Ice-rafted dropstones at midlatitudes in the Cretaceous of continental Iberia

The Cretaceous is widely considered to have been a period subjected to super-greenhouse conditions. Here, we provide multiscale sedimentologic evidence of glaciers developing at mid-paleolatitudes (∼45°N) in continental Iberia during the Hauterivian cold snap. Striated and faceted ice-rafted glacial dropstones (cobble to boulder size) and striated and grooved silt- to sand-sized grains (ice-rafted debris [IRD]) occur in a lacustrine sequence of the Enciso Group in the eastern Cameros Basin, Spain. The ice-rafted materials constitute the first evidence reported for a Cretaceous continental cryospheric record in Europe, and they are attributed to calving of glacier snouts, releasing icebergs into an ice-contact lake. The sedimentary succession resembles glacial-deglacial records in lakes overridden by the late Pleistocene Laurentide Ice Sheet in eastern Arctic Canada. The Iberian glacial succession was coeval with plateau permafrost in Asia and IRD records in the Arctic and Australia, revealing a stronger than previously thought cryosphere during the global Hauterivian cold snap

Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training

We sought to ascertain the time course of transcriptional events that occur in human skeletal muscle at the outset of resistance exercise (RE) training in RE naive individuals and determine whether the magnitude of response was associated with exercise-induced muscle damage. Sixteen RE naive men were recruited; eight underwent two sessions of 5 × 30 maximum isokinetic knee extensions (180°/s) separated by 48 h. Muscle biopsies of the vastus lateralis, obtained from different sites, were taken at baseline and 24 h after each exercise bout. Eight individuals acted as nonexercise controls with biopsies obtained at the same time intervals. Transcriptional changes were assessed by microarray and protein levels of heat shock protein (HSP) 27 and αB-crystallin in muscle cross sections by immunohistochemistry as a proxy measure of muscle damage. In control subjects, no probe sets were significantly altered (false discovery rate < 0.05), and HSP27 and αB-crystallin protein remained unchanged throughout the study. In exercised subjects, significant intersubject variability following the initial RE bout was observed in the muscle transcriptome, with greatest changes occurring in subjects with elevated HSP27 and αB-crystallin protein. Following the second bout, the transcriptome response was more consistent, revealing a cohort of probe sets associated with immune activation, the suppression of oxidative metabolism, and ubiquitination, as differentially regulated. The results reveal that the initial transcriptional response to RE is variable in RE naive volunteers, potentially associated with muscle damage and unlikely to reflect longer term adaptations to RE training. These results highlight the importance of considering multiple time points when determining the transcriptional response to RE and associated physiological adaptation

Marine mineral exploration with controlled source electromagnetics at the TAG Hydrothermal Field, 26°N Mid‐Atlantic Ridge

Seafloor massive sulfide (SMS) deposits are of increasing economic interest in order to satisfy the relentless growth in worldwide metal demand. The Trans‐Atlantic Geotraverse (TAG) hydrothermal field at 26°N on the Mid‐Atlantic Ridge hosts several such deposits. This study presents new controlled source electromagnetic, bathymetric, and magnetic results from the TAG field. Potential SMS targets were selected based on their surface expressions in high‐resolution bathymetric data. High‐resolution reduced‐to‐the‐pole magnetic data show negative anomalies beneath and surrounding the SMS deposits, revealing large areas of hydrothermal alteration. Controlled source electromagnetic data, sensitive to the electrical conductivity of SMS mineralization, further reveal a maximum thickness of up to 80 m and conductivities of up to 5 S/m. SMS samples have conductivities of up to a few thousand Siemens per meter, suggesting that remotely inferred conductivities represent an average of metal sulfide ores combined with silicified and altered host basalt that likely dominates at greater depths

Consequences of late-stage non-small cell lung cancer cachexia on muscle metabolic processes

Introduction: Loss of muscle is common in patients with advanced non-small cell lung cancer (NSCLC), and contributes to the high morbidity and mortality of this group. The exact mechanisms behind the loss of muscle are unclear. Patients and methods: To investigate this, 4 patients with stage IV NSCLC meeting the clinical definitions for sarcopenia and cachexia were recruited, along with 4 age-matched healthy volunteers. Following an overnight fast, biopsies were obtained from the vastus lateralis and key components associated with inflammation and the control of muscle protein, carbohydrate and fat metabolism assessed. Results: Compared to healthy volunteers, significant increases in mRNA levels for interleukin-6 and NFκB signalling were observed in NSCLC patients along with lower intramyocellular lipid content in slow-twitch fibres. While a significant decrease in phosphorylation of mTOR signalling protein 4E-BP1 (Ser65) was observed along with a trend towards reduced p70 S6K (Thr389) phosphorylation (P=0.06), there was no difference between groups for mRNA levels of MAFbx and MuRF1, chymotrypsin-like activity of the proteasome, or protein levels of multiple proteasome subunits. Moreover, despite decreases in intramyocellular lipid content, no robust changes in mRNA levels for key proteins involved in insulin signalling, glycolysis, oxidative metabolism or fat metabolism were observed.Conclusions: These findings suggest that an examination of the contribution of suppressed mTOR signalling in the loss of muscle mass in late-stage NSCLC patients is warranted and reinforces our need to understand the potential contribution of impaired fat metabolism and muscle protein synthesis in the aetiology of cancer cachexia

Upper cenozoic volcanic rocks in the Mariana Forearc recovered from drilling at ocean drilling program site 781: implications for forearc magmatism

