3 research outputs found
A Cadaveric Study of Radial Nerve Course and its Clinical Implications on Radial Nerve Block at Elbow
Introduction: Upper limb nerve blocks are done commonly by
brachial plexus (C5-T1) blocks via supraclavicular, infraclavicular
approaches. Sometimes a single peripheral nerve needs
additional block with local anaesthetic to achieve adequate
block. Peripheral nerve blocks are useful for minor surgical
procedures in a single nerve distribution.
Aim: To study the course and clinical significance of the radial
nerve in 50 cadaveric upper limbs.
Materials and Methods: A cross-sectional study was
conducted on 50 intact dissected upper limbs. The upper
limbs were obtained from the Department of Anatomy, Sri
Ramachandra Medical College from August 2020 to December
2020. Radial nerve was exposed by routine dissection in all the
upper limbs and its entire course was studied and observed for
any variation. The distance from the biceps tendon to the radial
nerve at the elbow, distance of the radial nerve in the Lateral
Intermuscular Septum (LIS) from the epicondyles at the elbow
were measured. The results obtained were statistically analysed
using SPSS version 16.0.
Results: In present study, the mean distance of the radial nerve
in the LIS to the medial epicondyle was 12.4±0.31 cm and to
the lateral epicondyle was 12.1±0.28 cm. The mean distance
from the biceps tendon to the radial nerve at the elbow was
1.75±0.22 cm.
Conclusion: From the present study, it can be inferred that
effective peripheral radial nerve block can be achieved by
blocking the nerve 1.75 cm lateral to the biceps tendon at
the elbow 3 cm above the elbow crease. This can be made
comfortable to the patient and more precise by ultrasound
localisation of the radial nerve
Targeting transcription factor STAT3 for cancer prevention and therapy.
Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpressed in tumor cells as well as tissue samples, and regulates the expression of numerous oncogenic genes controlling the growth and metastasis of tumor cells. The current review briefly discusses the importance of STAT3 as a potential target for cancer therapy and also provides novel insights into various classes of existing pharmacological inhibitors of this transcription factor that can be potentially developed as anti-cancer drugs