2,347 research outputs found
Physical characterization and origin of binary near-Earth asteroid (175706) 1996 FG3
The near-Earth asteroid (NEA) (175706) 1996 FG3 is a particularly interesting
spacecraft target: a binary asteroid with a low-DeltaV heliocentric orbit. The
orbit of its satellite has provided valuable information about its mass density
while its albedo and colors suggest it is primitive or part of the C-complex
taxonomic grouping. We extend the physical characterization of this object with
new observations of its emission at mid-Infrared (IR) wavelengths and with
near-IR reflection spectroscopy. We derive an area-equivalent system diameter
of 1.90 \pm 0.28 km (corresponding to approximate component diameters of 1.83
km and 0.51 km, respectively) and a geometric albedo of 0.039 \pm 0.012.
1996 FG3 was previously classified as a C-type asteroid, though the combined
0.4--2.5 micron spectrum with thermal correction indicates classification as
B-type; both are consistent with the low measured albedo. Dynamical studies
show that 1996 FG3 has most probably originated in the inner main asteroid
belt. Recent work has suggested the inner Main Belt (142) Polana family as the
possible origin of another low-DeltaV B-type NEA, (101955) 1999 RQ36. A similar
origin for 1996 FG3 would require delivery by the overlapping Jupiter 7:2 and
Mars 5:9 mean motion resonances rather than the nu-6 resonance, and we find
this to be a low probability, but possible, origin.Comment: Published in Ap
Unlocking Complex Soil Systems as Carbon Sinks: Multi-pool Management as the Key
Much research focuses on increasing carbon storage in mineral-associated organic matter (MAOM), in which carbon may persist for centuries to millennia. However, MAOM-targeted management is insufficient because the formation pathways of persistent soil organic matter are diverse and vary with environmental conditions. Effective management must also consider particulate organic matter (POM). In many soils, there is potential for enlarging POM pools, POM can persist over long time scales, and POM can be a direct precursor of MAOM. We present a framework for context-dependent management strategies that recognizes soils as complex systems in which environmental conditions constrain POM and MAOM formation
An Adjoint-Based Forecast Impact from Assimilating MISR Winds into the GEOS-5 Data Assimilation and Forecasting System
This study examines the benefit of assimilating cloud motion vector (CMV) wind observations obtained from the Multi-angle Imaging SpectroRadiometer (MISR) within a Modern-Era Retrospective Analysis for Research and Applications-2 (MERRA2) configuration of the Goddard Earth Observing System-5 (GEOS-5) model Data Assimilation System (DAS). Available in near real time (NRT) and with a record dating back to 1999, MISR CMVs boast pole-to-pole coverage and geometric height assignment that is complementary to the suite of Atmospheric Motion Vectors (AMVs) included in the MERRA2 standard. Experiments spanning September-October-November of 2014 and March-April-May of 2015 estimated relative MISR CMV impact on the 24-hour forecast error reduction with an adjoint based forecast sensitivity method. MISR CMV were more consistently beneficial and provided twice as large a mean forecast benefit when larger uncertainties were assigned to the less accurate component of the CMV oriented along the MISR satellite ground track, as opposed to when equal uncertainties were assigned to the eastward and northward components as in previous studies. Assimilating only the cross-track component provided 60 of the benefit of both components. When optimally assimilated, MISR CMV proved broadly beneficial throughout the Earth, with greatest benefit evident at high latitudes where there is a confluence of more frequent CMV coverage and gaps in coverage from other MERRA2 wind observations. Globally, MISR represented 1.6% of the total forecast benefit, whereas regionally that percentage was as large as 3.7%
Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study.
