Industrial scale : estratègies metropolitanes per l'eficiència del transport industrial

El projecte "Industrial Scale" preten detectar i potenciar les condicions de contorn que ofereix un espai com el de l'estació de RENFE de Rubí. En primer lloc, detectem que és una estació molt infrautilitzada i d'ús pràcticament marginal, en un context totalment perifèric.D'altra banda, veiem potencial i oportunitat en la connectivitat a xarxes de mobilitat territorials, i la proximitat a grans superfícies de teixit industrial de caire productiu. A través d'un procés d'investigació hem observat que el transport amb tren és més eficient a nivell econòmic, energètic i ambiental. Amb aquestes condicions de contorn decidim intervenir sobre l'espai de l'estació de RENFE, proposant un canvi d'ús d'estació, de passatgers a port sec de mercaderies. Aquesta actuació permetrà al teixit industrial local una alternativa al transport rodat, a part de noves oportunitats i relacions econòmiques vinculades al corredor mediterrani de mercaderies, i per tant, un impacte socio-econòmic a la zona

Propuesta de rediseño del proceso de alistamiento de pedidos del centro de distribución de C.I. Dugotex

Ingeniero (a) IndustrialPregrad

Escala de Calgary para el diagnóstico del síncope vasovagal. Estudio de pruebas diagnósticas

ResumenObjetivoEvaluar la utilidad de la escala de Calgary en el diagnóstico de síncope vasovagal comparada con los resultados de la prueba de mesa inclinada (Tilt test) bajo protocolo sensibilizado con medicamentos.MetodologíaEstudio prospectivo de pruebas diagnósticas en pacientes con sospecha de síncope vasovagal sometidos a prueba de mesa inclinada (Tilt test) con vasodilatación inducida con nitroglicerina por vía sublingual. Se incluyeron pacientes mayores de 18 años de edad y se excluyeron pacientes con cardiopatía estructural documentada.ResultadosSe analizaron 100 pacientes, promedio de 48,7 años (DE 19,7), 69% de género femenino y 4% residentes en área rural. La mediana de síncopes al momento del Tilt test fue de 5 (RIQ 2-15) con presentación del primer episodio a los 41 años (RIQ 21-57), en el 52% de los pacientes no se identificaron desencadenantes y las manifestaciones clínicas referidas en los episodios previos al Tilt test fueron diaforesis (58%), palidez (55%), mareo (70%), palpitaciones (50%) y náuseas (42%); durante el Tilt test se reportaron mareo (65%), diaforesis (19%), náuseas (18%) y visión borrosa (18%). Se obtuvo una sensibilidad del 77,7% (IC95%: 66,7-88,8) y una especificidad del 40,5% (IC95%: 23,3-57,7) para la escala de Calgary.ConclusionesDebido a su buena sensibilidad y fácil aplicación, la escala de Calgary es un instrumento útil para el abordaje diagnóstico de pacientes con sospecha de síncope vasovagal y corazón estructuralmente sano, especialmente en menores de 50 años de edad.AbstractObjectiveEvaluate the utility of Calgary score for the diagnosis of vasovagal syncope compared with the results of the Tilt table test using sensibilized protocol with medicines.MethodologyProspective study of diagnostic tests in patients with suspected diagnostic of vasovagal syncope who underwent tilt table test with induced vasodilation with sublingual nitroglycerin. Patients over 18 years were included and patients with documented structural heart disease were excluded.Results100 patients were analyzed, averaging 48.7 years of age (SD 19.7), 69% of feminine genre and 4% residents in rural area. Medium of syncope at the moment of tilt table test was 5 (IQR 2-15), with presentation of first episode at 41 years (IQR 21-57), in 52% of the patients triggers were not identified and the clinical manifestations referred in episodes previous to Tilt test were diaphoresis (58%), pallor (55%), dizziness (70%), palpitations (50%) and nausea (42%); during the test dizziness (65%), diaphoresis (19%), nausea (18%) and blurred vision (18%) were reported. A sensitivity of 77.7% was obtained (95% CI 88.8 66.7) and specificity of 40.5% (95% CI 23.3 - 57.7) for the Calgary score.ConclusionsDue to its high sensitivity and easy application, the Calgary score is a useful diagnostic approach instrument for patients with suspected vasovagal syncope and who have a structurally healthy heart, especially in those younger than 50 years

