Process of nursing care in a post-operative patient of complete correction of Tetralogy of Fallot. Case study and literature review.

Tetralogy of Fallot is a congenital heart disease cyanotic common in childhood, whose surgical treatment has a high rate of success in the short and long term. Complications of surgical treatment may and should be corrected promptly, being crucial the nursing intervention in the evolution of the patient: sign valuations of right ventricular dysfunction, implementation of interventions for minimize the effects of this dysfunction, collaboration in the treatment of the entity and the constant evaluation of the patient. A case of a patient of 1 year and 5 months, is presented where after a cardiac valuation and an electrocardiogram is diagnosed with Tetralogy of Fallot, and you are subsequently underwent surgery without reporting no complications during the surgery. They were handled several diagnoses nursing, with objectives to be followed and specific interventions carried out according to the presentation of the manifestations of the patient in the study.La Tetralogía de Fallot es una cardiopatía congénita cianógena frecuente en la infancia, cuyo tratamiento quirúrgico presenta alta tasa de éxito a corto y largo plazos. Las complicaciones del tratamiento quirúrgico pueden y deben ser corregidas oportunamente, siendo crucial la intervención de enfermería en la evolución del paciente: valoración de signos de disfunción ventricular derecha, ejecución de intervenciones para minimizar los efectos de dicha disfunción, colaboración en el tratamiento de la entidad y la evaluación constante del paciente. Se presenta un caso de un paciente de 1 año y 5 meses, donde después de una valoración cardiológica y un electrocardiograma se le diagnostica Tetralogía de Fallot, y posteriormente fue intervenido quirúrgicamente sin reportarse ninguna complicación durante la cirugía. Se manejaron diagnósticos de enfermería, con objetivos a seguir e intervenciones específicas que se realizaron de acuerdo con la presentación de las manifestaciones del paciente en estudio

Understanding the local and remote source contributions to ambient O3 during a pollution episode using a combination of experimental approaches in the Guadalquivir valley, southern Spain

The Guadalquivir Valley is one of three major O3 hotspots in Spain. An airborne and surface measurement campaign was carried out from July 9th to 11th, 2019 to quantify the local/regional O3 contributions using experimental approaches. Air quality and meteorology data from surface measurements, a microlight aircraft, a helium balloon, and remote sensing data (TROPOMI-NO2-ESA) were used to obtain the 3D distribution of O3 and various tracer pollutants. O3 accumulation over 2.5 days started with inputs from oceanic air masses transported inland by sea breezes, which drew O3 and its precursors from a local/regional origin to the northeastern end of the basin. The orographic–meteorological setting of the valley caused vertical recirculation of the air masses inside the valley that caused the accumulation by increasing regional background O3 concentration by 25–30 ppb. Furthermore, possible Mediterranean O3 contributions and additional vertical recirculation through the entrainment zone of the convective boundary layer also contributed. Using particulate matter finer than 2.5 μm (PM2.5), ultrafine particles (UFP), and black carbon (BC) as tracers of local sources, we calculated that local contributions increased regional O3 levels by 20 ppb inside specific pollution plumes transported by the breeze into the valley, and by 10 ppb during midday when flying over an area with abundant agricultural burning during the morning. Air masses that crossed the southern boundaries of the Betic system at mid-altitude (400–1850 m a.s.l.) on July 10th and 11th may have provided additional O3. Meanwhile, a decreasing trend at high altitudes (3000–5000 m a.s.l.) was observed, signifying that the impact of stratospheric O3 intrusion decreased during the campaign

Evolution of compact groups from intermediate to final stages: A case study of the HI content of HCG 16

Hickson Compact Group (HCG) 16 is a prototypical compact group of galaxies, apparently in an intermediate stage of evolution, where its galaxies are losing gas to the intra-group medium (IGrM). The wide variety of ongoing process in HCG 16 make it an ideal case study for exploring which processes are likely to dominate the late stages of evolution in compact groups. In order to build a coherent picture of the evolution of this group we make use of the multi-wavelength data available, but focus particularly on HI as a tracer of interactions and evolutionary phase. We reprocess archival VLA L-band data of HCG 16 using the multi-scale CLEAN algorithm to accurately recover diffuse features. Despite the clear disruption of the HI component of HCG 16 we find that it is not globally HI deficient, even though HCG 16a and b have lost the majority of their HI and almost 50% of the group's HI is in the IGrM, including a 160 kpc long tail extending towards the SE. This study indicates that in the recent past (~1 Gyr) galaxies HCG 16a and b likely underwent major interactions that unbound gas without triggering significant star formation. This gas was then swept away by a high speed, close encounter with NGC 848. The starburst events HCG 16c and d have triggered galactic winds which, in the case of HCG 16d, appears to have disrupted its HI reservoir. The tidal features still connected to these galaxies indicate that more HI will soon be lost to the IGrM, while that which remains in the discs will likely be consumed by star formation episodes. This is expected to result in a collection of gas-poor galaxies embedded in a diffuse HI structure, which will gradually be evaporated by the UV background, resembling the final stage of the evolutionary model of compact groups. This work is accompanied by a complete workflow to reproduce the final data products, intended to improve reproducibility. (Abridged)Comment: Accepted for publication in A&A, 35 pages, 18 figure

Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas

<p>Abstract</p> <p>Background</p> <p>Gliomas are the most common type of primary brain tumours, and in this group glioblastomas (GBMs) are the higher-grade gliomas with fast progression and unfortunate prognosis. Two major aspects of glioma biology that contributes to its awful prognosis are the formation of new blood vessels through the process of angiogenesis and the invasion of glioma cells. Despite of advances, two-year survival for GBM patients with optimal therapy is less than 30%. Even in those patients with low-grade gliomas, that imply a moderately good prognosis, treatment is almost never curative. Recent studies have demonstrated the existence of a small fraction of glioma cells with characteristics of neural stem cells which are able to grow <it>in vitro </it>forming neurospheres and that can be isolated <it>in vivo </it>using surface markers such as CD133. The aim of this study was to define the molecular signature of GBM cells expressing CD133 in comparison with non expressing CD133 cells. This molecular classification could lead to the finding of new potential therapeutic targets for the rationale treatment of high grade GBM.</p> <p>Methods</p> <p>Eight fresh, primary and non cultured GBMs were used in order to study the gene expression signatures from its CD133 positive and negative populations isolated by FACS-sorting. Dataset was generated with Affymetrix U133 Plus 2 arrays and analysed using the software of the Affymetrix Expression Console. In addition, genomic analysis of these tumours was carried out by CGH arrays, FISH studies and MLPA;</p> <p>Results</p> <p>Gene expression analysis of CD133+ vs. CD133- cell population from each tumour showed that CD133+ cells presented common characteristics in all glioblastoma samples (up-regulation of genes involved in angiogenesis, permeability and down-regulation of genes implicated in cell assembly, neural cell organization and neurological disorders). Furthermore, unsupervised clustering of gene expression led us to distinguish between two groups of samples: those discriminated by tumour location and, the most importantly, the group discriminated by their proliferative potential;</p> <p>Conclusions</p> <p>Primary glioblastomas could be sub-classified according to the properties of their CD133+ cells. The molecular characterization of these potential stem cell populations could be critical to find new therapeutic targets and to develop an effective therapy for these tumours with very dismal prognosis.</p

Unveiling the environment and faint features of the isolated galaxy CIG 96 with deep optical and HI observations

Asymmetries in HI in galaxies are often caused by the interaction with close companions, making isolated galaxies an ideal framework to study secular evolution. The AMIGA project has demonstrated that isolated galaxies show the lowest level of asymmetry in their HI integrated profiles, yet some present significant asymmetries. CIG 96 (NGC 864) is a representative case reaching a 16% level. Our aim is to investigate the HI asymmetries of this spiral galaxy and what processes have triggered the star-forming regions observed in the XUV pseudoring. We performed deep optical observations at CAHA 1.23m, 2.2m and VST telescopes. We reach surface brightness (SB) limits of mu_2.2m = 27.5 mag arcsec-2 (Cous R) and mu_VST = 28.7mag arcsec-2 (r) that show the XUV pseudoring of the galaxy in detail. Additionally, a wavelet filtering of the HI data cube from our deep observations with E/VLA telescope allowed us to reach a column density of N_HI = 8.9x10^18 cm -2 (5sigma) (28"x28" beam), lower than in any isolated galaxy. We confirm that the HI extends farther than 4xr_25 in all directions. Furthermore, we detect for the first time two gaseous structures (10^6 Msol) in the outskirts. The g-r colour index image from 1.23m shows extremely blue colours in certain regions of the pseudoring where N_HI>8.5x10^20 cm-2 , whereas the rest show red colours. Galactic cirrus contaminate the field, setting an unavoidable detection limit at 28.5mag arcsec-2 (r). We detect no stellar link within 1degx1deg or gaseous link within 40'x40' between CIG 96 and any companion. The isolation criteria rule out interactions with other similar-sized galaxies for at least 2.7Gyr. Using existing stellar evolution models, the age of the pseudoring is estimated at 1Gyr or older. Undetected previously accreted companions and cold gas accretion remain as the main hypothesis to explain the optical pseudoring and HI features of CIG 96.Comment: 23 pages, 18 figures, 4 table

Comprehensive analysis via exome sequencing uncovers genetic etiology in autosomal recessive nonsyndromic deafness in a large multiethnic cohort

Purpose:Autosomal recessive nonsyndromic deafness (ARNSD) is characterized by a high degree of genetic heterogeneity, with reported mutations in 58 different genes. This study was designed to detect deafness-causing variants in a multiethnic cohort with ARNSD by using whole-exome sequencing (WES).Methods:After excluding mutations in the most common gene, GJB2, we performed WES in 160 multiplex families with ARNSD from Turkey, Iran, Mexico, Ecuador, and Puerto Rico to screen for mutations in all known ARNSD genes.Results:We detected ARNSD-causing variants in 90 (56) families, 54 of which had not been previously reported. Identified mutations were located in 31 known ARNSD genes. The most common genes with mutations were MYO15A (13), MYO7A (11), SLC26A4 (10), TMPRSS3 (9), TMC1 (8), ILDR1 (6), and CDH23 (4). Nine mutations were detected in multiple families with shared haplotypes, suggesting founder effects.Conclusion:We report on a large multiethnic cohort with ARNSD in which comprehensive analysis of all known ARNSD genes identifies causative DNA variants in 56 of the families. In the remaining families, WES allows us to search for causative variants in novel genes, thus improving our ability to explain the underlying etiology in more families.Genet Med 18 4, 364-371. © American College of Medical Genetics and Genomics

Modificación del riesgo de inundación de Girona por el crecimiento de la isla del Ter

Se describe el crecimiento de cota y de la vegetación en una isla fluvial en Girona, en la confluencia de los ríos Onyar y Ter. Este hecho se relaciona con la regulación del río Ter con presas de embalses desde 1968. Se prueba la influencia de este crecimiento en los niveles de avenida que afectan a Girona por medio de un modelo hidrodinámico 1D. Con un cálculo integrado de transporte sólido se justifica el crecimiento de la isla en los últimos años y su evolución futura

Modificación del riesgo de inundación de Girona por el crecimiento de la Isla del Ter

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