Assessing the capability of multi-scale drought datasets to quantify drought severity and to identify drought impacts: An example in the Ebro Basin

Assessing the risk, the severity and the likely evolution of droughts are key tasks for improving preparedness of regions prone to drought conditions, and mitigation of drought consequences. The access to real-time and high-quality climatic information is essential for this purpose. Different climatic databases are being developed and made available on real time by climatic research institutions, but their capability for quantifying droughts characteristics including severity, or spatio-temporal variability, is uncertain given their low spatial resolution. In this study, we assessed the capability of three databases with contrasted spatial resolution for measuring spatial and temporal variability of drought occurrence. The standardized precipitation index, calculated for each database, showed that the low resolution datasets allow an acceptable measurement of the magnitude, intensity and duration of droughts, while failing mostly in detecting the spatial patterns of the specific drought episodes. Moreover, the capability of the datasets for assessing the impacts of droughts on surface hydrology and tree growth was examined. Results confirmed the usefulness of the drought index for assessing drought impacts on water resources and forest ecosystems even when low resolution databases are used. © 2012 Royal Meteorological Society.This work has been supported by the research projects CGL2008-01189/BTE, CGL2011-27574-CO2-02 and CGL2011-27536 financed by the Spanish Commission of Science and Technology and FEDER, EUROGEOSS (FP7-ENV-2008-1-226487) and ACQWA (FP7-ENV-2007-1-212250) financed by the VII Framework Programme of the European Commission, ‘Efecto de los escenarios de cambio climático sobre la hidrología superficial y la gestión de embalses del Pirineo Aragonés’ financed by ‘Obra Social La Caixa’ and the Aragón Government and Influencia del cambio climático en el turismo de nieve, CTTP01/10, Financed by the Comisión de Trabajo de los Pirineos.Peer Reviewe

Drought impacts on vegetation activity, growth and primary production in humid and arid ecosystems

9 Pags., 5 Figs.[EN] We have evaluated the response of the Earth biomes to drought using a new global dataset that captures drought effects on vegetation at various time scales. We show that arid and humid biomes are both affected by drought, and that the time scale on which droughts most intensively affects vegetation plays a key role in determining the sensitivity of biomes to drought. Arid biomes respond to drought at short time scales because plants have mechanisms allowing them to rapidly adapt to changing water availability. Humid biomes also respond to drought at short time scales, probably because there plant species show a poor adaptability to water shortage. Sub-humid biomes respond to drought at long time scales because plants are adapted to withstand water deficit, but they lack the rapid post-drought recovery observed in arid biomes.[ES] En este trabajo se evalúa la respuesta de los diferentes biomas terrestre a la sequía mediante una base de datos nueva que captura el efecto de la sequía sobre la vegetación a diferentes escalas temporales. Se ha comprobado que los biomas característicos de zonas áridas y húmedas se ven afectados por la sequía, y que la escala temporal de la sequía juega un papel clave al determinar la sensibilidad de los biomas a la sequía. Los biomas áridos responden a las sequías medidas a escalas temporales cortas, debido a que las plantas tienen mecanismos que les permitan adaptarse rápidamente a la disponibilidad de agua. Los biomas húmedos también responden a la sequía a escalas temporales cortas, probablemente debido a que las especies ubicadas allí muestran una mala adaptación a la escasez de agua. Los biomas subhúmedos responden a la sequía a escalas de tiempo más largas, porque las plantas están adaptadas para soportar el déficit de agua, pero carecen de la rápida recuperación observada tras la sequía en los biomas áridos.This work was supported by projects financed by the Spanish Commission of Science and Technology (CGL2O1 1-27574-C02-02, CGL2O1 1-27536 and CGL2O1 1-26654) and the Aragón Government. J.J.C. thanks the support of ARAID and A.S-L. was supported by a postdoctoral fellowship from the Generalitat de Catalunya (2009 BP-A 00035).Peer reviewe

Drought impacts on vegetation activity, growth and primary production in humid and arid ecoystems

We have evaluated the response of the Earth biomes to drought using a new global dataset that captures drought effects on vegetation at various time scales. We show that arid and humid biomes are both affected by drought, and that the time scale on which droughts most intensively affects vegetation plays a key role in determining the sensitivity of biomes to drought. Arid biomes respond to drought at short time scales because plants have mechanisms allowing them to rapidly adapt to changing water availability. Humid biomes also respond to drought at short time scales, probably because there plant species show a poor adaptability to water shortage. Sub-humid biomes respond to drought at long time scales because plants are adapted to withstand water deficit, but they lack the rapid post-drought recovery observed in arid biomes.Peer Reviewe

