Chaos around Holographic Regge Trajectories

Using methods of Hamiltonian dynamical systems, we show analytically that a dynamical system connected to the classical spinning string solution holographically dual to the principal Regge trajectory is non-integrable. The Regge trajectories themselves form an integrable island in the total phase space of the dynamical system. Our argument applies to any gravity background dual to confining field theories and we verify it explicitly in various supergravity backgrounds: Klebanov-Strassler, Maldacena-Nunez, Witten QCD and the AdS soliton. Having established non-integrability for this general class of supergravity backgrounds, we show explicitly by direct computation of the Poincare sections and the largest Lyapunov exponent, that such strings have chaotic motion.Comment: 28 pages, 5 figures. V3: Minor changes complying to referee's suggestions. Typos correcte

Chemical and biological investigations of Delonix regia (Bojer ex Hook.) Raf.

U radu je opisana izolacija pet sastojaka petroleterske i diklormetanske frakcije metanolnog ekstrakta kore biljke Delonix regia: lupeol (1), epilupeol (2), β-sitosterol (3), stigmasterol (4) i p-metoksibenzaldehid (5). Nadalje, testirano je antimikrobno djelovanje različitih ekstrakata difuzijskom metodom na disku (15 μg mm2). Zone inhibicije za sastojke topljive u petroleteru, tetraklormetanu i diklormetanu bile su 914 mm, 1113 mm, odnosno 920 mm, dok je zona inhibicije standarda kanamicina bila 2025 mm. U biološkom pokusu smrtnosti morskih kozica najveću toksičnost pokazali su spojevi topljivi u tetraklormetanu (LC50 = 0,83 μg mL1), dok je topljivost sastojaka topljivih u petroleteru i diklormetanu bila LC50 14,94, odnosno 3,29 μg mL1, a standarda vinkristin sulfata 0,812 μg mL1. Ovo je prvo izvješće o izolaciji sastojaka, antimikrobnom djelovanju i citotoksičnosti biljke D. regia.In this study five compounds, lupeol (1), epilupeol (2), β-sitosterol (3), stigmasterol (4) and p-methoxybenzaldehyde (5) were isolated from the petroleum ether and dichloromethane fractions of a methanolic extract of the stem bark of Delonix regia. Antimicrobial screening of the different extracts (15 μg mm2) was conducted by disc diffusion method. The zones of inhibition demonstrated by the petroleum ether, carbon tetrachloride and dichloromethane fractions ranged from 914 mm, 1113 mm and 920 mm, respectively, compared to kanamycin standard with the zone of inhibition of 2025 mm. In brine shrimp lethality bioassay, the carbon tetrachloride soluble materials demonstrated the highest toxicity with LC50 of 0.83 μg mL1, while petroleum ether and dichloromethane soluble partitionates of the methanolic extract revealed LC50 of 14.94 and 3.29 μg mL1, respectively, in comparison with standard vincristine sulphate with LC50 of 0.812 μg mL1. This is the first report on compounds separation from D. regia, their antimicrobial activity and cytotoxicity

VOSA: Virtual Observatory SED Analyzer. An application to the Collinder 69 open cluster

The physical properties of almost any kind of astronomical object can be derived by fitting synthetic spectra or photometry extracted from theoretical models to observational data. We want to develop an automatic procedure to perform this kind of fittings to a relatively large sample of members of a stellar association and apply this methodology to the case of Collinder 69. We combine the multiwavelength data of our sources and follow a work-flow to derive the physical parameters of the sources. The key step of the work-flow is performed by a new VO-tool, VOSA. All the steps in this process are done in a VO environment. We present this new tool, and provide physical parameters such as T$_{\rm eff}$, gravity, luminosity, etc. for $\sim$170 candidate members to Collinder 69, and an upper-limit for the age of this stellar association. This kind of studies of star forming regions, clusters, etc. produces a huge amount of data, very tedious to analyse using the traditional methodology. Thus, they are excellent examples where to apply the VO capabilities.Comment: Accepted for publication in A&

Panchromatic observations and modeling of the HV Tau C edge-on disk

We present new high spatial resolution (<~ 0.1") 1-5 micron adaptive optics images, interferometric 1.3 mm continuum and 12CO 2-1 maps, and 350 micron, 2.8 and 3.3 mm fluxes measurements of the HV Tau system. Our adaptive optics images reveal an unusually slow orbital motion within the tight HV Tau AB pair that suggests a highly eccentric orbit and/or a large deprojected physical separation. Scattered light images of the HV Tau C edge-on protoplanetary disk suggest that the anisotropy of the dust scattering phase function is almost independent of wavelength from 0.8 to 5 micron, whereas the dust opacity decreases significantly over the same range. The images further reveal a marked lateral asymmetry in the disk that does not vary over a timescale of 2 years. We further detect a radial velocity gradient in the disk in our 12CO map that lies along the same position angle as the elongation of the continuum emission, which is consistent with Keplerian rotation around an 0.5-1 Msun central star, suggesting that it could be the most massive component in the triple system. We use a powerful radiative transfer model to compute synthetic disk observations and use a Bayesian inference method to extract constraints on the disk properties. Each individual image, as well as the spectral energy distribution, of HV Tau C can be well reproduced by our models with fully mixed dust provided grain growth has already produced larger-than-interstellar dust grains. However, no single model can satisfactorily simultaneously account for all observations. We suggest that future attempts to model this source include more complex dust properties and possibly vertical stratification. (Abridged)Comment: 26 pages, 11 figures, editorially accepted for publication in Ap

ELISA in the multiplex era: potentials and pitfalls

Multiplex immunoassays confer several advantages over widely adopted singleplex immunoassays including increased efficiency at a reduced expense, greater output per sample volume ratios and higher throughput predicating more resolute, detailed diagnostics and facilitating personalised medicine. Nonetheless, to date, relatively few protein multiplex immunoassays have been validated for in vitro diagnostics in clinical/point-of-care settings. This review article will outline the challenges, which must be ameliorated prior to the widespread integration of multiplex immunoassays in clinical settings: (i) biomarker validation; (ii) standardisation of immunoassay design and quality control (calibration and quantification); (iii) availability, stability, specificity and cross-reactivity of reagents; (iv) assay automation and the use of validated algorithms for transformation of raw data into diagnostic results. A compendium of multiplex immunoassays applicable to in vitro diagnostics and a summary of the diagnostic products currently available commercially are included, along with an analysis of the relative states of development for each format (namely planar slide based, suspension and planar/microtitre plate based) with respect to the aforementioned issues