BackgroundPoor socioeconomic and health-related quality of life (HRQOL) outcomes in survivors of childhood cancer can lead to distress and overall negatively impact the lives of these individuals. The current report has highlighted the impact of stroke and stroke recurrence on mortality, psychological HRQOL, and socioeconomic outcomes within the Childhood Cancer Survivor Study (CCSS).MethodsThe CCSS is a retrospective cohort study with longitudinal follow-up concerning survivors of pediatric cancer who were diagnosed between 1970 and 1986. Mortality rates per 100 person-years were calculated across 3 periods: 1) prior to stroke; 2) after first stroke and before recurrent stroke; and 3) after recurrent stroke. Socioeconomic outcomes, the standardized Brief Symptoms Inventory-18, the Medical Outcomes Study 36-Item Short Form Health Survey, and the CCSS-Neurocognitive Questionnaire also were assessed.ResultsAmong 14,358 participants (median age, 39.7 years), 224 had a stroke after their cancer diagnosis (single stroke in 161 patients and recurrent stroke in 63 patients). Based on 2636 deaths, all-cause late mortality rates were 0.70 (95% CI, 0.68-0.73) prior to stroke, 1.03 (95% CI, 0.73-1.46) after the first stroke, and 2.42 (95% CI, 1.48-3.94) after the recurrent stroke. Among 7304 survivors, those with stroke were more likely to live with a caregiver (single stroke odds ratio [OR], 2.3 [95% CI, 1.4-3.8]; and recurrent stroke OR, 5.3 [95% CI, 1.7-16.8]) compared with stroke-free survivors. Stroke negatively impacted task efficiency (single stroke OR, 2.4 [95% CI, 1.4-4.1] and recurrent stroke OR, 3.3 [95% CI, 1.1-10.3]) and memory (single stroke OR, 2.1 [95% CI, 1.2-3.7]; and recurrent stroke OR, 3.5 [95% CI, 1.1-10.5]).ConclusionsStroke and stroke recurrence are associated with increased mortality and negatively impact HRQOL measures in survivors of pediatric cancer
Key Knowledge Gaps for Plasmodium vivax Control and Elimination
There is inadequate understanding of the biology, pathology,
transmission, and control of Plasmodium vivax, the
geographically most widespread cause of human malaria. During
the last decades, study of this species was neglected, in part
due to the erroneous belief that it is intrinsically benign. In
addition, many technical challenges in culturing the parasite
also hampered understanding its fundamental biology and
molecular and cellular responses to chemotherapeutics. Research
on vivax malaria needs to be substantially expanded over the
next decade to accelerate its elimination and eradication. This
article summarizes key knowledge gaps identified by researchers,
national malaria control programs, and other stakeholders
assembled by the World Health Organization to develop strategies
for controlling and eliminating vivax malaria. The priorities
presented in this article emerged in these technical
discussions, and were adopted by expert consensus of the
authors. All involved understood the priority placed upon
pragmatism in this research agenda, that is, focus upon tools
delivering better prevention, diagnosis, treatment, and
surveillance of P. vivax
Plant Litter Quality Affects the Accumulation Rate, Composition, and Stability of Mineral-associated Soil Organic Matter
Mineral-associated organic matter (MAOM) is a relatively large and stable fraction of soil organic matter (SOM). Plant litters with high rates of mineralization (high quality litters) are hypothesized to promote the accumulation of MAOM with greater efficiency than plant litters with low rates of mineralization (low-quality litters) because litters with high rates of mineralization maximize the synthesis of microbial products and most MAOM is microbial-derived. However, the effect of litter quality on MAOM is inconsistent. We conducted four repeated short-term incubations (46-d each) of four plant litters (alfalfa, oats, maize and soybean) in two low-carbon subsoils (sandy loam and silty loam) with and without nutrient addition. Our short-term incubations focused on the initial stage of litter decomposition during the time when litter quality has a measureable effect on mineralization rates. Plant litter quality had a much greater effect on litter-C mineralization rate and MAOM-C accumulation than did soil type or nutrient addition. Soils amended with high-quality oat and alfalfa litters had greater MAOM-C accumulation than soils amended with low-quality maize and soybean litters. However, soils amended with high-quality litters also had greater litter-C mineralization than soils amended with low-quality litters. As a result, the accumulation of MAOM-C per unit of litter-C mineralization was lower in soils amended with high-vs. low-quality litters (0.65 vs. 1.39 g MAOM-C accumulated g−1 C mineralized). Cellulose and hemicelluose indices of accumulated MAOM were greater for maize and soybean than oats and alfalfa, however, most carbohydrates in MAOM were plant-derived regardless of litter quality. At the end of the incubations, more of the accumulated MAOM-N was potentially mineralizable in soils amended with high quality litters. Nevertheless, most of the litter-C remained as residual litter; just 12% was mineralized to CO2 and 13% was transferred to MAOM. Our results demonstrate several unexpected effects of litter quality on MAOM stabilization including the direct stabilization of plant-derived carbohydrates
