Inertial Measurement Units (IMUs) in Drowning Prevention: An Exploratory Study

The use of inertial measurement unit (IMUs) sensors in competitive swimming movement analysis has become increasingly popular but has not been applied to measuring water competencies related to drowning prevention. This study explored the potential use of IMU sensors in three simulated water competency activities in a pool environment. Participants were a subset (n = 12) of a cohort of students (n = 37) taking part in the Can You Swim in Clothes? project. Participants undertook a swim for speed test over 25 m, a distance swim of 5-min duration, and a flotation test, also for 5 min, wearing swimwear and again in lightweight street clothing while wearing an IMU to measure leg acceleration forces. Results showed that clothing impeded swimming sprint speed and distance but not flotation. Authors suggest further research with regard to IMU placement, appropriate survival activities, and measurement protocols and recommend the need for expanded future IMU use

the Psychology of Breakup Sex: Exploring the Motivational Factors and Affective Consequences of Post-breakup Sexual Activity

Popular culture has recently publicized a seemingly new postbreakup behavior called breakup sex. While the media expresses the benefits of participating in breakup sex, there is no research to support these claimed benefits. The current research was designed to begin to better understand this postbreakup behavior. In the first study, we examined how past breakup sex experiences made the individuals feel and how people predict they would feel in the future (n = 212). Results suggested that men are more likely than women to have felt better about themselves, while women tend to state they felt better about the relationship after breakup sex. The second study (n = 585) investigated why men and women engage in breakup sex. Results revealed that most breakup sex appears to be motivated by three factors: relationship maintenance, hedonism, and ambivalence. Men tended to support hedonistic and ambivalent reasons for having breakup sex more often than women. The two studies revealed that breakup sex may be differentially motivated (and may have different psychological consequences) for men and women and may not be as beneficial as the media suggests

Mining drives extensive deforestation in the Brazilian Amazon

Mining poses significant and potentially underestimated risks to tropical forests worldwide. In Brazil\u27s Amazon, mining drives deforestation far beyond operational lease boundaries, yet the full extent of these impacts is unknown and thus neglected in environmental licensing. Here we quantify mining-induced deforestation and investigate the aspects of mining operations, which most likely contribute. We find mining significantly increased Amazon forest loss up to 70 km beyond mining lease boundaries, causing 11,670 km2 of deforestation between 2005 and 2015. This extent represents 9% of all Amazon forest loss during this time and 12 times more deforestation than occurred within mining leases alone. Pathways leading to such impacts include mining infrastructure establishment, urban expansion to support a growing workforce, and development of mineral commodity supply chains. Mining-induced deforestation is not unique to Brazil; to mitigate adverse impacts of mining and conserve tropical forests globally, environmental assessments and licensing must considered both on- and off-lease sources of deforestation

The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation

We thank Cowen lab members for helpful discussions. We also thank David Rogers (University of Tennessee) for sharing microarray analysis of the CAS5 homozygous mutant, and Li Ang (University of Macau) for assistance in optimizing the ChIP-Seq experiments. J.L.X. is supported by a Canadian Institutes of Health Research Doctoral award and M.D.L. is supported by a Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust 096072). B.T.G. holds an Ontario Graduate Scholarship. C.B. and B.J.A. are supported by the Canadian Institutes of Health Research Foundation Grants (FDN-143264 and -143265). D.J.K. is supported by a National Institute of Allergy and Infectious Diseases grant (1R01AI098450) and J.D.L.C.D. is supported by the University of Rochester School of Dentistry and Medicine PREP program (R25 GM064133). A.S. is supported by the Creighton University and the Nebraska Department of Health and Human Services (LB506-2017-55). K.H.W. is supported by the Science and Technology Development Fund of Macau S.A.R. (FDCT; 085/2014/A2). L.E.C. is supported by the Canadian Institutes of Health Research Operating Grants (MOP-86452 and MOP-119520), the Natural Sciences and Engineering Council (NSERC) of Canada Discovery Grants (06261 and 462167), and an NSERC E.W.R. Steacie Memorial Fellowship (477598).Peer reviewedPublisher PD

Evaluación de la prevención y factores asociados al control de enfermedades de transmisión sexual en adolescente.