Evidence of increasing drought severity caused by temperature rise in southern Europe

We use high quality climate data from ground meteorological stations in the Iberian Peninsula (IP) and robust drought indices to confirm that drought severity has increased in the past five decades, as a consequence of greater atmospheric evaporative demand resulting from temperature rise. Increased drought severity is independent of the model used to quantify the reference evapotranspiration. We have also focused on drought impacts to droughtsensitive systems, such as river discharge, by analyzing streamflow data for 287 rivers in the IP, and found that hydrological drought frequency and severity have also increased in the past five decades in natural, regulated and highly regulated basins. Recent positive trend in the atmospheric water demand has had a direct influence on the temporal evolution of streamflows, clearly identified during the warm season, in which higher evapotranspiration rates are recorded. This pattern of increase in evaporative demand and greater drought severity is probably applicable to other semiarid regions of the world, including other Mediterranean areas, the Sahel, southern Australia and South Africa, and can be expected to increasingly compromise water supplies and cause political, social and economic tensions among regions in the near future.This work has been supported by research projects CGL201127574CO202, CGL201127536 and CGL2011–24185 financed by the Spanish Commission of Science and Technology and FEDER, ‘Demonstration and validation of innovative methodology for regional climate change adaptation in the Mediterranean area (LIFE MEDACC)’ financed by the LIFE programme of the European Commission, CTTP1/12, financed by the Comunidad de Trabajo de los Pirineos, and QSECA (PTDC/AAGGLO/ 4155/2012) funded by the Portuguese Foundation for Science and Technology (FCT). ASL was supported by a postdoctoral fellowship from the Catalan Government (2011 BPB 00078) and CAM was supported by a Juan de la Cierva fellowship by the Spanish Government

The complex influence of ENSO on droughts in Ecuador

48 Pags.- 1 Tabl.- 18 Figs. The definitive version is available at: http://link.springer.com/journal/382In this study, we analyzed the influence of El Niño–Southern Oscillation (ENSO) on the spatio-temporal variability of droughts in Ecuador for a 48-year period (1965–2012). Droughts were quantified from 22 high-quality and homogenized time series of precipitation and air temperature by means of the Standardized Precipitation Evapotranspiration Index. In addition, the propagation of two different ENSO indices (El Niño 3.4 and El Niño 1 + 2 indices) and other atmospheric circulation processes (e.g., vertical velocity) on different time-scales of drought severity were investigated. The results showed a very complex influence of ENSO on drought behavior across Ecuador, with two regional patterns in the evolution of droughts: (1) the Andean chain with no changes in drought severity, and (2) the Western plains with less severe and frequent droughts. We also detected that drought variability in the Andes mountains is explained by the El Niño 3.4 index [sea surface temperature (SST) anomalies in the central Pacific], whereas the Western plains are much more driven by El Niño 1 + 2 index (SST anomalies in the eastern Pacific). Moreover, it was also observed that El Niño and La Niña phases enhance droughts in the Andes and Western plains regions, respectively. The results of this work could be crucial for predicting and monitoring drought variability and intensity in Ecuador.This work was supported by the EPhysLab (UVIGO-CSIC Associated Unit) and the research projects I-COOP H2O 2013CD0006: “Test multisectorial y actividades demostrativa sobre el potencial desarrollo de sistemas de monitorización de sequías en tiempo real en la región del oeste de Sudamérica” financed by the Spanish National Research Council, CGL2011-27574-CO2-02, CGL2014-52135-C03-01 and Red de variabilidad y cambio climático RECLIM (CGL2014-517221-REDT), financed by the Spanish Commission of Science and Technology and FEDER, and “LIFE12 ENV/ES/000536-Demonstration and validation of innovative methodology for regional climate change adaptation in the Mediterranean area (LIFE MEDACC)” financed by the LIFE programme of the European Commission. Cesar Azorin-Molina was supported by the JCI-2011-10263 Grant. Arturo Sanchez-Lorenzo was supported by the JCI-2012-12508 Grant. Miquel Tomas-Burguera was supported by a doctoral grant by the Ministry of Economy and Competitiveness and Natalia Martin-Hernandez was supported by a doctoral grant by the Aragón Regional Government. E. Aguilar was funded by the Grant CCI-009-ATN/OC-12439-RG-2012 from the Banco Iberoamericano de Desarrollo.Peer reviewe

Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging

19 Páginas.-- 7 FigurasATP-citrate lyase is a central integrator of cellular metabolism in the interface of protein, carbohydrate, and lipid metabolism. The physiological consequences as well as the molecular mechanisms orchestrating the response to long-term pharmacologically induced Acly inhibition are unknown. We report here that the Acly inhibitor SB-204990 improves metabolic health and physical strength in wild-type mice when fed with a high-fat diet, while in mice fed with healthy diet results in metabolic imbalance and moderated insulin resistance. By applying a multiomic approach using untargeted metabolomics, transcriptomics, and proteomics, we determined that, in vivo, SB-204990 plays a role in the regulation of molecular mechanisms associated with aging, such as energy metabolism, mitochondrial function, mTOR signaling, and folate cycle, while global alterations on histone acetylation are absent. Our findings indicate a mechanism for regulating molecular pathways of aging that prevents the development of metabolic abnormalities associated with unhealthy dieting. This strategy might be explored for devising therapeutic approaches to prevent metabolic diseases.This work was funded by grants from the Ministerio de Economía y Competitividad, Instituto de Salud Carlos III, co-funded by Fondos FEDER (PI15/00134, PI18/01590, CPII19/00023 to A.M.M.) and the Ministerio de Ciencia e Innovación (PID2021-123965OB-100 to A.M.M.). A.M.M. is funded by the Junta de Andalucía P20_00480, the Spanish Society of Diabetes, and CSIC 202220I059. M.S.K. is funded by the Nordea Foundation (#02-2017-1749), the Novo Nordisk Foundation (#NNF17OC0027812), the Neye Foundation, the Lundbeck Foundation (#R324-2019-1492), the Ministry of Higher Education and Science of Denmark (#0238-00003B). V.C.G. is funded by the Instituto de Salud Carlos III (CP19/00046), co-funded by FEDER. F.M. is funded by the CIBERDEM of the Instituto de Salud Carlos III. A.M.M. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. We acknowledge the support of the group of basic research on diabetes of the Spanish Society of Diabetes.Peer reviewe

Nutrición parenteral domiciliaria en España, 2019: informe del Grupo de Nutrición Artificial Domiciliaria y Ambulatoria NADYA

RESUMEN Objetivo: comunicar los datos de nutrición parenteral domiciliaria (NPD) obtenidos del registro del grupo NADYA-SENPE (www.nadyasenpe.com) del año 2019. Material y métodos: análisis descriptivo de los datos recogidos de pacientes adultos y pediátricos con NPD en el registro NADYA-SENPE desde el 1 de enero al 31 de diciembre de 2019. Resultados: se registraron 283 pacientes (51,9 %, mujeres), 31 niños y 252 adultos procedentes de 47 hospitales españoles, lo que representa una tasa de prevalencia de 6,01 pacientes/millón de habitantes/año 2019. El diagnóstico más frecuente en los adultos fue “oncológico paliativo” y “otros” (21,0 %). En los niños fue la enfermedad de Hirschsprung junto a la enterocolitis necrotizante, las alteraciones de la motilidad intestinal y la pseudoobstrucción intestinal crónica, con 4 casos cada uno (12,9 %). El primer motivo de indicación fue el síndrome del intestino corto tanto en los niños (51,6 %) como en los adultos (37,3 %). El tipo de catéter más utilizado fue el tunelizado tanto en los niños (75,9 %) como en los adultos (40,8 %). Finalizaron 68 episodios, todos en adultos: la causa más frecuente fue el fallecimiento (54,4 %). Pasaron a la vía oral el 38,2 %. Conclusiones: el número de centros y profesionales colaboradores con el registro NADYA va incrementándose. Se mantienen estables las principales indicaciones y los motivos de finalización de la NPD

Registro Español de Trasplante Cardiaco. XXXI Informe Oficial de la Asociación de Insuficiencia Cardiaca de la Sociedad Española de Cardiología

