La explotación de la sal como factor de dinamismo urbano: consideraciones sobre el yacimiento hispanorromano del Cerro del Milagro (Poza de la Sal, Burgos).

La sal ha sido a lo largo de la historia un recurso de carácter estratégico cuyo control ha generado áreas prósperas y dinámicas en torno a su explotación. En este trabajo se estudia la forma en la que la explotación de la sal pudo actuar en la promoción del yacimiento hispanorromano del Cerro del Milagro (Poza de la Sal, Burgos). Las características de sus restos arqueológicos y su relación con un importante depósito salino de original método de explotación hacen de éste un caso ejemplar de la influencia de la sal en los núcleos urbanos del interior peninsular durante el periodo imperial romano.Departamento de Prehistoria, Arqueología, Antropología Social y Ciencias y Técnicas HistoriográficasGrado en Histori

Inmigrantes latinoamericanas en Salamanca: estudio de experiencias y casos

This paper analyses the migration process of a group of Latin American women to Salamanca (Spain) from the socio-cultural consideration. Through qualitative interviewing and case study, the research team explored from a gender perspective their migration and adaptation processes: motivations for emigration, the previous expectations, difficulties in the process, as well as the recollection of the diversity of places they occupied in society, regarding to physical spaces, power, participation or communication. The results achieved show a positive perception of their transit, looking for personal and family well-being, despite of the numerous changes they had faced and the difficulties encountered.Este trabajo propone analizar desde la perspectiva sociocultural el proceso migratorio de un grupo de mujeres latinoamericanas que han emigrado a Salamanca (España). A través de entrevistas cualitativas en profundidad y el estudio de casos se investigan desde una perspectiva de género sus procesos migratorios y de adaptación en el lugar de destino: cuáles han sido las razones que las han impulsado a emigrar, sus expectativas previas y las dificultades que se han encontrado en el proceso, además de identificar los espacios materiales, de poder, participación y comunicación que ocupan en la sociedad. Los resultados obtenidos indican una percepción positiva de su tránsito en busca de la mejora de su bienestar personal y familiar a pesar de los numerosos cambios que han debido afrontar y de las dificultades encontradas.This paper analyses the migration process of a group of Latin American women to Salamanca (Spain) from the socio-cultural consideration. Through qualitative interviewing and case study, the research team explored from a gender perspective their migration and adaptation processes: motivations for emigration, the previous expectations, difficulties in the process, as well as the recollection of the diversity of places they occupied in society, regarding to physical spaces, power, participation or communication. The results achieved show a positive perception of their transit, looking for personal and family well-being, despite of the numerous changes they had faced and the difficulties encountered

Diseño y evaluación de un repositorio abierto de recursos didácticos para la enseñanza de la Historia reciente

El presente estudio describe el proceso de creación de un repositorio abierto de recursos didácticos ligados a la enseñanza de la Historia reciente, y su evaluación a través de una intervención con 86 alumnos de cuarto curso de la ESO en dos ciudades. Se detalla la integración de los materiales en un entorno digital, examinando su utilidad a través de un análisis cualitativo. Los resultados indican que el trabajo directo del alumnado con estas fuentes históricas mejora la comprensión de la materia, resultando especialmente motivadores los recursos audiovisuales menos usuales (canciones, concursos y viñetas). Se discute sobre la necesidad de favorecer la difusión y colaboración docente mediante un uso adecuado de los repositorios

The role of gut microbiota in cerebrovascular disease and related dementia.

In recent years, increasing evidence suggests that commensal microbiota may play an important role not only in health but also in disease including cerebrovascular disease. Gut microbes impact physiology, at least in part, by metabolizing dietary factors and host-derived substrates and then generating active compounds including toxins. The purpose of this current review is to highlight the complex interplay between microbiota, their metabolites. and essential functions for human health, ranging from regulation of the metabolism and the immune system to modulation of brain development and function. We discuss the role of gut dysbiosis in cerebrovascular disease, specifically in acute and chronic stroke phases, and the possible implication of intestinal microbiota in post-stroke cognitive impairment and dementia, and we identify potential therapeutic opportunities of targeting microbiota in this context.Instituto de Salud Carlos III (ISCIII), Grant/Award Number: PI20/00535; Leducq Foundation for Cardiovascular Research Grant/Award Numbers: TNE-21CVD04 (MAM, IL), TNE19CVD01 (MAM, MIC), TNE21CVD04, TNE19CVD01; Ministerio de Ciencia e Innovacion (MCIN), Grant/Award Numbers: PID2020-117765RB-I00, PID2019-106581RB-I00; RICORS-ICTUS, Grant/Award Number: RD21/0006/0001.N

High-intensity interval training dosage for heart failure and coronary artery disease cardiac rehabilitation: a systematic review and meta-analyses