The related sexually transmitted disease in adolescents has an atypical compartment in the incidence of case reports of diseases at an early age, affecting men and women of sexually active ages, affecting quality of life, and physical and mental well-being. The objective of this research was to describe factors associated with STDs in this age group and how the repercussions of these decisions develop. The methodology is oriented towards an updated systematic review of a scientific nature based on academic literature in relation to the importance of sexually transmitted diseases for adolescents. Based on the results, 20 articles were evidenced for the study variables on the evaluation of prevention and factors of sexual transmission in adolescents, which was followed up for a rigorous analysis. The study of sexually transmitted diseases is very important; as well as sexual behaviors, and the predisposing risks for its acquisition, as well as contracting unwanted pregnancies; Sex education is the best preventive measure in order to raise awareness among the youth population about the importance of having a sexual act.La enfermedad de transmisión sexual relacionada en adolescentes tiene un compartimento atípico en la incidencia de reportes de casos de enfermedades a temprana edad afectando a hombres y mujeres en edades sexualmente activas, repercutiendo en la calidad de vida, y el bienestar físico y mental. El objetivo de la presente investigación fue describir factores asociados a las ETS en este grupo etario y como se desarrolla la repercusión de dichas decisiones. La metodología se orienta a una revisión sistemática actualizada de carácter científico en base a literatura académica en relación a la importancia de las enfermedades de trasmisión sexual para los adolescentes. En base a los resultados, se evidencio 20 artículos para las variables de estudio sobre la evaluación de la prevención y factores de transmisión sexual en adolescentes, se hizo seguimiento de aquello para un análisis riguroso. Es muy importante el estudio de las enfermedades de transmisión sexual; así como las conductas sexuales, y los riesgos predisponentes para su adquisición, así mismo el contraer embarazos no deseados; la educación sexual es la mejor medida preventiva con la finalidad de concientizar a la población juvenil en la importancia que implica tener un acto sexual

Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life

The human gut microbiome matures towards the adult composition during the first years of life and is implicated in early immune development. Here, we investigate the effects of microbial genomic diversity on gut microbiome development using integrated early childhood data sets collected in the DIABIMMUNE study in Finland, Estonia and Russian Karelia. We show that gut microbial diversity is associated with household location and linear growth of children. Single nucleotide polymorphism- and metagenomic assembly-based strain tracking revealed large and highly dynamic microbial pangenomes, especially in the genus Bacteroides, in which we identified evidence of variability deriving from Bacteroides-targeting bacteriophages. Our analyses revealed functional consequences of strain diversity; only 10% of Finnish infants harboured Bifidobacterium longum subsp. infantis, a subspecies specialized in human milk metabolism, whereas Russian infants commonly maintained a probiotic Bifidobacterium bifidum strain in infancy. Groups of bacteria contributing to diverse, characterized metabolic pathways converged to highly subject-specific configurations over the first two years of life. This longitudinal study extends the current view of early gut microbial community assembly based on strain-level genomic variation.Peer reviewe

Sarcoma classification by DNA methylation profiling

Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features. Therefore, the diagnosis of sarcomas is burdened with a high inter-observer variability and misclassification rate. Here, we demonstrate classification of soft tissue and bone tumours using a machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma classifier is trained using a dataset of 1077 methylation profiles from comprehensively pre-characterized cases comprising 62 tumour methylation classes constituting a broad range of soft tissue and bone sarcoma subtypes across the entire age spectrum. The performance is validated in a cohort of 428 sarcomatous tumours, of which 322 cases were classified by the sarcoma classifier. Our results demonstrate the potential of the DNA methylation-based sarcoma classification for research and future diagnostic applications

New Pharmacological Agents to Aid Smoking Cessation and Tobacco Harm Reduction: What has been Investigated and What is in the Pipeline?

A wide range of support is available to help smokers to quit and aid attempts at harm reduction, including three first-line smoking cessation medications: nicotine replacement therapy, varenicline and bupropion. Despite the efficacy of these, there is a continual need to diversify the range of medications so that the needs of tobacco users are met. This paper compares the first-line smoking cessation medications to: 1) two variants of these existing products: new galenic formulations of varenicline and novel nicotine delivery devices; and 2) twenty-four alternative products: cytisine (novel outside of central and eastern Europe), nortriptyline, other tricyclic antidepressants, electronic cigarettes, clonidine (an anxiolytic), other anxiolytics (e.g. buspirone), selective 5-hydroxytryptamine (5-HT) reuptake inhibitors, supplements (e.g. St John’s wort), silver acetate, nicobrevin, modafinil, venlafaxine, monoamine oxidase inhibitors (MAOI), opioid antagonist, nicotinic acetylcholine receptors (nAChR) antagonists, glucose tablets, selective cannabinoid type 1 receptor antagonists, nicotine vaccines, drugs that affect gamma-aminobutyric acid (GABA) transmission, drugs that affect N-methyl-D-aspartate receptors (NMDA), dopamine agonists (e.g. levodopa), pioglitazone (Actos; OMS405), noradrenaline reuptake inhibitors, and the weight management drug lorcaserin. Six criteria are used: relative efficacy, relative safety, relative cost, relative use (overall impact of effective medication use), relative scope (ability to serve new groups of patients), and relative ease of use (ESCUSE). Many of these products are in the early stages of clinical trials, however, cytisine looks most promising in having established efficacy and safety and being of low cost. Electronic cigarettes have become very popular, appear to be efficacious and are safer than smoking, but issues of continued dependence and possible harms need to be considered