Bostonia. Volume 4

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

Recent Developments in Peptide-Based Nucleic Acid Delivery

Despite the fact that non-viral nucleic acid delivery systems are generally considered to be less efficient than viral vectors, they have gained much interest in recent years due to their superior safety profile compared to their viral counterpart. Among these synthetic vectors are cationic polymers, branched dendrimers, cationic liposomes and cell-penetrating peptides (CPPs). The latter represent an assortment of fairly unrelated sequences essentially characterised by a high content of basic amino acids and a length of 10–30 residues. CPPs are capable of mediating the cellular uptake of hydrophilic macromolecules like peptides and nucleic acids (e.g. siRNAs, aptamers and antisense-oligonucleotides), which are internalised by cells at a very low rate when applied alone. Up to now, numerous sequences have been reported to show cell-penetrating properties and many of them have been used to successfully transport a variety of different cargos into mammalian cells. In recent years, it has become apparent that endocytosis is a major route of internalisation even though the mechanisms underlying the cellular translocation of CPPs are poorly understood and still subject to controversial discussions. In this review, we will summarise the latest developments in peptide-based cellular delivery of nucleic acid cargos. We will discuss different mechanisms of entry, the intracellular fate of the cargo, correlation studies of uptake versus biological activity of the cargo as well as technical problems and pitfalls

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

World literature and its place in general culture / by Richard G. Moulton

WORLD LITERATURE AND ITS PLACE IN GENERAL CULTURE / BY RICHARD G. MOULTON World literature and its place in general culture / by Richard G. Moulton (1) Einband (1) Titelseite (3) Titelseite (5) Preface (7) Contents (9) Introduction. Inhalt (11) I. The Unity Of Literature And The Conception Of ... (13) II. Literary Pedigree Of The English-Speaking People (22) III. World Literature From The English Point Of View (65) Survey Of World Literature. Inhalt (69) Chapter I. The Five Literary Bibles - The Holy Bible (71) Chapter II. The Five Literary Bibles - Classical Epic And Tragedy (111) Chapter III. The Five Literary Bibles - Shakespeare (176) Chapter IV. The Five Literary Bibles - Dante And Milton: ... (191) Chapter V. The Five Literary Bibles - Versions Of The Story Of Faust (232) Chapter VI. Collateral Studies In World Literature (307) Chapter VII. Comparative Reading (363) Chapter VIII. Literary Organs Of Personality: Essays And Lyrics (393) Chapter IX. Strategic Points In Literature (419) Chapter X. World Literature The Autobiography Of Civilization (441) Kapitel (450) Conclusion. The Place Of World Literature In Education (451) Syllabus. List Of Books. General Index (479) Syllabus (481) List Of Books (495) General Index (507) Kapitel (515

The story of Faust : syllabus of course of six lecture-studies / by Richard G. Moulton

THE STORY OF FAUST : SYLLABUS OF COURSE OF SIX LECTURE-STUDIES / BY RICHARD G. MOULTON The story of Faust : syllabus of course of six lecture-studies / by Richard G. Moulton (1) Einband (1) Titelseite (2) The story of Faust (4

Shakespeare as a dramatic artist; a popular illustration of the principles of scientific criticism.

Introduction: Plea for an inductive science of literary criticism.--pt. 1. Shakespeare considered as a dramatic artist, in fifteen studies.--pt. 2. Survey of dramatic criticism as an inductive science.Mode of access: Internet

Ecclesiastes and the Wisdom of Solomon;

Mode of access: Internet

Genesis;

Half-title: The modern reader's Bible. History series.Mode of access: Internet