A horst block was drilled in the center of the Mariana forearc near 20°N during leg 125 of the Ocean Drilling Program. At this site 781, the drill penetrated a Pleistocene vesicular, porphyritic basalt at 72 m below the seafloor, and the top of the basalt corresponds to a high-amplitude reflection on seismic reflection profiles across the site. The thickness of the basalt unit can only be estimated to be between 13 and 25 m because of poor core recovery (28% to 55%). The presence of an upper glassy chilled zone and a lower, fine-grained margin suggest that the basalt unit is either a single lava flow or a near-surface sill. The basalt is an island-arc tholeiite (IAT) enriched in large-ion-lithophile elements relative to high-field-strength elements, similar to the submarine lavas of the southern Mariana Arc seamounts. The basalt layer, the youngest in situ igneous layer reported from the Izu-Bonin and Mariana forearcs, is enigmatic because of its location more than 100 km from the active volcanic arc. The sediment layers above and below the basalt unit are late Pliocene (about 2.5 Ma) and normally magnetized. The basalt has schlieren - like structures, reverse magnetization, and a K-Ar age of 1.68 ± 0.37 Ma. Thus, the basalt layer is probably a sill fed by magma intruded along a fault zone bounding the horst and graben in the forearc. The geochemistry of the basalt is consistent with a magma source similar to that of rocks from the magmatic axis (or volcanic front) of the island arc, and derived from a mantle source above the subducting Pacific plate

Architecture of North Atlantic contourite drifts modified by transient circulation of the Icelandic mantle plume

Overflow of Northern Component Water, the precursor of North Atlantic Deep Water, appears to have varied during Neogene times. It has been suggested that this variation is moderated by transient behavior of the Icelandic mantle plume, which has influenced North Atlantic bathymetry through time. Thus pathways and intensities of bottom currents that control deposition of contourite drifts could be affected by mantle processes. Here, we present regional seismic reflection profiles that cross sedimentary accumulations (Björn, Gardar, Eirik and Hatton Drifts). Prominent reflections were mapped and calibrated using a combination of boreholes and legacy seismic profiles. Interpreted seismic profiles were used to reconstruct solid sedimentation rates. Björn Drift began to accumulate in late Miocene times. Its average sedimentation rate decreased at ∼2.5 Ma and increased again at ∼0.75 Ma. In contrast, Eirik Drift started to accumulate in early Miocene times. Its average sedimentation rate increased at ∼5.5 Ma and decreased at ∼2.2 Ma. In both cases, there is a good correlation between sedimentation rates, inferred Northern Component Water overflow, and the variation of Icelandic plume temperature independently obtained from the geometry of diachronous V-shaped ridges. Between 5.5 and 2.5 Ma, the plume cooled, which probably caused subsidence of the Greenland-Iceland-Scotland Ridge, allowing drift accumulation to increase. When the plume became hotter at 2.5 Ma, drift accumulation rate fell. We infer that deep-water current strength is modulated by fluctuating dynamic support of the Greenland-Scotland Ridge. Our results highlight the potential link between mantle convective processes and ocean circulationThis work is partly supported by Natural Environment Research Council Grant NE/G007632/1. RPT was supported by the University of Cambridge Girdler Fund and by BP Exploration.This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1002/2015GC00594

Derivation of lowland riparian wetland deposit architecture using geophysical image analysis and interface detection

For groundwater-surface water interactions to be understood in complex wetland settings, the architecture of the underlying deposits requires investigation at a spatial resolution sufficient to characterize significant hydraulic pathways. Discrete intrusive sampling using conventional approaches provides insufficient sample density and can be difficult to deploy on soft ground. Here a noninvasive geophysical imaging approach combining three-dimensional electrical resistivity tomography (ERT) and the novel application of gradient and isosurface-based edge detectors is considered as a means of illuminating wetland deposit architecture. The performance of three edge detectors were compared and evaluated against ground truth data, using a lowland riparian wetland demonstration site. Isosurface-based methods correlated well with intrusive data and were useful for defining the geometries of key geological interfaces (i.e., peat/gravels and gravels/Chalk). The use of gradient detectors approach was unsuccessful, indicating that the assumption that the steepest resistivity gradient coincides with the associated geological interface can be incorrect. These findings are relevant to the application of this approach in settings with a broadly layered geology with strata of contrasting resistivities. In addition, ERT revealed substantial structures in the gravels related to the depositional environment (i.e., braided fluvial system) and a complex distribution of low-permeability putty Chalk at the bedrock surface—with implications for preferential flow and variable exchange between river and groundwater systems. These results demonstrate that a combined approach using ERT and edge detectors can provide valuable information to support targeted monitoring and inform hydrological modeling of wetlands

Boreal permafrost thaw amplified by fire disturbance and precipitation increases

Permafrost soils store huge amounts of organic carbon, which could be released if climate change promotes thaw. Currently, modelling studies predict that thaw in boreal regions is mainly sensitive to warming, rather than changes in precipitation or vegetation cover. We evaluate this conclusion for North American boreal forests using a detailed process-based model parameterised and validated on field measurements. We show that soil thermal regimes for dominant forest types are controlled strongly by soil moisture and thus the balance between evapotranspiration and precipitation. Under dense canopy cover, high evapotranspiration means a 30% increase in precipitation causes less thaw than a 1 °C increase in temperature. However, disturbance to vegetation promotes greater thaw through reduced evapotranspiration, which results in wetter, more thermally conductive soils. In such disturbed forests, increases in precipitation rival warming as a direct driver of thaw, with a 30% increase in precipitation at current temperatures causing more thaw than 2 °C of warming. We find striking non-linear interactive effects on thaw between rising precipitation and loss of leaf area, which are of concern given projections of greater precipitation and disturbance in boreal forests. Inclusion of robust vegetation-hydrological feedbacks in global models is therefore critical for accurately predicting permafrost dynamics; thaw cannot be considered to be controlled solely by rising temperatures