478 research outputs found
Somatic cell nuclear transfer in therapeutic clonning: an alternative in the treatment of genetic disorders
World state of quality: a frontier approach to benchmark the performance of countries worldwide
Purpose - The World State of Quality (WSQ) Project aims to evaluate, analyse, rank and categorise countries according to their performance in quality as a multidimensional concept. The Project involves the computation of an overall score for each country, obtained as a weighted average of ranking positions of 16 metrics, with weights determined by a panel of experts. Methodology-This work proposes an alternative strategy for that procedure, using a Benefit-of-the-Doubt (BoD) Composite Indicator approach under the framework of Data Envelopment Analysis (DEA). This strategy avoids the need of using subjective weights and normalising data by rank positions, using a more objective procedure to obtain the countries’ ranking. A new overall score of the World State of Quality is proposed, which allows the categorisation of countries’ performance. The novel insights resulting from the use of this methodology are discussed, including the identification of strengths and weaknesses of the various countries, and the peers that can be used for facilitating continuous improvements policies. Findings - The results show that the BoD approach and the original method used by the WSQ Project present comparable results. Countries’ strengths and weaknesses and their suitable peers and targets for benchmarking are presented with illustrative examples. Originality/value – A novel frontier approach for countries’ benchmarking regarding their performance in quality is proposed, incorporating new insights into the current method.FCT - Fundação para a Ciência e a Tecnologia(2021.05244)The authors acknowledge the financial support provided by FCT- Fundação para a Ciência e a Tecnologia (Portuguese National Funding Agency for Science, Research and Technology) through PhD research grants and SFRH/BD/131285/2017.
This work has been supported by FCT – Fundação para a Ciência e Tecnologia within the R&D Units
Project Scope: UIDB/00319/2020
Genetics: Is LADA just late onset type 1 diabetes?
Background: There is a controversy regarding Latent Autoimmune Diabetes in Adults (LADA) classification and whether it should be considered a slowly progressing form of type 1 (T1) diabetes (DM) or a distinct type of DM altogether.
Methods: This cross-sectional study assessed major genes associated with T1DM (class II
Results: A total of 578 participants were included: 248 with T1DM (70 diagnosed after the age of 30), 256 with T2DM and 74 with LADA. High risk HLA alleles were significantly more frequent in LADA than in T2DM, whereas the opposite was true for protective alleles. We found a lower frequency of the high-risk DRB1*04-DQB1*03:02-DQA1*03:01 haplotype in LADA (21.1%) than in the overall T1DM (34.7%) (p\u3c0.05), whereas no differences were found between these groups for DRB1*03-DQB1*02:01-DQA1*05:01 or for protective alleles. Only 12% the overall T1DM group had no risk alleles vs 30% of LADA (p\u3c0.0005). However, HLA allele distribution was similar in LADA and T1DM diagnosed after the age of 30. A total of 506 individuals (195 with T1DM [21 diagnosed after age 30] 253 with T2DM and 58 with LADA) were genotyped for the
Conclusion: In this relatively small cross-sectional study, the genetic profile of subjects with LADA showed a similar T1DM-related risk allele distribution as in participants with T1DM diagnosed after the age of 30, but fewer risk alleles than those diagnosed before 30. Differences were present for HLA, as well a
Les enseignants: à la recherche de leur profession
Les Enseignants: à la recherche de leur profession reprend les idées centrales présentées à la Conférence donnée, sur l'invitation de l'ATEE, au Séminaire de Barcelone, en 1993. Cet article est la reproduction du texte de support à la Conférence. Étant donné l'espace disponible, il n'a pas été possible de le travailler dans le sens d'une plus grande problématisation et élaboration théorique
Two-step approach for occupancy estimation in intensive care units based on Bayesian optimization techniques
Due to the high occupational pressure suffered by intensive care units (ICUs), a correct estimation of the patients’ length of stay (LoS) in the ICU is of great interest to predict possible situations of collapse, to help healthcare personnel to select appropriate treatment options and to predict patients’ conditions. There has been a high amount of data collected by biomedical sensors during the continuous monitoring process of patients in the ICU, so the use of artificial intelligence techniques in automatic LoS estimation would improve patients’ care and facilitate the work of healthcare personnel. In this work, a novel methodology to estimate the LoS using data of the first 24 h in the ICU is presented. To achieve this, XGBoost, one of the most popular and efficient state-of-the-art algorithms, is used as an estimator model, and its performance is optimized both from computational and precision viewpoints using Bayesian techniques. For this optimization, a novel two-step approach is presented. The methodology was carefully designed to execute codes on a high-performance computing system based on graphics processing units, which considerably reduces the execution time. The algorithm scalability is analyzed. With the proposed methodology, the best set of XGBoost hyperparameters are identified, estimating LoS with a MAE of 2.529 days, improving the results reported in the current state of the art and probing the validity and utility of the proposed approach.Agencia Gallega de Innovación | Ref. IN845D-2020/29Agencia Gallega de Innovación | Ref. IN607B-2021/1
Patterning total mercury distribution in coastal podzolic soils from an Atlantic area: influence of pedogenetic processes and soil components
Soils are the main Hg reservoir in the terrestrial ecosystems where it is deposited via wet or dry deposition and
litterfall. Once on the soil surface, different biogeochemical routes will determine the fate of Hg and the role of
terrestrial ecosystems as a Hg source or sink. The specific chemical and physical characteristics of Podzols and
podzolic soils contribute to the accumulation of Hg in their illuvial horizons, avoiding its leaching to groundwater.
The geographical location, state of pedogenesis, soil age, abundance of carrier phases and physical
properties can affect the presence and distribution of Hg in soils. Therefore, understand and relate these factors
with the behavior of Hg in Podzols and podzolic soils is key to define the role of this type of soil in the terrestrial
Hg cycle. In this work, ten podzolic soil profiles were collected in an Atlantic coastal forest area of Portugal and
analyzed for the main physico-chemical properties and Hg content to assess the influence of the intensity of
podzolization in the Hg depth distribution. Three different patterns of Hg distribution in the studied Podzols,
depending on the predominance of atmospheric deposition or the intensity of podzolization, have been defined.
The pattern I showed the maximum Hg contents in the surface A horizons (12.9–23.5 μg kg 1), pattern II
exhibited the highest peaks in the subsurface illuvial horizons (2.3–17.3 μg kg 1) and pattern III presented an
even distribution of Hg through the soil profile. We found that dissolved organic matter (DOM) is the main
carrier of Hg in the A and E horizons, whereas metal(Al, Fe)-humus complexes and/or oxyhydroxides contribute
to immobilizing Hg in the illuvial horizons (Bh, Bs and Bhs). The principal component regression (PCR) analysis
predicted satisfactorily the Hg distribution through soil organic matter and Al and Fe oxyhydroxides. The Hg
immobilized in the subsurface layers of Podzols is retained in the long term, avoiding its migration to other
components of terrestrial ecosystems where it could cause serious environmental damage such as groundwater
and superficial watersinfo:eu-repo/semantics/publishedVersio
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