Public service motivation, prosocial motivation and altruism : towards disentanglement and conceptual clarity

Research on public service motivation (PSM) has made great strides in terms of study output. Given the enormous scholarly attention on PSM, it is surprising that considerable conceptual ambiguities and overlaps with related concepts such as prosocial motivation, and altruism still remain. This study addresses this issue by systematically carving out the differences and similarities between these concepts. Taking this approach, this study clarifies the conceptual space of both PSM and the other concepts. Using data from semi-structured interviews with police officers, it is illustrated that PSM and prosocial motivation are different types of motivation leading to different types of prosocial behaviour

Uveal Melanoma: A European Network to Face the Many Challenges of a Rare Cancer

Uveal melanoma (UM) is the most frequent primary ocular cancer in adults, accounting for 5% of all melanomas. Despite effective treatments for the primary tumour, up to 50% of UM patients will develop metastasis, leading to a very poor prognosis and a median overall survival of 6 to 12 months, with no major improvements in the last 30 years. There is no standard oncological treatment available for metastatic UM patients, and BRAF/MEK and immune checkpoint inhibitors show disappointing results when compared to cutaneous melanoma (CM). Recent advances in biology, however, identified specific gene and chromosome alterations, potentially permitting an actively tailored surveillance strategy, and dedicated clinical studies. Being a rare cancer, UM patients have to overcome issues such as identifying referral centres, having access to information, and partnering with oncologists for specific management strategies and research priorities. Here, we describe how the EUropean Rare Adult solid CAacer Network (EURACAN) will help in addressing these challenges and accelerating international collaborations to enhance the development of innovative treatments in UM

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausible that epigenetic associations might arise from prenatal environmental exposures and/or genetic variation early in life. We investigated the association between cord blood DNA methylation at birth and cognitive skills assessed in children from eight pregnancy cohorts within the Pregnancy And Childhood Epigenetics (PACE) Consortium across overall (total N = 2196), verbal (total N = 2206) and non-verbal cognitive scores (total N = 3300). The associations at single CpG sites were weak for all of the cognitive domains investigated. One region near DUSP22 on chromosome 6 was associated with non-verbal cognition in a model adjusted for maternal IQ. We conclude that there is little evidence to support the idea that variation in cord blood DNA methylation at single CpG sites is associated with cognitive skills and further studies are needed to confirm the association at DUSP22.Peer reviewe

Off-label use of targeted therapies in osteosarcomas: data from the French registry OUTC'S (Observatoire de l'Utilisation des Thérapies Ciblées dans les Sarcomes):

BACKGROUND: The objective of this study is to explore the off-label use of targeted therapies (TTs) for patients with osteosarcoma registered within the French Sarcoma Group--Bone Tumor Study Group (GSF-GETO) national registry. METHODS: All patients with an osteosarcoma, registered between January 1, 2009 and July 15, 2013 were analyzed. RESULTS: Twenty-nine patients with refractory relapsed osteosarcomas received 33 treatment lines of TTs. The median age at the beginning of treatment was 19 years (range 9-72). The median number of previous lines of chemotherapy was 3 (range 1-8). Before inclusion, 3 patients were in second complete remission, 26 were in progression for metastatic relapse. Twenty-three patients received sirolimus (in combination with cyclophosphamide for 18); 5, sunitinib; 4, sorafenib; and one, pazopanib. Stable disease was observed for 45.5% of patients (95% Confidence Interval (CI) [20-52.8]). The median Progression-Free Survival (PFS) was 3 months (95% CI [2-5.4]) for patients treated by sirolimus and 1.8 months (95% CI [1.3-2.8]) for patients receiving multi-targeted tyrosine kinase inhibitors; 6-month PFS 15%. The median Overall Survival (OS) was 6.8 months (95% CI [4.7-12.1]), and one-year OS was 24%. In a multivariate analysis, PFS was superior for patients receiving sirolimus compared to other TTs (Hazard Ratio (HR) = 2.7, 95% CI [1.05-7.1]). No toxic death was reported. Grade 3 and 4 toxicities were observed in 27 and 6% of cases respectively. CONCLUSION: Off-label TTs, especially sirolimus, reported benefit in the treatment of refractory osteosarcomas with an acceptable toxicity profile, including in pediatric population

