Grid'5000: a large scale and highly reconfigurable grid experimental testbed

Large scale distributed systems such as Grids are difficult to study from theoretical models and simulators only. Most Grids deployed at large scale are production plat-forms that are inappropriate research tools because of their limited reconfiguration, control and monitoring capa-bilities. In this paper, we present Grid’5000, a 5000 CPU nation-wide infrastructure for research in Grid computing. Grid’5000 is designed to provide a scientific tool for com-puter scientists similar to the large-scale instruments used by physicists, astronomers, and biologists. We describe the motivations, design considerations, architec-ture, control, and monitoring infrastructure of this experi-mental platform. We present configuration examples and performance results for the reconfiguration subsystem

Place de l'implant dans les vertiges et troubles de l'équilibre des patients implantés cochléaires (Evaluation à long terme et corrèlations clinico-physiologiques)

L'implant cochléaire a bouleversé le pronostic fonctionnel des patients hypoacousiques séveres. Les vertiges font partie des plaintes post-opératoires couramment exprimées. Le rôle de l'implant cochléaire dans ces symptômes et dans la physiologie vestibulaire est mal connu. Notre travail, grace a une étude menée à long terme aprés implantation, a permis de mesurer les plaintes des patients implantés cochléaires. Les plaintes spécifiquement exprimées concernant le fonctionement de l'implant, sont fréquentes mais modérées. Nous avons pu, pour les patients les plus symptomatiques, corréler ces plaintes avec une déviation de la verticale visuelle subjective lors de l extinction de l implant. Par ailleurs, nousdécrivons l'existence de potentiels évoqués myogéniques obtenus par stimulation de l'implant. L existence de tels potentiels n est corrélée à aucune plainte fonctionnelle. Au total, la fonction vestibulaire de base ou la réponse à une stimulation par l'implant n'a aucun caractére prédictif des plaintes fonctionnelles. En revanche, il semble que les patients les plus vertigineux et les moins bien compensés soient plus sensibles aux stimulations par l implant. Ces observations accréditent l idée d une stimulation fréquente, de faible intensité, du nerf vestibulaire par l implant. Cette stimulation semble soumise à compensation et n être symptomatique qu'en cas de fluctuation de la fonction vestibulaire.BREST-BU Médecine-Odontologie (290192102) / SudocSudocFranceF

A new route to trihydroxamate-containing artificial siderophores and synthesis of a new fluorescent probe.

A fluorescent labelled artificial siderophore 1 was synthesized by coupling a 7-nitrobenz-2-oxa-1,3-diazole (NBD) derivative to the terminal amino group of a new trihydroxamate-containing amine 2, a ferrichrome-type siderophore that was obtained from tris(hydroxymethyl) amino methane. Compound I was shown to be a suitable tool for experiments on siderophore transport and uptake processes in various organisms cells and particularly in Candida albicans cells

Folate-equipped pegylated archaeal lipid derivatives: synthesis and transfection properties

International audienc

Grid'5000: a large scale, reconfigurable, controlable and monitorable Grid platform

Grid 2005 held in conjunction with SC'05, the International Conference for High Performance Computing, Networking and Storag

Grid'5000: a large scale, reconfigurable, controlable and monitorable Grid platform

Grid 2005 held in conjunction with SC'05, the International Conference for High Performance Computing, Networking and Storag

Grid'5000: A Large Scale And Highly Reconfigurable Experimental Grid Testbed

International audienceLarge scale distributed systems such as Grids are difficult to study from theoretical models and simulators only. Most Grids deployed at large scale are production platforms that are inappropriate research tools because of their limited reconfiguration, control and monitoring capabilities. In this paper, we present Grid'5000, a 5000 CPU nation-wide infrastructure for research in Grid computing. Grid'5000 is designed to provide a scientific tool for computer scientists similar to the large-scale instruments used by physicists, astronomers, and biologists. We describe the motivations, design considerations, architecture, control, and monitoring infrastructure of this experimental platform. We present configuration examples and performance results for the reconfiguration subsystem

Folate-Equipped Nanolipoplexes Mediated Efficient Gene Transfer into Human Epithelial Cells

Since recombinant viral vectors have been associated with serious side effects, such as immunogenicity and oncogenicity, synthetic delivery systems represent a realistic alternative for achieving efficacy in gene therapy. A major challenge for non-viral nanocarriers is the optimization of transgene expression in the targeted cells. This goal can be achieved by fine-tuning the chemical carriers and the adding specific motifs to promote cellular penetration. Our study focuses on the development of novel folate-based complexes that contain varying quantities of folate motifs. After controlling for their physical properties, neutral folate-modified lipid formulations were compared in vitro to lipoplexes leading to comparable expression levels. In addition, no cytotoxicity was detected, unlike what was observed in the cationic controls. Mechanistically, the delivery of the transgene appeared to be, in part, due to endocytosis mediated by folate receptor targeting. This mechanism was further validated by the observation that adding free folate into the medium decreased luciferase expression by 50%. In vivo transfection with the folate-modified MM18 lipid, containing the highest amount of FA-PEG570-diether co-lipid (w:w; 90:10), at a neutral charge ratio, gave luciferase transgene expression. These studies indicate that modification of lipids with folate residues could enhance non-toxic, cell-specific gene delivery

Doxorubicin Loaded Magnetic Polymersomes: Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy

Hydrophobically modified magnetic nanoparticles (MNPs) were encapsulated within the membrane of poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC-b-PGA) block copolymer vesicles using a nanoprecipitation process. This formulation method provides a high loading of MNPs (up to 70 wt %) together with a good control over the sizes of the vesicles (100 - 400 nm). The deformation of the vesicle membrane under an applied magnetic field was evidenced by anisotropic SANS. These hybrid objects display contrast enhancement properties in Magnetic Resonance Imaging, a diagnostic method routinely used for three-dimensional and non-invasive scans of the human body. They can also be guided in a magnetic field gradient. The feasibility of drug release triggered by magnetic induction was evidenced using the anticancer drug doxorubicin (DOX), which is co-encapsulated in the membrane. Magnetic polymersomes are thus proposed as multimodal drug nanocarriers for bio-imaging and magneto-chemotherapy.FP7 CP-IP 213631-2 NANOTHE