Ex senatu eiecti sunt: Expulsion from the Senate of the Roman Republic, c. 319-50 BC

One of the major duties performed by the censors of the Roman Republic was that of the lectio senatus, the enrolment of the Senate. As part of this process they were able to expel from that body anyone whom they deemed unequal to the honour of continued membership. Those expelled were termed ‘praeteriti’. While various aspects of this important and at-times controversial process have attracted scholarly attention, a detailed survey has never been attempted. The work is divided into two major parts. Part I comprises four chapters relating to various aspects of the lectio. Chapter 1 sees a close analysis of the term ‘praeteritus’, shedding fresh light on senatorial demographics and turnover – primarily a demonstration of the correctness of the (minority) view that as early as the third century the quaestorship conveyed automatic membership of the Senate to those who held it. It was not a Sullan innovation. In Ch.2 we calculate that during the period under investigation, c.350 members were expelled. When factoring for life expectancy, this translates to a significant mean lifetime risk of expulsion: c.10%. Also, that mean risk was front-loaded, with praetorians and consulars significantly less likely to be expelled than subpraetorian members. In Ch.3 and 4 we discuss the mechanics of the lectio and review legislative and personal responses to expulsion, including the observations that censors were sensible to a number of societal constraints, among them the opinions of outside actors; also, that expulsion was not necessarily an insuperable setback. Part II comprises a single chapter, a catalogue of all known named praeteriti. An Appendix presents all source testimonia that allude to each praeteritus’ expulsion. The chronological range is bookended by the promulgation of the plebiscitum Ovinium (which gave censors the responsibility of performing the lectio) and the final censorship of the functioning Republic

Impacts of climate variability and future climate change on harmful algal blooms and human health

This is the final version of the article. Available from BioMed Central via the DOI in this record.Anthropogenically-derived increases in atmospheric greenhouse gas concentrations have been implicated in recent climate change, and are projected to substantially impact the climate on a global scale in the future. For marine and freshwater systems, increasing concentrations of greenhouse gases are expected to increase surface temperatures, lower pH, and cause changes to vertical mixing, upwelling, precipitation, and evaporation patterns. The potential consequences of these changes for harmful algal blooms (HABs) have received relatively little attention and are not well understood. Given the apparent increase in HABs around the world and the potential for greater problems as a result of climate change and ocean acidification, substantial research is needed to evaluate the direct and indirect associations between HABs, climate change, ocean acidification, and human health. This research will require a multidisciplinary approach utilizing expertise in climatology, oceanography, biology, epidemiology, and other disciplines. We review the interactions between selected patterns of large-scale climate variability and climate change, oceanic conditions, and harmful algae.This work was funded in part through grants from the NSF/NIEHS Centers for Oceans and Human Health, grant numbers NSF OCE04-32479 and NIEHS P50 ES012740 (EAL), NSF OCE-0432368 and NIEHS P50 ES012736 (LEF), NIEHS P50 ES012762 and NSF OCE-0434087 (SKM, MSP). SKM, VLT and NJM also were supported in part by the West Coast Center for Oceans and Human Health (WCCOHH) as part of the NOAA Oceans and Human Health Initiative, and this is WCCOHH publication no. 26. The WCCOHH is part of the National Marine Fisheries Service's Northwest Fisheries Science Center, Seattle, Washington

Tensile Behaviour of S690QL and S960QL under High Strain Rate

Despite offering significant strength-to-weight advantages, high-strength structural steels, such as S690QL and S960QL, are used only in limited offshore applications. This is due to the lack of material characterisation in regard to their tensile behaviour, with little data available on loading rates other than those typically experienced offshore. The concern is that high strength structural steels with high yield-to-tensile ratio >0.90 are obtained at the expense of ductility and strain-hardening capacity. In this paper the tensile properties from two high strength structural steels were studied and characterised over a range of strain rates and, the results are compared against the performance of mild steel. High strength structural steels with yield-to-tensile ratios in excess of 0.90 were significantly less sensitive to the effect of strain rate than mild steel with yield-to-tensile < 0.85 at ambient temperature. The yield stress of S690QL and S960QL moderately increase to about 9% and 6% respectively from quasi-static to 100 s-1 strain rate, which is within typical strain rates encountered in primary offshore structural applications

