Are Guidelines Needed for the Diagnosis and Management of Incipient Alzheimer's Disease and Mild Cognitive Impairment?

Current research is aiming to push the boundaries of the point at which a diagnosis of Alzheimer Disease (AD) can be made. Clinical syndromes such as Mild Cognitive Impairment (MCI) and various clinical and biological markers of AD may help to identify people in the early stage of AD, before a full dementia syndrome is present. In the first part of this paper, we discuss whether MCI represents incipient AD, and examine some of the methods currently used in research to identify AD patients in the preclinical phase. In the second part, we discuss whether specific guidelines are needed for the diagnosis and management of MCI and incipient AD, and consider the potential impact of this on clinical practice and public health from the perspective of patients, caregivers, and healthcare providers

Mitochondrial caseinolytic protease p: A possible novel prognostic marker and therapeutic target in cancer

Caseinolytic protease P (ClpP) is a mitochondrial serine protease. In mammalian cells, the heterodimerization of ClpP and its AAA+ ClpX chaperone results in a complex called ClpXP, which has a relevant role in protein homeostasis and in maintaining mitochondrial functionality through the degradation of mitochondrial misfolded or damaged proteins. Recent studies demonstrate that ClpP is upregulated in primary and metastatic human tumors, supports tumor cell proliferation, and its overexpression desensitizes cells to cisplatin. Interestingly, small modulators of ClpP activity, both activators and inhibitors, are able to impair oxidative phosphorylation in cancer cells and to induce apoptosis. This review provides an overview of the role of ClpP in regulating mitochondrial functionality, in supporting tumor cell proliferation and cisplatin resistance; finally, we discuss whether this protease could represent a new prognostic marker and therapeutic target for the treatment of cancer

The Strategic Transfer of Intangible Assets via Twitter by Spanish Listed Companies in Times of Crisis

In times of crisis such as the one we have experienced due to COVID-19, listed companies have enhanced the communication of their intangible assets. Thus, the aim of this research is to study how listed companies in Spain have used one of the most popular social channels, such as Twitter, to transfer their intangible assets to their stakeholders. To this end, the communication of IBEX35 companies in Spain with a verified corporate profile on Twitter has been studied during the first phase of the COVID-19 pandemic. Among the main results, it should be noted that the transfer of intangible assets has been based on a strategy where providing added value was the connecting axis of the communication actions implemented and the content provided on Twitter. Hence, this work demonstrates that companies can provide added value in social networks to generate trust, build long-term relationships and strengthen their competitive advantage

AUTOMATIC POINT CLOUD SEGMENTATION FOR THE DETECTION OF ALTERATIONS ON HISTORICAL BUILDINGS THROUGH AN UNSUPERVISED AND CLUSTERING-BASED MACHINE LEARNING APPROACH

Abstract. The article describes an innovative procedure for the three-dimensional analysis of decay morphologies of ancient buildings, through the application of machine learning methods for the automatic segmentation of point clouds. In the field of Cultural Heritage conservation, photogrammetric data can be exploited, for diagnostic and monitoring support, to recognize different typologies of alterations visible on the masonry surface, starting from colour information. Actually, certain stone and plaster surface pathologies (biological patina, biological colonization, chromatic alterations, spots,…) are typically characterized by chromatic variations. To this purpose, colour-based segmentation with hierarchical clustering has been implemented on colour data of point clouds, considered in the HSV colour-space. In addition, geometry-based segmentation of 3D reconstructions has been performed, in order to identify the main architectural elements (walls, vaults), and to associate them to the detected defects. The proposed workflow has been applied to some ancient buildings' environments, chosen because of their irregularity both in geometrical and colorimetric characteristics

Remedio para una niñez descarriada

Reseña del libro: MÍGUEZ PASSADA, María Noel (2011) La Sujeción de los cuerpos dóciles. Medicación abusiva con psicofármacos en la niñez uruguaya. Buenos Aires: Estudios Sociológicos Editora (Colección Tesis). 370 páginas

La melodía: movimiento, direccionalidad y contorno

La interpretación de un conjunto de alturas y ritmos que se suceden organizados de un modo determinado y en un lapso de tiempo determinado, conforman lo que habitualmente denominamos melodía. Esa interpretación es una entidad que tiene existencia propia. Su existencia está dada por el movimiento y la energía que conlleva la música, tanto para quien la produce como para quien la percibe. Teniendo en cuenta esta idea de existencia propia que la música tiene en relación a los sujetos involucrados, la melodía puede ser entendida por ellos como un agente intencional, es decir, como un sujeto independiente que realiza cosas de manera intencionada (Johnson, 2007; Leman, 2008). Podemos decir entonces que la melodía cobra vida dentro de una interpretación musical y es por eso que suele ser percibida a través de su propia intencionalidad, en el contexto de un proceso de percepción-acción que transita el oyente durante la audición. Lo que permite al oyente vincular lo que escucha con una intención melódica es el modo activo en que interactúa con ella. En este sentido, el oyente hace su propia construcción de aquello que está escuchando como movimiento energético y en definitiva, esto es lo que contribuye al significado, entendiendo percepción, acción y pensamiento como un todo indisoluble (Nöe, 2004). De esta manera, no solo la configuración de los sonidos involucrados estaría proporcionando la identidad a la melodía, sino que además estarían participando las intenciones de los agentes involucrados, básicamente el modo en el que el oyente reconoce tal intencionalidad.Facultad de Arte