Subtly modulating glycogen synthase kinase 3 ß: Allosteric inhibitor development and their potential for the treatment of chronic diseases

Glycogen synthase kinase 3 ß (GSK-3ß) is a central target in several unmet diseases. To increase the specificity of GSK-3ß inhibitors in chronic treatments, we developed small molecules allowing subtle modulation of GSK-3ß activity. Design synthesis, structure¿activity relationships, and binding mode of quinoline-3-carbohydrazide derivatives as allosteric modulators of GSK-3ß are presented here. Furthermore, we show how allosteric binders may overcome the ß-catenin side effects associated with strong GSK-3ß inhibition. The therapeutic potential of some of these modulators has been tested in human samples from patients with congenital myotonic dystrophy type 1 (CDM1) and spinal muscular atrophy (SMA) patients. We found that compound 53 improves delayed myogenesis in CDM1 myoblasts, while compounds 1 and 53 have neuroprotective properties in SMA-derived cells. These findings suggest that the allosteric modulators of GSK-3ß may be used for future development of drugs for DM1, SMA, and other chronic diseases where GSK-3ß inhibition exhibits therapeutic effects.This work was financially supported by MINECO (grant no. SAF2012-37979-C03-01 and SAF2016-76693-R to A.M. and IJCI-2014-20767 to V.P.). CCHMC funds L.T. A.M. and C.G. are members of the CIB Intramural Program “Molecular Machines for Better Life” (MACBET).Peer Reviewe

A plasma miRNA-based classifier for small cell lung cancer diagnosis

IntroductionSmall cell lung cancer (SCLC) is characterized by poor prognosis and challenging diagnosis. Screening in high-risk smokers results in a reduction in lung cancer mortality, however, screening efforts are primarily focused on non-small cell lung cancer (NSCLC). SCLC diagnosis and surveillance remain significant challenges. The aberrant expression of circulating microRNAs (miRNAs/miRs) is reported in many tumors and can provide insights into the pathogenesis of tumor development and progression. Here, we conducted a comprehensive assessment of circulating miRNAs in SCLC with a goal of developing a miRNA-based classifier to assist in SCLC diagnoses.MethodsWe profiled deregulated circulating cell-free miRNAs in the plasma of SCLC patients. We tested selected miRNAs on a training cohort and created a classifier by integrating miRNA expression and patients’ clinical data. Finally, we applied the classifier on a validation dataset.ResultsWe determined that miR-375-3p can discriminate between SCLC and NSCLC patients, and between SCLC and Squamous Cell Carcinoma patients. Moreover, we found that a model comprising miR-375-3p, miR-320b, and miR-144-3p can be integrated with race and age to distinguish metastatic SCLC from a control group.DiscussionThis study proposes a miRNA-based biomarker classifier for SCLC that considers clinical demographics with specific cut offs to inform SCLC diagnosis

Estudios de prospectiva en educación. Diversidad, inclusión y aprendizaje

Fil: Ferreyra, Horacio Ademar. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Pérez Moreno, Elena Silvia. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Pellizón, Telma de Lourdes, Universidad Católica de Córdoba. Facultad de Educación; Argentin