Extending the Osmometer Method for Assessing Drought Tolerance in Herbaceous Species
Community-scale surveys of plant drought tolerance are essential for understanding semi-arid ecosystems and community responses to climate change. Thus, there is a need for an accurate and rapid methodology for assessing drought tolerance strategies across plant functional types. The osmometer method for predicting leaf osmotic potential at full turgor ((o)), a key metric of leaf-level drought tolerance, has resulted in a 50-fold increase in the measurement speed of this trait; however, the applicability of this method has only been tested in woody species and crops. Here, we assess the osmometer method for use in herbaceous grassland species and test whether (o) is an appropriate plant trait for understanding drought strategies of herbaceous species as well as species distributions along climate gradients. Our model for predicting leaf turgor loss point ((TLP)) from (o) ((TLP)=0.80(o)-0.845) is nearly identical to the model previously presented for woody species. Additionally, (o) was highly correlated with (TLP) for graminoid species ((tlp)=0.944(o)-0.611; r(2)=0.96), a plant functional group previously flagged for having the potential to cause erroneous measurements when using an osmometer. We report that (o), measured with an osmometer, is well correlated with other traits linked to drought tolerance (namely, leaf dry matter content and leaf vulnerability to hydraulic failure) as well as climate extremes linked to water availability. The validation of the osmometer method in an herb-dominated ecosystem paves the way for rapid community-scale surveys of drought tolerance across plant functional groups, which could improve trait-based predictions of ecosystem responses to climate change
Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines
BackgroundPolymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism. However, knowledge on antigenic diversity of key antigens, the impact of polymorphism on potential vaccine escape, and how sequence polymorphism relates to antigenic differences is very limited, yet crucial for vaccine development. Plasmodium falciparum apical membrane antigen 1 (AMA1) is an important target of naturally-acquired antibodies in malaria immunity and a leading vaccine candidate. However, AMA1 has extensive allelic diversity with more than 60 polymorphic amino acid residues and more than 200 haplotypes in a single population. Therefore, AMA1 serves as an excellent model to assess antigenic diversity in malaria vaccine antigens and the feasibility of multi-allele vaccine approaches. While most previous research has focused on sequence diversity and antibody responses in laboratory animals, little has been done on the cross-reactivity of human antibodies.MethodsWe aimed to determine the extent of antigenic diversity of AMA1, defined by reactivity with human antibodies, and to aid the identification of specific alleles for potential inclusion in a multi-allele vaccine. We developed an approach using a multiple-antigen-competition enzyme-linked immunosorbent assay (ELISA) to examine cross-reactivity of naturally-acquired antibodies in Papua New Guinea and Kenya, and related this to differences in AMA1 sequence.ResultsWe found that adults had greater cross-reactivity of antibodies than children, although the patterns of cross-reactivity to alleles were the same. Patterns of antibody cross-reactivity were very similar between populations (Papua New Guinea and Kenya), and over time. Further, our results show that antigenic diversity of AMA1 alleles is surprisingly restricted, despite extensive sequence polymorphism. Our findings suggest that a combination of three different alleles, if selected appropriately, may be sufficient to cover the majority of antigenic diversity in polymorphic AMA1 antigens. Antigenic properties were not strongly related to existing haplotype groupings based on sequence analysis.ConclusionsAntigenic diversity of AMA1 is limited and a vaccine including a small number of alleles might be sufficient for coverage against naturally-circulating strains, supporting a multi-allele approach for developing polymorphic antigens as malaria vaccines
- …