Actualización de la enfermedad renal crónica en la especie canina

La enfermedad renal crónica (ERC) se define como la presencia de anormalidades estructurales o funcionales en uno u ambos riñones, durante al menos tres meses y con repercusiones para la salud. Está considerada como una de las patologías con mayor importancia en la clínica de pequeños animales y presenta una elevada prevalencia en la población canina. La etiología de la ERC puede ser congénita, adquirida o idiopática, y, en lo que respecta a su cuadro clínico, la poliuria-polidipsia se presenta con una alta frecuencia. No obstante, también pueden aparecer otras manifestaciones como anorexia, vómitos, diarreas, hipertensión arterial, palidez de mucosas, debilidad, mal aspecto del pelo o desorientación, dependiendo de la situación específica de cada enfermo. El diagnóstico precoz y la clasificación de su estadio son necesarios para establecer un plan terapéutico adecuado y eficaz. Gracias a los avances en la investigación sobre estos aspectos, el pronóstico de la ERC está mejorando considerablemente y, en consecuencia, la calidad de vida de nuestros pacientes.<br /

Improving Cell Outage Management Through Data Analysis

Self-Organizing Networks (SON) is an important feature for network management automation in the new generation of mobile communications. While SON have been considered as part of the recent 3rd Generation Partnership Project (3GPP) standards such as Long Term Evolution (LTE), it is expected that next 5th Generation (5G) mobile networks present new challenges for SON solutions. One of the most important use cases in Self-Healing is Cell Outage Compensation (COC). This paper proposes an important improvement of COC function based on analyzing large real data sets from live networks in order to adapt compensation to the real neighboring context. First, two methods (offline and online) to classify outages depending on the degraded metrics in neighboring cells are proposed and results for a set of cell outages occurred in a live LTE network are presented. Second, a method for estimating the lost traffic due to cell outages is proposed in order to quantify the load that cannot be intrinsically absorbed by neighboring cells. Finally, a novel COC methodology is proposed by taking into account the results obtained in the two previous studies

Adaptive Cell Outage Compensation in Self-Organizing Networks.

Within Self-Organizing Networks (SON), the Cell Outage Compensation (COC) functionality is one of the most important use cases in Self-Healing in mobile communication networks. The state-of-the-art has proposed different COC techniques, each of them to be indistinctly applied to all cells in outage. Conversely, this paper presents an important improvement of the COC function by adapting different COC strategies to different cell outage situations. With this objective, a novel COC methodology is proposed. When a cell outage occurs in a network, a detailed analysis of the faulty situation is carried out. The result of this analysis allows to classify the degradation produced by the cell outage in the neighboring cells. Depending on this degradation, different COC algorithms should be applied to each affected neighboring cell. In addition, as another contribution, some COC algorithms based on handover parameters modifications have been applied to a cell outage compensation problem. Results have shown that, by adapting the strategy to the outage impact on neighboring cells, the proposed method outperforms classic strategies

High Mutational Heterogeneity, and New Mutations in the Human Coagulation Factor V Gene. Future Perspectives for Factor V Deficiency Using Recombinant and Advanced Therapies

Enfermedad de Owren; Análisis de mutaciones; ParahemofiliaMalaltia d'Owren; Anàlisi de mutacions; ParahemofíliaOwren’s disease; Mutation analysis; ParahemophiliaFactor V is an essential clotting factor that plays a key role in the blood coagulation cascade on account of its procoagulant and anticoagulant activity. Eighty percent of circulating factor V is produced in the liver and the remaining 20% originates in the α-granules of platelets. In humans, the factor V gene is about 80 kb in size; it is located on chromosome 1q24.2, and its cDNA is 6914 bp in length. Furthermore, nearly 190 mutations have been reported in the gene. Factor V deficiency is an autosomal recessive coagulation disorder associated with mutations in the factor V gene. This hereditary coagulation disorder is clinically characterized by a heterogeneous spectrum of hemorrhagic manifestations ranging from mucosal or soft-tissue bleeds to potentially fatal hemorrhages. Current treatment of this condition consists in the administration of fresh frozen plasma and platelet concentrates. This article describes the cases of two patients with severe factor V deficiency, and of their parents. A high level of mutational heterogeneity of factor V gene was identified, nonsense mutations, frameshift mutations, missense changes, synonymous sequence variants and intronic changes. These findings prompted the identification of a new mutation in the human factor V gene, designated as Jaén-1, which is capable of altering the procoagulant function of factor V. In addition, an update is provided on the prospects for the treatment of factor V deficiency on the basis of yet-to-be-developed recombinant products or advanced gene and cell therapies that could potentially correct this hereditary disorder.This study was supported by the Andalusian Association of Hemophilia (ASANHEMO FV 2016–20 grant) and Octapharma S.A. (OCPH-2019-20 grant)