PDE 7 Inhibitors: New Potential Drugs for the Therapy of Spinal Cord Injury

BACKGROUND: Primary traumatic mechanical injury to the spinal cord (SCI) causes the death of a number of neurons that to date can neither be recovered nor regenerated. During the last years our group has been involved in the design, synthesis and evaluation of PDE7 inhibitors as new innovative drugs for several neurological disorders. Our working hypothesis is based on two different facts. Firstly, neuroinflammation is modulated by cAMP levels, thus the key role for phosphodiesterases (PDEs), which hydrolyze cAMP, is undoubtedly demonstrated. On the other hand, PDE7 is expressed simultaneously on leukocytes and on the brain, highlighting the potential crucial role of PDE7 as drug target for neuroinflammation. METHODOLOGY/PRINCIPAL FINDINGS: Here we present two chemically diverse families of PDE7 inhibitors, designed using computational techniques such as virtual screening and neuronal networks. We report their biological profile and their efficacy in an experimental SCI model induced by the application of vascular clips (force of 24 g) to the dura via a four-level T5-T8 laminectomy. We have selected two candidates, namely S14 and VP1.15, as PDE7 inhibitors. These compounds increase cAMP production both in macrophage and neuronal cell lines. Regarding drug-like properties, compounds were able to cross the blood brain barrier using parallel artificial membranes (PAMPA) methodology. SCI in mice resulted in severe trauma characterized by edema, neutrophil infiltration, and production of a range of inflammatory mediators, tissue damage, and apoptosis. Treatment of the mice with S14 and VP1.15, two PDE7 inhibitors, significantly reduced the degree of spinal cord inflammation, tissue injury (histological score), and TNF-α, IL-6, COX-2 and iNOS expression. CONCLUSIONS/SIGNIFICANCE: All these data together led us to propose PDE7 inhibitors, and specifically S14 and VP1.15, as potential drug candidates to be further studied for the treatment of SCI

A global agenda for advancing freshwater biodiversity research

Global freshwater biodiversity is declining dramatically, and meeting the challenges of this crisis requires bold goals and the mobilisation of substantial resources. While the reasons are varied, investments in both research and conservation of freshwater biodiversity lag far behind those in the terrestrial and marine realms. Inspired by a global consultation, we identify 15 pressing priority needs, grouped into five research areas, in an effort to support informed stewardship of freshwater biodiversity. The proposed agenda aims to advance freshwater biodiversity research globally as a critical step in improving coordinated actions towards its sustainable management and conservation

A global agenda for advancing freshwater biodiversity research

Global freshwater biodiversity is declining dramatically, and meeting the challenges of this crisis requires bold goals and the mobilisation of substantial resources. While the reasons are varied, investments in both research and conservation of freshwater biodiversity lag far behind those in the terrestrial and marine realms. Inspired by a global consultation, we identify 15 pressing priority needs, grouped into five research areas, in an effort to support informed stewardship of freshwater biodiversity. The proposed agenda aims to advance freshwater biodiversity research globally as a critical step in improving coordinated actions towards its sustainable management and conservation.Peer reviewe

Diversidad, inclusión y aprendizaje ¿Hacía dónde y cómo puede evolucionar el escenario “Trayectorias educativas flexibles y autogestionadas (Carnavalito)” En los próximos 10 años, según los medios de comunicación masiva?

Fil: Bertolez, Alejandra Marta. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Cipollone, Martín Daniel. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Erramouspe, Carolina del Valle. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Fredes Quiroz, Karen. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: González Yepes, Esteban. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Guzmán, Clara Mabel. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Heredia, María Carolina. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Heredia, María Carolina. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Monzón, Nancy. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Morales, María Celeste. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Olivera, Susana. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Pellizón, Telma de Lourdes. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Pérez Gaudio, José Miguel. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Pérez Moreno, Elena Silvia. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Porello, Andrea Silvina. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Previgliano, Silvia. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Rubiolo, Paula. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Sierra Puerto, Luz Dary. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Skiba, María Marta. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Tapia Figueroa, Andrea del Pilar. Universidad Católica de Córdoba. Facultad de Educación, ArgentinaFil: Taranzano, Gabriela Susana. Universidad Católica de Córdoba. Facultad de Educación, Argentin