The application of optimal control theory to dynamic routing in data communication networks.

Thesis. 1977. Ph.D.--Massachusetts Institute of Technology. Dept. of Aeronautics and Astronautics.Microfiche copy available in Archives and Aeronautics.Vita.Bibliography : leaves 302-304.Ph.D

Electronic Cigarette Use and Associated Risk Factors in U.S.-Dwelling Pacific Islander Young Adults.

Background: E-cigarette use is rapidly increasing among US young adults, heightening their risk for vaping-related illnesses. Yet, little is known about e-cigarette use among young adult Native Hawaiians and Pacific Islanders (NHPI): an indigenous-colonized US racial group rarely described in research literature. This exploratory study provides the first known data on e-cigarette use and potential risk factors in NHPI young adults. Method: Self-report data were collected from 143 NHPI young adults (age 18-30 years) living in two large NHPI communities: Samoans in urban Los Angeles County and Marshallese in rural Arkansas. We assessed rates of e-cigarette, cigarette, alcohol, and marijuana use, and positive and negative outcome expectancies from e-cigarettes, that is expected outcomes from e-cigarette use. To identify potential risk factors for NHPI e-cigarette use, regressions explored associations between participants' current e-cigarette use with current cigarette, alcohol, and marijuana use, and e-cigarette outcome expectancies. Results: Among NHPI young adults, lifetime e-cigarette use rate was 53% and current use rate was 39%. Current rate of dual e-cigarette/cigarette, e-cigarette/alcohol, and e-cigarette/marijuana use was 38%, 35%, and 25%, respectively. In our regression models, current marijuana use and positive e-cigarette outcome expectancies were significantly associated with current e-cigarette use. Conclusions: E-cigarette use is common among NHPI young adults, exceeding rates for other at-risk racial groups. Marijuana use and positive expectations about e-cigarette use may represent potential e-cigarette use risk factors. Collectively, findings underscore the need for additional research to further explore the scope of, and risk and protective factors for, e-cigarette use in this understudied high-risk population

Dynamical variations of the differential rotation in the solar convection zone

Recent analyses of helioseismological observations seem to suggest the presence of two new phenomena connected with the dynamics of the solar convective zone. Firstly, there are present torsional oscillations with periods of about 11 years, which penetrate significantly into the solar convection zone and secondly, oscillatory regimes exist near the base of the convection which are markedly different from those observed near the top, having either significantly reduced periods or being non-periodic. Recently spatiotemporal fragmentation/bifurcation has been proposed as a possible dynamical mechanism to account for such observed multi-mode behaviours in different parts of the solar convection zone. Evidence for this scenario was produced in the context of an axisymmetric mean field dynamo model operating in a spherical shell, with a semi-open outer boundary condition and a zero order angular velocity obtained by the inversion of the MDI data, in which the only nonlinearity was the action of the Lorentz force of the dynamo generated magnetic field on the solar angular velocity. Here we make a detailed study of the robustness of this model with respect to plausible changes to its main ingredients, including changes to the alpha and eta profiles as well as the inclusion of a nonlinear alpha quenching. We find that spatiotemporal fragmentation is present in this model for different choices of the rotation data and as the details of the model are varied. Taken together, these results give strong support to the idea that spatiotemporal fragmentation is likely to occur in general dynamo settings.Comment: 14 pages, 30 figures, submitted to Astronomy and Astrophysics, also available at http://www.eurico.web.co

Bit-String Models for Parasex

We present different bit-string models of haploid asexual populations in which individuals may exchange part of their genome with other individuals (parasex) according to a given probability. We study the advantages of this parasex concerning population sizes, genetic fitness and diversity. We find that the exchange of genomes always improves these features.Comment: 12 pages including 7 figure