Extensão e educação, pensando em uma possível relação para a educação corporal

Este trabajo se enmarca en el proyecto de extension: “Diversidad cultural y cuerpo. Democratizando la ensenanza de las practicas corporales”. Aqui se propone pensar la relacion entre extension y educacion, mas precisamente con la educacion del cuerpo. Pero esta relacion que pensamos abandona aquella idea asistencialista entre extension y educacion. Muchas veces coincide con la extension una relacion directa entre educacion y asistencia, produciendo una logica de extension a partir del asistencialismo educativo. Se dice de esta idea que el trabajo fundamental es la ayuda sobre el proceso educativo de los individuos, se diagnostican las demandas entendidas en terminos de una necesidad y se arma el proyecto: extension-educacion-asistencia. Nuestra propuesta es incompatible con esa idea; ya que entendemos que la extension y la educacion del cuerpo no tienen que transformarse en una practica asistencialista.Tis work is part of the extension project: “Cultural diversity and body. Democratizing the teaching of bodily practices”. Here we propose to think about the relationship between extension and education, more precisely with the education of the body. But this relationship we think abandons that assistance idea between extension and education. Many times a direct relationship between education and assistance coincides with the extension, producing a logic extension based on educational assistance. It is said, from this idea, that the fundamental work is the help on the educational process of individuals, the demands understood in terms of a need are diagnosed and the project is put together: extension-education-assistance. Our proposal is incompatible with that idea, since we understand that the extension and education of the body do not have to be transformed into a welfare practice.Este trabalho se enquadra no projeto de extensão: “Diversidade cultural e corpo. Democratizando a transmição do conhecimento de praticas corporais”. Aquí se propãe pensar a relação entre extensão e educação do corpo. Mas esta relação que pensamos abandona aquela idéia assistencialista entre extensão e educação. Muitas vezes coincide com a extensão uma reloção direta entre educação e assistencia, produzindo uma lógica de extensão a partir do asistencialismo educativo. Se diz dessa ideia que o trabalho fundamenta é a ajuda sobre o processo educativo dos indivíduos, se diagnosticam as demandas entendidas em terminos de uma necessidade e se arma o projeto: extesão – educação – assistencia. Nossa proposta é incompativel com tal ideia; ja que entendemos que a extensão e a educação do corpo não tem que transformarse em uma pratica assistencialista.Facultad de Humanidades y Ciencias de la Educació

Danza, movimiento y pensamiento: algunas experiencias en la Ciudad de Buenos Aires

A través de este escrito se intenta dar cuenta de las vinculaciones posibles de rastrear entre danza, movimiento y pensamiento en la actualidad. Para ello, se recorren algunas de las formas en que estas se plasman concretamente en la Ciudad de Buenos Aires. Es decir, en qué se esta pensando/haciendo cuando se habla de danza y movimiento, qué es lo que realmente se mueve cuando se danza, y qué aporta todo esto a la pregunta por las sensibilidades sociales hoy. La pregunta que organiza el escrito es el por qué de una “vuelta al cuerpo”, y cómo se lleva adelante a la par de la reflexión sobre nuevas formas de constituirse a sí mismo y en la relación con el otro. Brevemente y sin pretensiones de exhaustividad, se citarán algunos de los proyectos que se llevan a cabo en esta ciudad.Fil: Musicco, Cecilia Laura. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Investigaciones "Gino Germani"; ArgentinaFil: D'hers, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Investigaciones "Gino Germani"; Argentin

La expresividad y el movimiento desde una mirada metodológica: reflexiones en torno a las "entrevistas bailadas"

Presentamos una reflexión en torno a la experiencia que hemos llamado “Entrevistas Bailadas”. Como parte del Grupo de Estudios sobre Sociología de las Emociones y los Cuerpos (IIGG/UBA), venimos trabajando en la comprensión de las sensibilidades sociales y sus configuraciones. Particularmente estudiamos las posibilidades del análisis del cuerpo en movimiento como camino expresivo y generador de información sobre la realidad social. Proponemos aquí un recorrido sobre dicha experiencia, donde presentamos las principales preguntas que surgen de esta práctica, y esbozamos algunas respuestas como puntapié para profundizar en sus desafíos y potencialidades.In the following pages we reflect on an experience we called “Danced Interviews”. As members of the GESEC (IIGG, UBA) we have been working on the understanding of social sensibilities and their configurations in our societies. In this context, we study the possibilities to analyze the body in movement, both as an expressive path and as an information supplier on social reality. Then, we feature our first steps on this project, depicting the questions that have arisen so far, along with some preliminary answers regarding its challenges and potentialities.Fil: D'hers, Victoria. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Investigaciones "Gino Germani"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Musicco, Cecilia Laura. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Investigaciones "Gino Germani"; Argentin

The patient with rhinitis in the pharmacy. A cross-sectional study in real life

In the practical management of allergic rhinitis (AR), pharmacists are usually the first-line contact, also because some medications are available as over the counter. Therefore, pharmacists may represent an important resource, in mediating the interaction between patients and physicians. We evaluated the clinical/demographic characteristics of patients with respiratory allergies who consulted their pharmacists as first-line contact. A patient-oriented questionnaire was developed by a scientific committee including pharmacists, GPs, allergists, pulmonologists and ENT specialists