Introducción y objetivos Se presentan las características clínicas y los resultados de los trasplantes cardiacos realizados en España con la actualización correspondiente a 2019. Métodos Se describen las características clínicas y los resultados de los trasplantes cardiacos realizados en 2019, así como las tendencias de estos en el periodo 2010-2018. Resultados En 2019 se realizaron 300 trasplantes (8.794 desde 1984; 2.745 entre 2010 y 2019). Respecto a años previos, los cambios más llamativos son el descenso hasta el 38% de los trasplantes realizados en código urgente, y la consolidación en el cambio de asistencia circulatoria pretrasplante, con la práctica desaparición del balón de contrapulsación (0, 7%), la estabilización del uso del oxigenador extracorpóreo de membrana (9, 6%) y el aumento de los dispositivos de asistencia ventricular (29%). La supervivencia en el trienio 2016-2018 es similar a la del trienio 2013-2015 (p = 0, 34), y ambas mejores que la del trienio 2010-2012 (p = 0, 002 y p = 0, 01 respectivamente). Conclusiones Se mantienen estables tanto la actividad del trasplante cardiaco en España como los resultados en supervivencia en los últimos 2 trienios. Hay una tendencia a realizar menos trasplantes urgentes, la mayoría con dispositivos de asistencia ventricular. Introduction and objectives: The present report describes the clinical characteristics and outcomes of heart transplants in Spain and updates the data to 2019. Methods: We describe the clinical characteristics and outcomes of heart transplants performed in Spain in 2019, as well as trends in this procedure from 2010 to 2018. Results: In 2019, 300 transplants were performed (8794 since 1984; 2745 between 2010 and 2019). Compared with previous years, the most notable findings were the decreasing rate of urgent transplants (38%), and the consolidation of the type of circulatory support prior to transplant, with an almost complete disappearance of counterpulsation balloon (0.7%), stabilization in the use of extracorporeal membrane oxygenation (9.6%), and an increase in the use of ventricular assist devices (29.0%). Survival from 2016 to 2018 was similar to that from 2013 to 2015 (P = .34). Survival in both these periods was better than that from 2010 to 2012 (P = .002 and P = .01, respectively). Conclusions: Heart transplant activity has remained stable during the last few years, as have outcomes (in terms of survival). There has been a trend to a lower rate of urgent transplants and to a higher use of ventricular assist devices prior to transplant

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Variabilidad interanual del manto de nieve en el Pirineo: tendencias observadas y su relación con índices de teleconexión durante el periodo 1985-2011

[ES] Desde diciembre de 1985 el Programa ERHIN realiza tres mediciones anuales (enero, marzo y finales de abril) del espesor de nieve en 114 balizas localizadas en el Pirineo central español. En este trabajo se han utilizado dichas series, junto a información de densidad de la nieve en alguna de las balizas para estudiar la evolución interanual del manto de nieve en el Pirineo, conocer su tendencia en las últimas décadas y relacionar dicha evolución temporal con la influencia de distintos índices de teleconexión atmosférica. Se ha aplicado un análisis de componentes principales que ha permitido distinguir cuatro patrones de evolución interanual del manto de nieve en la zona de estudio. Todos ellos indican una elevada variabilidad interanual en el manto de nieve. El principal patrón de la zona de estudio se encuentra negativamente correlacionado con la Oscilación del Atlántico Norte (NAO) y ha experimentado un ligero aumento de los espesores de nieve durante el periodo analizado. Las balizas más próximas a la divisoria de aguas principal no están afectadas por la NAO, mientras que muestran una correlación negativa con la oscilación del Mediterráneo Oriental (EM). Dos grupos definen a las balizas situadas en el sector más oriental de la zona de estudio. En esta zona se produce un descenso en la acumulación de nieve durante el periodo 1985-2011, pero la tendencia es significativa en pocas balizas, y los índices de teleconexión considerados no afectan a la variabilidad interanual del espesor de nieve.; [EN] Since December 1985, the ERHIN program performs three measurements during the year (January, March and late April) the snow depth in 114 points located in the central Spanish Pyrenees. In this paper we have used these series, with snow density information of some snow poles to study the interannual evolution of the snowpack in the Pyrenees, to know the trend in recent decades and to relate this temporal evolution with the influence of different teleconnection patterns. A principal component analysis (PCA) identified four patterns of inter-annual evolution of snow cover in the study area. They indicate a high interannual variability in the snowpack. The main pattern of the study area is negatively correlated with the North Atlantic Oscillation (NAO) and has experienced a slight increase in snow depths during the study period. The closest snow poles to the main divide of the Pyrenees are not affected by the NAO, VARIABILIDAD INTERANUAL DEL MANTO DE NIEVE EN EL PIRINEO: TENDENCIAS OBSERVADAS Y SU RELACIÓN CON ÍNDICES DE TELECONEXIÓN DURANTE EL PERIODO 1985-2011 Jesús REVUELTO BENEDÍ1 , Juan I. LÓPEZ MORENO1 , Enrique MORÁN TEJEDA2 , Steven FASSNACHT3 , Sergio M. VICENTE SERRANO1 , 1 Instituto Pirenaico de Ecología, CSIC Zaragoza 2 CI3, Climate Change and Climate Impacts Group. University of Geneva, Swizzerland. 3 ,Colorado State University, Fort Collins, Colorado, USA. [email protected], [email protected], [email protected], [email protected], [email protected] showing a negative correlation with the oscillation of the Eastern Mediterranean (EM). Two groups define the snow poles located in the eastern part of the study area. In this area there is a decrease in the accumulation of snow during the period 1985-2011, but the trend is significant only in a few points, and teleconnection indices considered do not affect the interannual variability of snow depthPeer Reviewe