SFDL: MVC Applied to Workflow Design

Process management based on workflow systems is a growing trend in collaborative environments. One of the most notorious areas of improvement is that of user interfaces, especially since business process definition languages do not address efficiently the point of contact between workflow engines and human interactions. With that in focus, we propose the MVC pattern design to workflow systems. To accomplish this, we have designed a new dynamic view definition language called SFDL, oriented towards the easy interoperability with the different workflow definition languages, while maintaining enough flexibility to be represented in different formats and being adaptable to several environments. To validate our approach, we have carried out an implementation in a real banking scenario, which has provided continuous feedback and enabled us to refine the proposal. The work is fully based on widely accepted and used web standards (XML, YAML, JSON, Atom and REST). Some guidelines are given to facilitate the adoption of our solution

Centro de producción deportiva extrema

Trabajo de gradoEl centro de producción deportiva extrema, se propone como un elemento espacial, transformador y re activador del des uso en oportunidad, para reconciliar la Zona Industrial con la ciudad sustentando una rentabilidad social deportiva que valora a los niños, jóvenes y adultos, para buenos hábitos deportivos donde descargar la energía, y den inicio a la creación de mercados en el ambiente deportivo.PregradoArquitect

Effect of ketotifen fumarate on experimental autoimmune orchitis and torsion of the spermatic cord

The aim of this work was to study effects of ketotifen fumarate (KF) on prevention of tissue damage in testes of rats with experimental autoimmune orchitis (EAO) and on the contralateral testis in a model of prolonged testicular cord torsion (TCT). Rats with EAO or TCT were injected intraperitoneally once daily with KF or saline solution (vehicle group). Incidence and severity of testicular damage were evaluated by histopathology using an EAO score or a Johnsen score. Mast cells (MC) were identified by histochemistry and quantified. In EAO model, KF significantly reduced severity of histopathological testicular damage compared to rats in the vehicle group. KF also reduced the number of testicular MC compared to vehicle group. Similarly, in TCT model, multifocal damage of the contralateral testis was observed 30 days after testicular torsion characterized by sloughing of the germinal epithelium, seminiferous tubule atrophy, and interstitial edema. Focal signs of inflammation and fibrosis of seminiferous tubular walls were also observed. In contrast, sections of contralateral testis of rats injected with KF and killed 30 days after surgery showed normal histological features. A significant decrease in the number of MC was observed in rats treated with KF compared to untreated animals. In conclusion, we demonstrated that treatment with KF reduced testicular inflammatory process and MC infiltrates in both EAO and TCT models. The results suggest a promising treatment for infertile male patients with testicular pathologies associated with inflammation and germ cell loss.Fil: Moreno, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Sobarzo, Cristian Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Lustig, Livia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Rodriguez Peña, Marcelo Javier. Ministerio de Defensa. Ejercito Argentino. Hospital Militar Campo de Mayo Cirujano Primero Doctor Juan Madera; ArgentinaFil: Guazzone, Vanesa Anabella. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentin

Maximal functions and the control of weighted inequalities for the fractional integral operator

We study weak-type (1, 1) weighted inequalities for the fractional integral operator Iα. We show that the fractional maximal operator Mα controls these inequalities when the weight is radially decreasing. However, we exhibit some counterexamples which show that Mα is not appropriate for this control on general weights. We do provide, nevertheless, some positive results related to this problem by considering other suitable maximal functions

Application of the liposuction techniques and principles in specific body areas and pathologies

The buttocks have been a symbol of attraction, sexuality and eroticism since ancient times and therefore, they have an important role in defining the posterior body contour. More and more people are talking about and understand the meaning and the role that buttocks play in modeling and physical beauty. The three dimensional gluteoplasty (3-DGP) is an innovative technique that allows us to change volume, shape and firmness, not only in the buttocks but also in the adjacent regions such as the thighs and trochanters, becoming an ideal tool to answer the frequent reasons of consultation of our patients about this particular area of the body: ..

