-Cheese Calabi-Yau used, that becomes Ricci flat in the large volume limit.Comment: v2: 1+25 pages, Title modified and text thoroughly expanded including a brief discussion on obtaining Ricci-flat Swiss Cheese Calabi-Yau metrics using the Donaldson's algorithm, references added, to appear in EPJ

Dilaton Quantum Cosmology in Two Dimensions

We consider a renormalizable two-dimensional model of dilaton gravity coupled to a set of conformal fields as a toy model for quantum cosmology. We discuss the cosmological solutions of the model and study the effect of including the backreaction due to quantum corrections. As a result, when the matter density is below some threshold new singularities form in a weak coupling region, which suggests that they will not be removed in the full quantum theory. We also solve the Wheeler-DeWitt equation. Depending on the quantum state of the Universe, the singularities may appear in a quantum region where the wave function is not oscillatory, i.e., when there is not a well defined notion of classical spacetime.Comment: 17 pages, UTTG-28-9

The Stretched Horizon and Black Hole Complementarity

Three postulates asserting the validity of conventional quantum theory, semi-classical general relativity and the statistical basis for thermodynamics are introduced as a foundation for the study of black hole evolution. We explain how these postulates may be implemented in a ``stretched horizon'' or membrane description of the black hole, appropriate to a distant observer. The technical analysis is illustrated in the simplified context of 1+1 dimensional dilaton gravity. Our postulates imply that the dissipative properties of the stretched horizon arise from a course graining of microphysical degrees of freedom that the horizon must possess. A principle of black hole complementarity is advocated. The overall viewpoint is similar to that pioneered by 't~Hooft but the detailed implementation is different.Comment: (some misprints in equations have been fixed), 48 pages (including figures), SU-ITP-93-1

Fermion Masses and Mixing in Intersecting Branes Scenarios

We study the structure of Yukawa couplings in intersecting D6-branes wrapping a factorizable 6-torus compact space T^6. Models with MSSM-like spectrum are analyzed and found to fail in predicting the quark mass spectrum because of the way in which the family structure for the left-handed, right-handed quarks and, eventually, the Higgses is `factorized' among the different tori. In order to circumvent this, we present a model with three supersymmetric Higgs doublets which satisfies the anomaly cancellation condition in a more natural way than the previous models, where quarks were not treated universally regarding their branes assignments, or some particular branes were singled out being invariant under orientifold projection. In our model, the family structures for the left, right quarks, left leptons and the Higgses arise from one of the tori and can naturally lead to universal strength Yukawa couplings which accommodate the quark mass hierarchy and the mixing angles.Comment: 21 pages, latex, matches the Phys. Rev. D versio

Multiple Sclerosis Susceptibility-Associated SNPs Do Not Influence Disease Severity Measures in a Cohort of Australian MS Patients

Recent association studies in multiple sclerosis (MS) have identified and replicated several single nucleotide polymorphism (SNP) susceptibility loci including CLEC16A, IL2RA, IL7R, RPL5, CD58, CD40 and chromosome 12q13–14 in addition to the well established allele HLA-DR15. There is potential that these genetic susceptibility factors could also modulate MS disease severity, as demonstrated previously for the MS risk allele HLA-DR15. We investigated this hypothesis in a cohort of 1006 well characterised MS patients from South-Eastern Australia. We tested the MS-associated SNPs for association with five measures of disease severity incorporating disability, age of onset, cognition and brain atrophy. We observed trends towards association between the RPL5 risk SNP and time between first demyelinating event and relapse, and between the CD40 risk SNP and symbol digit test score. No associations were significant after correction for multiple testing. We found no evidence for the hypothesis that these new MS disease risk-associated SNPs influence disease severity

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 - Meeting Abstracts - Antwerp, Belgium. 15–20 July 2017

This work was produced as part of the activities of FAPESP Research,\ud Disseminations and Innovation Center for Neuromathematics (grant\ud 2013/07699-0, S. Paulo Research Foundation). NLK is supported by a\ud FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR is partially\ud supported by a CNPq fellowship (grant 306251/2014-0)

An interdisciplinary course on domestic and family violence

No abstract provided