Ecuaciones lineales con una incógnita

Esta cartilla pertenece a la serie Unidades didácticas en Educación Matemática de “una empresa docente” (Facultad de Educación, Universidad de los An des) y ediciones SM. Propone el diseño de una unidad didáctica con el que se busca contribuir al aprendizaje de la solución de ecuaciones lineales con una incógnita. Para ello, la cartilla presenta el material que el profesor de matemáticas de educación media requiere para implementar la unidad didáctica en el aula. La cartilla fue elaborada por los grupos 2 y 3 de la primera promoción de la maestría en Educación Matemática de la Universidad de los Andes. La cartilla se compone de cuatro partes. La primera presenta los aspectos que el pro fesor debe tener en cuenta antes de implementar las tareas propuestas en la unidad didáctica. La segunda contiene los objetivos de aprendizaje propuestos para los estu diantes y la metodología sugerida al profesor. La tercera describe la fundamentación y secuencia de tareas que conforman la unidad didáctica, e incluye el material foto copiable para los estudiantes. Por último, se indican sugerencias para evaluar a los estudiantes y se presentan pautas para identi car su nivel de desempeño y determinar el logro de los objetivos de aprendizaje. La secuencia de tareas busca contribuir a que los estudiantes utilicen el lenguaje alge braico para traducir enunciados y plantear ecuaciones lineales, al aplicar las nociones de equilibrio e igualdad en diferentes sistemas de representación; desarrollen el algo ritmo para la solución de ecuaciones; y reconozcan y utilicen las ecuaciones lineales como herramienta para la solución de problemas. Las tareas están elaboradas para ser implementadas con estudiantes de grado octavo de educación básica. El diseño surge de la necesidad de contribuir al logro del estándar curricular “construyo expresiones algebraicas equivalentes a una expresión dada”

Evaluación de mecanismos de pago por servicios ambientales en la provincia de Loja y su relación con los planes de desarrollo local.

Los incentivos financieros-legales para promover mecanismos de pago por servicios ambientales – PSA son instrumentos nuevos, existe experiencia en muchas partes del mundo, que señalan que estos procesos solo pueden funcionar con una buena gobernanza basada en sistemas: políticos, legislativos, económicos, técnicos, ambientales, socioculturales e institucionales eficaces.&nbsp; Para apoyar la valoración de los servicios ambientales para que sean considerados en los PDOT de los GADs de la Provincia de Loja, se evaluaron iniciativas de pago por servicios ambientales en la Provincia de Loja, mediante evidencia bibliográfica, social e historia, a través de entrevistas a actores claves y aplicación de instrumentos de evaluación y sistematización de los resultados; y se generó una propuesta de inclusión de pago de los servicios ambientales mediante el establecimiento de pautas conceptuales, metodologías, técnicas e institucionales para la redacción de una propuesta; la cual sea incluida en los PDOT de los GADs de la Provincia de Loja. La propuesta de pago por servicio ambiental establecida tiene un esquema que consta de antecedentes, visión, objetivos, los servicios ambientales, programas y proyectos a implementar, articulación con instrumentos actuales, estructura de un esquema de PSA, estructura de una acuerdo o convenio y gobernanza; pero se debe entender que no es el único esquema, este va a depender de cada uno de los contextos que presente en la provincia, de las características y problema ambientales que se desarrolle

Field evaluation of a 4G “True-IP” network

This article presents field evaluation results of an IP-based architecture for heterogeneous environments, covering UMTS- like TD-CDMA (Time Division-Code Division Multiple Access) wireless access technology, wireless and wired LANs, that has been developed under the aegis of the IST Moby Dick project. The architecture treats all transmission capabilities as basic physical and data-link layers, and attempts to replace all higher-level tasks by IP-based strategies. The Moby Dick architecture incorporates mobile-IPv6, fast handover, AAA-control (Authentication, Authorization, Accounting), Charging and Quality of Service. The architecture allows for an optimized control on the radio link layer resources. The Moby Dick architecture has been implemented and was evaluated on field trials with multiple services