Influence of Loading Rate on the Fracture Toughness of High Strength Structural Steel

It is known that rates of loading influence the fracture behaviour of most ferritic steels. High loading rates could change a stable ductile tearing behaviour to an unstable brittle fracture by altering the ductile-to-brittle transition curve. This is predicted to be material dependent, with lower strength structural steels showing a larger tensile property loading rate sensitivity compared to high strength structural steels. A programme of mechanical testing was carried out on S690QL and S960QL to determine the influence of loading rate on the fracture behaviour of high strength structural steels with yield strength > 690 MPa and yield-to-tensile ratio above 0.90. The loading rates considered are those anticipated in offshore in-service conditions, with K-rates up to the order of magnitude of 106 MPa√m/s. Results from tensile tests show that the strengths of these grade of steels are relatively unaffected by the effect of loading rate. However, brittle fracture, which is controlled by material strengthening as a result of principal stress in front of the crack, is both loading rate and temperature dependent. Results from tests at quasi-static and elevated loading rates show changes in the fracture behaviour in terms of transition temperature. A shift to a higher ductile-to-brittle transition temperature was observed as the loading rate increases. This was associated with a reduction in the fracture toughness value on the lower transition region. The reference temperature, T0, at a K-rate of 1 MPa √m/s using Master Curve concepts is estimated to be around -116 °C and -108 °C for Charpy-sized pre-cracked and standard (25x25 mm) SENB specimens respectively, under quasi-static conditions for S690QL. The dynamic T0,d is -70.4 °C in the same steel for Charpy-sized pre-cracked specimens at K-rates up to 106 MPa √m/s.Lloyd’s Register Foundatio

Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function

GABAA receptor-mediated currents shift from excitatory to inhibitory during postnatal brain development in rodents. A postnatal increase in KCC2 protein expression is considered to be the sole mechanism controlling the developmental onset of hyperpolarizing synaptic transmission, but here we identify a key role for KCC2 phosphorylation in the developmental EGABA shift. Preventing phosphorylation of KCC2 in vivo at either residue serine 940 (S940), or at residues threonine 906 and threonine 1007 (T906/T1007), delayed or accelerated the postnatal onset of KCC2 function, respectively. Several models of neurodevelopmental disorders including Rett syndrome, Fragile × and Down’s syndrome exhibit delayed postnatal onset of hyperpolarizing GABAergic inhibition, but whether the timing of the onset of hyperpolarizing synaptic inhibition during development plays a role in establishing adulthood cognitive function is unknown; we have used the distinct KCC2-S940A and KCC2-T906A/T1007A knock-in mouse models to address this issue. Altering KCC2 function resulted in long-term abnormalities in social behavior and memory retention. Tight regulation of KCC2 phosphorylation is therefore required for the typical timing of the developmental onset of hyperpolarizing synaptic inhibition, and it plays a fundamental role in the regulation of adulthood cognitive function

N=4 Superconformal Algebra and the Entropy of HyperKahler Manifolds

We study the elliptic genera of hyperKahler manifolds using the representation theory of N=4 superconformal algebra. We consider the decomposition of the elliptic genera in terms of N=4 irreducible characters, and derive the rate of increase of the multiplicities of half-BPS representations making use of Rademacher expansion. Exponential increase of the multiplicity suggests that we can associate the notion of an entropy to the geometry of hyperKahler manifolds. In the case of symmetric products of K3 surfaces our entropy agrees with the black hole entropy of D5-D1 system.Comment: 25 pages, 1 figur

Latent cluster analysis of ALS phenotypes identifies prognostically differing groups

BACKGROUND Amyotrophic lateral sclerosis (ALS) is a degenerative disease predominantly affecting motor neurons and manifesting as several different phenotypes. Whether these phenotypes correspond to different underlying disease processes is unknown. We used latent cluster analysis to identify groupings of clinical variables in an objective and unbiased way to improve phenotyping for clinical and research purposes. METHODS Latent class cluster analysis was applied to a large database consisting of 1467 records of people with ALS, using discrete variables which can be readily determined at the first clinic appointment. The model was tested for clinical relevance by survival analysis of the phenotypic groupings using the Kaplan-Meier method. RESULTS The best model generated five distinct phenotypic classes that strongly predicted survival (p<0.0001). Eight variables were used for the latent class analysis, but a good estimate of the classification could be obtained using just two variables: site of first symptoms (bulbar or limb) and time from symptom onset to diagnosis (p<0.00001). CONCLUSION The five phenotypic classes identified using latent cluster analysis can predict prognosis. They could be used to stratify patients recruited into clinical trials and generating more homogeneous disease groups for genetic, proteomic and risk factor research

