Maximum-likelihood image estimation using photon-correlated beams

A theory is presented addressing the fundamental limits of image estimation in a setup that uses two photon-correlated beams. These beams have the property that their photon arrivals, as a point process, are ideally synchronized in time and space. The true image represents the spatial distribution of the optical transmittance (or reflectance) of an object. In this setup, one beam is used to probe the image while the other is used as a reference providing additional information on the actual number of photons impinging on the object. This additional information is exploited to reduce the effect of quantum noise associated with the uncertainty in the number of photons per pixel. A stochastic model for the joint statistics of the two observation matrices is developed and used to obtain a local maximum-likelihood estimator of the image. The model captures the nonideal nature of the correlation between the photons of the beams by means of a simple random translation model. The mean-square error of the estimator is evaluated and compared to the corresponding conventional techniques. Conditions for the performance advantage of the proposed estimator are examined in terms of key system parameters. The theoretical predictions are demonstrated by means of simulation

Impact of Software Metrics on Software Quality using McCall Quality Model: In-Depth Analysis

Software metrics plays a very vital role in life cycle of software development. Rapid software development techniques and tools have made it very complex to fully control the quality of a software. Software metrics are required to make sure that the quality of software is fully under control. Many software metrics have already been developed and applied to control the quality of software products. Software metrics is the measurement of quality in which performance is measured against quality standards to check whether they are according to the expectations. Quality metrics are also used to determine customer requirements into acceptable performance measures. This paper discusses the concepts of software quality, quality factor model, mapping according to McCall Quality Model & the quality metrics. The act of applying software quality measurements to functional components and to keep up with factors is a mind-boggling task. Effective software quality affirmation is exceptionally reliant upon quality methods. Future examination is needed to expand out and work on the approach to widen measurements that have been accepted on one venture, utilizing our rules, legitimate proportions of value on future software project. This paper also dives deep into the impacts of the various software metrics over different quality factors and explains the relationship between them

Dengue Outbreaks in Khyber Pakhtunkhwa (KPK), Pakistan in 2017: An Integrated Disease Surveillance and Response System (IDSRS)-Based Report

Snažni bočni vjetrovi koji pušu na mostovima i vijaduktima mogu dovesti do gubitka dinamičke stabilnosti vozila koja prelaze most. Da bi se omogućio nesmetan i siguran promet čak i u slučajevima nepovoljnih vremenskih uvjeta uzrokovanih snažnim bočnim vjetrom, na mostove se postavljaju zaštitni vjetrobrani. Karakteristike strujanja zraka preko mosta su značajno promijenjene u slučaju postavljanja vjetrobrana različitih visina i poroznosti. U okviru ovog rada ispitan je utjecaj visine vjetrobrana te utjecaj poroznosti vjetrobrana na karakteristike strujanja zraka oko vozila koje se nalazi na mostu. Vjetrobran je postavljen samo na uzvodni rub mosta, a za vozilo je korišten model Ahmedovog tijela koji je u svim simulacijama postavljen na udaljenost 2 m nizvodno od vjetrobrana. Pri računalnim simulacijama korišten je model stacionarnog trodimenzijskog turbulentnog strujanja nestlačivog fluida te k-ω SST model turbulencije sa standardnim zidnim funkcijama. Dobiveni rezultati ukazuju na značajan utjecaj vjetrobrana na koeficijente tlaka na površini vozila. Manja poroznost vjetrobrana i veća visina vjetrobrana uzrokuju smanjenje koeficijenta tlaka na nastrujavanoj površini vozila. Iako su vrijednosti koeficijenta tlaka na površini vozila za male poroznosti vjetrobrana relativno male, raspodjela vrtložnosti struje zraka sugerira da može doći do povećanih vrijednosti standardnih devijacija aerodinamičkih sila koje djeluju na vozilo. Karakteristike vjetrobrana imaju bitan utjecaj na raspodjelu brzine strujanja zraka uzvodno od vozila, odnosno u prostoru između vjetrobrana i vozila. Smanjenjem poroznosti vjetrobrana se brzine strujanja zraka u tom području značajno smanjuju. Utjecaj poroznosti vjetrobrana na raspodjelu brzine strujanja zraka u ovom području je značajniji u odnosu na utjecaj visine vjetrobrana. Aerodinamičke sile i momenti zabilježeni na vozilu su značajno smanjeni kada je vjetrobran postavljen na most. Rezultati dobiveni u okviru ovog rada sugeriraju da je, s obzirom na aerodinamičke sile koje djeluju na vozilo, optimalna visina vjetrobrana 5 m uz njihovu poroznost u iznosu od 30%.Strong cross winds that commonly blow on bridges and viaducts may cause dynamic instabilities of vehicles crossing the bridge. To allow for safe traffic even in the periods of bad weather conditions such as strong cross winds, bridges are equipped with wind barriers. Flow characteristics around the bridge are significantly modified with respect to the wind barrier height and porosity. In the present work, the influence of wind barrier height and porosity on flow characteristics around the vehicle passing the bridge was studied. The wind barrier was placed on the windward bridge-deck edge only, while the Ahmed body was used as a vehicle. It was placed 2 m downwind of the wind barrier. In the computational simulations, the stationary 3D turbulent incompressible flow was modeled together with the k-ω SST turbulence model and standard wall functions. The obtained results generally show a significant influence of the wind barrier on the pressure coefficients observed on the vehicle surface. Smaller porosity and larger height of the wind barrier causes smaller pressure coefficients on the windward side of the vehicle. Even though the pressure coefficients on the vehicle for the low-porous wind barrier are relatively small, the distribution of the flow vorticity suggests larger values of the standard deviation of the aerodynamic forces acting on the vehicle. Wind-barrier characteristics proved to have a large influence on the distribution of flow velocity in the area upstream of the vehicle and downstream of the wind barrier. For smaller porosities of the wind barrier, flow velocities in this area are significantly smaller. The influence of the porosity on the distribution of flow velocities in this area is relatively larger compared to the height of the wind barrier. The aerodynamic forces and moment are generally smaller when the wind barrier is in place. The obtained results suggest that the 5 m high and 30% porous wind barrier is optimal with respect to the aerodynamic forces and moment acting on the vehicle on the bridge

