Sinonasal Squamous Cell Carcinoma Survival Outcomes Following Induction Chemotherapy vs Standard of Care Therapy

Objective To compare oncologic outcomes in sinonasal squamous cell carcinoma (SNSCC) treated with standard of care (SOC) definitive therapy, consisting of surgery or chemoradiotherapy, vs induction therapy followed by definitive therapy. Study Design Retrospective review.SettingAcademic tertiary care hospital. Methods The medical records of patients with biopsy-proven SNSCC treated between 2000 and 2020 were reviewed for demographics, tumor characteristics, staging, treatment details, and oncologic outcomes. Patients were matched 1-to-1 by age, sex, and cancer stage according to treatment received. Time-to-event analyses were conducted. Results The analysis included 26 patients with locally advanced SNSCC who received either induction therapy (n = 13) or SOC (n = 13). Baseline demographics, Charlson Comorbidity Index, and median follow-up time were well balanced. Weekly cetuximab, carboplatin, and paclitaxel were the most common induction regimen utilized. Tolerance and safety to induction were excellent. Objective responses were observed in 11 of 13 patients receiving induction. No difference in disease-free survival was found between the induction and SOC groups at 1 or 3 years. However, when compared with SOC, induction therapy resulted in significant improvement in overall survival at 2 years (100% vs 65.3%, P = .043) and 3 years (100% vs 48.4%, P = .016) following completion of definitive therapy. Two patients in the SOC group developed metastatic disease, as compared with none in the induction group. Conclusions Induction therapy was safe and effective. When compared with SOC, induction therapy improved 3-year overall survival

Conjugate observations of traveling convection vortices: the field-aligned current system

Analysis of a single traveling convection vortex (TCV) event that combines magnetometer, auroral imager, and riometer observations from conjugate hemispheres provides a complete view of the field-aligned current (FAC) system associated with the TCV. Conjugate observations clearly show that the TCV is a pair of FACs that flow alternatively out of and then into both ionospheres. Imaging observations at 427.8 nm indicate that the upward FAC region is associated with a narrow arc 50-100 km wide and at least 600 km long. Mapping the imaging observations made in the Southern Hemisphere to the Northern Hemisphere shows excellent collocation of the precipitation with the flow vortex associated with the upward FAC as inferred from a large two-dimensional network of magnetometers. Also consistent with the flows inferred from the magnetometers, the arc is found to be skewed with respect to the direction of motion of the transient. Low-altitude spacecraft passes near the time of the event suggest that the FAC is coincident with, and possibly confined to, a relatively narrow region (less than 3 in latitude) in which 1-10 keV electrons characteristic of the central plasma sheet are present