Introduction and objectives High-interval intensity training (HIT) has been suggested to improve peak VO2 in cardiac rehabilitation programs. However, the optimal HIT protocol is unknown. The objective of this study was to identify the most effective doses of HIT to optimize peak VO2 in coronary artery disease (CAD) and heart failure (HF) patients. Methods A search was conducted in 6 databases (MEDLINE, Web of Science, LILACS, CINAHL, Academic Search Complete, and SportDiscus). Studies using a HIT protocol in CAD or HF patients and measuring peak VO2 were included. The PEDro Scale and Cochrane Collaboration tools were used. Results Analyses reported significant improvements in peak VO2 after HIT in both diseases (P = .000001), with a higher increase in HF patients (P = .03). Nevertheless, in HF patients, there were no improvements when the intensity recovery was ≤ 40% of peak VO2 (P = .19) and the frequency of training was ≤ 2 d/wk (P = .07). There were significant differences regarding duration in CAD patients, with greater improvements in peak VO2 when the duration was < 12 weeks (P = .05). In HF, programs lasting < 12 weeks did not significantly improve peak VO2 (P = .1). Conclusions The HIT is an effective method for improving peak VO2 in HF and CAD, with a significantly greater increase in HF patients. The recovery intervals should be active and be between 40% and 60% of peak VO2 in HF patients. Training frequency should be ≥ 2 d/wk for CAD patients and ≥ 3 d/wk for HF patients.Actividad Física y Deport

Tutoría y dirección de los Trabajos de Fin de Grado en Derecho

Memoria ID-0111. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2013-2014

Diseño de un modelo de evaluación de seminarios de asignaturas de Derecho Civil

Memoria ID-0100. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2014-2015

Validation of housekeeping genes for quantitative real-time PCR in in-vivo and in-vitro models of cerebral ischaemia

<p>Abstract</p> <p>Background</p> <p>Studies of gene expression in experimental cerebral ischaemia models can contribute to understanding the pathophysiology of brain ischaemia and to identifying prognostic markers and potential therapeutic targets. The normalization of relative qRT-PCR data using a suitable reference gene is a crucial prerequisite for obtaining reliable conclusions. No validated housekeeping genes have been reported for the relative quantification of the mRNA expression profile activated in in-vitro ischaemic conditions, whereas for the in-vivo model different reference genes have been used.</p> <p>The present study aims to determine the expression stability of ten housekeeping genes (Gapdh, β2m, Hprt, Ppia, Rpl13a, Oaz1, 18S rRNA, Gusb, Ywhaz and Sdha) to establish their suitability as control genes for in-vitro and in-vivo cerebral ischaemia models.</p> <p>Results</p> <p>The expression stability of the candidate reference genes was evaluated using the 2^-ΔC'Tmethod and ANOVA followed by Dunnett's test. For the in-vitro model using primary cultures of rat astrocytes, all genes analysed except for Rpl13a and Sdha were found to have significantly different levels of mRNA expression. These different levels were also found in the case of the in-vivo model of pMCAO in rats except for Hprt, Sdha and Ywhaz mRNA, where the expression did not vary. Sdha and Ywhaz were identified by geNorm and NormFinder as the two most stable genes.</p> <p>Conclusion</p> <p>We have validated endogenous control genes for qRT-PCR analysis of gene expression in in-vitro and in-vivo cerebral ischaemia models. For normalization purposes, Rpl13a and Sdha are found to be the most suitable genes for the in-vitro model and Sdha and Ywhaz for the in-vivo model. Genes previously used as housekeeping genes for the in-vivo model in the literature were not validated as good control genes in the present study, showing the need for careful evaluation for each new experimental setup.</p

Unveiling the collaborative effect at the cucurbit[8]urilMoS2 hybrid interface for electrochemical melatonin determination

Host-guest interactions are of paramount importance in supramolecular chemistry and in a wide range of applications. Particularly well known is the ability of cucurbit[n]urils (CB[n]) to selectively host small molecules. We show that the charge transfer and complexation capabilities of CB[n] are retained on the surface of 2D transition metal dichalcogenides (TMDs), allowing the development of efficient electrochemical sensing platforms. We unveil the mechanisms of host-guest recognition between the MoS2- CB[8] hybrid interface and melatonin (MLT), an important molecular regulator of vital constants in vertebrates. We find that CB[8] on MoS2 organizes the receptor portals perpendicularly to the surface, facilitating MLT complexation. This advantageous adsorption geometry is specific to TMDs and favours MLT electro-oxidation, as opposed to other 2D platforms like graphene, where one receptor portal is closed. This study rationalises the cooperative interaction in 2D hybrid systems to improve the efficiency and selectivity of electrochemical sensing platform

Coordinación de la tutorización de los trabajos fin de máster y puesta en común de metodologías de investigación social

Memoria ID12-0160. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2012-2013