A topological Dirac insulator in a quantum spin Hall phase : Experimental observation of first strong topological insulator

When electrons are subject to a large external magnetic field, the conventional charge quantum Hall effect \cite{Klitzing,Tsui} dictates that an electronic excitation gap is generated in the sample bulk, but metallic conduction is permitted at the boundary. Recent theoretical models suggest that certain bulk insulators with large spin-orbit interactions may also naturally support conducting topological boundary states in the extreme quantum limit, which opens up the possibility for studying unusual quantum Hall-like phenomena in zero external magnetic field. Bulk Bi$_{1-x}$Sb$_x$ single crystals are expected to be prime candidates for one such unusual Hall phase of matter known as the topological insulator. The hallmark of a topological insulator is the existence of metallic surface states that are higher dimensional analogues of the edge states that characterize a spin Hall insulator. In addition to its interesting boundary states, the bulk of Bi$_{1-x}$Sb$_x$ is predicted to exhibit three-dimensional Dirac particles, another topic of heightened current interest. Here, using incident-photon-energy-modulated (IPEM-ARPES), we report the first direct observation of massive Dirac particles in the bulk of Bi$_{0.9}$Sb$_{0.1}$, locate the Kramers' points at the sample's boundary and provide a comprehensive mapping of the topological Dirac insulator's gapless surface modes. These findings taken together suggest that the observed surface state on the boundary of the bulk insulator is a realization of the much sought exotic "topological metal". They also suggest that this material has potential application in developing next-generation quantum computing devices.Comment: 16 pages, 3 Figures. Submitted to NATURE on 25th November(2007

circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan

This is the final version. Available from Springer via the DOI in this record. Circular RNAs (circRNAs) are an emerging class of non-coding RNA molecules that are thought to regulate gene expression and human disease. Despite the observation that circRNAs are known to accumulate in older organisms and have been reported in cellular senescence, their role in aging remains relatively unexplored. Here, we have assessed circRNA expression in aging human blood and followed up age-associated circRNA in relation to human aging phenotypes, mammalian longevity as measured by mouse median strain lifespan and cellular senescence in four different primary human cell types. We found that circRNAs circDEF6, circEP300, circFOXO3 and circFNDC3B demonstrate associations with parental longevity or hand grip strength in 306 subjects from the InCHIANTI study of aging, and furthermore, circFOXO3 and circEP300 also demonstrate differential expression in one or more human senescent cell types. Finally, four circRNAs tested showed evidence of conservation in mouse. Expression levels of one of these, circPlekhm1, was nominally associated with lifespan. These data suggest that circRNA may represent a novel class of regulatory RNA involved in the determination of aging phenotypes, which may show future promise as both biomarkers and future therapeutic targets for age-related disease.University of Exeter, Medical Research Council Clinical Infrastructure awardWellcome TrustBBSRC LOLANI

Hereditary angioedema: New therapeutic options for a potentially deadly disorder

Although the biochemistry of hereditary angioedema (HAE) is fairly well understood today, the lag in diagnosis of a decade or more suggests that clinicians have low awareness of this disease. This lag in diagnosis and hence treatment certainly stems from the rarity and complexity of the presentation which can be easily mistaken for allergic and non-allergic reactions alike. The symptoms of the disease include acute swelling of any or multiple parts of the body. The attacks may be frequent or rare, and they may vary substantially in severity, causing stomach discomfort or periorbital swelling in mild cases and hypovolemic shock due to abdominal fluid shift or asphyxiation in the most severe cases. Given that these patients are at significant risk for poor quality of life and death, greater awareness of this disease is needed to ensure that newly available, effective medications are used in these patients. These new medications represent significant advances in HAE therapy because they are targeted at the plasma cascades implicated in the pathophysiology of this disease. The clinical presentation of HAE, overlapping symptoms with other angioedemas, and available therapies are reviewed