Galactic dynamos with captured magnetic flux and an accretion flow

We examine the behaviour of an axisymmetric galactic dynamo model with a radial accretion flow in the disc. We also introduce a vertical magnetic flux through the galactic midplane, to simulate the presence of a large scale magnetic field trapped by the galaxy when forming. The trapped vertical flux is conserved and advected towards the disc centre by the radial flow. We confirm that accretion flows of magnitude several km/s through a significant part of the galactic disc can markedly inhibit dynamo action. Moreover, advection of the vertical flux in general results in mixed parity galactic fields. However, the effect is nonlinear and non-additive -- global magnetic field energies are usually significantly smaller that the sum of purely dynamo generated and purely advected field energies. For large inflow speeds, a form of `semi-dynamo' action may occur. We apply our results to the accumulation and redistribution, by a radial inflow, of a vertical magnetic flux captured by the Galactic disc. Taking representative values, it appears difficult to obtain mean vertical fields near the centre of the Milky Way that are much in excess of 10 microgauss, largely because the galactic dynamo and turbulent magnetic diffusion modify the external magnetic field before it can reach the disc centre.Comment: 18 pages, 12 figures, LaTE

A complex of seven vaccinia virus proteins conserved in all chordopoxviruses is required for the association of membranes and viroplasm to form immature virions

AbstractEarly events in vaccinia virus (VAC) morphogenesis, particularly the formation of viral membranes and their association with viroplasm, are poorly understood. Recently, we showed that repression of A30 or G7 expression results in the accumulation of normal viral membranes that form empty-looking immature virions (IV), which are separated from large masses of electron-dense viroplasm. In addition, A30 and G7 physically and functionally interact with each other and with the F10 protein kinase. To identify other proteins involved in early morphogenesis, proteins from cells that had been infected with vaccinia virus expressing an epitope-tagged copy of F10 were purified by immunoaffinity chromatography and analyzed by gel electrophoresis. In addition to F10, A30, and G7, viral proteins A15, D2, D3, and J1 were identified by mass spectrometry of tryptic peptides. Further evidence for the complex was obtained by immunopurification of proteins associated with epitope-tagged A15, D2, and D3. The previously unstudied A15, like other proteins in the complex, was expressed late in infection, associated with virus cores, and required for the stability and kinase activity of F10. Biochemical and electron microscopic analyses indicated that mutants in which A15 or D2 expression was regulated by the Escherichia coli lac operator system exhibited phenotypes characterized by the presence of large numbers of empty immature virions, similar to the results obtained with inducible A30 and G7 mutants. Empty immature virions were also seen by electron microscopy of cells infected with temperature-sensitive mutants of D2 or D3, though the numbers of membrane forms were reduced perhaps due to additional effects of high temperature

Simulation of reproductive risk and emergence of female reproductive cessation

Using a simple computer model for evolution, we show that in a sexual population subject only to age-increasing reproductive risk, a cessation of female reproduction emerges.Comment: 11 pages including 3 figure

Enhanced triage for patients with suspected cardiac chest pain: the History and Electrocardiogram-only Manchester Acute Coronary Syndromes decision aid.

OBJECTIVES: Several decision aids can 'rule in' and 'rule out' acute coronary syndromes (ACS) in the Emergency Department (ED) but all require measurement of blood biomarkers. A decision aid that does not require biomarker measurement could enhance risk stratification at triage and could be used in the prehospital environment. We aimed to derive and validate the History and ECG-only Manchester ACS (HE-MACS) decision aid using only the history, physical examination and ECG. METHODS: We undertook secondary analyses in three prospective diagnostic accuracy studies that included patients presenting to the ED with suspected cardiac chest pain. Clinicians recorded clinical features at the time of arrival using a bespoke form. Patients underwent serial troponin sampling and 30-day follow-up for the primary outcome of ACS. The model was derived by logistic regression in one cohort and validated in two similar prospective studies. RESULTS: The HE-MACS model was derived in 796 patients and validated in cohorts of 474 and 659 patients. HE-MACS incorporated age, sex, systolic blood pressure plus five historical variables to stratify patients into four risk groups. On validation, 5.5 and 12.1% (pooled total 9.4%) patients were identified as 'very low risk' (potential immediate rule out) with a pooled sensitivity of 99.5% (95% confidence interval: 97.1-100.0%). CONCLUSION: Using only the patient's history and ECG, HE-MACS could 'rule out' ACS in 9.4% of patients while effectively risk stratifying remaining patients. This is a very promising tool for triage in both the prehospital environment and ED. Its impact should be prospectively evaluated in those settings