Investigation of the cardiac depressant effect of Caralluma tuberculate N.E.Br on isolated rabbit heart

Purpose: To investigate the histopathological and cardiac depressant effect of the aqueous methanol extract of Caralluma tuberculata N.E. Br (AMECT) (family: Asclepiadaceae)’ and to determine if there is a scientific basis for its cardiovascular diseases-related folkloric use. Methods: The effect of AMECT in different concentrations ranging from 0.00001 to 1.0 mg/mL were evaluated in isolated perfused rabbit heart to assess their effect on the force of contraction and heart rate using Langendorff’s apparatus. Atropine and adrenaline were used to identify the underlying mechanism of response produced by AMECT. The extract was studied for its possible mechanism in the absence and presence of atropine and adrenaline. In addition, sub-chronic toxicity and histopathological study of heart tissues in rats were assessed by administering 500 mg/kg of extract. Results: At all concentrations, AMECT produced significant (p < 0.001) negative ionotropic and negative chronotropic effects. The most significant effect was observed at 0.001 mg/mL and higher concentrations hence 0.001 mg/mL was selected for further studies. Pre-incubation with atropine did not significantly inhibit the effects of AMECT. However, AMECT significantly (p < 0.01) blocked the cardiac stimulant effect of adrenaline. In the histopathological studies, AMECT did not produce any significant cellular changes or signs of toxicity in the sub-chronic toxicity study. Conclusion: The cardiac-depressant responses of AMECT may involve the β-adrenergic receptors in the myocardium of isolated rabbit heart thus confirming the rationale for its use in ethnomedicine for cardiac diseases

Systemic Type I IFN Inflammation in Human ISG15 Deficiency Leads to Necrotizing Skin Lesions