Public Service Motivation, Prosocial Motivation and Altruism. Towards Disentanglement and Conceptual Clarity

Research on public service motivation (PSM) has made great strides in terms of study output. Given the enormous scholarly attention on PSM, it is surprising that considerable conceptual ambiguities and overlaps with related concepts such as prosocial motivation, and altruism still remain. This study addresses this issue by systematically carving out the differences and similarities between these concepts. Taking this approach, this study clarifies the conceptual space of both PSM and the other concepts. Using data from semi-structured interviews with police officers, it is illustrated that PSM and prosocial motivation are different types of motivation leading to different types of prosocial behaviour

Public service motivation, prosocial motivation, prosocial behavior, and altruism: Towards disentanglement and conceptual clarity

Research on public service motivation (PSM) has made great strides in terms of study output over the past decade. In light of the enormous scholarly attention that PSM has received, we find it all the more surprising that there still exist considerable conceptual ambiguities and overlaps with related concepts such as prosocial motivation, prosocial behavior, and altruism that remain unresolved. We address this issue by systematically carving out the differences and similarities between these concepts using three key criteria: theoretical foundations, reference categories (beneficiaries and temporal focus), and stages of human action. This allows us to clarify the conceptual space of PSM and the various other concepts, and to recommend a set of compatible definitions, which will help avoid confusion in future research. Combining qualitative and quantitative data sampled from three different sources, we find empirical support for our argument that PSM and prosocial motivation share similarities but are not identical. More specifically, the results of a confirmatory factor analysis suggest that PSM and prosocial motivation are empirically distinguishable concepts. The preliminary results of semistructured qualitative interviews indicate that prosocially motivated police officers strive to benefit others whom they are in personal contact with, and to engage in OCB and interpersonal altruistic behavior. Interestingly, we did not find any references to PSM-related motives among this group of street-levels bureaucrats, which is why we plan to carry out additional interviews with other types of public servants

Predictors associated with mortality of veno-venous extracorporeal membrane oxygenation therapy

BACKGROUND The use of veno-venous extracorporeal membrane oxygenation (V-V ECMO) has rapidly increased in recent years. Today, applications of V-V ECMO include a variety of clinical conditions such as acute respiratory distress syndrome (ARDS), bridge to lung transplantation and primary graft dysfunction after lung transplantation. The purpose of the present study was to investigate in-hospital mortality of adult patients undergoing V-V ECMO therapy and to determine independent predictors associated with mortality. METHODS This retrospective study was conducted at the University Hospital Zurich, a designated ECMO center in Switzerland. Data was analyzed of all adult V-V ECMO cases from 2007 to 2019. RESULTS In total, 221 patients required V-V ECMO support (median age 50 years, 38.9% female). In-hospital mortality was 37.6% and did not statistically vary significantly between indications (P=0.61): 25.0% (1/4) for primary graft dysfunction after lung transplantation, 29.4% (5/17) for bridge to lung transplantation, 36.2% (50/138) for ARDS and 43.5% (27/62) for other pulmonary disease indications. Cubic spline interpolation showed no effect of time on mortality over the study period of 13 years. Multiple logistic regression modelling identified significant predictor variables associated with mortality: age [odds ratio (OR), 1.05; 95% confidence interval (CI): 1.02-1.07; P=0.001], newly detected liver failure (OR, 4.83; 95% CI: 1.27-20.3; P=0.02), red blood cell transfusion (OR, 1.91; 95% CI: 1.39-2.74; P<0.001) and platelet concentrate transfusion (OR, 1.93; 95% CI: 1.28-3.15; P=0.004). CONCLUSIONS In-hospital mortality of patients receiving V-V ECMO therapy remains relatively high. Patients' outcomes have not improved significantly in the observed period. We identified age, newly detected liver failure, red blood cell transfusion and platelet concentrate transfusion as independent predictors associated with in-hospital mortality. Incorporating such mortality predictors into decision making with regards to V-V ECMO use may increase its effectiveness and safety and may translate into better outcomes