Host-Specific Enzyme-Substrate Interactions in SPM-1 Metallo-beta-Lactamase are Modulated by Second Sphere Residues

Pseudomonas aeruginosa is one of the most virulent and resistant non-fermenting Gram-negative pathogens in the clinic. Unfortunately, P. aeruginosa has acquired genes encoding metallo-beta-lactamases (MBLs), enzymes able to hydrolyze most beta-lactam antibiotics. SPM-1 is an MBL produced only by P. aeruginosa, while other MBLs are found in different bacteria. Despite similar active sites, the resistance profile of MBLs towards beta-lactams changes from one enzyme to the other. SPM-1 is unique among pathogen-associated MBLs in that in that it contains "atypical" second sphere residues (S84, G121). Codon randomization on these positions and further selection of resistance-conferring mutants was performed. MICs, periplasmic enzymatic activity, Zn(II) requirements, and protein stability was assessed. Our results indicated that identity of second sphere residues modulates the substrate preferences and the resistance profile of SPM-1 expressed in P. aeruginosa. The second sphere residues found in wild type SPM-1 give rise to a substrate selectivity that is observed only in the periplasmic environment. These residues also allow SPM-1 to confer resistance in P. aeruginosa under Zn(II)-limiting conditions, such as those expected under infection. By optimizing the catalytic efficiency towards beta-lactam antibiotics, the enzyme stability and the Zn(II) binding features, molecular evolution meets the specific needs of a pathogenic bacterial host by means of substitutions outside the active site.Fil: Gonzalez, Lisandro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Moreno, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Bonomo, Robert A.. Case Western Reserve University; Estados UnidosFil: Vila, Alejandro Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentin

SFDL: Definición de Vistas Dinámicas Optimizada para Flujos de Trabajo

La gestión de procesos basada en sistemas de work flow es una tendencia creciente en los entornos colaborativos. Así, cualquier optimización en las tecnologías que facilitan dicha labor, como los flujos de trabajo (work flows), multiplica los beneficios aportados a la colaboración entre individuos. Con el objetivo de mejorar las técnicas de work flow se ha diseñado un nuevo lenguaje de definición de vistas dinámicas denominado SFDL, orientado a la adaptabilidad en distintos entornos, con representaciones en diferentes formatos y pensado para su fácil integración en distintas arquitecturas. Para la validación del diseño expuesto se ha llevado a cabo su implementación en un escenario real, recibiendo realimentación y refinando las especificaciones. El trabajo se ha basado en el uso de estándares ampliamente usados en el ámbito web (XML, YAML, JSON, Atom y REST). Además, en el presente artículo se dan directrices que facilitan la adopción de la solución Palabras Clave- Flujo de trabajo (workflow), SFDL, trabajo colaborativo, interfaz de usuario (user interface

Streetlight Control System Based on Wireless Communication over DALI Protocol

Public lighting represents a large part of the energy consumption of towns and cities. Efficient management of public lighting can entail significant energy savings. This work presents a smart system for managing public lighting networks based on wireless communication and the DALI protocol. Wireless communication entails significant economic savings, as there is no need to install new wiring and visual impacts and damage to the facades of historical buildings in city centers are avoided. The DALI protocol uses bidirectional communication with the ballast, which allows its status to be controlled and monitored at all times. The novelty of this work is that it tackles all aspects related to the management of public lighting: a standard protocol, DALI, was selected to control the ballast, a wireless node based on the IEEE 802.15.4 standard with a DALI interface was designed, a network layer that considers the topology of the lighting network has been developed, and lastly, some user-friendly applications for the control and maintenance of the system by the technical crews of the different towns and cities have been developed

Causes of mortality among adults with Down syndrome before and after the COVID-19 pandemic in Spain

Background: The life expectancy of people with Down syndrome (DS) is limited by Alzheimer's disease (AD)-related deaths, mainly due to respiratory infections. The emergence of the COVID-19 pandemic could have changed known, past trends in mortality in this population. We analysed the differences in causes of mortality between individuals with DS deceased before and after the onset of the pandemic. Method: This is a cross-sectional study of adults with DS recruited at a tertiary, university outpatient clinic in Madrid, Spain. Demographic and clinical data were retrospectively collected from their medical records, including information on their deaths, if any. Results: Five hundred seventy-two adults were included in the study, and 67 (11.7%) died. The main cause of death was respiratory infections, which occurred in 36 participants [9 (45.0%) before, and 27 (58.7%) after the appearance of COVID-19]. No significant differences were found in the determinants of pre-pandemic and post-pandemic death after adjusting for age and AD, except for an association between the use of psychotropic medication and death in the post-pandemic period (odds ratio: 2.24; 95% confidence interval: 1.04–4.82). Vaccination against COVID-19 showed a marked protective effect against mortality (odds ratio: 0.0002; 95% confidence interval: 6.7e10−6 to 0.004). Conclusions: The appearance of COVID-19 has not impacted the overall trend of increase in mean age of death of adults with DS in our milieu, probably thanks to the very important protective effect of vaccination, which supports prioritising people with DS in future immunisation campaigns. The association between psychotropic medication use and mortality requires further explorationThis work was supported by a grant to Beatriz Sánchez (grant no. 2021b-2088) and Diego Real de Asúa (grant no. 2021a-2069) from the Fondation Jérôme Lejeun

Estudio de un sistema integral de generación eléctrica fotovoltaica conectado a la red de la Facultad de Educación Ciencia y Tecnología de la Universidad Técnica del Norte, e implementar un modelo demostrativo con acumulación de energía en el Taller de Ingeniería en Mantenimiento Eléctrico durante el año 2012

Realizar el estudio de un sistema integral de generación eléctrica fotovoltaica conectado a la red para la Facultad de Educación Ciencia y Tecnología de la Universidad Técnica del Norte en el año 2012. Implementar un modelo demostrativo con un sistema de acumulación de energía en el taller de electricidad de la carrera Ingeniería en Mantenimiento Eléctrico.El presente estudio investigativo, está diseñado con la finalidad de realizar un estudio de un sistema integral de generación eléctrica fotovoltaica conectado a la red para la Facultad de Educación Ciencia y Tecnología de la Universidad Técnica del Norte, e implementa un modelo demostrativo con acumulación de energía en el taller de Ingeniería en Mantenimiento Eléctrico para consolidar los conocimientos de las nuevas tendencias energéticas que se pueden adaptar a nuestro medio y contribuir en la preservación del ecosistema como es el compromiso de nuestra casona universitaria, de ahí que de acuerdo al presente estudio existen los aspectos favorables para la implementación del proyecto. El primer capítulo está enfocado a la ejecución de un diagnóstico situacional de cómo encontrar las nuevas alternativas energéticas que a futuro remplazaran a la tipo convencional que hoy utilizamos, este estudio permitirá conocer la situación real del problema, sus causas y consecuencias que ayudará a definir el problema. En el segundo capítulo se desarrolla el marco teórico, realizado a través de fuentes de información secundaria, en base a libros, textos, revistas, periódicos y páginas de internet; así también se ha tomado en cuenta documentos de instituciones involucradas en la investigación, con ello se ha determinado los fundamentos científicos de la misma. En el tercer capítulo se definen los tipos de investigación, métodos y técnicas que contribuyeron al cumplimiento de los objetivos planteados en el proyecto, en el cuarto capítulo se realizó un análisis de la demanda energética de la FECYT encontrando aquí la iniciativa para el diseño de la propuesta además se realizó el procesamiento de datos de radiación y heliófila. El capítulo quinto abarca las conclusiones y posteriormente las recomendaciones que se perfilan a la solución del problema. El capítulo seis detalla la propuesta tecnológica de solución que se plantea como alternativa al problema formulado en el capítulo I. Además describe cada uno de los materiales que son parte de la implementación del demo que se ejecutó y por ultimo quedan todos los anexos como son bibliografía, diagrama unifilar y fotografías del proyecto