Most monogenic disorders have a primary clinical presentation. Inherited ISG15 deficiency, however, has manifested with two distinct presentations to date: susceptibility to mycobacterial disease and intracranial calcifications from hypomorphic interferon-II (IFN-II) production and excessive IFN-I response, respectively. Accordingly, these patients were managed for their infectious and neurologic complications. Herein, we describe five new patients with six novel ISG15 mutations presenting with skin lesions who were managed for dermatologic disease. Cellularly, we denote striking specificity to the IFN-I response, which was previously assumed to be universal. In peripheral blood, myeloid cells display the most robust IFN-I signatures. In the affected skin, IFN-I signaling is observed in the keratinocytes of the epidermis, endothelia, and the monocytes and macrophages of the dermis. These findings define the specific cells causing circulating and dermatologic inflammation and expand the clinical spectrum of ISG15 deficiency to dermatologic presentations as a third phenotype co-dominant to the infectious and neurologic manifestations.Fil: Martin Fernandez, Marta. Icahn School Of Medicine At Mount Sinai; Estados Unidos. King Saud University; Arabia SauditaFil: Bravo García Morato, María. Instituto de Investigacion del Hospital de la Paz.; EspañaFil: Gruber, Conor. Icahn School Of Medicine At Mount Sinai; Estados Unidos. King Saud University; Arabia SauditaFil: Murias Loza, Sara. Instituto de Investigacion del Hospital de la Paz.; EspañaFil: Malik, Muhammad Nasir Hayat. Twincore; Alemania. University Of Lahore; Países Bajos. Leibniz Universitat Hannover; Alemania. Helmholtz Gemeinschaft; AlemaniaFil: Alsohime, Fahad. King Saud University; Arabia SauditaFil: Alakeel, Abdullah. King Saud University; Arabia SauditaFil: Valdez, Rita. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; ArgentinaFil: Buta, Sofija. Icahn School Of Medicine At Mount Sinai; Estados UnidosFil: Buda, Guadalupe. Bitgenia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Biología Celular e Histología; ArgentinaFil: Marti, Marcelo Adrian. Bitgenia; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Biología Celular e Histología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Larralde, Margarita. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Boisson, Bertrand. L'institut Des Maladies Génétiques Imagine; Francia. The Rockefeller University; Estados Unidos. Universite de Paris; FranciaFil: Feito Rodriguez, Marta. Instituto de Investigacion del Hospital de la Paz.; EspañaFil: Qiu, Xueer. Icahn School Of Medicine At Mount Sinai; Estados UnidosFil: Chrabieh, Maya. L'institut Des Maladies Génétiques Imagine; FranciaFil: Al Ayed, Mohammed. Najran University; Arabia SauditaFil: Al Muhsen, Saleh. King Saud University; Arabia SauditaFil: Desai, Jigar V.. National Institutes of Health; Estados UnidosFil: Ferre, Elise M.N.. National Institutes of Health; Estados UnidosFil: Rosenzweig, Sergio D.. National Institutes of Health; Estados UnidosFil: Amador-Borrero, Blanca. Icahn School Of Medicine At Mount Sinai; Estados UnidosFil: Bravo-Gallego, Luz Yadira. Instituto de Investigacion del Hospital de la Paz.; EspañaFil: Olmer, Ruth. Hannover Medical School; Alemania. German Center for Lung Research; AlemaniaFil: Merkert, Sylvia. Hannover Medical School; Alemania. German Center for Lung Research; AlemaniaFil: Bret, Montserrat. Instituto de Investigacion del Hospital de la Paz.; EspañaFil: Sood, Amika K.. University of North Carolina; Estados UnidosFil: Al-rabiaah, Abdulkarim. King Saud University; Arabia SauditaFil: Temsah, Mohamad Hani. King Saud University; Arabia SauditaFil: Halwani, Rabih. University of Sharjah; Emiratos Arabes UnidosFil: Hernandez, Michelle Marilyn. University of North Carolina; Estados UnidosFil: Pessler, Frank. Twincore; Alemania. Helmholtz Centre for Infection Research; AlemaniaFil: Casanova, Jean Laurent. The Rockefeller University; Estados Unidos. Necker Hospital for Sick Children; Francia. Howard Hughes Medical Institute; Estados Unidos. Universite de Paris; FranciaFil: Bustamante, Jacinta. The Rockefeller University; Estados Unidos. Necker Hospital for Sick Children; Francia. Universite de Paris; FranciaFil: Lionakis, Michail S.. National Institutes of Health; Estados UnidosFil: Bogunovic, Dusan. Icahn School Of Medicine At Mount Sinai; Estados Unido

Subnational mapping of HIV incidence and mortality among individuals aged 15–49 years in sub-Saharan Africa, 2000–18 : a modelling study

Background: High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods: In this modelling study, we developed a framework that used the geographically specific HIV prevalence data collected in seroprevalence surveys and antenatal care clinics to train a model that estimates HIV incidence and mortality among individuals aged 15–49 years. We used a model-based geostatistical framework to estimate HIV prevalence at the second administrative level in 44 countries in sub-Saharan Africa for 2000–18 and sought data on the number of individuals on antiretroviral therapy (ART) by second-level administrative unit. We then modified the Estimation and Projection Package (EPP) to use these HIV prevalence and treatment estimates to estimate HIV incidence and mortality by second-level administrative unit. Findings: The estimates suggest substantial variation in HIV incidence and mortality rates both between and within countries in sub-Saharan Africa, with 15 countries having a ten-times or greater difference in estimated HIV incidence between the second-level administrative units with the lowest and highest estimated incidence levels. Across all 44 countries in 2018, HIV incidence ranged from 2 ·8 (95% uncertainty interval 2·1–3·8) in Mauritania to 1585·9 (1369·4–1824·8) cases per 100 000 people in Lesotho and HIV mortality ranged from 0·8 (0·7–0·9) in Mauritania to 676· 5 (513· 6–888·0) deaths per 100 000 people in Lesotho. Variation in both incidence and mortality was substantially greater at the subnational level than at the national level and the highest estimated rates were accordingly higher. Among second-level administrative units, Guijá District, Gaza Province, Mozambique, had the highest estimated HIV incidence (4661·7 [2544·8–8120·3]) cases per 100000 people in 2018 and Inhassunge District, Zambezia Province, Mozambique, had the highest estimated HIV mortality rate (1163·0 [679·0–1866·8]) deaths per 100 000 people. Further, the rate of reduction in HIV incidence and mortality from 2000 to 2018, as well as the ratio of new infections to the number of people living with HIV was highly variable. Although most second-level administrative units had declines in the number of new cases (3316 [81· 1%] of 4087 units) and number of deaths (3325 [81·4%]), nearly all appeared well short of the targeted 75% reduction in new cases and deaths between 2010 and 2020. Interpretation: Our estimates suggest that most second-level administrative units in sub-Saharan Africa are falling short of the targeted 75% reduction in new cases and deaths by 2020, which is further compounded by substantial within-country variability. These estimates will help decision makers and programme implementers expand access to ART and better target health resources to higher burden subnational areas

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely