Experimental and topological determination of the pressure-temperature phase diagram of morniflumate, a pharmaceutical ingredient with anti-inflammatory properties

The pressure-temperature phase diagram of morniflumate (niflumic acid ß-morpholinoethyl ester) has been obtained by high-pressure thermal analysis. In addition, calorimetric melting data (TI¿L = (348.1 ± 0.4) K and ¿HI¿L = (89 ± 2) J·g-1) and the specific volumes of the solid and the liquid state have been obtained under normal pressure. Comparison of the measured high-pressure melting data with the equilibrium curve obtained through the Clapeyron equation indicates that the initial slopes are the same (dP/dT = (2.96 ± 0.06) MPa·K-1) at the melting point under normal pressure. The fact that the Clapeyron equation can be used to construct topological phase diagrams may be of interest for the food and pharmaceutical industries.Peer ReviewedPostprint (author's final draft

Valoración reproductiva de toros jóvenes de testaje de raza Parda de montaña

raza Parda de montañaPublishe

La prótesis Bicontact resultados a 11 años de seguimiento

Peer Reviewe

Characterization of IHF Binding to DNA Four-Way Junctions and Forks

The objective of the study is to characterise the mechanical properties of Ti-15Zr binary alloy dental implants and to describe their biomechanical behaviour as well as their osseointegration capacity compared with the conventional Ti-6Al-4V (TAV) alloy implants. The mechanical properties of Ti-15Zr binary alloy were characterised using Roxoli

Ultracold molecules for quantum simulation: rotational coherence in CaF and RbCs

Polar molecules offer a new platform for quantum simulation of systems with long-range interactions, based on the electrostatic interaction between their electric dipole moments. Here, we report the development of coherent quantum state control using microwave fields in $^{40}$Ca$^{19}$F and $^{87}$Rb$^{133}$Cs molecules, a crucial ingredient for many quantum simulation applications. We perform Ramsey interferometry measurements with fringe spacings of $\sim 1~\rm kHz$ and investigate the dephasing time of a superposition of $N=0$ and $N=1$ rotational states when the molecules are confined. For both molecules, we show that a judicious choice of molecular hyperfine states minimises the impact of spatially varying transition-frequency shifts across the trap. For magnetically trapped $^{40}$Ca$^{19}$F we use a magnetically insensitive transition and observe a coherence time of 0.61(3)~ms. For optically trapped $^{87}$Rb$^{133}$Cs we exploit an avoided crossing in the AC Stark shifts and observe a maximum coherence time of 0.75(6)~ms

A low frequency persistent reservoir of a genomic island in a pathogen population ensures island survival and improves pathogen fitness in a susceptible host

The co-evolution of bacterial plant pathogens and their hosts is a complex and dynamic process. Host resistance imposes stress on invading pathogens that can lead to changes in the bacterial genome enabling the pathogen to escape host resistance. We have observed this phenomenon with the plant pathogen Pseudomonas syringae pv. phaseolicola where isolates that have lost the genomic island PPHGI-1 carrying the effector gene avrPphB from its chromosome are infective against previously resistant plant hosts. However, we have never observed island extinction from the pathogen population within a host suggesting the island is maintained. Here we present a mathematical model which predicts different possible fates for the island in the population; one outcome indicated that PPHGI-1 would be maintained at low frequency in the population long term if it confers a fitness benefit. We empirically tested this prediction and determined that PPHGI-1 frequency in the bacterial population drops to a low but consistently detectable level during host resistance. Once PPHGI-1-carrying cells encounter a susceptible host, they rapidly increase in the population in a negative frequency dependent manner. Importantly, our data show that mobile genetic elements can persist within the bacterial population and increase in frequency under favourable conditions

Late glacial and post-glacial deposits of the Navamuno peatbog (Iberian Central System): Chronology and paleoenvironmental implications

The Navamuno peatbog (Sierra de Bejar, western Spain) is a ~14 ha pseudo-endorheic depression with boundaries defined by a lateral moraine of the Cuerpo de Hombre paleoglacier and fault-line scarps on granite bedrock. The stratigraphy of the Navamu~no peatbog system is characterized here using borehole data to a depth of 20 m. An integrated interpretation from direct-push coring, dynamic probing boreholes and handheld auger drillings advances our knowledge of the Navamu~no polygenetic infill. Correlating this data with those obtained in other studies of the chronology and evolutionary sequence of the Cuerpo de Hombre paleoglacier has enabled us to establish the sequence of the hydrological system in the Navamuno depression. During the Late Pleistocene (MIS2), the depression was dammed by the Cuerpo de Hombre glacier and fed by its lateral meltwaters, and was filled with glaciolacustrine deposits. The onset of the Holocene in Navamuno is linked to a flat, fluviotorrential plain with episodes of local shallow pond/peat bog sedimentation. This evolutionary sequence is congruent with the age model obtained from available radiocarbon dating, obtaining 19 ages from ~800 cal yr BP (at depth 1.11 m) to ~16800 cal yr BP (at depth 15.90e16.0 m). Finally, the sedimentary record enabled interpretation of the environmental changes occurring in this zone during the late glacial (from the Older Dryas to the Younger Dryas) and postglacial (Holocene) stages, placing them within the paleoclimatic context of the Iberian Peninsula and Mediterranean regions

Prevalence of impairments, disabilities, handicaps and quality of life in the general population: a review of recent literature

International audienc

Friction coefficients and wear rates of different orthodontic archwires in artificial saliva

The aim of this paper is to analyze the influence of the nature of the orthodontic archwires on the friction coefficient and wear rate against materials used commonly as brackets (Ti–6Al–4V and 316L Stainless Steel). The mate- rials selected as orthodontic archwires were ASI304 stainless steel, NiTi, Ti, TiMo and NiTiCu. The array archwire’s materials selected presented very similar roughness but different hardness. Materials were chosen from lower and higher hardness degrees than that of the brackets. Wear tests were carried out at in artificial saliva at 37 C. Results show a linear relationship between the hardness of the materials and the friction coefficients. The material that showed lower wear rate was the ASI304 stainless steel. To prevent wear, the wire and the brackets have high hardness values and in the same order of magnitude.Peer ReviewedPostprint (published version