Circulating miRNAs as predictive biomarkers of type 2 diabetes mellitus development in coronary heart disease patients fromt he CORDIOPREV study

Circulating microRNAs (miRNAs) have been proposed as type 2 diabetes biomarkers, and they may be a more sensitive way to predict development of the disease than the currently used tools. Our aim was to identify whether circulating miRNAs, added to clinical and biochemical markers, yielded better potential for predicting type 2 diabetes. The study included 462 non-diabetic patients at baseline in the CORDIOPREV study. After a median follow-up of 60 months, 107 of them developed type 2 diabetes. Plasma levels of 24 miRNAs were measured at baseline by qRT-PCR, and other strong biomarkers to predict diabetes were determined. The ROC analysis identified 9 miRNAs, which, added to HbA1c, have a greater predictive value in early diagnosis of type 2 diabetes (AUC = 0.8342) than HbA1c alone (AUC = 0.6950). The miRNA and HbA1cbased model did not improve when the FINDRISC was included (AUC = 0.8293). Cox regression analyses showed that patients with low miR-103, miR-28-3p, miR-29a, and miR-9 and high miR-30a-5p and miR-150 circulating levels have a higher risk of disease (HR = 11.27; 95% CI = 2.61–48.65). Our results suggest that circulating miRNAs could potentially be used as a new tool for predicting the development of type 2 diabetes in clinical practice

Impact of coronavirus syndromes on physical and mental health of health care workers: Systematic review and meta-analysis

Background: Health care workers (HCW) are at high risk of developing physical/mental health outcomes related to coronavirus syndromes. Nature and frequency of these outcomes are undetermined. Methods: PRISMA/MOOSE-compliant (PROSPERO-CRD42020180205) systematic review of Web of Science/grey literature until 15th April 2020, to identify studies reporting physical/mental health outcomes in HCW infected/exposed to Severe Acute Respiratory Syndrome -SARS-, Middle East Respiratory Syndrome -MERS-, Novel coronavirus -COVID-19-. Proportion random effect meta-analyses, I2 statistic, quality assessment and sensitivity analysis. Results: 115 articles were included (n=60,458 HCW, age 36.1±7.1, 77.1% female). Physical health outcomes: 75.9% HCW infected by SARS/MERS/COVID-19 reported fever (95%CI=65.9–83.7%, k=12, n=949), 47.9% cough (95%CI=39.2–56.8%, k=14, n=970), 43.6% myalgias (95%CI=31.9–56.0%, k=13, n=898), 42.3% chills (95%CI=20.2–67.9%, k=7, n=716), 41.2% fatigue (95%CI=18.2–68.8%, k=6, n=386), 34.6% headaches (95%CI=23.1–48.2%, k=11, n=893), 31.2% dyspnoea (95%CI=23.2–40.5%, k=12, n=1003), 25.3% sore throat (95%CI=18.8–33.2%, k=8, n=747), 22.2% nausea/vomiting (95%CI=14.9–31.8%, k=6, n=662), 18.8% diarrhoea (95%CI=11.9–28.4%, k=9, n=824). Mental health outcomes: 62.5% HCW exposed to SARS/MERS/COVID-19 reported general health concerns (95%CI=57.0–67,8%, k=2, n=2254), 43.7% fear (95%CI=33.9–54.0%, k=4, n=584), 37.9% insomnia (95%CI=30.9–45.5%, k=6, n=5067), 37.8% psychological distress (95%CI=28.4–48.2%, k=15, n=24,346), 34.4% burnout (95%CI=19.3–53.5%, k=3, n=1337), 29.0% anxiety features (95%CI=14.2–50.3%, k=6, n=9191), 26.3% depressive symptoms (95%CI=12.5–47.1%, k=8, n=9893), 20.7% post-traumatic stress disorder features (95%CI=13.2–31%, k=11, n=3826), 16.1% somatisation (95%CI=0.2–96.0%, k=2, n=2184), 14.0% stigmatisation feelings (95%CI=6.4–28.1%, k=2, n=411). Limitations: Limited amount of evidence for some outcomes and suboptimal design in several studies included. Conclusions: SARS/MERS/COVID-19 have a substantial impact on the physical and mental health of HCW, which should become a priority for public health strategies